• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1096-1101
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• 2003

To enhance the liver targeting and reduce the side effects of 5-fluorouracil (5-Fu), it was acylated by stearyl chloride to obtain .$\b{N}_{\b{1}}$stearyl-5-Fu (5-FuS). The chemical structure of the prodrug was confirmed by Nuclear Magnetic Resonance and Infrared Spectrometry. 5-FuS was incorporated into solid lipid nanoparticles (SLN), which were prepared by the physical agglomeration method. The mean diameter of 5-FuS-SLN was 240.19 nm and the drug loading was 20.53%. The release characteristics in vitro of 5-FuS-SLN were fitted to the first-order pharmacokinetic model. Compared with 5-Fu injection, a study on the distribution of 5-FuS-SLN in mice showed that 5-FuS-SLN could double 5-Fu concentration in mice livers. The main pharmacokinetic parameters of 5-FuS-SLN in rabbits is shown as follows: $V_d$=0.04336L/kg, $T_{1/2} \beta$=1.2834h, CL=0.1632 L/h. In conclusion, 5-FuS-SLN has significant liver targeting properties. The employment of a prodrug to enhance drug liposoluble properties and the preparation method presented in this paper, seem to be an alternative strategy to the traditional colloidal delivery system.

• Journal of Pharmaceutical Investigation
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• v.40 no.6
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• pp.373-378
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• 2010

In order to develop a topical preparation which has a high occlusive property with skin moisturization, nano-structured lipid carrier (NLC) systems along with solid lipid nanoparticle (SLN) were designed. Various NLC dispersions were successfully formulated with Compritol 888 ATO as a solid lipid, Labrafil M 1944 CS as an oil, and Tween 80 as a surfactant. The increase of oil content (5 to 50%) led to the decrease in the occlusion factor in the order of SLN > NLC-5 > NLC-15 = NLC-30 > NLC-50. Particle size of lipid particulates was in the range of 100 to 160 nm. NLC-based carbogels were prepared by the employment of humectants such as urea, glycerin, and Tinocare GL to carbomer gel. NLC-30 gel formulations containing 4 or 8 % of lipid particles showed improved occlusive effect in vitro, compared to NLC-free gel base. Even though NLC-free gel base revealed comparable occlusion effect by itself, the occlusion factor of 4 % NLC-30 gel was about 2-fold higher than that of NLC-free gel base.

• Journal of Korean Academy of Nursing
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• v.54 no.3
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• pp.358-371
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• 2024

Purpose: This study aimed to analyze the experiences of new nurses during their first year of hospital employment to gather data for the development of an evidence-based new nurse residency program focused on adaptability. Methods: This study was conducted at a tertiary hospital in Korea between March and August 2021 with 80 new nurses who wrote in critical reflective journals during their first year of work. NetMiner 4.5.0 was used to conduct a text network analysis of the critical reflective journals to uncover core keywords and topics across three periods. Results: In the journals, over time, degree centrality emerged as "study" and "patient understanding" for 1 to 3 months, "insufficient" and "stress" for 4 to 6 months, and "handover" and "preparation" for 7 to 12 months. Major sub-themes at 1 to 3 months were: "rounds," "intravenous-cannulation," "medical device," and "patient understanding"; at 4 to 6 months they were "admission," "discharge," "oxygen therapy," and "disease"; and at 7 to 12 months they were "burden," "independence," and "solution." Conclusion: These results provide valuable insights into the challenges and experiences encountered by new nurses during different stages of their field adaptation process. This information may highlight the best nurse leadership methods for improving institutional education and supporting new nurses' transitions to the hospital work environment.

• The Journal of the Korea Contents Association
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• v.22 no.8
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• pp.297-306
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• 2022

This study aims to verify the influence of coffee education service quality recognized by trainees wishing to get a job at coffee-related companies on job preparation behavior through education satisfaction and recommendation intention. In order to achieve the research purpose, this study posited five research hypotheses based on relative literature and also established a research model with the five hypotheses. This study shows the following research results. First, the study found that coffee education service quality had a positive and significant impact on education satisfaction. Second, the study found that educational satisfaction had a positive and significant impact on recommendation intention. Third, the study found that educational satisfaction had a positive and significant impact on job preparation behavior. Fourth, the study found that education satisfaction had a positive and significant impact on the effect of coffee education service quality on recommendation intention. Fifth, the study found that education satisfaction had a positive and significant impact on the effect of coffee education service quality on employment recommendation intention. Such findings of this study imply practical suggestions that the characteristics of a wide range of trainees in the study of coffee education service quality and satisfaction, and provide practical suggestions to help improve the future direction of education services and competitiveness of coffee education institutions.

• Korean Security Journal
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• no.11
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• pp.21-36
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• 2006

This study aims to grasp the general conditions regarding university students in security related majors in Korea. Followings will be covered here: what motivated them to choose those majors, how much are they satisfied with major curriculum course after matriculation, whether they got jobs through the education, what is their consciousness on their majors, jobs, and courses like, and what effects their job preference. And this study also aims at helping the students with their future plans such as admission to a school of higher grade and choosing their job. For this study, we distributed 340 cpoies to the students in security related majors at 4 four-year colleges and 1 two-year college, and collected 298 copies by means of quota sampling method. For collected questionnaires, we used individual T-test verification and one-way ANOVA analysis to grasp the situation. Significance standard for the test results was set as p<0.05. Following are the test results. First, the analysis on students' satisfaction rate resulted in male students' average of 2.42, compared to female students' average of 2.10, which shows female students have higher satisfaction rate in choosing their majors than male students. Secondly, The results on analysis of satisfaction rate on their curriculums, classes, and majors show that students in security-related majors showed different satisfaction rate and different averages according to their sex and the year of the college. The study indicates that males have higher satisfaction rate on curriculum than females, with male students' average of 2.63 and female students' average 2.88. According to the year of the college, there was a significant difference statistically, Statistics show that students at two-year college have higher satisfaction rate than those at four-year college, with two-year college students' average of 2.48 and four-year college students' of 2.74. students have the average of 3.56. The higher year they were in, the more improvement the curriculum required. When it comes to convenience offer for employment, male students expected more from school than female students, with males' average of 2.74 and females' average of 4.07. Male students marked higher than female students in the extent of job information offer, with males' average of 2.96 and females' average of 2.59. Fourthly, when students in security-related majors were surveyed on their consciousness of their future plans such as getting jibs, two-year college students had more certificates of qualification for employment than four-year college students. What they do preponderantly in preparation for employment was studying foreign languages, which took up 40.4%. And when they were asked on their confidence for employment, positive answers were far more than negative ones with the percentage of 39.6%, while negative took up just 14.0%. Fifthly, when it come to the students in security-related students' job preferences, 49.2% preferred safe job conditions in public security area and 34% preferred private guard or private security organizations. And in the public security area, the highest percentage of 28.6 preferred to work in presidential security service. In the area of private security, 21.2% showed interests in private guard and private security organizations.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.4
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• pp.1585-1593
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• 2012

Year 2010 was the first year in which the baby boomer generation began to regularly retire by the corporate retirement system. For the following 10 years from then, large scale retirement of the baby boomer generation that used to be the driving force of economic growth in Korean society is expected to cause various social problems such as reduction in labor force and economic loss from transfer to welfare subjects. In relation to reemployment of the baby boomer generation after retirement, this study was attempted first, for analysis on the difference in the course of retirement according to average monthly income and current occupation and second, with an assumption that career self efficacy will influence the course of retirement. Total of 500 surveys for this study were distributed to baby boomer generations through direct visit or mail post in Seoul, Gyeonggi, Gangwon, Chungnam, Gyeongnam, Jeonnam and Jeju for one month during January 17 and February 16, 2012. 443 surveys were returned, among which 400 effective responses were selected as study subjects. As a result, the course of retirement according to average monthly income was verified to be significant for all factors. Significant results were found for the course of retirement according to current occupation in job transfer, complete non-employment and repetitive non-employment. In relation to the effect of career self efficacy on the course of retirement, job movement factor was affected by 21%. This study will be a good guide for the establishment of a social policy and retirement life preparation of the baby boomer generation.

• Journal of the Korean School Mathematics Society
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• v.17 no.4
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• pp.679-695
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• 2014

In this paper we survey the career awareness, demand, and preparation of the students of the department of mathematics education and provide basic data for establishment of career diversification strategies. For this we examined the followings: (1) department selected time and motivation, (2) satisfaction with the selection and training courses, (3) hope and change for a career after graduation, (4) related jobs and career awareness. As a result, most of the students over the course of the high school and middle school chose a career in mathematics education, the biggest motivation appeared to be due to selection was deemed suitable for individual aptitudes. Due to this reason he/she is satisfied with the selection and training process and the curriculum of mathematics education appeared to think it would be helpful to his/her career. It can be observed that the number of students increased to think of another job, depending on the grade ascent. Mostly due to the difficulty of major study as grade up, high competition and low success rate of teacher employment test, employment reduction in the number of teachers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.522-528
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• 2020

The purpose of this study is to improve the reemployment rate of unemployed job seekers aged 50 to 59 by supporting the foundation of our society and enhancing their value of life. We analyzed the impact of resilience, a psychological factor, on job seeking of unemployed people in their fifties. Subjects were visited and provided employment services in the Employment Welfare Plus Center in the Seoul Metropolitan Area. We devised a questionnaire consisting of three variables of general characteristics, resilience, and job search. Also, the resilience variables comprised sub-variables of control, positiveness, and sociality, and the job search variables involved sub-variables of job preparation, attitude, and willness. Study results the resilience of unemployed persons aged 50 to 59 is above average, and sub-variables of positiveness are highest compared to other sub-variables. Second, there is no significant gender difference in resilience for job search activities. Third, resilience and its sub-variables, such as control and affirmation, affect job-seeking activities. Therefore, this study suggests strengthening the resilience of job seekers in their fifties as well as providing psychological counseling and job training for job-seeking activities.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.33 no.1
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• pp.12-18
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• 2023

Objectives: Personal protective equipment (PPE) is an essential means for protecting workers against hazardous agents or risks that threaten their safety and health. Governmental organizations related to safety and health in the workplace regulate the PPE rules to protect workers and to minimize damage from hazardous agents. This study discussed current PPE rules overseen by the Korea Ministry of Environment and explores future perspectives on the matter. Methods: This study was based on a review of PPE regulations with which every stakeholder should comply in the workplace. Both South Korean regulations enforced by the Ministry of Employment and Labor and the Ministry of Environment and cases from other countries were reviewed. Results: Regulations related to the PPE required for handling chemical substances in the workplace are enforced by the Occupational Safety and Health Act, Enforcement Decree, Enforcement Rules, and Notification of Protective Equipment Certification under the Ministry of Employment and Labor. The Ministry of Environment also regulates the PPE standards for 97 substances requiring preparation for accidents and adjustment of work conditions, but a recent amendment (partially amended on September 30, 2022) loosened some unreasonable or excessive provisions. It requires workers simply to carry or otherwise keep PPE handy instead of wearing it for some tasks in which hazardous chemicals are not handled directly. Conclusions: It is important to regularly review provisions that need to be improved or supplemented to help all stakeholders. Considerations should be also made to build a reasonable regulatory system that can induce more mature safety management in each workplace.

• Journal of Intelligence and Information Systems
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• v.26 no.4
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• pp.149-171
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• 2020

The period at university is to make decision about getting an actual job. As our society develops rapidly and highly, jobs are diversified, subdivided, and specialized, and students' job preparation period is also getting longer and longer. This study analyzed the log data of college students to see how the various activities that college students experience inside and outside of school might have influences on employment. For this experiment, students' various activities were systematically classified, recorded as an activity data and were divided into six core competencies (Job reinforcement competency, Leadership & teamwork competency, Globalization competency, Organizational commitment competency, Job exploration competency, and Autonomous implementation competency). The effect of the six competency levels on the employment status (employed group, unemployed group) was analyzed. As a result of the analysis, it was confirmed that the difference in level between the employed group and the unemployed group was significant for all of the six competencies, so it was possible to infer that the activities at the school are significant for employment. Next, in order to analyze the impact of the six competencies on the qualitative performance of employment, we had ANOVA analysis after dividing the each competency level into 2 groups (low and high group), and creating 6 groups by the range of first annual salary. Students with high levels of globalization capability, job search capability, and autonomous implementation capability were also found to belong to a higher annual salary group. The theoretical contributions of this study are as follows. First, it connects the competencies that can be extracted from the school experience with the competencies in the Human Resource Management field and adds job search competencies and autonomous implementation competencies which are required for university students to have their own successful career & life. Second, we have conducted this analysis with the competency data measured form actual activity and result data collected from the interview and research. Third, it analyzed not only quantitative performance (employment rate) but also qualitative performance (annual salary level). The practical use of this study is as follows. First, it can be a guide when establishing career development plans for college students. It is necessary to prepare for a job that can express one's strengths based on an analysis of the world of work and job, rather than having a no-strategy, unbalanced, or accumulating excessive specifications competition. Second, the person in charge of experience design for college students, at an organizations such as schools, businesses, local governments, and governments, can refer to the six competencies suggested in this study to for the user-useful experiences design that may motivate more participation. By doing so, one event may bring mutual benefits for both event designers and students. Third, in the era of digital transformation, the government's policy manager who envisions the balanced development of the country can make a policy in the direction of achieving the curiosity and energy of college students together with the balanced development of the country. A lot of manpower is required to start up novel platform services that have not existed before or to digitize existing analog products, services and corporate culture. The activities of current digital-generation-college-students are not only catalysts in all industries, but also for very benefit and necessary for college students by themselves for their own successful career development.