• Psychiatry investigation
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• v.15 no.12
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• pp.1188-1202
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• 2018

Objective This study protocol aims to determine, using a rigorous approach in patients with bipolar disorder (BD) and non-seasonal major depressive episode (MDE), the characteristics of bright light therapy (BLT) administration (duration, escalation, morning and mid-day exposures) depending on the tolerance (hypomanic symptoms). Methods Patients with BD I or II and treated by a mood stabilizer are eligible. After 1 week of placebo, patients are randomized between either morning or mid-day exposure for 10 weeks of active BLT with glasses using a dose escalation at 7.5, 10, 15, 30 and 45 minutes/day. A further follow-up visit is planned 6 months after inclusion. Patients will be included by cohorts of 3, with at least 3 days of delay between them, and 1 week between cohorts. If none meet a dose limiting toxicity (DLT; i.e hypomanic symptoms), the initiation dose of the next cohort will be increased. If one patient meet a DLT, an additionnal cohort will start at the same dose. If 2 or 3 patients meet a DLT, from the same cohort or from two cohorts at the same dose initiation, the maximum tolerated dose is defined. This dose escalation will also take into account DLTs observed during the intra-subject escalation on previous cohorts, with a "Target Ceiling Dose" defined if 2 DLTs occured at a dose. Discussion Using an innovative and more ergonomic device in the form of glasses, this study aims to better codify the use of BLT in BD to ensure a good initiation and tolerance.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.263-269
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• 2019

In this study, the characteristics and operation of a multi-purpose loader equipped with various sensors such as a sensor capable of measuring the boom length, an angle sensor capable of measuring the tilt of the left and right sides of the boom and the loader, and a load cell capable of measuring the weight during lifting We have implemented a system that displays related data values. The configuration of the system reads the values from the sensors, sends them to the vehicle controller, and transmits the calculated results of the overturn rate and other important information to the display device using the CANOpen protocol. Also, in the calculation of the overturn ratio, the structure of the multi-purpose loader is similar to that of the crane belonging to the heavy equipment, and the crane overturn rate calculation method is used. Through this study, we can observe the condition of the heavy equipment and recognize the emergency situations such as abalone through the display device.

• Health Policy and Management
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• v.31 no.3
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• pp.244-254
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• 2021

The management of emerging infectious diseases cannot help but completely depend on non-pharmaceutical interventions in the early stages of the outbreak. Consequently, South Korea has developed and implemented the 3T (test-trace-treat) models, non-pharmaceutical infection prevention and control (IPC) measures, in response to the coronavirus disease 2019 (COVID-19) pandemic. The IPC measures have gained global attention, rendering them to be essential in the development of a shareable, reusable, and applicable protocol for future pandemics. This study was conducted to identify the requirements necessary for standardizing the IPC measures. Three new work items of the 18 3T models were proposed to ISO/TC 304 (International Organization for Standardization/Technical Committee 304; healthcare organization management). Requirements for each IPC measure, identified by participating members (P-members) countries during the ISO ballots, were analyzed in this study. The three new work items were approved by the P-members countries after a 3-month ballot. There was a consensus that the three IPC measure models should be International Standards (IS). Other comments include (1) the models should include not only COVID-19 but also any respiratory pandemic; and (2) keep donning of level D protection at screening sites as an optional protocol, in consideration for the lack of personal protective equipment. Standardization is a systematic process of developing internationally agreed-upon wisdom and knowledge that consider and respect the diversity and universality of each country. It is expected that such standardized applicable IPC measure models contribute to global efforts to rapidly respond to a public health emergency of international concern during its early stages.

• Journal of The Korean Society of Clinical Toxicology
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• v.17 no.2
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• pp.58-65
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• 2019

Purpose: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and whether green tea extract (GTE) offers protection against hepatic damage caused by α-amanitin (AMA) induced apoptosis in vivo. Methods: The effects of GTE and SIL on the cell viability of cultured murine hepatocytes induced by AMA were evaluated using an MTT assay. Apoptosis was assessed by an analysis of DNA fragmentation and caspase-3. In the in vivo protocol, mice were divided into the following four groups: control group (0.9% saline injection), AMA group (α-amanitin 0.6 mg/kg), AMA+SIL group (α-amanitin and silibinin 50 mg/kg), and AMA+GTE group (α-amanitin and green tea extract 25 mg/kg). After 48 hours of treatment, the hepatic aminotransferase and the extent of hepatonecrosis of each subject was evaluated. Results: In the hepatocytes exposed to AMA and the tested antidotes, the cell viability was significantly lower than the AMA only group. An analysis of DNA fragmentation showed distinctive cleavage of hepatocyte nuclear DNA in the cells exposed to AMA. In addition, the AMA and GTE or SIL groups showed more relief of the cleavage of the nuclear DNA ladder. Similarly, values of caspase-3 in the AMA+GTE and AMA+SIL groups were significantly lower than in the AMA group. The serum AST and ALT levels were significantly higher in the AMA group than in the control and significantly lower in the AMA+GTE group. In addition, AMA+GTE induced a significant decrease in hepatonecrosis compared to the controls when a histologic grading scale was used. Conclusion: GTE is effective against AMA-induced hepatotoxicity with its apoptosis regulatory properties under in vitro and in vivo conditions.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.5
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• pp.966-978
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• 2014

Currently, majority small ship's clutch for power transmission to propeller relies on multi plate hydraulic clutch regardless its size. Most of the small ships do not have a spare equipments of clutch. Furthermore, many ship engineers do not have an ability as well as enough experience to solve this problem related to the hydraulic clutch during the voyage. Therefore, any small problems cause many serious marine accidents. Once the clutch has problem, almost of all ships can not sail by itself anymore and it must be towed by salvage boat, maritime police ships, or fish guidance boat etc. In this case, all the accidents will be categorized as a marine accident and they all need to go through marine accident court inquiries. In this study, an understanding of each crew on hydraulic clutch system has been profoundly measured. Furthermore, the knowledge on an emergency navigation protocol of each crew has been also profoundly checked. Additionally, various surveys on hydraulic clutch classes has been performed and its satisfaction of crews on this topic have been carefully checked based on various feedback from students who took these courses. All of the above data from this study will be used to reduce marine accidents in current marine industry.

• Journal of Korean Society of Water and Wastewater
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• v.32 no.2
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• pp.193-200
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• 2018

Owing to the development in information and communications technologies have improved the technology for high-speed transmission of massive data, which has changed closed-circuit television (CCTV) video transmission technology. In particular, digitization of the CCTV video format and streaming technology has made it possible to minimize transmission loss and integrate video transmission and camera control(pan/tilt). It has also become possible to provide additional services like remote emergency warning broadcasting with just Internet Protocol (IP). However, because of the structural problems of IP, these changes have also brought about the threat of hacking of CCTV monitoring systems. In this study, we propose a methode to optimize network management by examining cases of enhancement of operational efficiency and security by improving the structure of CCTV monitoring network.

• Journal of Chest Surgery
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• v.51 no.4
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• pp.286-289
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• 2018

We report a case of acute type I aortic dissection in which an emergency graft replacement of the ascending aorta and innominate artery was performed. We performed false lumen thrombosis through hybrid thoracic endovascular aortic repair to seal the primary entry tear, followed by false lumen obliteration at the level of the descending thoracic aorta, abdominal aorta, and right common iliac artery. Over a period of 4.5 years, we used Amplatzer vascular plugs and coils based on our computed tomography angiography follow-up protocol.

• IEMEK Journal of Embedded Systems and Applications
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• v.5 no.4
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• pp.243-253
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• 2010

Multihop data delivery in vehicular ad hoc networks (VANETs) suffers from the fact that vehicles are highly mobile and inter-vehicle links are frequently disconnected. In such networks, for efficient multihop routing of road safety information (e.g. road accident and emergency message) to the area of interest, reliable communication and fast delivery with minimum delay are mandatory. In this paper, we propose a multihop vehicle-to-infrastructure routing protocol named Vertex-Based Predictive Greedy Routing (VPGR), which predicts a sequence of valid vertices (or junctions) from a source vehicle to fixed infrastructure (or a roadside unit) in the area of interest and, then, forwards data to the fixed infrastructure through the sequence of vertices in urban environments. The well known predictive directional greedy routing mechanism is used for data forwarding phase in VPGR. The proposed VPGR leverages the geographic position, velocity, direction and acceleration of vehicles for both the calculation of a sequence of valid vertices and the predictive directional greedy routing. Simulation results show significant performance improvement compared to conventional routing protocols in terms of packet delivery ratio, end-to-end delay and routing overhead.

• Journal of Digital Convergence
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• v.10 no.11
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• pp.419-425
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• 2012

In these days, the trends of home networking system is implementation of easily configured system with home security of emergency alarm and visitor verification services. In this paper, we implemented push server system based on Arduino of open source physical computation platform to verify visitors for the homes without home networking services. In the suggested system, visitor verification is performed in and out of home, and home access security of the system could be constructed with low-cost price by use of windows push server system and smart devices with alarm operation in corresponding to not allowed access trying.

• Korea Journal of Hospital Management
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• no.spc
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• pp.85-95
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• 2016

This study is to introduce a comprehensive framework of a crisis management system developed at a prominent hospital in South Korea. Throughout recent decades, especially in the recent years, the way in which to cope with both internal and external challenges has been one of the most critical issues. Since the incident management system in the U.S. is acknowledged as the most advanced crisis management model in the world, a portion of this study refers to the Hospital Incident Command System(HICS) provided by the California Emergency Medical Services Authority(EMSA). Nevertheless, the framework suggested in this article was designed based on a distinctive Korean hospital setting. The main contents of this study are as follows; categorization of each type of crisis, organization of a crisis management team in a non-crisis or crisis state, crisis assessment by life cycle stage, and establishment of crisis management protocol. Even though many types of crises are unspecified, those can be categorized into external crisis, medical crisis, and utility & activity failure. A crisis management organization should be operated and consisted differently- depending on a crisis or non-crisis situation. From a life-cycle perspective, the range by which the crisis should be managed extends from pre-stage to post-stage of the crisis. It is important to set proper scenarios and manuals by crisis type to develop a crisis management framework of high quality. With continuous efforts, hospitals can prepare for the uncertainty to better concentrate on core business operations.