• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2003년도 식물바이오벤처 페스티발
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• pp.98-98
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• 2003

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 1998년도 가을 학술발표대회 논문집 디자인 학 연구
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• pp.24-25
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• 1998

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2001년도 10주년 기념 국제학술 심포지움 및 추계학술대회
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• pp.30-30
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• 2001

• 한국작물학회:학술대회논문집
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• 한국작물학회 2004년도 춘계 학술대회지
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• pp.56-57
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• 2004

• Plant Biotechnology Reports
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• 제5권2호
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• pp.121-126
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• 2011

Isoflavonoid production in cell cultures of Pueraria tuberosa as influenced by an angiospermic parasite, Cuscuta reflexa, was studied. During the time course, maximum isoflavonoid content was recorded when Cuscuta elicitor was added on day 15 of culture. Among various concentrations of elicitor tried, $1g\;l^{-1}$ of Cuscuta elicitor was found to be the most effective. The optimized elicitation conditions were used in vessels of varying capacity where maximum yield of ${\sim}91mg\;l^{-1}$ of isoflavonoid was recorded in a 2-l bioreactor which was about 19% higher than the control cultures. In this case, puerarin content increased up to $11mg\;l^{-1}$ which was 580% higher that the value recorded in the control cultures. In the bioreactor, 8 days of elicitation was optimal for the high accumulation of isoflavonoid, giving productivity of ${\sim}4mg\;l^{-1}\;day^{-1}$. The study showed persistent high isoflavonoid yield even during scale-up. Use of a preparation of Cuscuta reflexa as an elicitor is reported for the first time. The increase in isoflavonoid content was elicitor dose-dependent and can be explored to trigger high yields of isoflavonoid/secondary metabolites in production.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.278-282
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• 2001

The discovery of tacit knowledge from domain experts is one of the most exciting challenges in today\`s knowledge management. The nature of decision knowledge in determining the quality a firm\`s short-term liquidity is full of abstraction, ambiguity, and incompleteness, and presents a typical tacit knowledge extraction problem. In dealing with knowledge discovery of this nature, we propose a scheme that integrates both knowledge elicitation and knowledge discovery in the knowledge engineering processes. The knowledge elicitation component applies the Verbal Protocol Analysis to establish industrial cases as the basic knowledge data set. The knowledge discovery component then applies fuzzy clustering to the data set to build a fuzzy knowledge based system, which consists of a set of fuzzy rules representing the decision knowledge, and membership functions of each decision factor for verifying linguistic expression in the rules. The experimental results confirm that the proposed scheme can effectively discover the expert\`s tacit knowledge, and works as a feedback mechanism for human experts to fine-tune the conversion processes of converting tacit knowledge into implicit knowledge.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제16권12호
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• pp.1259-1263
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• 2010

SaaS는 소프트웨어 개발 및 배포에 있어 전체적인 비용을 크게 줄일 수 있는 새로운 패러다임으로 분산 컴퓨팅, 그린 컴퓨팅, 클라우드 컴퓨팅 동의 최신 컴퓨팅 플랫폼에 있어 중요한 기반기술로 여겨지고 있다. 이러한 SaaS는 기존의 소프트웨어와 달리 높은 수준의 설정 가능성(Configurability)을 요구받고 있으며, 이에 따라 설정 요구사항(Configuration Requirements)의 추출에 있어 모든 설정 가능성을 빠짐 없이 고려하는 것이 매우 중요하다. 본 연구에서는 SaaS의 특성에 따라 각 요구사항에 대한 설정 가능성이 누락되지 않도록 결정할 수 있는 분류 기법을 제안한다.

• 정보과학회 논문지
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• 제44권1호
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• pp.27-35
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• 2017

사용자 및 기기의 상황을 파악하고 이에 따라 실시간으로 사용자 인터페이스를 변경하는 '적응형 사용자 인터페이스 (Adaptive User Interface)' 연구가 진행되어 왔다. 기존 관련 연구들은 주로 설계 방법론에 초점을 맞추고 있으며, 요구공학 방법론에 대해서는 거의 다루어지지 않았다. 본 연구에서는 적응형 사용자 인터페이스를 요구공학 관점에서 조명하고, 자가 적응 시스템 분야에서 연구되어 온 개념들에 기초한 요구사항 도출 및 명세 방법을 제안한다. 잘 알려진 자가 적응 소프트웨어 개념들을 재정의 및 해석한 후, 적응형 사용자 인터페이스 요구사항을 도출 및 명세하는 방법을 단계적으로 보인다. 사례연구에서는 제안하는 방법에 따라 적응형 사용자 인터페이스 요구사항을 도출 및 명세하여 본 기법이 효과적임을 보인다.

• 대한한의학회지
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• 제30권3호
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• pp.51-60
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• 2009

Objectives : It has been known that immune reaction plays an important role in the pathogenesis of otitis media (OM). We investigated the change of middle ear mucosal inflammation induced by lipopolysaccharide (LPS) following administration of Taglisodog-eum (TSE) in experimental animals. Materials and Methods : Otitis media was induced by injecting 1 mg/kg of Pseudomonas aeruginosa LPS transtympanically in 60 rats. These rats were divided into two groups, the LPS group (n=30, remained naive after OM elicitation) and the TSE group (n=30, treated with TSE after OM elicitation) and 6 additional rats were kept as a normal control group (n=6, remained naive until tissue collection). The rats were killed at the 1st, 3rd, and 7th days after challenge. The temporal bones in each group were harvested and examined histopathologically by hematoxyline-eosin stain. Middle ear mucosa were taken at the 1st, 3rd, and 7th days after challenge. The levels of spicing variants of TNF-${\alpha}$ transcription were evaluated by Realtime-PCR. Results : TSE suppressed LPS-induced TNF-${\alpha}$ mRNA expression and thickness of the submucosal layer and infiltration of inflammatory cells in rat middle ear epithelium. Conclusion : The results suggest that TSE may be effective in decreasing inflammation with particular application to mucosal metaplasia in OM.

• 대한한방내과학회지
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• 제31권3호
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• pp.477-487
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• 2010

Objectives : This study was carried out to investigate the effects of sihogeji-tang on indomethacin-induced gastric mucosal lesions in rats. Methods : Experimental rats were classified into three groups. The normal group had no inflammation elicited. The control group was rats administered water after elicitation of gastro-inflammation. The sample group were administered sihogeji-tang after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, the control group were observed to have various injuries by hemorrhagic erosion, while the sample group had noticeably fewer injuries than the control. In the immunohistochemical change, the distribution of HSP-70, PCNA treated with sihogeji-tang noticeably increased over the control group. The distribution of NF-kB, COX-2 treated with sihogeji-tang noticeably decreased compared to the control group. (p<0.05) Conclusions : Sihogeji-tang had significant effects on indomethacin-induced gastric mucosal lesions in rats.