The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of Sihogeji-tang Extract on Indomethacin-Induced Gastric Mucosal Lesions in Rats

Indomethacin으로 유발된 백서의 위점막 손상에 대한 시호계지탕의 효과

  • Kim, Bo-Ram (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Guk University) ;
  • Huh, Kyung (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Guk University) ;
  • Lim, Seong-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Guk University)
  • 김보람 (동국대학교 한의과대학 한방내과) ;
  • 허경 (동국대학교 한의과대학 한방내과) ;
  • 임성우 (동국대학교 한의과대학 한방내과)
  • Published : 2010.09.30
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Abstract

Objectives : This study was carried out to investigate the effects of sihogeji-tang on indomethacin-induced gastric mucosal lesions in rats. Methods : Experimental rats were classified into three groups. The normal group had no inflammation elicited. The control group was rats administered water after elicitation of gastro-inflammation. The sample group were administered sihogeji-tang after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, the control group were observed to have various injuries by hemorrhagic erosion, while the sample group had noticeably fewer injuries than the control. In the immunohistochemical change, the distribution of HSP-70, PCNA treated with sihogeji-tang noticeably increased over the control group. The distribution of NF-kB, COX-2 treated with sihogeji-tang noticeably decreased compared to the control group. (p<0.05) Conclusions : Sihogeji-tang had significant effects on indomethacin-induced gastric mucosal lesions in rats.

Keywords

References

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