• Wind and Structures
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• 제37권2호
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• pp.153-161
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• 2023

Wind speed data from Nepal and adjoining countries have been analyzed to estimate an extreme wind speed climatology for the region. Previously wind speed information for Nepal was adopted from the Indian National Standard and applied to two orographically different regions: above and below 3000 m elevation respectively. Comparisons of the results of this analysis are made with relevant codes and standards. The study confirms that the assigned basic wind speed of 47 m/s for the plains and hills of Nepal (below 3000 m) is appropriate, however, data to substantiate a basic wind speed of 55 m/s above 3000 m is unavailable. Using a composite analysis of 15 geographically similar stations, the study also generated 435 years of annual maxima wind data and fitted them to Type I and Type III extreme value distributions. The results suggest that Type III distribution may better represent the data. The findings are also consistent with predictions made by Holmes and Weller (2002) and to a certain extent those of Sarkar et al. (2014), but lower than the analysis undertaken by Lakshmanan et al. (2009) for northern India. The study also highlights that the use of a load factor of 1.5 on wind load implies lower strength design MRI's of around 260 years compared to the 700 years of ASCE 7-22.

• The Korean Journal of Physiology and Pharmacology
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• 제5권2호
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• pp.139-146
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• 2001

L-type $Ca^{2+}$ channels play an important role in regulating cytosolic $Ca^{2+}$ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type $Ca^{2+}$ channel currents in rat pituitary $GH_3$ cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and vanadate, a protein tyrosine phosphatase (PTP) inhibitor, increased the $Ba^{2+}$ current through the L-type $Ca^{2+}$ channels. In contrast, bisindolylmaleimide I (BIM I), a PKC inhibitor, and genistein, a protein tyrosine kinase (PTK) inhibitor, suppressed the $Ba^{2+}$ currents. Forskolin, an adenylate cyclase activator, and isobutyl methylxanthine (IBMX), a non-specific phosphodiesterase inhibitor, reduced $Ba^{2+}$ currents. The above results show that the L-type $Ca^{2+}$ channels are activated by PKC and PTK, and inhibited by elevation of cyclic nucleotides such as cAMP. From these results, it is suggested that the regulation of hormone secretion by various kinase activity in $GH_3$ cells may be attributable, at least in part, to their effect on L-type $Ca^{2+}$ channels.

• 한국산림과학회지
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• 제110권4호
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• pp.530-542
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• 2021

백두대간 보호지역 일본잎갈나무림의 생태적 관리를 위한 기본 단위 설정을 위하여 총 119개 조사구에서 수집한 식생 정보를 바탕으로 TWINSPAN과 DCA ordination 분석을 통하여 현존식생의 유형을 분류하고 그 공간 배열 상태를 파악, 기술하였다. 현존식생 유형은 신갈나무-철쭉형, 신갈나무-조록싸리형, 층층나무-산뽕나무형, 신갈나무-까치박달형, 비목나무-찔레꽃형, 졸참나무-산초나무형, 졸참나무-조릿대형 등 총 7개 유형이 도출되었고 대개 위도, 해발고도, 성립 기간, 시업 이력, 주변 임분 특성, 교란 정도 등에 따른 종조성적 차이를 반영하고 있었다. 또한 일본잎갈나무림과 주변 잠재자연식생(신갈나무림와 졸참나무림)의 종구성적 유사성을 Jaccard 계수에 의해 비교한 결과, 식생유형 간 다소 차이가 있지만 신갈나무림과는 평균 0.21, 졸참나무림과는 평균 0.32로 나타나 아직 전반적으로 종구성이 이질적인 경향이었다.

• 환경영향평가
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• 제8권3호
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• pp.61-76
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• 1999

For the effective management of urban forest, a variety of informations on urban forest needs to be accurately measured and effectively used in decision-making processes. This study aims at developing an urban forest management system with reference to GIS and making it possible to effectively manage urban forests. A detailed forest type map were constructed with the help of aerial photograph and terrestrial inventory. A geographical map in terms of slope, aspect and altitude were also prepared by Digital Elevation Model(DEM). A soil type map containing chemical characteristics were also made through soil analysis. These thematic maps which contain informations on forest type, geography and soil were digitalized with reference to GIS, and an urban forest management system of user interface were developed. With the help of this urban forest management system, various spatial and attribute informations which need for urban forest management could be easily used in decision-making processes in relation to urban forest.

• Molecules and Cells
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• 제22권1호
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• pp.51-57
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• 2006

Haloperidol is a classical neuroleptic drug that is still in clinical use and can lead to abnormal motor activity following repeated administration. However, there is little knowledge of how it triggers neuronal impairment. In this study, we report that it induced calcium ion influx via L-type calcium channels and that the elevation of calcium ions induced by haloperidol appeared to render hippocampal cells more susceptible to oxidative stress. Indeed, the level of cytotoxic reactive oxygen species (ROS) and the expression of pro-apoptotic Bax increased in response to oxidative stress in haloperidol-treated cells, and these effects were inhibited by verapamil, a specific L-type calcium channel blocker, but not by the T-type calcium channel blocker, mibefradil. These findings indicate that haloperidol induces calcium ion influx via L-type calcium channels and that this calcium influx influences neuronal fate.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2497-2504
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• 2013

본 연구는 1975년 서울시 교육위원회에서 발간한 '학교시설 표준설계도'가 중학교 대상 표준도의 초기 사례임에 주목하여 그 계획특성을 살펴보았다. 연구결과를 정리하면 다음과 같다. 첫 째, 평면계획에서는 편복도형 블록플랜이 전형적으로 적용된 가운데 유형별로 복도를 없앤 평면형, 일조조건 개선을 위한 $9.9{\times}6.6m$ 교실 모듈, 수납공간의 적극적 계획 등의 변화도 보인다. 둘 째, 일체의 의장이 배제된, 채광면적의 확보를 우선으로 하는 기능적인 입면계획이 적용되었다. 셋 째, 층고, 천정고, 창틀의 설치 위치 등에서 규준화된 단면 치수들이 적용되었으며 노출 천정 구조, 단열구조의 미비, 초기 유형의 목재 바닥틀 혼용 등과 같은 철근 콘크리트조 교사의 과도기적 특성이 보인다. 넷 째, 체육관 계획에서는 다양한 입면구성과 매스의 조형적 처리로 교사동과 대비되는, 학교건축의 상징성을 표출하고자 하는 의도가 나타난다. 다섯 째, 교사동과 이격 배치를 전제로 하는 화장실과 관리실 등의 별동형 계획에서도 동시대 학교건축으로 전환해 가는 과도기적 특성을 발견할 수 있다. 이와 같은 특성들은 표준도에 의한 과거 학교건축의 전형을 보여주면서도 동시에 당시 학교건축에서 요구되는 조건들에 대한 대응 방식과 변화 과정을 파악할 수 있게 한다. 이는 '75년 서울시 표준도'가 가지는 교육시설사 연구 사료로서의 주요한 가치라고 할 수 있다.

• The Korean Journal of Ecology
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• 제10권2호
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• pp.63-80
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• 1987

Detrended correspondence analysis(DCA) and two way indicator species analysis(TWINSPAN) were applied to Pinus densiflora stands nearby Seoul area in order to classify them into several groups based on herbaceous species and environmental relationships. The eighteen Pinus densiflora stands were perferenially selected, In each stand, 30 to 60 quadrats, (20X20)cm, were randomly estabilished. In each quadrat, all stems for herbaceous plants were recorded by species and their covers were measured. In addition environmental factors such as soil depth, thickness of litter layer, soil compressibility, tree density, basal area, elevation, slope and exposure were detemined for each stand. Four to twelve soil cores were collected and physical and KDICical properties were determined. This survey was conducted form 15, July, 1985 to 22, September, 1985. Analysis of the vegetation and environmental data were performed with DECORANA and TWINSPAN. Stand ordination (DECORANA) and classification (TWINSPAN) based on herbaceous species suggest that the stands can be classified into five groups in terms of herbaceous species composition and environmental relationships. Type I, Type II, Type III, Type IV and Type V were classified to SUBMESIC-CLO-SED-CANOPY (Artemisia keiskeana, Carex nanella), MESIC-CLOSED CANOPY (Spodiopogon sibiricus, Miscanthus sinensis, Carex nanella, Pteridum aquilinum, Melampyrum rosium), SUBMESIC-OPEN CANOPY (Carex nanella, Spodiopogon sibiricus, Miscanthus sinensis), XERIC-CLOSED CANOPY (Carex nanella, Spodiopogon sibiricus, Carex nanella), and XERIC-OPEN CANOPY (Arundinella hirts, Spodiopogon sibiricus, Carex nanella), respectively. These results were consitent with environmental trends on stan ordination. Application of the ordination and classifiaction to Pinus densiflora stands were effective as a approach on obtaining perliminary ecological information.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.630-636
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• 2021

Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated the effect of eupafolin on glutamate release in rat cerebrocortical synaptosomes and explored the possible mechanism. We discovered that eupafolin depressed 4-aminopyridine (4-AP)-induced glutamate release, and this phenomenon was prevented in the absence of extracellular calcium. Eupafolin inhibition of glutamate release from synaptic vesicles was confirmed through measurement of the release of the fluorescent dye FM 1-43. Eupafolin decreased 4-AP-induced [Ca²⁺]_i elevation and had no effect on synaptosomal membrane potential. The inhibition of P/Q-type Ca²⁺ channels reduced the decrease in glutamate release that was caused by eupafolin, and docking data revealed that eupafolin interacted with P/Q-type Ca²⁺ channels. Additionally, the inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) prevented the effect of eupafolin on evoked glutamate release. Eupafolin also reduced the 4-AP-induced activation of CaMK II and the subsequent phosphorylation of synapsin I, which is the main presynaptic target of CaMKII. Therefore, eupafolin suppresses P/Q-type Ca²⁺ channels and thereby inhibits CaMKII/synapsin I pathways and the release of glutamate from rat cerebrocortical synaptosomes.

• 한국발생생물학회지:발생과생식
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• 제24권4호
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• pp.297-306
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• 2020

Repetitive changes in the intracellular calcium concentration ([Ca²⁺]i) triggers egg activation, including cortical granule exocytosis, resumption of second meiosis, block to polyspermy, and initiating embryonic development. [Ca²⁺]i oscillations that continue for several hours, are required for the early events of egg activation and possibly connected to further development to the blastocyst stage. The sources of Ca²⁺ ion elevation during [Ca²⁺]i oscillations are Ca²⁺ release from endoplasmic reticulum through inositol 1,4,5 tri-phosphate receptor and Ca²⁺ ion influx through Ca²⁺ channel on the plasma membrane. Ca²⁺ channels have been characterized into voltage-dependent Ca²⁺ channels (VDCCs), ligand-gated Ca²⁺ channel, and leak-channel. VDCCs expressed on muscle cell or neuron is specified into L, T, N, P, Q, and R type VDCs by their activation threshold or their sensitivity to peptide toxins isolated from cone snails and spiders. The present study was aimed to investigate the localization pattern of N and P/Q type voltage-dependent calcium channels in mouse eggs and the role in fertilization. [Ca²⁺]i oscillation was observed in a Ca²⁺ contained medium with sperm factor or adenophostin A injection but disappeared in Ca²⁺ free medium. Ca²⁺ influx was decreased by Lat A. N-VDCC specific inhibitor, ω-Conotoxin CVIIA induced abnormal [Ca²⁺]i oscillation profiles in SrCl₂ treatment. N or P/Q type VDC were distributed on the plasma membrane in cortical cluster form, not in the cytoplasm. Ca²⁺ influx is essential for [Ca²⁺]i oscillation during mammalian fertilization. This Ca²⁺ influx might be controlled through the N or P/Q type VDCCs. Abnormal VDCCs expression of eggs could be tested in fertilization failure or low fertilization eggs in subfertility women.

• 한국전통조경학회지
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• 제36권1호
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• pp.109-119
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• 2018

본 연구는 2016년 9월 12일 발생한 경주지진으로 인해 피해를 입은 국가지정문화재를 보유한 전통공간 44곳을 대상으로 다각적인 문화재 연구를 위해 지형적 입지정보 데이터화와 지형별 유형에 따른 피해 경향을 파악해 보고자 하였다. 지형의 유형은 위요형이 가장 많이 추출되었으며, 위치형은 도시와 농촌과 같이 주변이 건물인 지역의 빈도가 더 많았다. 수문형은 산의 정상쪽을 제외하고는 모두 강, 하천, 계곡, 호수, 바다를 끼고 입지하였으나 이 지역은 퇴적층 지역으로 위요형과 함께 지질학적인 면에서도 지진에 취약한 곳으로 밝혀져 지진과 문화재 관리적 측면에서 참고하여야 할 것으로 파악되었다. 전체 44개 중 26곳이 사찰이었으며, 평지형, 배경형, 위요형, 산지형, 정상형으로 갈수록 고도와 경사가 높아졌으며, 1-20% 경사지에 가장 많이 입지하였으며, 사면향은 남쪽을 끼고 있지 않는 경우가 더 많았다. 진원지에서 10km 범위 내에 23%가 집중되어 있었으며, 거의 65km 범위 내에 있었으며, 배경형이 가장 가까웠고, 진원지로부터 북동쪽과 남서쪽에 집중되어 있었다. 본 연구는 지진피해를 조경문화재인 전통공간의 입장에서 다각도로 분석한 의의가 있으며, 앞으로 전통공간 계획과 설계, 관리에 활용할 수 있을 것이다.