• Wind and Structures
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• v.37 no.2
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• pp.153-161
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• 2023

Wind speed data from Nepal and adjoining countries have been analyzed to estimate an extreme wind speed climatology for the region. Previously wind speed information for Nepal was adopted from the Indian National Standard and applied to two orographically different regions: above and below 3000 m elevation respectively. Comparisons of the results of this analysis are made with relevant codes and standards. The study confirms that the assigned basic wind speed of 47 m/s for the plains and hills of Nepal (below 3000 m) is appropriate, however, data to substantiate a basic wind speed of 55 m/s above 3000 m is unavailable. Using a composite analysis of 15 geographically similar stations, the study also generated 435 years of annual maxima wind data and fitted them to Type I and Type III extreme value distributions. The results suggest that Type III distribution may better represent the data. The findings are also consistent with predictions made by Holmes and Weller (2002) and to a certain extent those of Sarkar et al. (2014), but lower than the analysis undertaken by Lakshmanan et al. (2009) for northern India. The study also highlights that the use of a load factor of 1.5 on wind load implies lower strength design MRI's of around 260 years compared to the 700 years of ASCE 7-22.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.139-146
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• 2001

L-type $Ca^{2+}$ channels play an important role in regulating cytosolic $Ca^{2+}$ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type $Ca^{2+}$ channel currents in rat pituitary $GH_3$ cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and vanadate, a protein tyrosine phosphatase (PTP) inhibitor, increased the $Ba^{2+}$ current through the L-type $Ca^{2+}$ channels. In contrast, bisindolylmaleimide I (BIM I), a PKC inhibitor, and genistein, a protein tyrosine kinase (PTK) inhibitor, suppressed the $Ba^{2+}$ currents. Forskolin, an adenylate cyclase activator, and isobutyl methylxanthine (IBMX), a non-specific phosphodiesterase inhibitor, reduced $Ba^{2+}$ currents. The above results show that the L-type $Ca^{2+}$ channels are activated by PKC and PTK, and inhibited by elevation of cyclic nucleotides such as cAMP. From these results, it is suggested that the regulation of hormone secretion by various kinase activity in $GH_3$ cells may be attributable, at least in part, to their effect on L-type $Ca^{2+}$ channels.

• Journal of Korean Society of Forest Science
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• v.110 no.4
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• pp.530-542
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• 2021

To establish the basic unit for the ecological management of the Larix kaempferiplantations in the Baekdudaegan protected area, we classified the vegetation types using TWINSPAN and DCA ordination analysis based on the vegetation information collected from 119 plots and analyzed their spatial arrangement status. Vegetation types were classified into seven types, including Quercus mongolica-Rhododendron schlippenbachii type, Q. mongolica-Lespedeza maximowiczii type, Cornus controversa-Morus australis type, Q. mongolica-Carpinus cordata type, Lindera erythrocarpa-Rosa multiflora type, Q. serrata-Zanthoxylum schinifolium type, and Q. serrata-Sasa borealis type and they have usually reflected differences in the floristic composition according to latitude, elevation, establishment period, operation history, characteristics of the surrounding stands, and degree of disturbance. Furthermore, using the Jaccard coefficient to comparethe floristic composition similarity between Larix kaempferiplantations and surrounding potential natural vegetation (Q. mongolica and Q. serrata forests), although some differences depended on vegetation types, it was 0.21 on average with Q. mongolica forest and 0.32 with Q. serrata forest, indicating that the floristic composition was still heterogeneous.

• Journal of Environmental Impact Assessment
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• v.8 no.3
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• pp.61-76
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• 1999

For the effective management of urban forest, a variety of informations on urban forest needs to be accurately measured and effectively used in decision-making processes. This study aims at developing an urban forest management system with reference to GIS and making it possible to effectively manage urban forests. A detailed forest type map were constructed with the help of aerial photograph and terrestrial inventory. A geographical map in terms of slope, aspect and altitude were also prepared by Digital Elevation Model(DEM). A soil type map containing chemical characteristics were also made through soil analysis. These thematic maps which contain informations on forest type, geography and soil were digitalized with reference to GIS, and an urban forest management system of user interface were developed. With the help of this urban forest management system, various spatial and attribute informations which need for urban forest management could be easily used in decision-making processes in relation to urban forest.

• Molecules and Cells
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• v.22 no.1
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• pp.51-57
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• 2006

Haloperidol is a classical neuroleptic drug that is still in clinical use and can lead to abnormal motor activity following repeated administration. However, there is little knowledge of how it triggers neuronal impairment. In this study, we report that it induced calcium ion influx via L-type calcium channels and that the elevation of calcium ions induced by haloperidol appeared to render hippocampal cells more susceptible to oxidative stress. Indeed, the level of cytotoxic reactive oxygen species (ROS) and the expression of pro-apoptotic Bax increased in response to oxidative stress in haloperidol-treated cells, and these effects were inhibited by verapamil, a specific L-type calcium channel blocker, but not by the T-type calcium channel blocker, mibefradil. These findings indicate that haloperidol induces calcium ion influx via L-type calcium channels and that this calcium influx influences neuronal fate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.5
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• pp.2497-2504
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• 2013

This study aims to analyze the 'Standard Drawings for School Facilities' issued by Seoul Education Committee in 1975 because it is the early example for middle school architecture. The results of this study are summarized as follows 1) In general trend of single-corridor type block plan, there are also changes in floor plan like no-corridor type block plan, $9.9{\times}6.6m$ classroom unit for the better daylight condition, built-in storage for students. 2) As for elevation design, it is characterized as daylight-oriented, functional exterior for without making full use of design elements. 3) Standardized dimensions are used as a rule in the height of story, ceiling, window sill and etc. Transitional characteristics of the early RC school architecture are found in exposed ceiling, incomplete insulation structure and mixed use of wood framed floor of earlier type. 4) Contrast to main school building, gymnasium shows the intend to express the symbolism of school architecture with diverse elevation design elements and the plasticity of building mass. 5) Separated plan of toilet and night-duty building also show the transitional characteristics. As conclusion, though showing the stereotyped school architecture, on the other hand, 'Standard Drawings for School Facilities' (1975) makes it possible to see the way of coping with the demands for school architecture in that time and the transition of school architecture. This is the main value of it as the material for the studies related to the history of educational facilities.

• The Korean Journal of Ecology
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• v.10 no.2
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• pp.63-80
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• 1987

Detrended correspondence analysis(DCA) and two way indicator species analysis(TWINSPAN) were applied to Pinus densiflora stands nearby Seoul area in order to classify them into several groups based on herbaceous species and environmental relationships. The eighteen Pinus densiflora stands were perferenially selected, In each stand, 30 to 60 quadrats, (20X20)cm, were randomly estabilished. In each quadrat, all stems for herbaceous plants were recorded by species and their covers were measured. In addition environmental factors such as soil depth, thickness of litter layer, soil compressibility, tree density, basal area, elevation, slope and exposure were detemined for each stand. Four to twelve soil cores were collected and physical and KDICical properties were determined. This survey was conducted form 15, July, 1985 to 22, September, 1985. Analysis of the vegetation and environmental data were performed with DECORANA and TWINSPAN. Stand ordination (DECORANA) and classification (TWINSPAN) based on herbaceous species suggest that the stands can be classified into five groups in terms of herbaceous species composition and environmental relationships. Type I, Type II, Type III, Type IV and Type V were classified to SUBMESIC-CLO-SED-CANOPY (Artemisia keiskeana, Carex nanella), MESIC-CLOSED CANOPY (Spodiopogon sibiricus, Miscanthus sinensis, Carex nanella, Pteridum aquilinum, Melampyrum rosium), SUBMESIC-OPEN CANOPY (Carex nanella, Spodiopogon sibiricus, Miscanthus sinensis), XERIC-CLOSED CANOPY (Carex nanella, Spodiopogon sibiricus, Carex nanella), and XERIC-OPEN CANOPY (Arundinella hirts, Spodiopogon sibiricus, Carex nanella), respectively. These results were consitent with environmental trends on stan ordination. Application of the ordination and classifiaction to Pinus densiflora stands were effective as a approach on obtaining perliminary ecological information.

• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.630-636
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• 2021

Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated the effect of eupafolin on glutamate release in rat cerebrocortical synaptosomes and explored the possible mechanism. We discovered that eupafolin depressed 4-aminopyridine (4-AP)-induced glutamate release, and this phenomenon was prevented in the absence of extracellular calcium. Eupafolin inhibition of glutamate release from synaptic vesicles was confirmed through measurement of the release of the fluorescent dye FM 1-43. Eupafolin decreased 4-AP-induced [Ca²⁺]_i elevation and had no effect on synaptosomal membrane potential. The inhibition of P/Q-type Ca²⁺ channels reduced the decrease in glutamate release that was caused by eupafolin, and docking data revealed that eupafolin interacted with P/Q-type Ca²⁺ channels. Additionally, the inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) prevented the effect of eupafolin on evoked glutamate release. Eupafolin also reduced the 4-AP-induced activation of CaMK II and the subsequent phosphorylation of synapsin I, which is the main presynaptic target of CaMKII. Therefore, eupafolin suppresses P/Q-type Ca²⁺ channels and thereby inhibits CaMKII/synapsin I pathways and the release of glutamate from rat cerebrocortical synaptosomes.

• Development and Reproduction
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• v.24 no.4
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• pp.297-306
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• 2020

Repetitive changes in the intracellular calcium concentration ([Ca²⁺]i) triggers egg activation, including cortical granule exocytosis, resumption of second meiosis, block to polyspermy, and initiating embryonic development. [Ca²⁺]i oscillations that continue for several hours, are required for the early events of egg activation and possibly connected to further development to the blastocyst stage. The sources of Ca²⁺ ion elevation during [Ca²⁺]i oscillations are Ca²⁺ release from endoplasmic reticulum through inositol 1,4,5 tri-phosphate receptor and Ca²⁺ ion influx through Ca²⁺ channel on the plasma membrane. Ca²⁺ channels have been characterized into voltage-dependent Ca²⁺ channels (VDCCs), ligand-gated Ca²⁺ channel, and leak-channel. VDCCs expressed on muscle cell or neuron is specified into L, T, N, P, Q, and R type VDCs by their activation threshold or their sensitivity to peptide toxins isolated from cone snails and spiders. The present study was aimed to investigate the localization pattern of N and P/Q type voltage-dependent calcium channels in mouse eggs and the role in fertilization. [Ca²⁺]i oscillation was observed in a Ca²⁺ contained medium with sperm factor or adenophostin A injection but disappeared in Ca²⁺ free medium. Ca²⁺ influx was decreased by Lat A. N-VDCC specific inhibitor, ω-Conotoxin CVIIA induced abnormal [Ca²⁺]i oscillation profiles in SrCl₂ treatment. N or P/Q type VDC were distributed on the plasma membrane in cortical cluster form, not in the cytoplasm. Ca²⁺ influx is essential for [Ca²⁺]i oscillation during mammalian fertilization. This Ca²⁺ influx might be controlled through the N or P/Q type VDCCs. Abnormal VDCCs expression of eggs could be tested in fertilization failure or low fertilization eggs in subfertility women.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.1
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• pp.109-119
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• 2018

The purpose of this study is to analyze the geographical location information data and the damage trends according to the type of landform for the study of various cultural properties in 44 traditional places with national designated cultural properties damaged by the racing earthquake on September 12, 2016. The landform type was the most enclosed type, and the location type was more frequent in the surrounding area, such as urban and rural areas. The waterside type was located along rivers, rivers, valleys, lakes, and oceans except for the top of the mountain, but this area was found to be vulnerable to earthquakes, It is understood that it should be referred from cultural property management the side. 26 of the total 44 were temples. The elevation and slope increased with increasing of the flat type, the background type, the enclosed type, the mountain type, and the top type. Most often located on 1-20 % slopes, with the slope facing south more often than not. Within the 10 km range from the epicenter, 23% were concentrated, within the range of nearly 65 km, the background type was closest, and was concentrated in the northeast and southwest from the epicenter. In this study, it is meaningful to analyze earthquake damage in various aspects from the viewpoint of traditional space which is a landscaping cultural property and it will be used for planning, designing and managing traditional spaces.