• 한국간호교육학회지
• /
• 제18권2호
• /
• pp.248-258
• /
• 2012

Purpose: The purpose of this study was to compare the effects of CEDA (Cross Examination Debate Association) debate with those of traditional lecture education on moral judgment and ethical values using the Korean version of DIT and the ethical values. Methods: The experiment was performed for 9 weeks, from September 2 to November 12, 2010. Participants were 71 undergraduate nursing students in a nursing college, assigned to an experimental group (36 students) or a control group (35 students). The design of this study was a non equivalent control group pretest-posttest design. Results: The experimental group reported significantly higher scores of the 4 stage scores of moral judgment (t=-2.19, p=.036) and ethical values (t=3.04, p=.004) than the control group. However, no significant differences were found in the P score of moral judgment between the two groups. Conclusion: The findings of this study showed the benefits of providing a CEDA debate course for nursing ethics education. Therefore, in further studies, it is necessary to develop various teaching strategies or educational programs to improve nursing ethical values and moral judgment.

• International Journal of Railway
• /
• 제2권2호
• /
• pp.60-69
• /
• 2009

In recent years, technology developments in different countries, especially in newly industrialized countries, are extremely indebted to appropriate technology transfer by these countries. Nevertheless the technology transfer process in the present situation is complex, and its success is related to the coordination rate with the political, economic, social, and environmental objectives of countries. Today debates related to the transfer of the technical know how accompanied by equipment hardware has found remarkable importance such that countries seek increasing comprehensive capabilities in the field of transferred technology for which Preventive Maintenance (PM) is one of the aspects. This research with the purpose to determine the technological capability level and to study the role of PM in the effective & appropriate technology transfer in subway industry is carried out for presenting a suitable model for the technology transfer in this industry with an attitude towards the effects of principal PM factors. For this purpose, after the study of different and relevant models existing in the field of suitable methods for technology transfer, some equipment PM theories and models were selected as the base for the compilation of the questionnaire. With the help of questionnaire, main PM factors that are effective in the field of technology transfer were extracted, and finally, their effects on technology transfer were analyzed, identified and a comprehensive model suggested in this connection.

• 규제연구
• /
• 제27권1호
• /
• pp.123-151
• /
• 2018

이 논문은 대형소매점 영업제한의 경제적 효과에 대한 쟁점들과 그동안의 연구 결과들을 정리하고 평가하였으며, 정책적 대안들을 제시하였다. 첫째, 대형소매점 영업제한으로 인하여 공급 측면의 효율성은 크게 감소하여 사회후생을 낮춘다. 둘째, 대형소매점 영업제한은 소비자의 선택권을 제한하고 거래비용을 높임으로써, 수요 측면의 효율성을 악화시킨다. 셋째, 대형소매점 영업제한이 경제 전체의 형평성을 개선시킨다고 보기 어렵다. 넷째, 설령 대형소매점 영업제한으로 인하여 형평성이 개선된다 해도, 동일한 형평성 개선 효과를 내면서 효율성 훼손을 피할 수 있는 정책적 대안들이 많으므로, 대형소매점 영업제한 정책을 형평성의 측면에서 정당화하기는 어렵다.

• 한국언론정보학보
• /
• 제44권
• /
• pp.108-143
• /
• 2008

후보자 이미지는 다양한 차원의 속성들로 구성되는 후보자에 대한 총체적 인상이다. 본 연구는 온 오프라인 뉴스미디어, 정치광고, 텔레비전 토론회, 후보자 웹사이트 등의 캠페인 미디어, 그리고 대인 간 정치 대화가 후보자의 개인적 품성과 직무수행 및 정책능력에 대한 이미지에 어떠한 영향력을 행사하는지를 분석하고, 더 나아가 정치적 의사결정 과정에서 이미지가 담당하는 역할을 탐색했다. 분석은 2007년 12월 실시된 17대 대통령 선거에서 50% 가까운 득표를 통해 당선된 이명박 후보를 중심으로 수행되었다. 주요 분석 결과는 다음과 같다. 첫째, 신문 뉴스 열독은 개인 품성 이미지에 긍정적 효과를 보였으나, 인터넷신문 이용은 직무수행과 정책능력 이미지에 부정적 영향력을 행사했다. 둘째, 캠페인 미디어 중 특히 텔레비전 정치광고와 후보자 웹사이트는 다양한 차원에서 긍정적인 이미지 형성에 매우 높은 효과를 나타냈지만 투표 행위에 대해서는 직접적인 효과를 보이지 않음으로써, 주로 간접적 경로로 정치적 선택에 영향력을 행사했음을 알 수 있었다. 텔레비전 후보 토론회의 경우, 1, 2, 3차 토론회가 각각 상이한 방식으로 이미지 형성과 정치적 행위에 영향을 미친 것으로 관찰되었다. 셋째, 정치 대화의 빈도와 규모는 각각 개인적 품성과 경제정책능력에 대한 평가에 부정적인 효과를 보였으나, 대화 규모는 이명박 투표에 긍정적인 효과를 나타났다. 넷째, 다양한 차원의 후보자 이미지는 투표 행위에 매우 높은 설명력을 보였는데, 특히 이명박 후보의 도덕성, 정직성, 신뢰성, 서민성 등 개인적 품성에 대한 이미지가 그에 대한 투표 행위에 가장 중요한 예측 요인이었던 것으로 나타났다.

• Annals of Clinical Neurophysiology
• /
• 제19권2호
• /
• pp.93-100
• /
• 2017

In this article, we review the differences of the brain morphology according to age, sex, and handedness. Age is a well-known factor affecting brain morphology. With aging, progressive reduction of brain volume is driven. Sex also has great effects on brain morphology. Although there are some reports that the differences of brain morphology may originate from the differences of weight between the 2 sexes, studies have demonstrated that there are regional differences even after the correction for weight. Handedness has long been regarded as a behavioral marker of functional asymmetry. Although there have been debates about the effect of handedness on brain morphology, previous well-established studies suggest there are differences in some regions according to handedness. Even with the studies done so far, normal brain morphology is not fully understood. Therefore, studies specific for the each ethnic group and standardized methods are needed to establish a more reliable database of healthy subjects' brain morphology.

• Bulletin of the Korean Chemical Society
• /
• 제33권10호
• /
• pp.3265-3268
• /
• 2012

Nanoparticles (NPs) are increasingly used in consumer products, which have aroused many concerns and debates regarding their fate in biological systems from a point of their safety/toxicity. Although a number of studies on the biological effects of NPs have been published, these are often complicated by the possible toxicity of conventional NPs, caused by contamination with chemical precursors or additives during their synthesis and/or purification procedures. To explicitly understand the toxicity basis of NPs, it is necessary to directly address a main problem related to their intrinsic/inherent toxicity and/or incompatibility with biological objects. The present study is designed to take advantage of a novel laser-assisted method called laser ablation to generate Ag, Au, Co, and Cu NPs in biocompatible aqueous solution, and to evaluate the toxicity of the resulting ultra-pure NPs. Our results show that the ultra-pure NPs with nascent surfaces possess moderate cytotoxicity to human cells in a cell-dependent manner.

• 대기
• /
• 제9권1호
• /
• pp.12-19
• /
• 1999

고구려와 수나라의 제 l차 전쟁은 정사의 기록이 부실하여 추측과 논쟁이 난무하는 상태이다. 이에 관한 작금의 기록을 수집하고 분석하여 다음 네 가지의 결론을 얻었다. 첫째, 장마가 전투에 가장 큰 영향을 미쳤다. 둘째, 정사의 기록과는 달리, 전쟁은 장마만으로 인해 종료된 것이 아니고 두 군대의 접전이 있었다. 셋째, 이 전쟁은 임유관을 주무대로 전개되었다. 넷째, 당시 고구려 군은 우연히 장마의 혜택을 입은 것이 아니라, 계획적으로 장마를 전투에 이용하여 대승을 거두었다. 다섯째, 이 전쟁의 지휘관이 강이식이었는지에 관해서는 여러 가지 기록에도 불구하고 의문의 여지가 남아 있다.

• 대한예방한의학회지
• /
• 제20권1호
• /
• pp.145-159
• /
• 2016

Objectives : The aim was to investigate the characteristics of low dose effect and non monotonic dose responses(NMDRs) and to predict the influence it might have on the health and medicine, traditional Korean medicine. Methods : By investigating recently published major literatures related to low dose effect and NMDRs, the definition, mechanism, major related fields, and the influence on public health and medicine has been categorized and summarized. Results : Although there are still heated debates about the definition of low dose, it implies the biological responses in environmental exposure level and the NDMDRs means the nonlinear relationship between the dose-response in the slope sign change. Also, it implies the new form of the curve showing a U, reverse U shape, and the slop sign constantly changing showing various forms. This mechanism is because the two acceptor shows opposing effects to toxic materials and the affinity is different along with the numerical value that increase and decrease being different. These characteristics generally appear in endocrine disrupters such as bisphenol A, agricultural pesticides, metal, and radiation. The research field in the public health and medical treatment is obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause and phytoestrogen. Conclusions : As a result of discussing implications, NMDRs is a particular effect in low dose and heated debates surround this response, research is being conducted surrounding the field of obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause, and phytoestrogen. More research and interest in needed as it can have a massive influence in the public health and medicine.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제17권1호
• /
• pp.33-41
• /
• 2012

Nanoscale zero-valent iron (nZVI) has recently received much attention for remediation of soil and groundwater contaminated with trichloroethylene (TCE). But there have been many debates on the toxic or inhibitory effects of nZVI on the environment. The objective of this study was to investigate the effects of nZVI on the activity of Geobacter lovleyi and to determine the potent effect of combination of abiotic and biotic treatment of TCE dechlorination. TCE degradation efficiencies of Geobacter lovleyi along with nZVI were more increased than those when nZVI was solely used. The amount of total microbial protein was increased in the presence of nZVI and hydrogen evolved from nZVI was consumed as electron donor by Geobacter lovleyi. In addition, dechlorination of TCE to cis-DCE by Geobacter lovleyi along with nZVI in respiking of exogenous of TCE shows that the reactivity of Geobacter lovleyi was also maintained. These results suggest that the application of Geobacter lovleyi along with nZVI for the dehalorination is beneficial for the enhancement of TCE degradation rate and reactivity of Geobacter lovleyi.

• Genomics & Informatics
• /
• 제19권4호
• /
• pp.39.1-39.8
• /
• 2021

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)-positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To achieve a better understanding of the ER-independent antifungal action mechanisms of TAM, we systematically identified TAM-sensitive genes through microarray screening of the heterozygous gene deletion library in fission yeast (Schizosaccharomyces pombe). Secondary confirmation was followed by a spotting assay, finally yielding 13 TAM-sensitive genes under the drug-induced haploinsufficient condition. For these 13 TAM-sensitive genes, we conducted a comparative analysis of their Gene Ontology (GO) 'biological process' terms identified from other genome-wide screenings of the budding yeast deletion library and the MCF7 breast cancer cell line. Several TAM-sensitive genes overlapped between the yeast strains and MCF7 in GO terms including 'cell cycle' (cdc2, rik1, pas1, and leo1), 'signaling' (sck2, oga1, and cki3), and 'vesicle-mediated transport' (SPCC126.08c, vps54, sec72, and tvp15), suggesting their roles in the ER-independent cytotoxic effects of TAM. We recently reported that the cki3 gene with the 'signaling' GO term was related to the ER-independent antifungal action mechanisms of TAM in yeast. In this study, we report that haploinsufficiency of the essential vps54 gene, which encodes the GARP complex subunit, significantly aggravated TAM sensitivity and led to an enlarged vesicle structure in comparison with the SP286 control strain. These results strongly suggest that the vesicle-mediated transport process might be another action mechanism of the ER-independent antifungal or cytotoxic effects of TAM.