• 대한한방부인과학회지
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• 제19권3호
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• pp.83-94
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• 2006

Purpose : This study examined effects of Paljin-tang on endometriosis. Methods : Sugically induced endometriosis in rats were given an oral dose of Paljin-tang for 40 days. The size of the ectopic uterine implants at the serosal wall and the concentration of progesterone, estradiol, tumor necrosis factor(TNF)-${\alpha}$ and interleukin(IL)-2, IL-4, IL-6, and IL-10 in the blood were examined and compared with the control group. Results : The size of the ectopic uterine implants in the experimental group was much smaller than of that in the control group. The concentration of estradiol was significantly lower in the experimental group than in the control group. The TNF-${\alpha}$, IL-4, IL-6 levels was significantly lower in the experimental group than the control group and IL-10 level was higher in the experimental group than the control group. The progesterone, IL-2 levels were similar in the experimental and control groups. Conclusion : These results indicate that Paljin-tang reduces the size of ectopic uterine implants at the serosal wall and inhibits the growth of ectopic uterine implants. This suggests that Paljin-tang is an effective treatment for endometriosis.

• 한국임상수의학회지
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• 제32권1호
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• pp.112-114
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• 2015

10개월령 한우 암송아지가 경북대학교 동물병원에 진료 의뢰되었다. 주증상은 가슴 등쪽에 다리 하나가 더 있는 것이었다. 딴곳 다리는 정상다리에 비해 작고 부분적으로 갈비뼈와 유착되어 있었다. 수술로 절제하였으며 등다리증은 효과적으로 치료할 수 있었다. 여러다리증은 신체 특정 부위에 하나 이상의 다리가 더 있는 것을 의미한다. 본 증례에서는 암송아지 등다리증의 형태학적 소견과 방사선 특징을 관찰해 보았다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권3호
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• pp.196-200
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• 2014

Co-existing pyloric submucosal masses with hypertrophic pyloric stenosis (HPS) are very rare and treating these lesions is always a problem. A 20-day-old boy presented with recurrent episodes of projectile non-bilious vomiting lasting for 5 days. HPS was suspected due to the presenting age and the symptoms. The sonography demonstrated not only circumferential wall thickening of the pylorus, but also a pyloric submucosal mass. At laparotomy, a 0.8 cm sized pyloric submucosal mass was identified along with a hypertrophied pylorus. Pyloric excision was performed due to the possibility of sustaining the symptoms and malignancy. The pathological report of the submucosal mass was ectopic pancreas. Coexisting pyloric lesions can be diagnosed along with HPS, and surgical excision, not just pyloromyotomy, should be considered in these circumstances. To the best of our knowledge, this is the first case report of pyloric ectopic pancreas and HPS to be diagnosed concurrently.

• 대한소아치과학회지
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• 제44권2호
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• pp.147-153
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• 2017

본 연구는 5 - 10세 아동에서 상악 제1대구치의 이소맹출과 골격적 부정교합 유형 사이의 연관성을 평가하고자 하였다. 상악 제1대구치의 이소맹출이 있는 93명의 아동을 실험군으로, 이소맹출이 없는 693명의 아동을 대조군으로 분류하였다. 제1대구치가 맹출 전이거나 제2대구치가 맹출을 완료한 경우는 연구대상에서 제외하였다. 측모 두부 방사선 사진 계측을 통해 골격적 부정교합의 유형을 조사, 분석하였다. 실험군의 경우, 골격성 3급 부정교합이 57.0% 이었고, 대조군에 비해 골격성 3급 부정교합의 비율이 유의하게 높았다. SNA, ANB, A to N-perpendicular는 실험군에서 작은 경향을 보였고, A-B plane angle과 APDI는 더 크게 나타났다. 반면, SNB와 mandibular plane angle은 두 군 사이에서 유의한 차이가 없었다. 본 연구를 통해 상악의 열성장이 상악 제1대구치의 이소맹출에 영향을 미칠 수 있음을 확인하였다.

• 한국미생물·생명공학회지
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• 제44권4호
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• pp.563-570
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• 2016

S. griseus wild type에서 dasA 유전자의 과발현에 의해 유도된 기저균사의 ectopic sporulation 관련 유전자를 알아보기 위해서, empty vector가 삽입된 균주와 dasA가 과발현된 균주의 전사체를 DNA microarray법으로 비교하였다. DNA microarray 결과를 토대로 dasA 유전자 과발현 균주에서 2배이상 발현량이 증가되었으며 p-value가 0.05 미만(p-value < 0.05)인 유전자들 중에서 false positive 를 제외시키는 작업을 통하여 최종적으로 4개의 유전자(SGR794, SGR2469, SGR3656, SGR3657)와 3개의 cluster (SGR795-797, SGR2377-2378, SGR6997-6998)를 선발하였다. 이들의 전사량은 low resolution Sl nuclease mapping 법을 통하여 dasA 유전자 과발현 균주에서 증가된 것을 확인하였다.

• 대한두경부종양학회지
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• 제26권1호
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• pp.37-40
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• 2010

Ectopic hamartomatous thymoma is a rare benign tumor of the lower neck occurring in the male adult predominantly. The origin of this tumor has been debated, but it is now believed to arise from remnants of the cervical sinus of His from early development. They are composed of epithelial, adipocytic, and spindle cells in variable amounts. Recognition of ectopic harmatomatous thymoma is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor. We here report on a case of ectopic hamartomatous thymoma arising in the left lateral neck of 33-year-old male patient.

• 대한소아치과학회지
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• 제33권4호
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• pp.704-709
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• 2006

이소맹출은 발육과정 중 그 발생지에서의 정상적 맹출 경로에서 벗어난 치아의 맹출을 의미한다. 이소맹출의 극단적인 형태로 전위가 있는데 이것은 두 치아의 위치가 서로 바뀐 것이다. 이러한 이소맹출 및 전위된 치아의 치료는 치아가 맹출되는 방향, 치근단의 완성정도, 맹출공간의 존재여부 등에 따라 단순한 관찰에서 외과적 노출 후 교정적 견인까지 매우 다양하며, 위치 이상이 심한 경우에는 외과적 자가이식이나 발치를 고려할 수 있다. 이중 자가치아이식은 치아를 구강내의 한 위치에서 다른 발치와나 외과적으로 형성된 치조와로 이동시키는 술식으로, 치아가 교정력을 가할 수 없는 위치에 존재하거나 치아 이동에 제한이 있어 통상적인 치료가 불가능할 경우 발거에 앞서 고려할 수 있는 술식이다. 본 증례들은 교정적 견인 및 배열이 어렵다고 판단되는 이소맹출하는 상악 측절치와 상악 견치를 자가이식함으로써 심미적, 기능적으로 양호한 결과를 얻을 수 있었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제29권6호
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• pp.499-508
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• 2007

Background and Purpose: Some subtypes of malignant salivary gland tumors such as adenoid cystic carcinoma (ACC) frequently result in distant metastasis of vascular origin, which are main causes of treatment failure. The reasons for the affinity for vascular metastatic potential are unclear. Therefore, molecular characteristics that influence the dissemination of metastatic tumor cells are important for the design of more effective treatment of salivary ACC. Tumor angiogenesis has been known to be essential for the distant metastasis of malignant cells. So, we determined expressions of vascular metastasis related factors in orthotopic (parotid) murine models of parotid ACC and compared with those in ectopic (subcutis) tumors of athymic mice. Experimental Design: Using specimens from murine parotid (orthotopic, experimental group) and subcutaneous (ectopic, control group) tumors, which have developed via transplantation of tumor cells, originated from human parotid ACC, we performed immunohistochemical assays with anti-vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF, FGF2), matrix metalloproteinase (MMP)-9, and interleukin (IL)-8 antibodies. We also performed immunohistochemical assays with VEGF receptor (VEGFR)-1, VEGFR-2, VEGFR-3, and phosphorylated VEGFR-2. Results: Transplantation of human ACC tumor cell $(5{\times}10^5)$ into the parotid and subcutis successfully resulted in orthotopic (parotid) and ectopic (subcutaneous) tumors in athymic mice. Immunohistochemical staining demonstrated higher expression of major angiogenic factors (VEGF, bFGF, MMP-9) in the orthotopic tumors than in ectopic tumors (P<0.05). But the expression level of angiogenic receptors were same in orthotopic and ectopic tumors of parotid ACC. Conclusion: VEGF, bFGF, and MMP-9 could be a good candidates for antiangiogenic therapy for the contol of vascular metastatic lesions of salivary ACC.

• 대한한방부인과학회지
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• 제21권3호
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• pp.1-17
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• 2008

Purpose: Scutellaria baicalensis is a herb which has effect of eliminating heat, drying dampness, purging away fire, detoxicating. Clinically, has been used to remove fever and control of inflammation. We have studied in series to investigate the effective traditional oriental medicines of treatment for endometriosis. In this study, the effects of Scutellaria baicalensis administrated orally or rectally on surgically induced endometriosis in rat were investigated. Methods: The endometrial tissues of rats were autografted to their small intestine. Rats with surgically induced endometriosis were administered with Scutellaria baicalensis extracts for 40 days orally or rectally. We observed the tissue size of ectopic uterine implants at the mesenteric with the naked eye and examined the concentration of estradiol, progesterone, $TNF-{\alpha}$ and IL-2, IL-4, IL-6 and IL-10 in serum. Also, we inquired which was more effective between oral administration groups and rectal administration groups. Results: The size of ectopic uterine implants of orally or rectally treated groups was much smaller than those of control groups. The concentrations of estradiol, progesterone, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in oral administration experimental group compared with the control group. The concentrations of progesteron, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in rectal administration experimental group compared with the control group. The efficiency of oral administration group was better than that of rectal administration group at the serum concentration of estradiol and IL-4. Conclusion: Our data suggest that Scutellaria baicalensis inhibit the inflammation induced from ectopic uterine implants at the mesenteric wall and inhibit the growth of ectopic uterine implants. Judging from the above results, it can be suggested that Scutellaria. baicalensis should be a useful agent for inhibiting the inflammation induced from ectopic uterine implants and the proliferation of endometriosis. Maybe, oral administration of Scutellaria baicalensis is more effective than rectal administration.

• 대한두경부종양학회지
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• 제20권1호
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• pp.52-54
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• 2004

Ectopic cervical thymic tissue is rarely reported in medical literature, but it should be included in the differential diagnosis of neck masses, especially in children. It occurs in the line of descent of the thymus from the angle of the mandible to the superior mediastinum. A preoperative diagnosis is seldom considered and is often misdiagnosed as a possible tumor or a lymph node. We present a case of a 2-month-old infant with an asymptomatic enlarging right neck mass. Patient underwent complete excision of the mass.