A Case of Ectopic Hamartomatous Thymoma

이소성 유과오종성 흉선종 1예

  • Oh, Young-Taek (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Yoo, Young-Sam (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Choi, Jeong-Hwan (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Cho, Kyoung-Rai (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Heo, Geon (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Kim, Sang-Woo (Department of Otolaryngology Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Kim, Hyun-Jung (Department of Pathology, Sanggye Paik Hospital, College of Medicine, Inje University)
  • 오영택 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 유영삼 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 최정환 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 조경래 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 허건 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 김상우 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 김현정 (인제대학교 의과대학 상계백병원 병리학교실)
  • Published : 2010.05.31

Abstract

Ectopic hamartomatous thymoma is a rare benign tumor of the lower neck occurring in the male adult predominantly. The origin of this tumor has been debated, but it is now believed to arise from remnants of the cervical sinus of His from early development. They are composed of epithelial, adipocytic, and spindle cells in variable amounts. Recognition of ectopic harmatomatous thymoma is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor. We here report on a case of ectopic hamartomatous thymoma arising in the left lateral neck of 33-year-old male patient.

Keywords

References

  1. Rosai J, Limas C, Husband EM. Ectopic hamartomatous thymoma: A distinctive benign lesion of lower neck. Am J Surg Pathol. 1984;8:501-513. https://doi.org/10.1097/00000478-198407000-00002
  2. Kim JM, Won NH, Paik SY. Ectopic hamartomatous thymoma: A case report. Korean J Pathol. 1990;24:50-57.
  3. Lee SN, Cho MS, Koo H, Han WS. Ectopic hamartomatous thymoma: A case report showing CD99+ lymphocytes and a low proliferation index. Arch Pathol Lab Med. 2003;127:378-381.
  4. Seok SH, Lee DH, Kang SH, Bae YK. Ectopic hamatomatous thymoma-A Case Report along with a Review of the Literature Concerning the Histogenesis and New Nomenclature. Korean J Pathol. 2006;40:292-296.
  5. Fetsch JF, Laskin WB, Michal M, Remotti F, Heffner D, Ellis G, et al. Ectopic hamartomatous thymoma: A clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor. Am J Surg Pathol. 2004;28:1360-1370. https://doi.org/10.1097/01.pas.0000135518.27224.3f
  6. Fukunaga M. Ectopic hamartomatous thymoma: A case report with immunohistochemical and ultrastructural studies. APMIS. 2002;110:565-570. https://doi.org/10.1034/j.1600-0463.2002.11007808.x
  7. Armour A, Williamson JM. Ectopic cervical hamartomatous thymoma showing extensive myoid differentiation. J Laryngol Otol. 1993;107(2):155-158. https://doi.org/10.1017/S0022215100122509
  8. Zhao C, Yamada T, Kuramochi S, Yamazaki K, Mukai M, Kameyama K, et al. Two cases of ectopic hamartomatous thymoma. Virchows Arch. 2000;437:643-647. https://doi.org/10.1007/s004280000309
  9. Kushida Y, Haba R, Kobayashi S, Ishikawa M, Doi T, Kadota K. Ectopic hamartomatous thymoma: A case report with immunohistochemical study and review of the literature, J Cutan Pathol. 2006;33:369-372. https://doi.org/10.1111/j.0303-6987.2006.00424.x
  10. Michal M, Neubauer L. Carcinoma arising in ectopic hamartomatous thymoma. A previously unpublished occurrence. Report of two cases Zentralbl Pathol. 1990;139(4-5):381-386.