• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.05a
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• pp.147-148
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• 2019

Long-life housing should be durable enough to maintain structural safety even after long-term use by applying a durable structural system. Also, the residence space can be repaired according to the life cycle of the resident, and the space can be easily changed. The purpose of this study is to propose a plan which can increase the variability of unit space of long - lived houses in terms of architectural planning. We propose a new plan that can embody flexibility and ease of repair through the design of long life.

• BMB Reports
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• v.53 no.7
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• pp.341-348
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• 2020

The targeted nuclease clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) system has recently emerged as a prominent gene manipulation method. Because of its ease in programming targeted DNA/protein binding through RNA in a vast range of organisms, this prokaryotic defense system is a versatile tool with many applications in the research field as well as high potential in agricultural and clinical improvements. This review will present a brief history that led to its discovery and adaptation. We also present some of its restrictions, and modifications that have been performed to overcome such restrictions, focusing specifically on the most common CRISPR/Cas9 mediated non-homologous end joint repair.

• Land and Housing Review
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• v.12 no.4
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• pp.103-117
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• 2021

With the current rapid changes in population and technology, the long-lastig housing certification system is a means of prolonging the physical and functional lifespan of a building. The certification requires differentiation between the structure and infill elements to allow for variability and ease of repairs. This works well with prefabricated houses so this study investigated the possibility of applying the long-lastig housing certification requirements to apartment construction using off-site construction (OSC) methods focused on the installation of bathrooms (plumbing and toilet) that differ from the traditional wet method. This study examined three different sized floor plans at 22 m², 46 m², and a combined one resulting in 69 m². The larger 69 m² plan utilized a removeable non-load bearing wall to increase flexibility in the layout of the floorplan. The apartments are constructed of steel reinforced concrete composite columns on a 9 m × 10.5 m grid with integrated slabs. The exterior and interior infill walls are all non-load bearing with some containing plumbing. This separation of the structure and infill walls can help meet some of the criteria in the long-lastig housing certification, particularly with the ease of repairs. Technologies that facilitate the replacement of infill elements that contain plumbing and other building services can benefit the nation by reducing carbon emissions and therefore tax incentives should be introduced to increase the adoption of the proposed construction methods.

• Journal of Chest Surgery
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• v.6 no.2
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• pp.243-248
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• 1973

Eventration of the diaphragm is, by definition, abnormally high or elevated position of diaphragm as a result of paralysis, aplasia or atrophy of varing degrees of muscle fibers, and the cause of which may be congenital or acquired. The unbroken continuity of the diaphragm differentiates it from diaphragmatic hernia. The clinical manifestations of the condition, if present, are usually due to the interference of the ventilatory function of the lung and digesive dysfunction due to gastrointestinal distorsion. Treatment consists of surgical repair of the relaxed diaphragm to it`s normal position. A ease of left sided eventuration of the diaphragm, 31 year old officer, was found by chance after traffic accident with chief complaints of hemoptysis and multiple superficial contusions. Routine chest roentgenogram and barium study of the colon revealed moderately elevated left hemidiaphragm with displacement of the splenic flexure of the colon into the left chest. Past history revealed frequent attack of upper respiratory infection and some abnormal condition on his left chest announced by screen cheek of chest X-ray at the time of entrance for his army service 3 years before. Plication of the relaxed diaphragm through left thoracotomy was done and result was excellent as seen on Fig. 5. Cause of eventration of the left hemidiaphragm was due to paralysis of the left phrenic nerve which was tested during thoracotomy.

• Steel and Composite Structures
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• v.44 no.6
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• pp.803-816
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• 2022

Composite materials are effective in forming externally bonded reinforcements which find applications related to existing structures repair, attributed to their high strength-to-weight ratio and ease of installation. Among various composites, fibre reinforced polymers (FRP) have somewhat been largely accepted as a commonly utilized composite for such purposes. It is only recently that steel fibres have been considered as additional members of the FRP fibre family, intuitively termed as steel reinforced polymer (SRP). Owing to its low cost and permissibility of fibre bending at sharp corners, SRP is rapidly becoming a viable contender to other FRP systems. This paper investigates the bond behaviour of SRP-concrete joints with different bonded lengths (50, 75, 100, 150 and 300 mm) and widths (15, 30, 40, 50, and 75 mm) using single-lap shear tests. The experimental specimens contain SRP strips with a fixed density of steel fibres (0.472 cords/mm) bonded to the face of concrete prisms. The load responses were obtained and compared in terms of corresponding load and slip boundaries of the constant region and the peak loads. The failure modes of SRP composites are discussed, and the range of effective bonded length is evaluated herein. In the end, a new analytical model was proposed to estimate the SRP-concrete bond strength using a genetic algorithm, which outperforms 22 existing FRP-concrete bond strength models.

• Korean Journal of Computational Design and Engineering
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• v.9 no.4
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• pp.373-381
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• 2004

Using standard components of a press die is recognized as a way for a cost reduction and a short lead time. It also provides a way for a quick maintenance of a die under repair. It is expected to contribute to integration of CAD/CAM system for manufacturing dies in the future. This paper presents a 3D CAD library which is constructed using the standard components and is used for designing a press die. This 3D CAD library is generated by a database system made of Microsoft Access for standard components and by CATIA V5 R10 API for geometric features. The library is implemented using Visual Basic 6.0 utility of CATIA API function in the Windows NT environment. It creates a 3D model of the standard components of press die easily when a die designer inputs numerical values of geometric features and the BOM of the completely assembled parts. It also generates automatically the assembly drawing of die set by using variables for standard values of die parts. Therefore users can save the cost of time to design the press die components, and even a beginner can use this program with ease. The test results of the 3D CAD library for designing shearing and bending dies verify its usefulness and feasibility.

• Journal of Veterinary Clinics
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• v.35 no.1
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• pp.10-12
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• 2018

Mitral regurgitation is the most frequent cause of cardiac disability and death in dogs. A wide range of medical and surgical treatments have been used for mitral regurgitation. Surgical treatments for complete correction of mitral regurgitation include valve repair and valve replacement, which have the advantages of eliminating or correcting the primary cause. Surgical treatments approach the mitral valve via right- or left-side thoracotomy. Aortic root exposure is needed for cardiopulmonary bypass. To compare right-side and left-side approaches, 10 dog cadavers were used in this study. Subsequently, the left-side surgical approach was used in vivo and in conjunction with cardiopulmonary bypass and cardioplegic arrest. Based on the results, and considering ease of access to the aortic root, valve incision site, and visualization of the surgical field, a left-side approach is recommended.

• Archives of Craniofacial Surgery
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• v.16 no.3
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• pp.125-130
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• 2015

Background: Poly-L-lactide materials combined with hydroxyapatite (u-HA /PLLA) have been developed to overcome the drawbacks of absorbable materials, such as radiolucency and comparably less implant strength. This study was designed to evaluate the usefulness of u-HA/PLLA material in the repair of orbital medial wall defects. Methods: This study included 10 patients with pure medial wall blow-out fractures. The plain radiographs were taken preoperatively, immediately after, and 2 months after surgery. The computed tomography scans were performed preoperatively and 2 months after surgery. Patients were evaluated for ease of manipulation, implant immobility, rigidity and complications with radiologic studies. Results: None of the patients had postoperative complications, such as infection or enophthalmos. The u-HA/PLLA implants had adequate rigidity, durability, and stable position on follow-up radiographic studies. On average, implants were thawed 3.4 times and required 14 minutes of handling time. Conclusion: The u-HA/PLLA implants are safe and reliable for reconstruction of orbital medial wall in terms of rigidity, immobility, radiopacity, and cost-effectiveness. These thin yet rigid implants can be useful where wide periosteal dissection is difficult due to defect location or size. Since the u-HA/PLLA material is difficult to manipulate, these implants are not suitable for use in complex 3-dimensional defects.

• Journal of Microbiology and Biotechnology
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• v.27 no.2
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• pp.207-218
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• 2017

Clustered regulatory interspaced short palindromic repeats (CRISPR) in association with CRISPR-associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make the CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects, and optimizing of innovative strategies. In summary, the CRISPR-Cas system could be employed in a number of applications, including providing model systems, rectification of detrimental mutations, and antiviral therapies.

• Archives of Reconstructive Microsurgery
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• v.7 no.1
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• pp.10-14
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• 1998

When covering a skin defect of the finger with a local flap is difficult, a vascular island flap is often used. For a palmar skin defect, it is desirable to add a sensory supply to the flap. This report describes a neurovascular island flap that was used to repair a palmar skin defect, the donor skin coming from the dorsal region of the middle phalanx. This flap is elevated with a vascular pedicle of the palmar digital artery and its dorsal skin branch, including the dorsal digital veins, palmar digital nerve and its cutaneous branches. The advantage of this flap are that it can be transferred with ease and without any tension. No special manipulation is required under a microscope and operation can be performed under a simple nerve-block. There if little possibility that the flap itself undergoes ischemic change or congestion. The disadvantage of this flap are that a skin graft is required at the donor skin site and one palmar digital aretery is lost. We think that this neurovascular island flap is one of the useful methods for skin defects that are difficult to cover with a local flap.