• 한국발생생물학회지:발생과생식
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• 제18권4호
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• pp.233-240
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• 2014

The early growth response protein 1 (Egr-1) is a widely reported zinc finger protein and a well known transcription factor encoded by the Egr-1 gene, which plays key roles in many aspects of vertebrate embryogenesis and in adult vertebrates. The Egr-1 expression is important in the formation of the gill vascular system in flounders, which develops during the post-hatching phase and is essential for survival during the juvenile period. However, the complete details of Egr-1 expression during embryo development in olive flounder are not available. We assessed the expression patterns of Egr-1 during the early development of olive flounders by using reverse transcription polymerase chain reaction (RT-PCR) analysis. Microscopic observations showed that gill filament formation corresponded with the Egr-1 expression. Thus, we showed that Egr-1 plays a vital role in angiogenesis in the gill filaments during embryogenesis. Further, Egr-1 expression was found to be strong at 5 days after hatching (DAH), in the development of the gill vascular system, and this strong expression level was maintained throughout all the development stages. Our findings have important implications with respect to the biological role of Egr-1 and evolution of the first respiratory blood vessels in the gills of olive flounder. Further studies are required to elucidate the Egr-1-mediated stress response and to decipher the functional role of Egr-1 in developmental stages.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• 아동학회지
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• 제30권3호
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• pp.161-175
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• 2009

The purpose of this study is to develop proper early childhood information communication ethics education program and apply it to children based on previous researches and demands of early childhood teacher in order to protect children who remain defenseless in the information society. The draft was developed after analyzing previous research and survey of early childhood teachers' perception and demands on early childhood information communication ethics education. On the basis of the draft and the survey, the early childhood information communication ethics education program was developed after examining the adequacy of each item and subordinate areas which was conducted by early childhood professionals and applied 17 children. Moreover, early childhood information communication ethics attitude surveys were carried out before and after the program to obtain effects of the early childhood information communication ethics education program. The early childhood information communication ethics education program was effective. There was significant difference (t=-2.27, p<.05) of mean score between experiment group and control group.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.441-448
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• 2018

이 연구는 글 없는 그림책 활동이 유아의 그림 표상능력과 사회성 발달에 미치는 영향을 알아보는데 그 목적이 있다. 이를 위해 연구대상은 K유치원에 재학 중인 만 3세 유아 30명으로 하였다. 그 중 15명을 실험집단으로 나머지 15명을 비교집단으로 선정하였다. 실험처치는 실험집단에 8주간 글 없는 그림책 활동을 실시하였으며, 두 집단 모두 그림 표상능력과 사회성 발달 검사를 사전 사후에 실시하였다. 그 결과, 글 없는 그림책 활동이 유아의 그림 표상능력 하위 영역 중 다양한 색채, 세부적 묘사, 조화로운 공간 표상, 다양한 형체, 주제 관련 표상, 표상의 독특성, 그림 표상의 완성도, 언어 표상의 연결에 효과가 있는 것으로 나타났다. 다음으로 글 없는 그림책 활동이 유아의 사회성 발달 하위영역 중 협동성, 자율성, 또래 간 상호작용에서 효과가 있는 것으로 나타났다. 이러한 연구결과는 글 없는 그림책 활동이 유아의 그림 표상능력과 사회성 발달에 효과적인 교수-학습 자료로 유아교육기관에서 유용하게 활용될 수 있음을 시사한다.

• 한국응용곤충학회지
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• 제51권4호
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• pp.443-447
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• 2012

유리나방류는 사과, 복숭아, 포도와 같은 과수의 주요 해충으로서, 유충이 기주식물의 줄기 속에서 형성층을 섭식한다. 수원지역에서 3년에 걸쳐, 성페로몬 트랩을 이용하여 사과유리나방, 복숭아유리나방, 포도유리나방, 큰유리나방의 연중 발생소장을 조사하였다. 사과원에서 사과유리나방 성충은 트랩에 5월부터 10월까지 유인되었으며, 6월 상중순과 8월 하순~9월 상순에 각각 발생최성기를 보였다. 비슷하게, 복숭아원에서 복숭아유리나방은 5월부터 10월까지 유인되었으며, 발생최성기는 5월 하순과 8월 하순~9월 중순이었다. 포도원에서 포도유리나방은 5월 하순부터 6월 중순까지 유인되었으며, 5월 하순~6월 상순에 발생최성기를 보였다. 한편, 포도원에서 큰유리나방은 6월 상순부터 7월 하순까지 유인되었으며, 발생최성기는 6월 하순~7월 상순이었다.

• 천문학회보
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• 제40권1호
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• pp.56.2-56.2
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• 2015

The KMTNet Supernovae Project utilizes the large $2^{\circ}{\times}2^{\circ}$ field of view of the three KMTNet telescopes to search and monitor supernovae, especially early ones, and other optical transients. A key component of the project is to build a data pipeline with a descent latency and an early alerting system that can handle the large volume of the data in an efficient and a prompt way, while minimizing false alarms, which casts a significant challenge to the software development. Here we present the current status of their development. The pipeline utilizes a difference image analysis technique to discover candidate transient sources after making correction of image distortion. In the early phase of the program, final selection of transient sources from candidates will mainly rely on multi-filter, multi-epoch and multi-site screening as well as human inspection, and an interactive web-based system is being developed for this purpose. Eventually, machine learning algorithms, based on the training set collected in the early phase, will be used to select true transient sources from candidates.

• 아동학회지
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• 제30권5호
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• pp.41-55
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• 2009

This study explored the meaning of beginning teachers' first-year experience in an eco child educare center. Participants were 4 teachers at survival stages of teacher development; they had had the same preservice experience. Data were collected by semi-structured in-depth interviews, participant observation, researcher's field notes, and document collection. Five themes emerged as first year teachers' struggles and strategies for survival : (1) caring for children's daily lives vs. responsibility for formal education, (2) planned lessons vs. ease in teaching, (3) agreement or disagreement on philosophy of running the education program, (4) paradox of teacher empowerment, (5) overcoming struggle through voluntary peer supervision. These results indicated that beginning teacher' experiences at the survival stage varied by contextual and personal factors.

• 비파괴검사학회지
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• 제27권6호
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• pp.501-508
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• 2007

This paper presents the feasibility of using electromechanical impedance based active sensing technique for nondestructive strength gain monitoring of early-age concrete by employing piezoelectric lead-zirconate-titanate (PZT) patches on concrete surface. The strength development of early age concrete is actively monitored by performing a series of experiments on concrete specimens under moist curing condition. The electrical admittance signatures are acquired for five different curing ages and compared with each other. The resonant frequency shifts of PZT patches with increasing days is observed which is on account of additional stiffening due to strength gain of concrete during curing and level of stiffening being related to strength obtained from compression tests on companion cylinder specimens. The proposed approach is found to be suitable for monitoring the development of compressive strength in early-age concrete. It is also observed in this study that root mean square deviation (RMSD) in admittance signatures of the PZT patches can also be used as an indicator of concrete strength development.

• Clinical and Experimental Reproductive Medicine
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• 제42권3호
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• pp.77-85
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• 2015

One of the key factors of early development is the specification of competence between the oocyte and the sperm, which occurs during gametogenesis. However, the starting point, growth, and maturation for acquiring competence during spermatogenesis and oogenesis in mammals are very different. Spermatogenesis includes spermiogenesis, but such a metamorphosis is not observed during oogenesis. Glycosylation, a ubiquitous modification, is a preliminary requisite for distribution of the structural and functional components of spermatids for metamorphosis. In addition, glycosylation using epididymal or female genital secretory glycans is an important process for the sperm maturation, the acquisition of the potential for fertilization, and the acceleration of early embryo development. However, nonemzymatic unexpected covalent bonding of a carbohydrate and malglycosylation can result in falling fertility rates as shown in the diabetic male. So far, glycosylation during spermatogenesis and the dynamics of the plasma membrane in the process of capacitation and fertilization have been evaluated, and a powerful role of glycosylation in spermatogenesis and early development is also suggested by structural bioinformatics, functional genomics, and functional proteomics. Further understanding of glycosylation is needed to provide a better understanding of fertilization and embryo development and for the development of new diagnostic and therapeutic tools for infertility.

• Journal of Plant Biology
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• 제22권3호
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• pp.55-57
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• 1979

These studies were undertaken to determine the $CO^2$fixation patterns following the chloroplast development in maize leaves. At the early stage of chloroplast development $^{14}C$ was incorporated into aspartate (41%) and malate (22%) respectively. Whereas the incorporation of $^{14}C$ into malate was higher than that of aspartate as chloroplast developed. Activity of NADPH-dependent malate dehydrogenase was increased throughout chloroplast development, but that of aspartate transaminase was not. Much incorporation of $^{14}C$ into aspartate at the early stage of chloroplast development and into malate at later stage of chloroplast development lead us to conclude that NADPH-dependent malate dehydrogenase activity is closely associated with chloroplast development, but activity of aspartate transaminase is not.