• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2001년도 The 8th International Symposium
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• pp.20-33
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• 2001

A major portion of drugs used in Ayurvedic system of medicine which has been practiced since the early human civilization in Indian subcontinent were of plant origin. It should be noted that 70% of the population in this region depends on Ayurveda for their medical treatment and 60% of the drug resources are obtained from the Himalayan region. Therefore, Nepal becomes a potential source of plant drug resource since it occupies a major portion of the Himalaya. In the present paper, in general a current status of medicinal plant resources of Himalayan region especially Nepal will be discussed. In addition to this, a typical example of antidiabetic activity of Shilajit will be taken for the discussion. Shilajit is one of the crucial elements in several formulations including those of Rasayana, a therapy in Ayurveda, which has been practiced in the prevention of ageing and mental disorder. Although, Shilaiit is widely used for the treatment of diabetes, no satisfactory scientific reports are available up to now. The crude Shilajit in the market is a dark brown or black rock-like substance collected from the Himalayan region with a strong smell of cow's stale urine. In our studies, Shilajit (collected in the central Himalayan region) prevented the diabetes in nonobese diabetic (NOD) mice model. Shilajit also prevented the diabetes in the rats against the action of multiple low-dose (10 ㎎/㎏, i.v., 5 times) of streptozotocin. On the other hand, Shilajit did not show antioxidative activity. The preventive action of Shilajit on diabetes is mainly focused on the Th1 and Th2 cell activities, since Th2 cells activity was found to be significantly upregulated. Shilajit, however, showed a mild action in controlling the blood sugar level in young, old, and mild diabetic rats, but not in the severe diabetic rats. It also stimulated the nitric oxide production in macrophages. Based on these evidences, the antidiabetic activities of Shilajit appear to be immunomodulative probably by protecting or strengthening insulin-producing b-cells In the pancreas. further systematic research on constituents of Shilajit and its quality evaluation is necessary to enable the use of natural medicines in the treatment of diabetes.

• Parasites, Hosts and Diseases
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• 제57권4호
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• pp.359-368
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• 2019

In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmanicidal activity against promastigote and amastigote, apoptosis and gene expression levels of free solution and niosomal-encapsulated tioxolone along with benzoxonium chloride. Span/Tween 60 niosome had good physical stability and high encapsulation efficiency (more than 97%). The release profile of the entrapped compound showed that a gradual release rate. The combination of niosomal forms on promastigote and amastigote were more effective than glucantime. Also, the niosomal form of this compound was significantly less toxic than glucantime ($P{\leq}0.05$). The flowcytometric analysis on niosomal form of drugs showed that higher number of early apoptotic event as the principal mode of action (89.13% in $200{\mu}g/ml$). Also, the niosomal compound increased the expression level of IL-12 and metacaspase genes and decreased the expression level of the IL-10 gene, which further confirming the immunomodulatory role as the mechanism of action. We observed the synergistic effects of these 2 drugs that induced the apoptotic pathways and also up regulation of an immunomodulatory role against as the main mode of action. Also, niosomal form of this combination was safe and demonstrated strong anti-leishmaniasis effects highlights further therapeutic approaches against anthroponotic cutaneous leishmaniasis in future planning.

• 한국산학기술학회논문지
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• 제20권5호
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• pp.417-426
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• 2019

본 연구는 예비유아교사를 대상으로 따돌림에 대한 인식을 확인해봄으로써, 유아교육현장에서 발생하는 따돌림에 대한 예방 및 대처를 위한 실천적 함의를 제공하고자 한다. 이를 위해 예비유아교사 313명에 대한 설문조사 자료를 토대로 SPSS Win 프로그램을 이용하여 빈도분석, 분산분석을 실시하였다. 주요 결과는 다음과 같다. 첫째, 따돌림 인식은 학년과 보육실습유무, 현장관찰수업유무, '학교폭력 예방 및 학생의 이해' 교과목 수강유무에 따라 통계적으로 유의미한 차이가 있었다. 둘째, 따돌림 행동에 대한 인식으로 '때리거나 발로 차는 등 폭력을 가하는 일이 빈번함', '공동으로 쓰는 물건을 사용하지 못하게 하는 경우가 많음', '다른 친구 앞에서 창피를 주거나 모함을 하는 일이 잦음'을 높게 인식하였다. 셋째, 따돌림 가해자의 특성에 대한 인식으로 '공격적인 행동과 말을 많이 함'이 가장 높았고 따돌림 피해자의 특성에 대한 인식으로 '수줍음이 많고 말이 별로 없음'이 가장 높았다. 넷째, 가해 이유에 대한 인식으로 '특별한 이유없이 그냥 재미로'가 가장 높았고 따돌림 현상 원인에 대한 인식으로 '부모의 양육태도나 가정환경의 문제'가 가장 높았다. 마지막으로, 따돌림 예방 및 대처의 주요 수행기관은 교사, 부모와 가정, 지역사회 및 국가, 유아교육기관, 교육청 순이었다. 교사의 역할로는 '학급에서 고립되는 유아들을 지속적으로 관찰하기'가 가장 높았고, 부모의 역할로는 '자녀에게 관심을 갖고 대화를 많이 하기'가 가장 높았으며, 유아교육기관의 역할로는 '교육과정 중에서 따돌림 방지교육 시간을 마련하여 운영하기'를 가장 높게 인식하였다. 이에 본 연구는 예비유아교사들의 따돌림에 대한 인식을 높이기 위한 다양한 노력들이 필요함을 시사한다.

• The Korean Journal of Physiology
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• 제15권1호
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• pp.61-66
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• 1981

In 1944 Cavallito and Bailey first extracted an essential oil, a powerful antibacterial principle, from the garlic and named it allicin. Later Stoll and Seeback elucidated that allicin was produced from alliin by the enzymatic action of arinase. Damaru observed the depressor responses following intraperitoneal administration of garlic juice in cats. And Thiersch presented evidence that garlic had a protective action against experimental arterosclerosis in cholesterol-fed animals. On the other hand it was also reported that anemias were caused by long-term ingestion of garlic as a result of reduction in hemoglobin and RBC. From the experiment in which the effect of garlic on the blood sugar level was studied, Lee insisted garlic elevated blood sugar level. However, August and Jain claimed that hypoglycemia was induced by garlic administration. Recently Bordia and Bansal suggested that essential oils extracted from onion and garlic have a strong preventive effect on hyperlipemia and prolonged coagulation time resulted from fat-feeding. Furthermore Bordia et al indicated that garlic exerted a strong fibrinolytic activity. In early 1920 s Sugihara reported that essential oil of garlic not only decreased arterial blood pressure but also had a paralytic effect on the isolated heart and intestinal strip of animals. The present study was proposed to investigate the effect of garlic juice and the mechanism of its action on the motility of the isolated rabbit duodenum. The motility of the isolated duodenum was recorded on polygraph by means of force transducer connected with Magnus apparatus. And the isolated duodenum was separtely pretreated with $acetylcholine(5{\times}10^{-7}\;gm/ml)$, $pilocarpine(2.5{\times}10^{-6}\;gm/ml)$, $histamine(5{\times}10^{-6}\;gm/ml)$ and barium $chloride(2.5{\times}10^{-5}\;gm/ml)$ in order to find out interations of these drugs with ASJ. The results obtained were as follows; At concentrations of 0.25%, 0.5% and 1.0% ASJ markedly inhibited contractions of isolated duodenum while tonus as well as contractility of the isolated intestine were decreased also with 0.5% and 1.0% ASJ. Since ASJ markedly abolished augmented motility of isolated intestine by histamine and partly reduced that by $BaCl_2$, it is strongly suggested that inhibitory action of ASJ on the intestinal motility is caused mainly by its antihistamine effect and partly by its direct action on the intestinal smooth muscle.

• Journal of Microbiology and Biotechnology
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• 제25권2호
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• pp.227-233
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• 2015

Two recombinant arabinosyl hydrolases, α-_L-arabinofuranosidase from Geobacillus sp. KCTC 3012 (GAFase) and endo-(1,5)-α-_L-arabinanase from Bacillus licheniformis DSM13 (BlABNase), were overexpressed in Escherichia coli, and their synergistic modes of action against sugar beet (branched) arabinan were investigated. Whereas GAFase hydrolyzed 35.9% of _L-arabinose residues from sugar beet (branched) arabinan, endo-action of BlABNase released only 0.5% of _L-arabinose owing to its extremely low accessibility towards branched arabinan. Interestingly, the simultaneous treatment of GAFase and BlABNase could liberate approximately 91.2% of _L-arabinose from arabinan, which was significantly higher than any single exo-enzyme treatment (35.9%) or even stepwise exo- after endo-enzyme treatment (75.5%). Based on their unique modes of action, both exo- and endo-arabinosyl hydrolases can work in concert to catalyze the hydrolysis of arabinan to _L-arabinose. At the early stage in arabinan degradation, exo-acting GAFase could remove the terminal arabinose branches to generate debranched arabinan, which could be successively hydrolyzed into arabinooligosaccharides via the endo-action of BlABNase. At the final stage, the simultaneous actions of exo- and endo-hydrolases could synergistically accelerate the _L-arabinose production with high conversion yield.

• 동서간호학연구지
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• 제10권1호
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• pp.27-40
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• 2004

Relapse is one of the most series problems in alcoholics treatment. Previous studies have shown that significant proportions of treated alcoholics show an early relapse and go through a chronic phase. It is necessity to find more effective relapse prevention program. The Purpose of this study was to develop a relapse prevention program that emphasis on group activities using various action methods. Previous studies revealed that there was no effective therapeutic strategy to prevent relapse and proposed that action methods were more practical ways to be able ti cope with high-risk situation than verbal methods such as discussions and lectures. The special attempt of this program was the application of various actions methods and the integration of many psychosocial therapeutic strategies as compared with many relapse prevention programs. The theoretical framework of this relapse prevention program was based on mainly the Marlatt's Relapse Prevention model and Prochescha and DiClemente's Transtheoretical model. This Program consists of eight structure sessions. Every session has three phase: Warm-up phase, action phase, and sharing phase as sociodrama structure. Sociodrama is based on many of the principles of adult learning. And sociodrama looks at how groups work through an understanding of systems and role theory. Therefore, in working with a group a therapist might explore with them the roles that people play, roles that are missing at present such a visionary and how people can develop new roles or new ways of playing existing roles. The researchers explained the purpose of this study to all participants after their agreement to participate. Voluntary informed consent was obtained from all participants. Every session allows participants to recognize personal specific high-risk situation and to examine possible coping behaviors creatively. Multiple solutions can be proposed, tested and evaluated dramatically, giving new insights or breakthroughs in thinking. This is vital for the initiation of change, and if appropriate, expanding new role development. The first two sessions aim at understanding of relapse process and recognize of high-risk situations focused on orientation about action methods. The next four sessions deal with high-risk situations. The last two sessions give participants opportunities to venture new life-styles. The methods and approaches used in this program utilized as a tool to explore and practice possible coping strategies. and this program can contribute to prevent relapse episode if tune with the particular high-risk situation by using active practices in safe environment.

• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.203-212
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• 1986

Hypertension is one of the most well known risk factors for cerebrovascular or coronary heart disease and is a major public health problem. Early detection and treatment of hypertension are essential, but the compliance of treatment on hypertension is not easy to achive. Hypertensive workers are being detected by the annual screening under the Labour Standard Law in Korea but the solidified control system for them is not existing. This study about workers 'Motive-Belief-Action in non-drug and drug treatment of their hypertension would be worthwhile to interpret how the workers actually behave in coping with hypertension, and also would be advisable to construct the follow-up program in Korea. In the field research process two criteria were used to select sample group. The first criterion included the workers who were screened to be hypertensive with their blood pressure above 160/95 in this survey. The second one was used to classify study-group respondents who had known their hypertension by successive annual screening. From such criteria a total of 156 male workers were sampled in 21 industries, the author interviewed them using the structured questionnaire which consisted of Belief-Motive-Action items about non-drug and drug treatment for hypertension with open-ended question on symptom of hypertension. The summary is as follows: 1) Sixty-one percent of respondents had ever checked their blood pressure somewhere besides the annual screening. 2) Most respondents(97.2%) complained no symptoms of hypertension at all. 3) Belief level of non-drug treatment was relatively high (82.1%-64.7%), but motive(55.1%-28.2%) and action(38.5%-16.7%) levels were low. 4) Belief level of drug treatment was relatively lower than that of non-drug treatment, blue collar workers showed higher artier level of drug treatment than white collar workers, and correlation coefficient between belief and motive on drug treatment was lower in group of not-recognizing their family history of hypertension than recognized group. Such findings indicated that belief on drug treatment of hypertensive workers would be problematic. 5) White collar workers showed significant lower correlation coefficients between Motive and Action of salt restriction, restriction of fatty diet and relaxation than blue collar workers. 6) Mild hypertension group showed low levels of Motive and Action of non-drug treatment(salt restriction, restriction of fatty diet and relaxation) and also showed low correlation coefficient between Belief and Motive of above non-drug treatment.

• 기독교교육논총
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• 제61권
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• pp.165-201
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• 2020

본 연구는 성경에 기초한 유아 언어 교육 활동 개발을 통한 기독 예비 유아교사의 변화를 탐구하여 기독유아교육의 언어교육 개발 방향을 모색하는데 목적이 있다. 유아 언어 교육의 세부 주제인 '성경에 기초한 유아 언어 교육 활동 개발'에 참여한 기독교교육과 학생 19명을 대상으로 2018년 9월 3일 ~ 12월 28일 동안 면담, 설문조사, 활동계획안, 성찰이 담긴 포트폴리오 등을 통해 자료를 수집하였다. 수집된 자료를 분석하여 핵심 범주를 도출하고 이를 범주화 하였다. 자료 분석 및 해석의 객관화를 위해 신학 및 유아교육 전문가 2인의 동료 확인을 거쳤다. 연구 결과, 성경에 기초한 유아 언어 교육 활동 개발에 대한 기독 예비 유아교사 경험은 인지적 변화, 인성적 변화, 실천적 변화로 범주화하였다. 첫째, 성경에 기초한 유아 언어 교육 활동을 개발하면서 기독 예비 유아교사는 유아 언어교육의 발달적 성취와 결과보다는 '언어교육활동의 과정'의 인지적 변화를 경험하였다. 또한, 유아 언어 교육 영역의 분리가 아닌 '듣기-말하기-읽기-쓰기의 통합'의 필요성을 인식하였다. 기독 예비 유아교사는 교사중심의 형식적 언어교육과 더불어 '유치원 생활 속의 비형식 언어교육'의 중요성을 인식하였고, 유아 언어 교육의 효과성 검증보다는 '유아 중심의 의미 있는 언어교육 경험'이 중요하다는 인지적 변화가 이루어졌다. 둘째, 성경에 기초한 유아 언어 교육 활동을 개발하면서 기독 예비 유아 교사는 '자신감 있는 교사', '전문성 있는 교사', '반성적 사고와 태도를 가진 교사'로서 인성적 변화를 나타났다. 마지막으로 성경에 기초한 유아 언어 교육 활동을 개발하면서 기독 예비 유아 교사는 '긍정 언어의 힘'을 인식하였고, '바른 언어 사용 습관' 형성과 '기독교 교육과 유아교육 연계'를 위해 노력하는 실천적 변화가 있었다. 성경에 기초한 유아 언어교육 활동 개발을 통해 기독 예비 유아교사는 예측할 수 없는 교육 상황과 빠르게 변화하는 교육 현실 속에서 유아를 위한 진정한 유아 교사가 되기 위한 마음 자세와 교사로서 요구되는 열정의 자질을 함양하게 되어 교사 효능감이 증진되었다. 향후, 기독교교육과 유아교육이 연계된 다양한 교사 교육 프로그램이 지속적이고 체계적으로 이루어지길 기대한다.

• Child Health Nursing Research
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• 제2권1호
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• pp.55-68
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• 1996

Although nursing researchers have performed studies on parent-child relationship actively since early 1980s in Korea, nothing hasn't been tried on the analysis of the contents of researches. We researchers tried examining the trend of researches by investigating treaties on mother-child relationship conducted from 1981 to 1994. The purpose of this study was to analyze the trend of research on the mother-child relationship and to suggest direction for future study. The total numbers of the studies were 27 cases, These studies were analyzed for 1) time of publication 2) research design 3)main concept 4)thesis for a degree or nondegree 5) measurement tool The finding of the analysis were as follows. 1) In the chronological situation, the research on mother-child relationship began to perform in 1981 in the country and had been made most for five years to 1986 with 14 treaties and has decreased since 1990. 2) In the research plan, there are 21 survey(the most) ,5 quasi experimental(before 1986), 1 qualitative. 3) In the subject, the researches on mother-child are the most, 22 and of them 17 treaties on normal infant,4 comparative research on high risk infant and normal infant,5 treaties on mother, 4) The conception of mother-child relationship was used as various conceptions such as affection, union, bonding in early research of 1980s, but it hasn't been used as union bonding but studied mostly as the conception of 'mother-child interaction'since 1986. 5) The measurement tool of research was used variously, the Cropley's tool was used in early 1980s, but Walker's MIPS, Barnard's NCAST were used mostly in 1990. 6) Mother-child interaction influence on mother's self-conception, stress, care and feeding of child, frequency of delivery, planned pregnancy and delivery and health condition of child, birth weight, fetal period, period of mother-child life. Aspects of mother-child interaction composed on visual contact, looking at each other, skinship and caress with finger and fingertip. The leading action of mother-child interaction was mostly uttering action. 7) I suggest that the program for professional education is necessary for the establishment of the aspects of mother-child interaction.

• 한국측량학회지
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• 제36권3호
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• pp.177-184
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• 2018

In case that limited resources can be mobilized, non-structural countermeasures such as 'monitoring using Information and Communication Technology might be one of solutions to mitigate disaster risks. Having established the monitoring system, operational and maintenance costs to maximize the effectiveness might trouble the authority concerned or duty attendant who is in charge. In this respect, "Guerrilla Sensor" would be very cost effective because of the inherent mobility characteristic. The sensor device with the IRIS camera and GPS (Global Positioning System) equipped, is basically battery-operated and communicates with WCDMA (Wideband Code Division Multiple Access). It has a strong advantage of capabilities for 'Disaster Response' with immediate and prompt action on the spot, making the best use of IoT (Internet of Things), especially with the mobile web. This paper will explain how the sensor system works in real-time GIS (Geographic Information System) pinpointing the exact location of the abnormal movement/ground displacement and notifying the registered users via SMS (Short Message Service). Real time monitoring with early warning and evaluation of current situations with LBS (Location Based Service), live image and data information can help to reduce the disaster impact. Installation of Guerrilla sensor for a real site application at Gimcheon, South Korea is also reported.