• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.4 s.304
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• pp.159-166
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• 2005

This thesis deals with a method to deliver more realistic sound by cancelling the cross-talk which is inherent to the 5.1 channel speaker system. First, the cross-talk cancellation method that eliminates cross-talks on the path from left speaker to right ear and from right speaker to left ear is explained. Then the application and replaying method using the cross-talk cancellation explained here is introduced. The acoustical model for cross-talk cancellation is the free field model This model minimizes distortion of sound. Many experts also make studies on this model. I used the bark scale sound quality compensation based on psycho-acoustic. For the surround channels, band-limited sound quality compensation is performed in the frequency domain.

• Archives of Pharmacal Research
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• v.28 no.7
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• pp.848-853
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• 2005

Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1 % inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7 -day model of multiple treatment of TPA (38.1 % inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin $E_2$ production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

• BMB Reports
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• v.53 no.2
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• pp.106-111
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• 2020

Glutaredoxin 1 (GLRX1) has been recognized as an important regulator of redox signaling. Although GLRX1 plays an essential role in cell survival as an antioxidant protein, the function of GLRX1 protein in inflammatory response is still under investigation. Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation. In LPS-exposed Raw 264.7 cells, PEP-1-GLRX1 inhibited cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), activation of mitogen activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-κB) expression levels. In a TPA-induced mouse-ear edema model, topically applied PEP-1-GLRX1 transduced into ear tissues and significantly ameliorated ear edema. Our data reveal that PEP-1-GLRX1 attenuates inflammation in vitro and in vivo, suggesting that PEP-1-GLRX1 may be a potential therapeutic protein for inflammatory diseases.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.19-19
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• 1982

Pathogenesis of otitis media was studied in an animal model of rats from a histopathological and biochemical point of view. Basic anatomical outline, and distribution and type of normal epithelial cells of the rat bulla were described as a background study. Pseudomonas otitis media was developed in rats by inoculating $10^{9}$ bacteria into the tympanic bulla. Histopathologic change of the mucoperiosteal layer showed acute stage of infection from 3 days to 3 weeks, and it became chronic after 4 weeks animals through 12 weeks. Enzyme profile in the extracts of the inflammatory middle ear tissue was studied. The levels of three enzymes, PZ-peptidase, LDH, and lysozyme were much higher in the middle ear tissue than in the corresponding sera as might be expected. Tissue/serum ratios of the enzyme activities were 13-38 for PZ-peptidase, 63-177 for LDH, and 18-94 for lysozyme. Possible role of the PZ-peptidase and possible origins of the three enzymes detected in the tissue were discussed.

• Archives of Plastic Surgery
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• v.37 no.1
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• pp.12-21
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• 2010

Purpose: This work aimed to elucidate the anti-inflammatory effect of pegmatite in vitro and in vivo. Methods: Author evaluated the suppressive effects of pegmatite on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, TNF-${\alpha}$ and IL-6 release in the RAW 264.7 murinemacrophages. Results: Treatment of RAW 264.7 cells with pegmatite significantly reduced LPS-stimulated NO production and inflammatory cytokine such as TNF-${\alpha}$ and IL-6 secretion in a concentration-dependent manner. Also pegmatite showed topical anti-inflammatory activity in the arachidonic acid (AA)-induced ear edema and acetic acid-induced increase in capillary permeability assessment in mice. It was also found that pegmatite (10 mg per ear in DW) inhibited arachidonic acid induced edema at 24 h more profoundly than 1 h by topical application. Furthermore, the vascular permeability increase induced by acetic acid was significantly reduced in mice that received pegmatite in 50 mg per mouse. Conclusion: Therefore the results of the present study suggest that pegmatite is a potent inhibitor of the LPS-induced NO and inflammatory cytokine in RAW 264.7 macrophages and showed anti-inflammatory activities in vivo animal model.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.12 no.4
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• pp.168-180
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• 2000

In the Part I, the three dimensional model testing with NNW deep water wave direction gave the results such that the occurrence of breaking waves over the peak of Ear-Do caused very small wave height at the structure position. But the measured wave forces were rather greater than the calculated forces based on deep water wave height. Furthermore, It was also perceived that the time series of the forces looked like corresponding to the case that waves were superimposed by an unidirectional current. In the present Part II, the current is presumed to be a flow secondly induced by breaking waves, and an extensive study to clarify the current in a quantitative sense is performed through numerical analysis and hydraulic experiment. The results showed that a strong circulation can surely occur in the vicinity of the structure due to radiation stress differentials given by the breaking waves. It was also recognized that the velocity of the induced current varied with the magnitude of energy dissipation rate introduced in the numerical analysis. The numerical analysis was tuned adjusting the dissipation rate so that the calculated wave field could closely match with the experimental results of Part I. The fluid force (in prototype) for the optimal match showed approximately 2.2% increased over the calculated value based on the deep water wave height (24.6m) whereas the force corresponding to the average of the experimental values showed the increase of about 13.0%.

• Journal of Sensor Science and Technology
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• v.13 no.6
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• pp.479-487
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• 2004

The prevention of noise induced hearing loss is very important, because there is no treatment for it. There are some kinds of devices for hearing protection, and those are effective in preventing a noise induced hearing loss. However, people often resist the use of hearing protection devices because it is difficult to have a conversation. Therefore, a hearing protection device is must effective not only in hearing protection but also in preserving communication ability. In this paper, we proposed a small acoustic filter for ITE type noise protector to solving the problem about the difficulties of conversation. That is applied a principle of acoustic filters that have been used for a muffler of automobiles, guns, and etc. To find out the sound transmission characteristic at the eardrum, we regarded an acoustic filter and external ear canal as a coupled system. So, we simulated the coupled system with OrCad, and experimented with a designed acoustic filter and a 2 cc coupler which has the same transmission characteristic as the external ear canal has. We confirmed that it is possible to adjustment acoustic transmission characteristics through simulation of electrical model for acoustic filter and external ear and experiments using designed small acoustic filters.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.1
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• pp.23-28
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• 1999

ALP (alkaline phosphatase) is a membrane-bound metalloenzyme that is expressed in osteoblasts, hepatocytes, lung, kidney, endothelial cells, leukocytes and other cells. Normal soft tissue and skin show little tissue nonspecific ALP (TN-AP), However, scar tissue contains high levels of TN-AP activity, and in fact, TN-AP is expressed intensely in regenerating connective tissue after the wounding. The purpose of this study was to evaluate the change of ALP expression in hypertrophic scar model in rabbits and the effect of triamcinonolone on ALP expression. Adult male New Zealand white rabbits, weighing about 2.5 kg, were used. After full-thickeness wounding over the ventral surface of each ear, either saline (control ear) or triamcinolone (contralateral ear) was injected on day 16. Rabbits were sacrificed on day 3, 7, 15, 17, 19, 23, and the specimens were retrieved en bloc. Histologic and immunohistochemical examinations of tissue samples were done. The results obtained were as follows: On day 3, ALP reaction was observed on fibroblasts and inflammatory cells in wound margin. On day 7, ALP reaction was more intense than day p in capillaries, inflammtory cells, and fibroblasts behind newly formed epithelium. On day 15, ALP reaction was lessened in both groups and appeared mainly in subepidermal capillary network, Since day 17, ALP reaction was lessened in both groups and weaker in triamcinolone-injected group than in saline-injected group. These results suggest that ALP reaction isn't increased in triamcinolone-injected scar and triamcinolone reduces scar not by increasing TN-AP expression but other mechanism.

• Safety and Health at Work
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• v.8 no.4
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• pp.364-370
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• 2017

Background: Labeled noise reduction (NR) data presented by manufacturers are considered one of the main challenging issues for occupational experts in employing hearing protection devices (HPDs). This study aimed to determine the actual NR data of typical HPDs using the objective fit testing method with a microphone in real ear (MIRE) method. Methods: Five available commercially earmuff protectors were investigated in 30 workers exposed to reference noise source according to the standard method, ISO 11904-1. Personal attenuation rating (PAR) of the earmuffs was measured based on the MIRE method using a noise dosimeter (SVANTEK, model SV102). Results: The results showed that means of PAR of the earmuffs are from 49% to 86% of the nominal NR rating. The PAR values of earmuffs when a typical eyewear was worn differed statistically (p < 0.05). It is revealed that a typical safety eyewear can reduce the mean of the PAR value by approximately 2.5 dB. The results also showed that measurements based on the MIRE method resulted in low variability. The variability in NR values between individuals, within individuals, and within earmuffs was not the statistically significant (p > 0.05). Conclusion: This study could provide local individual fit data. Ergonomic aspects of the earmuffs and different levels of users experience and awareness can be considered the main factors affecting individual fitting compared with the laboratory condition for acquiring the labeled NR data. Based on the obtained fit testing results, the field application of MIRE can be employed for complementary studies in real workstations while workers perform their regular work duties.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.8
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• pp.1035-1044
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• 2010

Head-related transfer function (HRTF) is an acoustic transfer function from a sound source to the ear canal entrance position. HRTFs are very important information in the construction of virtual sound fields. HRTFs also vary for different individuals. In this study, characteristics of HRTF for an average Korean are investigated numerically by comparing with the HRTF for a standard Knowles Electronics Manikin for Acoustic Research (KEMAR). A boundary element (BE) model for an adult Korean is developed using the computerized tomography (CT) data in order to investigate the variation in HRTFs for different individuals. The boundary conditions of the BE model are identified by comparing the numerical results with the experimental results. The numerical model shows that accurate HRTFs can be calculated efficiently over full audible frequency range for individuals.