Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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The Anti-Inflammatory Effect of Pegmatite by in Vivo and in Vitro Study

In vivo 및 in vitro 시험을 통한 페그마타이트의 항염증 효과

  • Lee, Min-Hyuk (Department of Plastic & Reconstructive Surgery, College of Medicine, Dong-A University) ;
  • Kim, Seok-Kwun (Department of Plastic & Reconstructive Surgery, College of Medicine, Dong-A University) ;
  • Kwon, Yong-Seok (Department of Plastic & Reconstructive Surgery, College of Medicine, Dong-A University) ;
  • Lee, Jang-Ho (Department of Plastic & Reconstructive Surgery, College of Medicine, Dong-A University) ;
  • Lee, Keun-Cheol (Department of Plastic & Reconstructive Surgery, College of Medicine, Dong-A University)
  • 이민혁 (동아대학교 의과대학 성형외과학교실) ;
  • 김석권 (동아대학교 의과대학 성형외과학교실) ;
  • 권용석 (동아대학교 의과대학 성형외과학교실) ;
  • 이장호 (동아대학교 의과대학 성형외과학교실) ;
  • 이근철 (동아대학교 의과대학 성형외과학교실)
  • Received : 2009.02.03
  • Accepted : 2009.08.26
  • Published : 2010.01.10
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Abstract

Purpose: This work aimed to elucidate the anti-inflammatory effect of pegmatite in vitro and in vivo. Methods: Author evaluated the suppressive effects of pegmatite on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, TNF-${\alpha}$ and IL-6 release in the RAW 264.7 murinemacrophages. Results: Treatment of RAW 264.7 cells with pegmatite significantly reduced LPS-stimulated NO production and inflammatory cytokine such as TNF-${\alpha}$ and IL-6 secretion in a concentration-dependent manner. Also pegmatite showed topical anti-inflammatory activity in the arachidonic acid (AA)-induced ear edema and acetic acid-induced increase in capillary permeability assessment in mice. It was also found that pegmatite (10 mg per ear in DW) inhibited arachidonic acid induced edema at 24 h more profoundly than 1 h by topical application. Furthermore, the vascular permeability increase induced by acetic acid was significantly reduced in mice that received pegmatite in 50 mg per mouse. Conclusion: Therefore the results of the present study suggest that pegmatite is a potent inhibitor of the LPS-induced NO and inflammatory cytokine in RAW 264.7 macrophages and showed anti-inflammatory activities in vivo animal model.

Keywords

References

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