• The Korea Journal of Herbology
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• v.29 no.6
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• pp.165-173
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• 2014

Objectives : Platycodon Root is frequently used in traditional medicine to treat inflammatory diseases of the throat. The purpose of this study was to characterize the effect of the EtOH extract of fermented Platycodon grandiflorum on the ameliorative effects on the Antipruritic Effect of atopic dermatitis mouse model induced by compound 48/80 and ovalbumin (OVA)-induced allergic responses in mice. Methods : In the present study, we examined the anti allergic effect of Platycodon grandiflorum (PR) and its fermented production (FPR) in several mouse model. We measured acute ear edema in a mouse model caused by TPA and consecutively histological change of Ear tissue was observed by hematoxylin and eosin (H&E) staining. and also Scratching behaviors by compound 48/80 was investigated. The levels of allergic mediators such as immunoglobulin (Ig) E, and anti-oxidant markers such as SOD and MDA in the sera of OVA induced allergic mice were measured by enzyme-linked immunosorbent assay. Results : FPR inhibited compoud 48/80-induced scratching behavior in mice, as well as acetic acid-induced writhing in mice. The anti-scratching behavioral effect of FPR was more potent than PR. FPR extract significantly decreased the serum levels of IgE and MDA compared with those of OVA control group. Conclusions : These results indicate that Anti allergic effect of Platycodon grandiflorum is enhanced by fermentation with Saccharomyces cerevisae and FPR may be useful for protection from the itching reactions, which are IgE-mediated representative skin allergic diseases.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.65-81
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• 2016

Objectives : Haedoksamul-tang (HSTE), a water extract from a mixture of Phellodendri Cortex, Coptidis, Scutellariae Radix, Gardeniae Fructus, Angelica acutiloba Radix, Cnidii Rhizoma, Paeoniae Radix, Rehmanniae Radix, has been traditionally used for allergic skin diseases such as atopic dermatitis and contact dermatitis in oriental countries. However, little is known about the effects of aqueous extract of HSTE on trimellitic anhydride (TMA)-induced contact hypersensitivity (CHS) in a mouse model. Methods : In this study, we investigate the pharmacological effects of HSTE on TMA-induced CHS in Balb/c mice. Contact hypersensitivity was induced in mice by topically sensitizing and challenging with TMA in flank skin and ears during oral administration (for 17 days) and topical treatment (30 min before challenge) with HSTE. We examined the effects of HSTE on IgE and IgG1 levels, inflammatory parameters in ear tissues, CD4⁺/CD8⁺ ratio, cytokine and chemokine production in sera, tissues, and immune cells from TMA-sensitized mice.Results : Oral and topical administration with HSTE reduced, in a dose dependent manner, thickness and leukocyte infiltration of ear tissues and IgE levels in serum from mice sensitized with TMA. In addition, auricula lymph node cells isolated from TMA-sensitized mice significantly elevated the expression ratio of CD4⁺/CD8⁺ as well as increased the production of IL-4, IL-5, IL-13 and IFN-γ by ex vivo stimulation with antibodies against CD3 and CD28, and these inflammatory indexes, except for IFN-γ, were significantly suppressed by orally and topically administration of HSTE. Furthermore, stimulation of auricula lymph node cells from TMA-sensitized mice with antibodies against CD3 and CD28 increased the production of MCP-1/CCL2 and MIP-1α/CCL3, and these effects were inhibited in a dose-dependent manner in cells from mice treated with HSTE. Conclusions : These results suggest that HSTE can be used for treating contact hypersensitivity by inhibiting leukocyte infiltration as well as production of serum IgE and chemokine/Th2 cytokine in an animal model.

• Journal of Korea Society of Digital Industry and Information Management
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• v.12 no.3
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• pp.299-309
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• 2016

This study proposed a logistics plan for sending supply to be distributed to areas other than producing areas to wholesalers and allocating supply to be distributed to areas near producing areas to local distribution center in the vicinity instead of shipping the entire quantity to wholesalers for fruits auction to increase the competitive edge of the domestic fruits and vegetables logistics market in the ear of infinite competition. A video auction-based short distance division logistics operation model was developed to enhance competitiveness related to the circulation of fruits and vegetables, reduce logistics costs, and rationalize logistics by distributing the items sent to wholesalers through field auction and the shipments at local distribution center to neighboring areas through video auction connected to wholesalers real-time. The study especially came up with a logistics rationalization plan by examining and analyzing the stages and costs of transportation between producing areas and wholesalers on the circulation routes of fruits.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1991.10a
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• pp.285-292
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• 1991

객체-관계성(ER:entity-relationship)모델을 이용한 지식표현모델은 실세계를 객체(entity)들 또는 객체들의 집합들 사이의 서로간에 관계성(relationship)으로 나타낸다. 그러나 고정된 측면에서 표현되기 때문에 하나의 객체를 여러가지 측면에서 관찰할 수 없다. 반면 객체-측면(EA:entity-aspect)모델은 객체노드와 측면노드의 두가지 형을 갖는 노드들로 구성되어 측면에 따라 서로 다른 지식을 표현 할 수 있으므로 하나의 객체를 여러가지 측면에서 관찰할 수 있고, 그 세부적 계층구조를 나타낼 수 있는 장점이 있으나 너무 계층성을 강조하며, 객체간의 관계성을 나타낼 수가 없어 계층구조 속에 포함되지 않은 객체는 지식으로 표현 할 수 없어 실세계의 다양한 지식을 표현하는데 부자연스럽다. 따라서 본 논문에서는 객체-관계성(ER)모델의 관계성과 객체-측면(EA)모델의 측면성을 통합하여 객체 측면-관계성(EAR)모델을 제시하고, 이 모델에서 객체간의 관계성을 하나의 객체로 간주함으로 IS-A측면에 의하여 하위레벨로 계승할 수 있음을 보였다.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.114-114
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• 2002

Purpose： To know the fate of Gadophrin-2-enhanced areas in hearts with acute reperfused myocardial infarction. Method： The left anterior descending branches of coronary arteries were occluded for 90 min and reperfused for 60 min in 15 rabbits. Then, Gadophrin-2 (0.05 mmol/kg) was injected via ear veins. Short-axial T1-weighted spin echo images and fast cine images were obtained 24 hours after injection of Gadophrin-2. After four weeks, short-axial cine MRI was performed and T1-weighted spin echo Images were obtained 5 min and 15 min after injection of Gd-DTPA (0.2 mmol/kg). The animals were sacrificed and short-axial slices of the specimen were stained with 1.5% triphenyltetrazolium chloride (TTC) solution.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1977.06a
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• pp.5.1-5
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• 1977

Since Metz first introduced the conceps of Impedance Audiometry in 1946. Many pioneers studied for the development of the acoustic Impedance bridge. It is now widely used in clinical audiology and it plays an important role in otology. Recently there was the literature stated on normal value of various test c Impedance. This paper is dealing with the clinical evaluation of type c in comparison with following subjects as; 1. Comparison with the otoscopic finding. 2. Correlation with the pure tone audiometry. 3. Correlation with the stapedial reflex. 4. Correlation between pathologic negative pressure range and middle ear fluid.

• Archives of Plastic Surgery
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• v.32 no.4
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• pp.516-520
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• 2005

Multilayered cartilage graft has been clinically used at tip plasty, total ear reconstruction, and cleft lip nasal deformities. Perichondrial flap or a free perichondrium has been also commonly used for induction of neocartilage. However, the influence of perichondrium on multilayered cartilage graft to strength and growth rate is still unknown. The purpose of this study was to compare the strength and growth rate of different multilayered cartilage graft and to present the most ideal model of multilayered cartilage graft. Twenty New-zealand white rabbit were used. Triple layers of cartilage grafts with various perichondrium were inserted into six separate pockets in paravertebral region of rabbits. The grafts were grossly and microscopically observed on 8 and 16 weeks after grafting. On gross observation, the grafts showed marked enlargement of three layers of cartilage grafts with perichondrium compare with three layers of cartilage grafts without perichondrium In histologic examination, the number of PCNA-labelled cells were significantly high on three layers of cartilage grafts with perichondrium. In conclusion, this study suggested that triple-layer graft of cartilage grafts with perichondrium on the outside of triple-layer graft has strength and an effect on chondrogenetic induction by the perichondrium.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.5
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• pp.460-471
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• 1992

By setting a new model to describe the time-discontinuous operation of PLL loop which used tri-state and sample-hold method, the stability analysis of nonlinear PLL has been performed in z-domain and the state equations for the transient response has been introduced. Until now, the lin-ear analysis by approximation of time-discontinuous to time-continuous operation had not found then stable region of time-discontinuous digital PLL exactly. However, the analysis In z-domain by the new model has been found the unstable region where the time-continuous analysis had have not. 1'herefore the limit of loop coefficient has been computed to design digital PLL optimally.

• Herbal Formula Science
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• v.21 no.1
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• pp.80-90
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• 2013

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2012.10a
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• pp.546-552
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• 2012

This paper is a study on squeal noise simulation under the consideration of temperature and pressure dependent material properties of friction material. For this, data of pressure and temperature dependent material properties of lining is achieved by using lining data base and exponential curve fit. Complex eigenvalue analysis is performed for predicting squeal noise frequency and instability and chassis dynamo test is performed for achieving squeal noise frequency, sound pressure level, occurrence temperature & pressure. Initial multi models are composed for considering complex interface conditions such as pad ear-clip, piston-housing and guide pin-torque member. The simulation result of base models is compared with the test result. Squeal noise simulation under the consideration of temperature and pressure dependent material properties of friction material is performed and analyzed using multi models. And additional condition is disc material property variation. Entire simulation conditions are combined and analyzed. Finally, this paper proposes direction of the warm squeal noise model.