Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Multilayer Onlay Cartilage Graft with Perichondrium: Comparing Growth Rate and Strength in a Rabbit Model

연골막을 포함한 중첩 연골 이식의 성장률 및 견고성에 관한 연구

  • Kim, Hyung Taek (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Song, Ji Young (Fraumedi Hospital) ;
  • Seo, Sang Won (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Chang, Choong Hyun (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Sohn, Jin Hee (Department of Pathology, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University)
  • 김형택 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 송지영 (프라우메디병원 성형외과) ;
  • 서상원 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 장충현 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 손진희 (성균관대학교 의과대학 강북삼성병원 병리학교실)
  • Received : 2005.03.14
  • Published : 2005.07.10
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Abstract

Multilayered cartilage graft has been clinically used at tip plasty, total ear reconstruction, and cleft lip nasal deformities. Perichondrial flap or a free perichondrium has been also commonly used for induction of neocartilage. However, the influence of perichondrium on multilayered cartilage graft to strength and growth rate is still unknown. The purpose of this study was to compare the strength and growth rate of different multilayered cartilage graft and to present the most ideal model of multilayered cartilage graft. Twenty New-zealand white rabbit were used. Triple layers of cartilage grafts with various perichondrium were inserted into six separate pockets in paravertebral region of rabbits. The grafts were grossly and microscopically observed on 8 and 16 weeks after grafting. On gross observation, the grafts showed marked enlargement of three layers of cartilage grafts with perichondrium compare with three layers of cartilage grafts without perichondrium In histologic examination, the number of PCNA-labelled cells were significantly high on three layers of cartilage grafts with perichondrium. In conclusion, this study suggested that triple-layer graft of cartilage grafts with perichondrium on the outside of triple-layer graft has strength and an effect on chondrogenetic induction by the perichondrium.

Keywords

References

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