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http://dx.doi.org/10.6116/kjh.2014.29.6.165.

Anti-pruritic Effect of Ethanol Extracts from Platycodon grandiflorum and its fermented production in Scratching Behavior Mouse Models  

Ha, Mi-Ae (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Kim, Jin-Woo (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Lee, Shin-Woo (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Chun, Hyun-Sik (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Cho, Young-Son (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Shin, Yong-Wook (Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Publication Information
The Korea Journal of Herbology / v.29, no.6, 2014 , pp. 165-173 More about this Journal
Abstract
Objectives : Platycodon Root is frequently used in traditional medicine to treat inflammatory diseases of the throat. The purpose of this study was to characterize the effect of the EtOH extract of fermented Platycodon grandiflorum on the ameliorative effects on the Antipruritic Effect of atopic dermatitis mouse model induced by compound 48/80 and ovalbumin (OVA)-induced allergic responses in mice. Methods : In the present study, we examined the anti allergic effect of Platycodon grandiflorum (PR) and its fermented production (FPR) in several mouse model. We measured acute ear edema in a mouse model caused by TPA and consecutively histological change of Ear tissue was observed by hematoxylin and eosin (H&E) staining. and also Scratching behaviors by compound 48/80 was investigated. The levels of allergic mediators such as immunoglobulin (Ig) E, and anti-oxidant markers such as SOD and MDA in the sera of OVA induced allergic mice were measured by enzyme-linked immunosorbent assay. Results : FPR inhibited compoud 48/80-induced scratching behavior in mice, as well as acetic acid-induced writhing in mice. The anti-scratching behavioral effect of FPR was more potent than PR. FPR extract significantly decreased the serum levels of IgE and MDA compared with those of OVA control group. Conclusions : These results indicate that Anti allergic effect of Platycodon grandiflorum is enhanced by fermentation with Saccharomyces cerevisae and FPR may be useful for protection from the itching reactions, which are IgE-mediated representative skin allergic diseases.
Keywords
Platycodon grandiflorum; fermentation; allergic response; compound 48/80; anti-oxidant;
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Times Cited By KSCI : 6  (Citation Analysis)
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