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Detection of Testosterone-like Activities of Hydrothermal and Ethanol Extracts of Oriental Medicines Using an in Vitro Detection System (In vitro 검출 시스템을 이용한 한약재 열수 및 에탄올 추출물의 남성호르몬 유사활성 검출)

  • Lee, Dong-Geun;Jo, Jung-Kwon;Lee, Sang-Hyeon
    • Journal of Life Science
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    • v.30 no.6
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    • pp.550-554
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    • 2020
  • The purpose of this study was to screen the testosterone-like activities of eight oriental medicines with an in vitro testosterone compound detection (TCD) system. Distilled water and 80% ethanol, both at 80℃, were used to obtain extracts from Cervus nippon temminck (Nokgaksang), Cynanchum wilfordii (Baeksuo), Lespedeza cuneata (Yagwanmun), Panax ginseng (Hongsam), Smilax china (Toryeong), Taraxacum platycarpum (Mindlre), Tribulus terresteis (Namgase), and Trigonella foenum-graecum (Horopa), and extracts at concentrations of 5, 50, and 500 ㎍/ml were assessed using the TCD system. The testosterone-like activities of the 80% ethanol extracts were seen to increase with concentration and ranged from 0.9 to 5.0 times higher than those of the negative control; Horopa and Yagwanmun exhibited superior testosterone-like activities, followed by Mindlre and Hongsam at the same concentration. Toryeong and Namgase, on the other hand, showed low activity with Nokgaksang and Baeksuo exhibiting very low levels. Compared with the activities of the positive control (5α-DHT), the 80% ethanol extracts of Horopa and Yagwanmun at a concentration of 500 ㎍/ml showed higher testosterone-like activities than 10-8 M 5α-DHT. The water extracts showed lower activity levels than the ethanol samples, and the change of activity with concentration was also lower. It was confirmed that the 80% ethanol extracts of Horopa, Yagwanmun, and Mindlre etc. enhance the transcription efficiency of testosterone-related genes and may therefore be useful in developing health food or medicinal treatments for the improvement of male menopausal symptoms.

A Study on Practical Analyzing and Improving Disaster Management Organization of Korean Government (재난관리조직의 실태분석과 발전방안)

  • 권오한;남상화;이춘하
    • Fire Science and Engineering
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    • v.15 no.1
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    • pp.127-138
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    • 2001
  • I. introduction. A government goal at the present is established to make a welfare nation and to keep people's safe living, but it is criticised that when a large-scale disaster happens, the authority concerned could not deal with it, causing many people injured and material damage. Moreover, in these days, cities have many risk factors. extremely large and intelligent building, industrial facilities and underground equipment have many risk themselves along with scientific progress. The cope with disaster effectively, government must have efficient organization, skillful personnel, tool, facilities and so on. To reduce the damages, what's the most effective government organization\ulcorner II. Government organization for managing disaster In a few decades, a large-sized accidents broke out in korea, for example, collapse of Sampoong department store, break of Sungso bridge, explosion of Daegu city gas, gas explosion accident at Ahyon-dong etc. but government has not any adequate disaster response organization. Especially, after collapse of Sampoong department store broke out, Disaster Management Act is enacted to solve the past problem. According to Disaster management Act, disaster is limited in manmaid disaster. Therefore, in this thesis, disaster management is inspected theoretically, organization of disaster management for pattern of disaster, and role, duty of government organization, emergency relief organization system and actual conditions are analyzed. there are some problems. there are trials and errors. the government has changed the disaster management organization by the disaster management law. the organization consists of central and local government. but both of government do not work together harmoniously. in thesis, I would like to introduce the advanced nations disaster management organization, and study our central, local government organization. III. Conclusion Change and development of the government disaster management organization is the goal of this thesis. we have to increase public service in response and manage disaster. protecting civilian's life from the disaster is very important responsibility of government. there would be better way of government disaster management organization.

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Spectrophotometric Determination of Trace Selenium in Aqueous Solutions by Catalytic Reaction (촉매반응을 이용한 수용액중 흔적량 셀렌의 분광광도법 정량)

  • Lee, Seung Hwa;Choe, Jong Mun;Choe, Hui Seon;Kim, Yeong Sang
    • Journal of the Korean Chemical Society
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    • v.38 no.5
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    • pp.351-358
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    • 1994
  • The spectrophotometric determination of trace selenium(Ⅳ) using its catalytic reaction has been studied in aqueous solutions. The catalytic reaction of phenylhydrazine hydrochloride with selenium(Ⅳ) in an acidic aqueous medium produces benzenediazonium ion which will be converted into a red-coloured azo dye by coupling with H-acid(8-amino-1-naphtol-3,6-disulfonic acid disodium salt). For the reaction, the experimental conditions such as amounts of the reagents and pH of the sample solutions were optimized. After 15 ml of the sample solution was treated with 1 ml of 0.1 M EDTA solution to mask $Fe^{3+}$, etc., 1 ml of 0.06 M phenylhydrazine hydrochloride, 1 ml of 0.02 M H-acid, and 3 ml of 0.3 M-$KClO_3$ were added into the solution, sequentially. The solution was adjusted to pH 1.4 with HCl. After it was heated in a steam bath for 30 minutes, the solution was cooled down to a room temperature and then diluted to 25 ml with deionized distilled water. A blank solution for the absorbance measurement was prepared from the deionized water. The absorbance was measured at 527 nm. Using the above procedure, the trace amount of selenium was determined in natural waters such as tap, river and pond waters by a standard curve method and recoveries of Se spiked to samples were also obtained. From the recoveries of 104 to 111%, it could be concluded that this method was applicable to the quantitative determination of ng/ml level of selenium in natural waters.

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A Study on the accuracy of speed measuring system by the Doppler effect -The error of speed single beam Doppler log over the ground by various trim- (Doppler 효과(效果)에 의한 속도계측장치(速力計測裝置)의 정도(精度)에 관(關)한 연구(硏究) -Single beam Doppler log의 트림 변화에 따른 대지속력(對地速力) 오차(誤差)-)

  • Kim, Koang-Hong
    • Journal of Fisheries and Marine Sciences Education
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    • v.9 no.2
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    • pp.179-187
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    • 1997
  • Doppler log and current meter are based on the measurment of the doppler effect. Ship's speed over the ground measured by means of doppler log effect of underwater ultrasonic intends to get infulence by the difference of sound velocity, the ship's course, the sea bottom inclination, the trim and tranducer installation etc. This paper investigated on the error of speed over the ground by change of the trim comparing the real speed obtained by the mile post with the speed of single beam type doppler log on the trainning ship Kyeongyangho. The results are as follows ; 1. Indicating speed of doppler log is very much greatly influenced on variation of trim, but the real speed is less affected variation by trim. 2. The range of variation and error of speed over ground are smallest when ship's trim is 2.15m trim by the stern.

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Calculation of the Yield of Bank Filtration by Using the Horizontal Collector Wells (방사형 집수정에 의한 강변여과수 산출량 산정에 관한 연구)

  • Chung Ji-hoon;Park Jae-hyeon;Park Chang-kun;Yang Jung-suk;Kim Dae-kun;Jeong Kyo-cheol;Choi Youg-sun;Bu Sung-an
    • The Journal of Engineering Geology
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    • v.14 no.4 s.41
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    • pp.417-427
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    • 2004
  • The horizontal collector well is used to treat some weak points of the vertical well in the bank filtration site. In this study two empirical formulas(Milojevic and Petrovic) are selected to examine the applicability for calculating the yield of the horizontal collector. And they are compared with the compute simulation results for multiple wells. Milojevic empirical formula which considers the conditions such as aquifer, well location, the diameter of screen etc. is more applicable than Petrovic formula. Draw-down characteristics of horizontal collector was well simulated by using the computer simulation for multiple wells. The results are well agreement with Milojevic formula, and the draw-down and the retention time of the horizontal collector can be controlled by adjusting the angle of lateral screens.

Cooperative Education Between Industry and School Recognized by Teachers in Charge of Cooperative Education Between Industry and School in Vocational High School in Incheon Area (인천지역 특성화 고등학교의 산학협력 담당교사가 인식하는 산학협동교육)

  • Ahn, Jaeg-Gong;Go, Chang-Ryong;Yi, Sang-Bong
    • 대한공업교육학회지
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    • v.36 no.1
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    • pp.47-73
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    • 2011
  • The purpose of the study was to examine cooperative education between industry and school recognized by tentatively called managers of cooperative education, teachers in charge of cooperative education between industry and school, in vocational high school in Incheon Area. In order to accomplish the study purpose, the study conducted a research through questionnaire and examined their recognition for cooperative education between industry and school focusing on curriculum (purpose and content), operational system including supporting system (establishment and operational level) and educational type (process, effectiveness, problems and reinforcing measures). The study conducted a survey using Likert 5 score scale and analyzed the survey results using technical statistics such as frequency, average, standard deviation, etc. From the comprehensive results from the survey, it was found that although outcomes from industry-school cooperation are relatively high, participation is insufficient and intermediating organizations connecting concerned parties and mediating them are not enough because recognition and will of interested parties of industry-school cooperation are not sufficient. In addition, policies, legal and systematical and financial infrastructure for activation and efficiency of industry-school cooperation are not established perfectly, therefore, there are a lot of things to be improvement in operation. In particular, it was observed that establishment of internal organization and infrastructure for the number of workers in vocational training organizations are decisively inadequate.

Study on inhibition effects on metastasis and recurrence of Traditional Herb Medicine(THM) (한약의 전이재발억제 효과에 관한 연구)

  • Lee, Sang-Seob;Yoo, Hwa-Seung;Cho, Jung-Hyo;Son, Chang-Kyu;Lee, Yeon-Weol;Cho, Chong-Kwan
    • THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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    • v.9 no.1
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    • pp.75-87
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    • 2003
  • Recently, the occurrence and death rates of cancer have increased rapidly. Metastasis and recurrence is the most important factor of death from cancer. So inhibition of recurrence and metastasis can increase the cure rate of cancer disease. At the basic chinese traditional medicine(TCM), there are a lot of theory related to neoplasm treatment. The metastasis and recurrence of neoplasm was the basis of yudu(餘毒) on remained neoplasm cell and stagnation of blood, thermotoxo, phlegm, asthenia of healthy enerngy and stagnation of vital energy. The principles therapy of neoplasm on metastasis and recurrence was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of neoplasm was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distingction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. This paper's results indicate that identification and effective use of THM can inhibite netastasis and recurrence and then it will help increasing survival rate. Also as BioTechnology(BT) has developed rapidly nowadays, as genes related to cancer have revealed. So it will give rise to the development of searching the mechanism of herb medicines which have inhibition effects of metastasis and recurrence.

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Development Strategies for Local Assemblers of Agricultural Products (농산물 산지유통인의 제도권 편입 방안)

  • Kim, Dong-Hwan
    • Journal of Distribution Research
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    • v.16 no.5
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    • pp.1-18
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    • 2011
  • Local assemblers of agricultural products perform important distribution functions such as providing sales outlets, labor forces, market information, and financing, forward contracting, farming, physical distribution, and etc. However, their business activities are not transparent and producers are not effectively protected from unfair practices done by local assemblers. In order to enhance transparency and to increase effectiveness of governmental policies, local assemblers, which are mostly private management, should be organized as corporations. In order to organize corporations, the government should emphasize the importance of education and should provide corporations with governmental funds for improvement of agricultural distribution. Corporations should be developed to marketing cooperatives in the long run, and are requested to form their federations. It is also necessary to have transparent forward contracting system by local assemblers. In order to have transparent system, producers and local assemblers are guided to use standard contract forms and to operate offices handling unfair trade practices by local assemblers. We also need a place to exchange forward contracts, which can be developed to a futures market in the long run. In summary, local assemblers of agricultural products, which are mostly private management, should be developed to corporations and be operated by a transparent manner in order to protect agricultural producers and increase efficiency of trading.

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Case Study for Information Quality Maturity Model (정보 품질 성숙도 모델에 관한 연구)

  • Kim Chang-Jae;Choi Yong-Rak;Rhew Sung-Yul
    • The KIPS Transactions:PartD
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    • v.13D no.4 s.107
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    • pp.557-564
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    • 2006
  • Information is used effectively and contributes in profit creation and not only support management judgment quick but important resource to be possible recycled. The recent information systems improve enterprise's competitive power by reflection of user's various requirements and becoming big and complex for adaptation of rapidly circumstance change. Also it is trend that importance of information quality is emphasized gradually. The biggest problem in user requirement that is based on low quality data support. In case of business management is achieved by low quality information, company can not help dropping their competitive power such as company's strategy establishment, strategy achievement and management concentration breakup against competitor. Information of low quality increase time and expense to improve inaccurate data or revise and it is hard to accept correct information from specific situation. To solve these problems, we have to gain high quality data through definite comprehension, data management system establishment, and systematic data management achievement etc. Up to now, information quality and connected study were developed partially, but systematic methodology of information quality management's whole condition was not existed. Therefore, in this paper can show you how to extract process for information quality management & related evaluate factor with CMM (Capacity Maturity Mode]) 5 steps that is information warranty of quality process step. This paper whishes to contributes in competitive company or organization activity through information quality improvement management process.

Analyzation and Improvements of the Revised 2015 Education Curriculum for Information Science of Highschool: Focusing on Information Ethics and Multimedia (고등학교 정보과학의 2015 개정 교육과정에 대한 분석 및 개선 방안: 정보윤리와 멀티미디어를 중심으로)

  • Jeong, Seungdo;Cho, Jungwon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.8
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    • pp.208-214
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    • 2016
  • With the rising interest in intelligence information technology built on artificial intelligence and big data technologies, all countries in the world including advanced countries such as the United States, the United Kingdom, Japan and so on, have launched national investment programs in preparation for the fourth industrial revolution centered on the software industry. Our country belatedly recognized the importance of software and initiated the 2015 revised educational curriculum for elementary and secondary informatics subjects. This paper thoroughly analyzes the new educational curriculum for information science in high schools and, then, suggests improvements in the areas of information ethics and multimedia. The analysis of the information science curriculum is applied to over twenty science high schools and schools for gifted children, which are expected to play a leading role in scientific research in our country. In the future artificial intelligence era, in which our dependence on information technology will be further increased, information ethics education for talented students who will play the leading role in making and utilizing artificial intelligence systems should be strongly emphasized, and the focus of their education should be different from that of the existing system. Also, it is necessary that multimedia education centered on digital principles and compression techniques for images, sound, videos, etc., which are commonly used in real life, should be included in the 2015 revised educational curriculum. In this way, the goal of the 2015 revised educational curriculum can be achieved, which is to encourage innovation and the efficient resolution of problems in real life and diverse academic fields based on the fundamental concepts, principles and technology of computer science.