• Journal of the Korea Institute of Military Science and Technology
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• v.19 no.1
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• pp.95-104
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• 2016

To make a firing table of artillery with trajectory simulation, a precise trajectory model which corresponds with real firing test is required. Recent 4-DOF modified point mass trajectory model is considered accurate as a theoretical model, but fitting coefficients are used in calculation to match with real firing test results. In this paper, modified point mass trajectory model is presented and method of setting ballistic coefficient is introduced by applying optimization algorithms. After comparing two different algorithms, Particle Swarm Optimization and Covariance Matrix Adaptation - Evolutionary Strategy, we found that using CMA-ES algorithm gives fine optimization result. This fitting coefficient setting method can be used to make trajectory simulation which is required for development of new projectiles in the future.

• Journal of Astronomy and Space Sciences
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• v.36 no.2
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• pp.61-68
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• 2019

We have investigated the variations of sporadic E (Es) layer using the measurements of digisondes at Icheon ($37.14^{\circ}N$, $127.54^{\circ}E$, IC) and Jeju ($33.4^{\circ}N$, $126.30^{\circ}E$, JJ) in 2011-2018. The Es occurrence rate and its critical frequency (foEs) have peak values in summer at both IC and JJ in consistent with their known seasonal variations at mid-latitudes. The virtual height of the Es layer (h'Es) during equinox months is greater than that in other months. It may be related to the similar variation of meteor peak heights. The h'Es shows the semidiurnal variations with two peaks at early in the morning and late in the afternoon during equinoxes and summer. However, the semi-diurnal variation is not obvious in winter. The semi-diurnal variation is generally thought to be caused by the semi-diurnal tidal variation in the neutral wind shear, whose measurements, however, are rare and not available in the region of interest. To investigate the formation mechanism of Es, we have derived the vertical ion drift velocity using the Horizontal Wind Model (HWM) 14, International Geomagnetic Reference Field, and Naval Research Laboratory Mass Spectrometer and Incoherent Scatter Radar-00 models. Our results show that h'Es preferentially occur at the altitudes where the direction of the vertical ion velocity changes. This result indicates the significant role of ion convergence in the creation of Es.

• Toxicological Research
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• v.29 no.4
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.65-80
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• 2007

Purpose: This study is to examine anti-obesity effect and cytotoxicity of the long-term oral administration of Ephedra Sinica(Ma-hwang, ES) Methods: Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and DNA chip expression and cytotoxicity of the long-term oral administration of this herbal extract were investigated. Results: The herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. ES fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of ES treatments. However, we found significant changes in gene expression profile in ES treated group by micro-array analysis. In case of ES group, up-regulated genes were 113 and down-regulated were 120. Some of lipid metabolism related genes also significantly changed in treatment groups. Conclusion: ES had effects of increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

• Journal of Internet Computing and Services
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• v.8 no.2
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• pp.105-115
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• 2007

The up-to-moment dataset is built by combining the past dataset and the recent dataset. The proposal is to compute association rules in real time. This study proposed the model, $EM_{past'}$ and algorithm that is sensitive to time. It can be utilized in real time by applying partitioned combination law after dividing the past dataset into(k-1). Also, we suggested $EM^{ES}_{past}$ applying the exponential smoothing method to $EM^p_{past'}$ When the association rules of $EM_{past'}\;EM^w_{past'\;and\;EM^{ES}_{past}$ were compared, The simulation results showed that $EM^{ES}_{past}$ is most accurate for testing dataset than $EM_{past}$ and $EM^w_{past}$ in huge dataset.

• Development and Reproduction
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• v.12 no.1
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• pp.1-8
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• 2008

Specific protocols to increase the differentiation of neuronal cells from embryonic stem (ES) cells have been well established, such as retinoic acid induction and lineage selection of neuronal cells. For the neuropathological studies, ES-derived neurons (ES neurons) must show normal physiological characteristics related to cell death and survival and should be maintained in vitro for a sufficient time to show insults-specific cell death without spontaneous death. When mouse ES cells were plated onto astrocytes monolayer after retinoic acid induction, most ES cells differentiated into neuronal cells, which were confirmed by the presence of specific neuronal markers, and the cultures were viable for at least four weeks. When these cultures were examined for vulnerability to glutamate excitotoxicity, ES neurons were vulnerable to excitotoxic insults mediated by agonist-specific receptors. The vulnerability to excitotoxic death increased with developmental age of ES neurons in vitro. Specific receptors for Neurotrophin and GDNF family ligands were present in ES neurons. GDNF and NT-3 could modulate the survival and excitotoxic vulnerability of ES neurons. The vulnerability and resistance to toxic insults, which are essential requirements of model culture systems for neuropathological studies, make ES neurons to a useful model culture system. Especially ES cell are highly amenable to genetic modification unlikely to primary neuronal cells, which will give us a chance to answer more complicated neurophysiological questions. Recently there was an outstanding attempt to explore the cellular toxicity using human ES cells (Schrattenholz & Klemm, 2007) and it suggested that ES cells could be a new model system for neurophysiological studies soon and go further a large-scale screening system for pharmacological compounds in the future.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.24 no.10
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• pp.149-156
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• 2010

In this paper, the optimal design of a wind generator, implemented with the hybridized GA(Genetic Algorithm) and ES(Expert System), has been performed to maximize the AEP(Annual Energy Production) over the whole wind speed characterized by the statistical model of wind speed distribution. In particular, to solve the problem of calculation iterate, ES finds the superior individual and apply to initial generation of GA and it makes reduction of search domain. Meanwhile, for effective searching in reduced search domain, it propose Intelligent GA algorithm. Also, it shows the results of optimized model 500[kW] wind generator using hybridized algorithm and benchmark result of compare with GA.

• Journal of Navigation and Port Research
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• v.48 no.2
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• pp.88-96
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• 2024

This study examined challenges posed by two ferry routes, namely, Likoni and Mtongwe crossings, in the Mombasa Channel and their impact on navigational safety. Utilizing the Environmental Stress (ES) model, this study analyzed current ship traffic and assessed stress levels imposed by ferry crossing traffic on navigators. ES values revealed significant stress at these ferry crossings attributed to varying transit speeds. Standardizing transit speeds at two ferry passages can reduce high stress levels, presenting a viable solution. Furthermore, the IWRAP Mk2 simulation underscores crossing collisions as a significant concern, particularly at Likoni and Mtongwe crossings, due to increased ferry traffic. This research offers valuable insights for stakeholders, such as the Kenya Ports Authority (KPA), to develop targeted safety measures and enhance the flow of ship traffic in the channel.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.1
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• pp.67-74
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• 2005

Toxicity tests were performed to evaluate the feasibility of application with prediction models to 10 mixture chemicals (chloroneb, butylbenzylphthalate, pendimethaline, di-n-butylphthalate, di-iso-butylphthalate, diazinon, isofenphos, 2-chlorophenol, 2,4,6-trichlorophenol and p-octylphenol) detected in effluents from wastewater treatment plants (WWTPs). Ten chemicals were selected in the basis of their toxicities to Daphnia magna and the concentrations in effluents measured by GC/MS. Three models including concentration addition (CA), independent action (IA) and effect summation (ES) were employed for the comparison of the predicted and the observed mortality of D. magna exposed to 10 mixture chemicals for 48 hours. With a comparative study it was ineffective to predict the mortality through the CA and the ES prediction model, while the IA prediction model showed a high correlation($r^2\;=\;0.85$). Moreover, the ES model over-estimated the toxicity observed by bioassay experiments about five-fold. Consequently, IA model is a reasonable tool to predict the mixture toxicity of the discharging water from WWTPs.

• Development and Reproduction
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• v.17 no.4
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• pp.379-387
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• 2013

Embryonic stem (ES) cells can self-renew and differentiate to various cells depending on the culture condition. Although ES cells are a good model for cell type specification and can be useful for application in clinics in the future, studies on ES cells have many experimental restraints including low transfection efficiency and transgene expression. Here, we observed that transgene expression after transfection was enhanced by treatment with histone deacetylse (HDAC) inhibitors such as trichostatin A, sodium butyrate, and valproic acid. Transfection was performed using conventional transfection reagents with a retroviral vector encoding GFP under the control of CMV promoter as a reporter. Treatment of ES cells with HDAC inhibitors after transfection increased population of GFP positive cells up to 180% compared with untreated control. ES cells showed normal expression of stem cell markers after treatment with HDAC inhibitors. Transgene expression was further enhanced by modifying transfection procedure. GFP positive cells selected after transfection were proved to have the stem cell properties. Our improved protocol for enhanced gene delivery and expression in mouse ES cells without hampering ES cell properties will be useful for study and application of ES cells.