• Journal of Life Science
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• v.21 no.4
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• pp.613-615
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• 2011

ERp29 is a endoplasmic reticulum (ER) lumenal resident protein that shows sequence similarity to the protein disulfide isomerase family. Its biological function is thought to play a role in the processing of secretory proteins within the ER, possibly by participating in the folding of proteins in the ER. Although some data on ERp29 have been reported, its normal functions are still unclear. To gain insights into the function of ERp29, we identified ARF5 protein as a protein that interacts with ERp29 using yeast two-hybrid screening and GST pull-down assay. Interaction between ERp29 and ARF5 was detected under normal cell conditions but not under ER stress conditions. This result may provide a clue for understanding ERp29 biological functions.

• Proceedings of the Korean Society of Life Science Conference
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• 2002.12a
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• pp.61-67
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• 2002

ERp29는 ER chaperone의 한 종류이지만 아직까지 세포내에서 그 기능은 명확하지 않다. 배양 갑상선세포 (FRTL-5)에서 ERp29의 발현은 TSH (thyroid stimulating hormone) 의존적으로 조절되며, ERp29가 과발현된 세포에서는 ERp29-ER chaperone가 긴밀한 관계를 유지하여 분비단백질인 Thyroglobulin의 분비량이 약 30% 증가되었다.

• Journal of Life Science
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• v.10 no.2
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• pp.150-156
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• 2000

This experiment was performed to evaluate the effect of TSH (thyroid-stimulating) on the ERp29 (endoplasmic reticulum resident 29 kDa protein) gene expression in the rat thyrocytes of FRTL-5 cells. Although ERp29 mRNA was constantly expressed, its expression began to increase remarkably from 10-9 M TSH. and its maximum expression was at 5×10-9 M TSH (about 3.5 fold). On the other hand, the effect of TSH on the abundance of ERp29 mRNA started within 6 h, and peaked at 8 h (about 2.5 fold). Actinomycin D (transcription inhibitor) strongly blocked this effect while cycloheximide (translation inhibitor) did not. The half-life of ERp29 mRNA was about 4.5 h in the presence or absence of TSH that was not affected by the stability of ERp29 mRNA. The effect of TSH on the ERp29 gene expression was specific, while other growth factors (transfferin, insulin, and hydrocortisone) did not alter its expression. Our data indicate for the first time that the expression of ERp29 is regulated transcriptionally by TSH in the thyrocytes.

• Journal of Life Science
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• v.31 no.6
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• pp.568-573
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• 2021

This study identified genomic factors associated with endoplasmic reticulum protein (ERp)29 gene expression in a genome-wide association study (GWAS) of genetic variants, including single-nucleotide polymorphisms (SNPs). In total, 373 European genes from the 1000 Genomes Project were analyzed. SNPs with an allelic frequency of less than or more than 5% were removed, resulting in 5,913,563 SNPs including in the analysis. The following expression quantitative trait loci (eQTL) from the long noncoding RNA LOC105372577 were strongly associated with ERp29 expression: rs6138266 (p<4.172e10), rs62193420 (p<1.173e10), and rs6138267 (p<2.041e10). These were strongly expressed in the testis and in the brain. The three eQTL were identified through a transcriptome-wide association study (TWAS) and showed a significant association with ERp29 and osteosarcoma amplified 9 (OS9) expression. Upstream sequences of rs6138266 were recognized by ChIP-seq data, while HaploReg was used to demonstrate how its regulatory DNA binds upstream of transcription factor 1 (USF1). There were no changes in the expression of OS9 or USF1 following ER stress.

• Animal cells and systems
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• v.7 no.3
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• pp.271-277
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• 2003

Regulation of endoplasmic reticulum(ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down-regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.

• The Journal of Information Systems
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• v.22 no.4
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• pp.71-84
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• 2013

The main purpose of this study is to identify the factors influencing the implementation performance of ERP system from the investment such as hardware, software and consulting fee. The main goal of this study to analyze of ERP system implementation in various sections depending on the amount of investment and research about the contribution of ERP utilization on overall PCB business activities. Survey questionnaires were distributed via post and fax to PCB (Printed Circuit Board)Company in Korea. The results of this study can be summarized as follow. First, only 43.1% of respondents implemented ERP system at the enterprise level, which shows that ERP system does not completely play its role as a truly integrated system. Second, companies shows higher satisfaction rate with selectively invested on particular sub-modules. Third, the efficiency of ERP system can be maximized by improving efficiency on core areas through selective investments. Also, this can be maximized by performing overall investments on the general environment in addition to the direct investment on ERP. Lastly, 59.26% of respondents reported that the utilization of ERP has highly significant effects on the contribution of business whereas 29.63% respondents reported as significant effects on the business. These shows positive effects of ERP on the contribution of business.

• Asia pacific journal of information systems
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• v.16 no.3
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• pp.29-47
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• 2006

Many companies have been implementing Enterprise resource planning (ERP) systems for their organizational transformation in order to survive and achieve strategic advantages in an increasing competitive business environment. Thus, it is meaningful to identify factors that affect ERP system operation positively. Organizational citizenship behaviors (OCB) are discretionary, extra-role behaviors of employees which go beyond the prescribed formal roles, and are known as to be the contribution factors for organization performance. The purpose of this study is to develop the measurements for the OCB constructs in ERP system context and empirically test the relationships between the OCB construct and ERP system success. The four constructs - altruism, conscientiousness and courtesy, civic virtue, and sportsmanship - and fifteen measurements on the OCB were developed based on previous studies (i.e. Organ 1988) and empirically verified by confirmatory factor analysis. The results of testing the relationships between the OCB and ERP system success show that the OCB have a significant direct impact on the information quality and intention of IT innovation while they have an indirect impact on work efficiency mediated by information quality. This study enhances the OCB model into information system arena and helps better understand the user behaviors of information systems.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3C
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• pp.127-136
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• 2009

The objective of this study is the development and verification of the 4-electrode resistivity probe (4ERP) for the estimation of electrical properties of the saturated soils. The 4ERPs with wedge and plane types are manufactured to obtain the electrical resistivity without polarization at the electrodes by using Wenner array. The wedge type is for the penetration into the soil samples and the plane type is for the installation into the cells used for the laboratory tests. The consolidation tests are carried out by using 6 types of glass beads and 3 types of sands in size. The test results show that the electrical resistivity increases with a decrease in the porosity, and the constant m used in Archie's law is dependent on the particle shape rather particle size. The one dimensional liquefaction tests show that the porosity obtained by the 4ERP is similar to that determined by the volume fraction. The penetration of the 4ERP into the large scale calibration chamber produces the resistivity profiles. This study demonstrates that the 4ERP may effectively estimate the porosity of the saturated soils.

• The Journal of Information Technology
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• v.12 no.2
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• pp.13-29
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• 2009

ERP in the past, primarily centering on large enterprises and the introduction of competition in the global e-business, but along with the proliferation of small and medium-sized enterprises are now in earnest, or to take advantage of the introduction of the ERP plan. However, the introduction of the ERP cost and the effort required to develop, because many never previously introduced ERP expect that the introduction of cost and performance comparisons with the measurement is necessary. Until now, however, the introduction of a framework of analysis followed the introduction of ERP primarily to measure performance of a major improvement. This research, in addition to improving the performance of these tasks have been overlooked until now for the system's user satisfaction BSC (Balanced Scorecard) models and techniques using AHP-specific understanding of the Company (Group executives, middle managers groups, and user groups) Importance of priorities you want to analyze. In summary, the key findings of this study follows. First, ERP user satisfaction measurement for the balanced scorecard indicators in terms of the redevelopment. Second, the information system user satisfaction to the user layer (Layer 3), grouped by the measure. Thirdly, the user satisfaction of the important topics for attention as quantified by measuring the hierarchy. This model is for satisfaction levels as quantitative of future users of the new system, information systems and the introduction of a new model of development based on the evaluation data will be able to take advantage of.

• Management & Information Systems Review
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• v.29 no.1
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• pp.177-205
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• 2010

The major purpose of this study is to investigate the relationships between change management characteristics and implementation performance of ERP. In addition, this research examines the moderating effects of organization characteristics as contextual variables on the relationship between change management characteristics and implementation performance. For these purposes, a research model is developed based on the relevant literature reviews of ERP systems and change management theory. The data have been collected from the 148 enterprises which have implemented ERP systems at least one year ago. The respondents were person in charge of ERP system of each corporation. The results of this study are summarized as follows. Firstly, top management concern and support, consultant support goodness, education, and communication have positive influence upon internal performance. Secondly, consultant support goodness and education are positive influence upon external performance. Lastly, organization characteristics including formalization and centralization have partial moderating effect on the relationship between change management characteristics and implementation performance of ERP. From the analyses, this research have identified change management activities according to the organization structural contexts for the successful implementation of ERP.