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http://dx.doi.org/10.5352/JLS.2011.21.4.613

Characterization of ERp29 and ADP-Ribosylation Factor 5 Interaction  

Kwon, Ki-Sang (Department of Anatomy, School of Medicine, Chungnam National University)
Seog, Dae-Hyun (Department of Biochemistry, College of Medicine, Inje University)
Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University Hospital)
Yu, Kweon (Aging Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kwon, O-Yu (Department of Anatomy, School of Medicine, Chungnam National University)
Publication Information
Journal of Life Science / v.21, no.4, 2011 , pp. 613-615 More about this Journal
Abstract
ERp29 is a endoplasmic reticulum (ER) lumenal resident protein that shows sequence similarity to the protein disulfide isomerase family. Its biological function is thought to play a role in the processing of secretory proteins within the ER, possibly by participating in the folding of proteins in the ER. Although some data on ERp29 have been reported, its normal functions are still unclear. To gain insights into the function of ERp29, we identified ARF5 protein as a protein that interacts with ERp29 using yeast two-hybrid screening and GST pull-down assay. Interaction between ERp29 and ARF5 was detected under normal cell conditions but not under ER stress conditions. This result may provide a clue for understanding ERp29 biological functions.
Keywords
Endoplasmic reticulum protein 29 (ERp29); binding protein; ADP-ribosylation factor 5 (ARF5);
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