• Korean Journal of Food Science and Technology
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• v.51 no.4
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• pp.361-368
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• 2019

The present study aimed to evaluate the effect of Dendropanax morbifera (DM) extract on postmenopausal syndrome and to develop DM extract as an alternative for hormonal therapy. The following seven groups of rats; normal control (sham), ovariectomized (OVX) control, Punica granatum (PG)-treated group (770 mg/kg), estradiol treated group (0.5 mg/kg), and three DM-treated groups (200, 500, 1000 mg/kg) were compared. Indicated compounds were administrated once a day for eight weeks. To evaluate the estrogenic effect of DM extract, western blot analysis was performed on the liver tissue to confirm the expression of estrogen receptor ($ER-{\alpha}$, $ER-{\beta}$). Our analysis showed that after DM administration, collagen cross-linked C-telopeptide (CTX) value decreased while $ER-{\alpha}$ protein expression increased in a dose-dependent manner through the MAPK/ERK pathway in OVX rats. These results suggest that Dendropanax morbifera exerts estrogenic effect by inducing estrogen receptor expression and activating MAPK/ERK pathway.

• Journal of Life Science
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• v.33 no.3
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• pp.252-259
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• 2023

A decrease in ovarian function and sex hormone production with aging results in hormone deficiency, which causes menopause in women. Natural products have been investigated to develop estrogen-like substances to improve menopausal status in women. This study was performed to evaluate the efficacy of Gastrodia elata Blume extract (TVB-1000) in ovariectomized rats. After a recovery period of 7 days, the TVB-1000 treatment group was orally administered at 16, 40, and 100 mg/kg for 12 weeks. In the OVX-positive control group, 17β-estradiol was injected subcutaneously into the dorsal region of rats at a dose of 10 ㎍/kg. Results show that TG and LDL-C, which are cardiovascular disease markers, were significantly decreased in all concentrations of TVB-1000 administration in the treatment group, and the LDL-C/HDL-C ratio significantly decreased in the medium and high TVB-1000 concentrations of the treatment group. In addition, in the high concentration TVB-1000 treatment group, the weight of abdominal fat decreased with statistical significance. The low-dose and medium-dose administration groups showed statistical significance and the expression level of their ER-α increased, but ER-β did not show a significant change. The above experiment shows that owing to the estrogen-like effect of TVB-1000, it can be useful as a functional food material to prevent cardiovascular disease, which is one of the menopausal symptoms.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.2
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• pp.331-337
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• 2001

The effect of Phellinus linteus methanol extract on the lipid metabolism in the liver of rat was investigated in this study. Rats were randomly divided into 6 groups including the control, $CCl_4$and high fat group plus sub-groups with Phellinus linteus methanol extract administration. Methanol extracts of Phellinus linteus were fed 50mg/kg B.W daily via drinking water. A 1.2mL of $CCl_4/kg$ body weight was administered by oral intubation twice a week for total six times. The administration of $CCl_4$ increased total cholesterol, TG, LDL and LDL-phospholipid. However, the level of liver cholesterol and triglycerides were significantly decreased while HDL-cholesterol was increased by the extract feeding. The activities of GOT, GPT, AP and LDH were greatly enhanced by the extract feeding. Electronmicrograph showed that $CCl_4$ treatment deteriorated the structure of cytoplasmic matrix with its uneven distribution. However, the extract treatment reconstituted the damaged cytoplasm and stimulated mitochondriagenesis. From these results, it was suggested that Phellinus linteus can help to recover the damaged liver function and further may help to prevent senescence diseases such as fatty liver, hypertension and hyperlipidemia.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.577-580
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• 2003

The purpose of this study was to make a database model for financial feasibility study of buildings offered for sale which is helpful for improvement of business ability in construction and confidence of a project from a related participant. At first, we studied several thesis and met some professionalist which work for construction and did a first survey for examining latest situation of a feasibility study in construction. As a result, even though feasibility study is important, factors for information management wasn't systemized. So we did a second survey for fixing Factors of the database model. The database model was composed of the factors that we got from the second survey. ER(Entity-Relationship) analysis was used to making it. We expect thar we can get more reasonable information to study financial feasibility study and can diminish risks of project through the database model. So the result of this study was to make a database model for more reasonable financial feasibility study of building offered for sale.

• Tunnel and Underground Space
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• v.27 no.2
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• pp.100-108
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• 2017

As a measure of the combined effect of fracture geometry, the fabric tensor parameters could quantify the status of the connected fluid flow paths in discrete fracture network (DFN). The correlation analysis between fabric tensor parameters and hydraulic properties of the 2-D DFN was performed in this study. It is found that there exists a strong nonlinear relationship between the directional conductivity and the fabric tensor component estimated in the direction normal to the direction of hydraulic conductivity. The circular radial plots without significant variation of the first invariant ($F_0$) of fabric tensor for different sized 2-D DFN block are a necessary condition for treating representative element volume (REV) of a fractured rock mass. The relative error (ER) between the numerically calculated directional hydraulic conductivity and the theoretical directional hydraulic conductivity decreases with the increase in $F_0$. A strong functional relation seems to exist between the $F_0$ and the average block hydraulic conductivity.

• Journal of Digital Convergence
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• v.15 no.1
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• pp.287-299
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• 2017

This study aims to suggest the improvement plan for clinical practice after examining the reality and the situation of clinical practice of EMT students. Clinical practice is as important as right to a variety of job experience in the convergence society and heating up according to appearance of NCS. Subjects were 115 EMT students. Data were collected for Jun. 16-17(2016), and analyzed by SPSS v. 18.0. Sophomores, who experienced only ER have a negative view about their future job prospect. On the other hand, juniors, who experienced ER and 119 rescue team have not virtually changed the way they view their future job prospect, supposedly due to the halo effect of the 119 rescue team clinical practices. Both groups wish to have opportunities to experience diverse clinical practices. This study suggests that will help students have a positive view about their job prospects by providing clinical practice institutions and solve the problem of difficulty in getting jobs.

• Food Science and Preservation
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• v.14 no.5
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• pp.516-525
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• 2007

The effect on quality improvement of Chokochujang by the addition of green tea extract (GT) was evaluated on the basis of total cell numbers, pH, acidity, sugar content and sensory evaluation during its storage at $25^{\circ}C$ and $37^{\circ}C$ for 3 weeks. A dorminant strain was isolated from the Chokochujang and identified as Bacillus amyloliquefaciens ER282 based on the 16S rDNA sequence. The ethanol extract from GT was investigated for its antibacterial activity aid showed good activities enough to use for Chokochujang as a natural preservative. Growth of microorganisms was significantly inhibited by adding GT extract to Chokochujang but pH, acidity, sugar content and color was not much changed. Sensory evaluation and overall preference, however, was continuously declined as storage period increased, whereas the addtion of 3% GT extract could delay the quality loss of Chokochujang during storage at $25^{\circ}C$ and $37^{\circ}C$ for 3 weeks.

• The Transactions of the Korea Information Processing Society
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• v.4 no.11
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• pp.2745-2755
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• 1997

Many large-scale enterprises have developed software systems to build management information system for their business. However, it is hard to maintain share ability of data, compatibility of operation methedology, and interoperability among subsystems when the development project progresses since each distributed team prepares a development plan for its subsystem and must have poor communication problem among those teams. We must apply software configuration management to the whole life cycle of the software system in order to solve those Problems. We need a model and a repository in order to execute configuration management on configuration products like document, data, and source code which are generated through the life cycle of software development. In this paper, we suggest a model for configuration change control where cross- referencing among life cycle Phases and data-sharing are highlighted, and define ER model to use IRDS(Information Resource Dictionary system) and IRD schemas.

• Journal of Life Science
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• v.31 no.4
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• pp.425-429
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• 2021

We have investigated the expression of early growth response protein 1 (EGR1) in INS-1 pancreatic β-cells treated with Allomyrina dichotoma hemolymph. The Korean rhinoceros beetle, A. dichotoma (Coleoptera: Scarabaeidae), is important in the insect industry for medical applications. We have already established a method for purification of A. dichotoma hemolymph that can be used in many experiments. EGR1 is reported as a multifunctional transcription factor that is implicated in virus infections. EGR1 has therefore been revealed as a major mediator and regulator in the physiological and pathological conditions of several cell and tissue types. New findings in this study are that A. dichotoma hemolymph, which promotes a dose- and time-dependent upregulation of EGR1 gene expression, shows an enhancement of this gene expression when combined with hypothermia or endoplasmic reticulum (ER) stress. These results suggest that A. dichotoma hemolymph may provide clues to EGR1-associated disease therapies involving gene regulation of EGR1.

• The Korea Journal of Herbology
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• v.35 no.3
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• pp.1-8
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• 2020

Objectives : In this study, we examined the estrogenic activities and anti-osteo clastogenesis effects of PCE17, a mixture of PE (an extract of Puerariae Flos), and CE (an extract of Citri Unshius Pericarpium). Methods : The estrogenic effect of PCE17, PE and CE were examined by ER-β/ERE reporter gene assay and proliferation assay in 293 T and MCF-7 cells. The expression of estrogen-responsive gene and protein were checked by Real Time-PCR (RT-PCR) and Western blotting in MCF-7 cells. Inhibitory effect of PCE17, PE and CE on RANKL-induced osteoclast differentiation were evaluated by TRAP staining and RT-PCR in primary osteoclast precursors from rat bone marrow cells. Results : PCE17 and PE bind to ERs (estrogen receptors) and show estrogenic activities in 293T cells. They also stimulated the proliferation of MCF-7 cells and increased the expression of ER response gene, pS2. Tectorigenin, an active ingredient of PE, shows similar estrogenic activities in MCF-7 cells. PCE17 and CE inhibited RANKL-induced osteoclastogenesis in rat primary osteoclast precursor cells and down-regulated the osteoclast-specific genes of Nfatc1, Ctsk, and Acp5. Conclusions : In conclusion, PCE17 may have therapeutic potential in cases of menopause and osteoporosis.