• 대한한방부인과학회지
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• 제28권1호
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• pp.13-28
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• 2015

Objectives: To observe the in vitro anti-inflammatory effects of Hyunbulikyung-tang aqueous extracts (HBLKT) and the possible synergic combination effects with a nonsteroidal anti-inflammatory drug, piroxicam. Methods: Anti-inflammatory effects of HBLKT (yield=16.17%) were observed on LPS activated raw 264.7 cells based on $ED_{50}$ to cell viability, NO, $PGE_2$, $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 productions as compared with piroxicam, in the present study. In addition, the combination effects of HBLKT with piroxicam were observed after treatment of HBLKT 1/4 $ED_{50}$ + piroxicam 1/4 $ED_{50}$, 1/8 $ED_{50}$, 1/16 $ED_{50}$, 1/32 $ED_{50}$ and 1/64 $ED_{50}$ concentrations, respectively. Results: Significant (p<0.01 or p<0.05) increases of cell viabilities and decreases of NO, $PGE_2$, $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 cytokine releases were detected in HBLKT 1/4 $ED_{50}$ + piroxicam 1/4 $ED_{50}$, 1/8 $ED_{50}$, 1/16 $ED_{50}$ and 1/32 $ED_{50}$ concentration co-treatment as compared with each of single 1/4 $ED_{50}$ concentration of piroxicam and HBLKT treatments, respectively. Although significant (p<0.01 or p<0.05) increases of cell viabilities and decreases of NO, $PGE_2$, $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 cytokine releases were also demonstrated in piroxicam 1/64 $ED_{50}$ + HBLKT 1/4 $ED_{50}$ co-treatment as compared with LPS control, no significant changes were detected as compared with each of single 1/4 $ED_{50}$ concentration of piroxicam and HBLKT treatments, in this experiment. Conclusions: Hyunbulikyung-tang showed cell protective and anti-inflammatory effects against LPS activated raw 264.7 cells. It, therefore, expected that HBLKT will be showed favorable effects to relieve dysmenorrhea related to over expressed inflammatory cytokines, and it also expected that the clinical dosages of piroxicam can be reduced as 1/8 levels as combination with HBLKT.

• 한국표면공학회지
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• 제47권3호
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• pp.137-146
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• 2014

The important drawback of epoxy electrodeposition(ED) coatings is the lack of the weathering resistance caused by the structure of bisphenol A. To improve this yellowing phenomena, acryl ED coatings have been developed. Compared with the epoxy ED coatings, however, acryl ED coatings are relatively weak in the corrosion resistance and mechanical properties. The purpose of this study is complemented their drawbacks by mixing epoxy and acryl ED paints. The salt spray, accelerated weathering test(QUV) and cupping, bending, impact test were employed to investigate the corrosion resistance, weathering resistance, and mechanical properties of ED coatings. When the ratio of acryl to epoxy resin of ED coating is 0.33, the weathering resistances are appropriately improved in condition maintaining the corrosion resistance. It was shown that the weathering resistance for epoxy ED coating was adjusted by optimally mixing acryl ED paint.

• International Journal of Control, Automation, and Systems
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• 제6권4호
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• pp.468-476
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• 2008

This paper presents a novel approach to economic dispatch (ED) with nonconvex fuel cost function as combinatorial optimization problems (COP) while most of the conventional researches have been developed as function optimization problems (FOP). One nonconvex fuel cost function can be divided into several convex fuel cost functions, and each convex function can be regarded as a generation type (G-type). In that case, ED with nonconvex fuel cost function can be considered as COP finding the best case among all feasible combinations of G-types. In this paper, a genetic algorithm is applied to solve the COP, and the $\lambda$-P table method is used to calculate ED for the fitness function of GA. The $\lambda$-P table method is reviewed briefly and the GA procedure for COP is explained in detail. This paper deals with three kinds of ED problems, namely ED considering valve-point effects (EDVP), ED with multiple fuel units (EDMF), and ED with prohibited operating zones (EDPOZ). The proposed method is tested for all three ED problems, and the test results show an improvement in solution cost compared to the results obtained from conventional algorithms.

• 한국응급구조학회지
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• 제26권1호
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• pp.151-166
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• 2022

Purpose: The severity classification in association with the time of visit to and the appropriateness of using a public ambulance for visiting the emergency department (ED) have not been thoroughly evaluated, and we aimed to evaluate these aspects. Methods: In this descriptive research, we retrospectively reviewed and analyzed the medical records of patients who visited the ED of the B General Hospital, Seoul from January to December 2019. Results: Of the 54,297 patients who were included in the analysis, 34,629 (63.8%) and 14,065 (25.9%) visited the ED directly and through public ambulances, respectively; 10,328 (73.4%) patients who used public ambulances were discharged home. In the daytime and nighttime, 24,891 (45.8%) and 29,406 (54.2%), respectively, visited the ED. The mean length of ED stay (LoS) of emergency and non-emergency patients was 326 and 159 minutes, respectively, and of patients classified as Korean Triage and Acuity Scale levels 1 and 2 was 427 and 430 minutes, respectively, which was longer than the total of 236 minutes. Conclusion: Patients who visited the ED using public ambulances constituted nearly 25% of all ED visits, and more than 70% of these patients were discharged home. Patients with high severity had a longer mean LoS, and daytime ED visits were characterized by higher numbers and severity of patients than nighttime ED visits.

• 한국수학교육학회지시리즈A:수학교육
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• 제62권2호
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• pp.211-236
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• 2023

이 연구는 미국 예비교사 교육 양성 과정에서 활용되는 edTPA의 사례를 분석하여 우리나라 예비 수학 교사 교육의 시사점을 도출하는 데 목적이 있다. 최근 예비 수학 교사의 인지적인 차원의 지식 개발뿐만 아니라 실제 수업을 바탕으로 상황적 차원의 영역까지 고려한 전문적인 역량을 진작시키는 것에 관한 관심이 높아지고 있다. 미국 edTPA 평가는 예비교사가 학교 현장에서 수행하는 수업에 기초한 수행 기반 평가이다. 이 연구에서는 미국의 예비 수학 교사가 참여하는 edTPA의 사례가 상세히 서술된 편람을 검토하여 예비 수학 교사에게 요구되는 전문적인 역량에 대해서 분석한다. edTPA 평가는 수업 설계, 실행, 평가 과제로 구성되어 있고, 수업과 연계하여 지속성 있는 평가를 수행한다. 따라서 수업 설계, 실행, 평가 과제 서술에서 평가 항목 및 평가 기준의 연계가 되는 지점과 그 연계로부터 요구하는 전문적인 역량이 무엇인지 분석한다. edTPA 편람을 분석한 결과 edTPA 평가에서 예비 수학 교사에게 요구되는 전문적인 역량은 특정 수학 수업 차시에 대한 초점화 및 이행 역량, 특정 수학 수업 차시 실행 및 평가의 성찰적 이해 역량, 학생들의 언어 및 표상 사용, 학생들의 학습에 대한 학생 성취의 점진적인 판단 역량이다. 이러한 분석의 결과는 우리나라 예비 수학 교사 교육과정 및 실습학기제 운영에서 평가하는 역량의 구인으로 활용할 수 있다.

• Journal of Nutrition and Health
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• 제37권1호
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• pp.5-14
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• 2004

The purpose of this study was to investigate the effect of dietary sea-tangle extracts on blood glucose levels, serum lipid levels, thiobarbituric acid reactive substance (TBARS) and glutathione enzymes in diabetic rats treated with streptozotocin (STZ) Four groups of rats (Sprague-Dawley male rats, 180 - 200g) were consisted of normal rats fed control diet (C), diabetic rats fed control diet (CD), normal rats fed sea-tangl extracts diet (E), and diabetic rats fed sea-tangle extracts diet (ED). Diabetes was induced by single injection of streptozotocin (60 mg/kg B.W.). After 7 weeks, rats were sacrificed, serum glucose, serum total cholesterol, triglyceride levels and glutathione enzymes were measured. Urine was significantly higher in CD and ED groups than those of others (p < 0.05). Levels of amylase, calcium, uric acid, hemoglobin, cholesterol and low density lipoprotein (LDL)-cholesterol were different among four groups. But high density cholesterol (HDL)-cholesterol of ED group was significantly higher (p < 0.05) than other groups (C and E group) And the weekly change of serum glucose was decreased in the 3th,4th and 5th weeks. But serum triglyceride (TG) of diabetic rats fed sea-tangle extracts diet (ED) was lower than diabetic rats fed control diet (CD). Activity of hepatic microsomal G6Pase was significantly increased CD and ED groups higher than C and E group, but kidney was decreased ED group. Hepateic glutathione S-transferase (GST) of CD and ED group were significantly lower than C and E group (p<0.05), glutathione peroxidase (GPX) of E and ED group were significantly higher than C and CD group (p<0.05), glutathione reductase (GR) activities of ED group was significantly lower than other groups, malondialdehyde (MDA) of ED was lower than E and CD group, but kidney was increased significant in ED group compared to liver. These results suggested that dietary sea-tangle extracts reduce .hepatic disorders such as oxidant than kidney. In conclusion, dietary sea-tangle extracts groups reduced blood TG and hepatic MDA levels in STZ-induced diabetic rats.

• 한국안전학회지
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• 제21권1호
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• pp.96-104
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• 2006

This study is to find out how the sawdust-mixed RC beam with holes acts compared to two case of normal one with sawdust without hole, without sawdust. variables are ED3H1, ED3H2, ED3H1UB, ED3H2L, ED5H1, ED5H1UB, ED5H2, ED5H2L, Normal with sawdust PLA without sawdust. All sand, aggregate, cement are in accordance with KS. mixing design is also in accordance with KS and done at D remicon company in order to decrease any error in mixing manually. ED3H1 showed 7tone of maximum load capacity having only minor tensile deformation around hole, compared to the center of the beam. ED5H2L showed almost same shape of tensile strain between hole area and center of two beam length, while having 9.5 tone load capacity, incase of two holes being in the longitudinal axis. But ED5H2 in case of two holes being in same forcing direction showed 8.4tone of load capacity while having minor tensile chape around hole and normal tensile shape in the center of beam length. Two diameter 3cm hole in longitudinal axis give more effective behavior than the other case, practically. Capacity decrease between 5cm and 3cm in eccentric position form the longitudinal axis is less than percents. There is minor capacity difference between hole diameter 3cm hole, but 13tone difference of load capacity between hole diameter 5cm.

• 약학회지
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• 제50권4호
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• pp.254-262
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• 2006

This study had been done for the investigation of the effect of Vitis vinifera extract(V), Schisandra chinensis extract (S), Taraxacum officinale extract (T), Gardenia jasminoides extract (G), Angelica acutiloba extract (A) and Paeonia japonica extract (P), and their mixtures on the antioxidant and ethanol oxidation system which was induced by Lieber-DeCarli ethanol liquid diet. Male Sprague-Dawley rats were randomly divided into eight groups: ethanol diet (ED), normal diet (ND), ED+V (100 mg/kg/day), ED+S, ED+T, ED+G, ED+A and ED+P (300 mg/kg/day). We studied the effect on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) after herbal extracts administration for 6 weeks in rats induced by Lieber-DeCarli ethanol liquid diet. The differences in ADH and ALDH activity of the rats treated with herbal extracts and ED group were not significant. Phase I enzyme activity was found to be significantly higher in the ED+V than the ED group. Phase II enzymes (glutathione-S-transferase, phenol sulfatransferase) activities were found to be higher in the herbal extracts than the ED group. Herbal extracts not only reduced ethanol-induced elevation of level malondialdehyde but also protected against ethanol-induced decrease of reduced glutathione, gluthione reducatse, glutathione peroxidase, catalase and superoxide dismutase activities. Therefore, they can be utilized as a health functional food or new drug candidate for fatty liver and hepatotoxicity which was induced by chronic alcohol consumption.

• 한국환경농학회지
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• 제35권4호
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• pp.278-285
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• 2016

토양에 잔류된 엔도설판(ED) 살충제의 ${\alpha}$, ${\beta}$ 이성질체 및 sulfate 대사체의 무 흡수이행 양상을 조사하고 무 재배지 토양에 대한 ED의 안전관리기준을 설정하기 위하여 생물농축계수(BCF)를 산출하였다. 토양은 2 및 10 mg/kg의 농도가 되도록 처리하였으며 각각의 처리구에 파종한 무를 40일부터 70일까지 재배 후 10일 간격으로 수확하고 수확된 무는 지상부와 지하부로 나누어 ED의 잔류분석을 실시하였다. 토양으로부터 무 한 개체로 흡수된 total ED (이성질체와 대사체의 합) 잔류량에 대해 ED-sulfate가 48.5-100.0%로 가장 많이 분포하였고 그 다음으로 ${\alpha}$- (0.0-35.2%) 및 ${\beta}$-ED (0.0-16.4%) 순이었다. ED 잔류분석 결과를 바탕으로 무와 토양사이에 total ED의 잔류량 비로써 BCF를 산출하였으며 그 값은 무 지상부에 대해 0.0002-0.0429, 지하부에 대해 0.0077-0.2345로 지하부의 BCF 값들이 더 컸다. 이 값들로부터 얻어진 회귀방정식( $R^2$ >0.86)을 이용하여 장기적인 BCF 값들을 예측하고 무에 대한 ED의 MRL 값인 0.1 mg/kg과 비교하여 무 재배지 토양 중 ED의 안전관리기준을 산출하고 발생할 수 있는 오차를 고려한 결과, 무와 무청 둘 다에 대해 2.0 mg/kg이었다.

• Journal of Plant Biotechnology
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• 제39권4호
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• pp.281-287
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• 2012

본 연구에서는 용암해수가 지닌 독특한 미네랄 구성을 바탕으로 자란의 생육에 적합한 농도를 규명하기 위해 실험을 수행하였다. 자란의 기내배양용 고체배지구성을 위해 30 g/L sucrose와 3.0과 8.0 g/L의 gelrite 및 plant agar를 동일하게 처리한 MS 배지와 RO(Reverse Osmosis) 탈염수, ED(Electrodialsis) 탈염수 배지를 각각 제조하여 배지경도를 측정한 결과, plant agar가 첨가된 MS, RO, 및 ED 배지의 경도는 각각 60,000, 40,000 및 $38,000g/cm^2$의 경도가 측정되었다. 하지만 gelrite가 첨가된 배지는 MS를 제외한 RO, ED배지는 $2,000g/cm^2$ 내외의 경도를 보였다. 제조된 배지에서 식물체의 생육을 확인한 결과, RO 탈염수 0%에서는 88%, RO 50%에서는 57%, RO 100%에서는 31%의 생존율을 보였다. 하지만 잎 길이, 엽폭은 모두 RO 탈염수 100%에서 높았다. ED배지는 ED 100%를 제외한 배지에서 모두 양호한 생장을 보였다. 엽록소 함량 분석을 통한 생리적 건전도를 측정한 결과, 대조구에서는 총엽록소 함량이 66.3 ug/ml인데 비해 RO 10%, RO 50%, RO 100%, ED 10%, ED 50%, ED 100%에서는 각각 77.3, 69.3, 76.4, 79.0, 75.7, 74.4 ug/ml로 모두 대조구보다 높은 총엽록소 함량을 나타냈다. 또한 용암해수 내 유용성분의 식물체내로의 축적은 스토론튬, 바나듐, 셀레늄 등이 원활하게 이루어짐을 확인한 바, 용암해수를 이용한 식물조직배양용 배지로의 산업적 이용가치가 높을 것으로 보이고 더 나아가 용암해수가 원예작물뿐만 아니라 유용성분 함유 약용작물의 생산에도 충분히 활용 가능할 것으로 사료된다.