• Journal of Acupuncture Research
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• 제25권4호
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• pp.59-69
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• 2008

Objectives : The purpose of this study was to observe the effects of acupuncture and electro-acupuncture(EA) at $LI_{11}$ on intestinal motility in rats. Methods : We made over-activated and suppressed state of intestinal motility with carbachol and loperamide in rat and carried out acupuncture with needle retained(NR), low frequency(2 Hz) EA and high frequency(100Hz) EA at $LI_{11}$ before or after the administration of carbachol or loperamide. The charcoal travel rate was measured to evaluate the intestinal motility. Results : 1. NR, 2Hz EA and 100Hz EA at $LI_{11}$ showed no significant influences on intestinal motility of rat in normal state. 2. All of the pre-treatment and post-treatment of NR, 2Hz EA and 100Hz EA at $LI_{11}$ showed no significant effects than control group on intestinal motility of rat which was over-activated with carbachol. 3. The pre-treatment of 2Hz EA and 100Hz EA at $LI_{11}$ on intestinal motility of rat which was suppressed with loperamide showed no significant influences but in the L-$LI_{11}$-EA(L) and L-$LI_{11}$-EA(H) groups, intestinal motility was significantly increased than L-control group. Conclusions : These results suggest that acupuncture and EA on $LI_{11}$ have preventive effect and therapeutic effect on suppressed intestinal motility, and EA is more effective than NR.

• 한국임상수의학회지
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• 제16권1호
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• pp.230-234
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• 1999

Canine medial patellar luxation can cause hindlimb lameness in toy breeds and surgical operation needs when the lameness does not improve or worsen. In this study, the 2 dogs that showed postoperative non-weight bearing lameness were treated with electroacupuncture (EA) and the effects of postoperative EA were examined. Xue Hai (Sea of Blood), Du Bi (calf's nose, 2 acupoint), Zu San Li (leg 3 miles) acupoints were used in acupuncture. Xue Hai acupoint was connected to positive pole and Zu San Li was negative for 20 min with 2~5 volt, 5~30 Hz in EA. In case 1, EA were performed eight times for 26 days after 29th postoperative day and walking was improved from 6th EA. In case 2, EA were conducted five times for 17 day after 26th postoperative day and walking was improved from 4th EA. It may be possible to improve walking by EA treatment in the dogs that show post-operative non-weight bearing lameness, but the relationship between the effects of EA and the injury of stifle joint should be inspected.

• 전자공학회논문지SC
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• 제39권2호
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• pp.116-122
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• 2002

위상정합(coherent) 레이더에 대한 EA 효과를 다양하게 분석할 수 있는 타이밍 (timing) 신호 발생기를 설계 및 제작하였다. 제작한 신호발생기는 EA 장비 및 위상정합 레이더에 필요한 각종 타이밍 신호 및 모의 표적신호를 실시간으로 발생하며, 모의 표적신호 발생기능은 레이더에 대한 EA 효과를 쉽게 확인할 수 있도록 하여준다. 타이밍신호의 모든 파라미터는 프로그램에 의해 변경 가능하기 때문에, 다양한 형태의 시험 시나리오를 쉽게 구성할 수 있다.

• Journal of Dairy Science and Biotechnology
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• 제36권2호
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• pp.121-124
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• 2018

Ellagic acid (EA) is a naturally occurring polyphenolic compound in vegetables, nuts, and fruits such as berries. EA has antioxidant, anticancer, anti-allergy, and anti-inflammatory activities. The objectives of this research were to investigate the physicochemical properties of nanoparticles before and after nano-encapsulation of EA in dairy protein and to develop a functional (anti-inflammatory) dairy protein-based beverage containing EA. A particle size analyzer was used to determine the physicochemical and morphological properties. High performance liquid chromatography was used to evaluate the entrapment efficiency of EA. The nanoparticles containing EA were 100 to 200 nm in diameter. The determined poly dispersity index value of 0.3 to 0.4 indicated that the nanoparticles were uniformly distributed with similar size. Zeta-potential values were also similar between the control groups. The entrapment efficiency of EA was nearly 90%. The results indicate the potential for development of nanoparticles containing EA beverage products with anti-inflammatory activity.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2006년도 추계학술대회
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• pp.103-108
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• 2006

정보시스템의 효율적 도입 및 운영 등에 관한 법률이 2005년 12월에 고시됨에 따라, 대통령령이 정하는 기준에 부합하는 공공기관에서는 ITA/EA를 의무적으로 도입하게 되었다. 이에 따라 향후 2-3년 동안 다수의 ITA/EA 구축 프로젝트가 진행될 것이며, 프로젝트 계획시 구축을 위한 비용의 산정은 중요한 이슈로 제기될 것이다. 지금까지 공공기관에서 진행된 ITA/EA 구축 프로젝트를 살펴보면, 대부분이 소프트웨어사업대가기준에서 정하는 정보전략계획(ISP)수립비 산정기준을 바탕으로 비용을 산정하고 있으나, ISP와 ITA/EA 구축은 그 성격상 여러 부분에서 차이점을 보인다. 본고에서는 현재 국내 ${\cdot}$ 외에서 사용되고 있는 ITA/EA 구축비용 산정방법들을 살펴보고, 이에 대한 문제점을 제기하고, ITA/EA 구축비용 산정 기준 작성을 위한 개선방향을 제시하고 한다.

• Journal of Acupuncture Research
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• 제20권4호
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• pp.157-169
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• 2003

Objective : The effects of electroacupuncture(EA) stimulation on heart rate variability(HRV) for healthy adults are investigated with power spectrum analysis(PSA) of HRV. Methods : The HRVs of every 10 minute for 22 healthy volunteers(13 men and 9 women) were measured for an hour with SA-3000P(Medicore Co., Ltd., Korea). The median age with arithmetic range of 13 men and 9 women was 26.00 years with 22.75~27.00 years. The initial 20 minutes were defined as baseline period(pre-EA period), the following 20 minutes as the EA period and the last 20 minutes as the post-EA period. In each EA periods, volunteers received EA(2Hz, 0.6~0.8ms duration, maximal tolerated stimulation without discomfort) on the right Zusanli(ST36), Shangjuxu(ST37) acupoints while supine, resting. Results : Heart rate of volunteers at post-EA period was significantly decreased compare to that of pre-EA period, while SDNN at post-EA period was significantly increased. Heart rate at EA period was significantly decreased compare to that of pre-EA period, but Ln(LF) and LF/HF at EA period were significantly increased. Ln(HF) at post-EA period was significantly decreased compare to that of EA period, while the other variables were not significantly changed. Conclusions : The results suggest that EA in healthy adults is associated with changed activity in the sympathetic and parasympathetic nervous system. Further study is needed for investigating the effects of EA on HRV and autonomic nervous system.

• 한국환경생태학회지
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• 제32권5호
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• pp.486-496
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• 2018

본 연구는 지형구조 차이에 따른 이온지수를 파악하고자 월악산국립공원 내 일본잎갈나무림을 연구대상지로 선정하였다. 측정지점은 월악산국립공원 내 일본잎갈나무가 우점하고 있는 동일한 생태적 구조로 조성된 능선(Ridge)과 계곡(Vally)의 위치에서 기상과 이온을 고정 측정하였다. 기상 측정 결과 기온은 능선부에서 평균 $28.22^{\circ}C$, 최고 $29.9^{\circ}C$, 최저 $26.4^{\circ}C$였으며, 계곡부에서 평균 $27.08^{\circ}C$, 최고 $27.8^{\circ}C$, 최저 $25.5^{\circ}C$로 분석되었다. 상대습도의 경우 능선부에서 평균 67.02%, 최고 75.25%, 최저 61.95%였으며, 계곡부에서 평균 69.74%, 최고 76.8%, 최저 63.75%로 분석되었다. 이온측정 결과 능선부에서는 양이온 발생량 평균 $698.40{\pm}59.80ea/cm^3$, 최대 $885.88ea/cm^3$, 최소 $597.88ea/cm^3$이었으며, 음이온 발생량 평균 $736.07{\pm}83.89ea/cm^3$, 최대 $934.53ea/cm^3$, 최소 $599.32ea/cm^3$이었다. 이를 이온지수로 산출한 결과 1.06으로 분석되었다. 계곡부에서는 양이온 발생량 평균 $1,732.49{\pm}354.08ea/cm^3$, 최대 $2,652.10ea/cm^3$, 최소 $1,110.92ea/cm^3$이였으며, 음이온 발생량 평균 $1,990.47{\pm}433.57ea/cm^3$, 최대 $3,126.75ea/cm^3$, 최소 $1,352.17ea/cm^3$이었다. 이를 이온지수로 산출한 결과 1.16으로 분석되었다. 이 연구의 결과는 국립공원 내 기후적 측면의 건강관리 기초자료로 제공하고자 하였다.

• 생명과학회지
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• 제28권6호
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• pp.648-655
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• 2018

신령버섯 액체배양추출물(Agaricus blazei mycelial liquid culture extract: ABMLCE)과 eritadenine (EA)의 mouse 정소 Leydig TM3 세포에서 testosterone (TS) 생성에 관한 연구를 정상 조건과 산화스트레스 조건에서 수행하였다. 정상 조건에서는 TM3 세포를 DMEM 배지에 배양하면서 EA (0~100 ppm)와 EA (0~50 ppm) + ABMLCE (10 ppm)를 24 hr처리하였다. 산화스트레스 조건에서는 TM3 세포를 $H_2O_2$ ($50{\mu}M$)를 4 hr 처리하고 정상 조건과 동일하게 처리하였다. DMEM 배양물에 함유된 TS 함량, HSD3B2 효소 활성, $5{\alpha}-R2$ 효소 활성과 NO 함량을 assay kit를 사용하여 측정하였다. EA는 정상 조건이나 산화스트레스 조건에서 TS 함량을 유의성 있게 증가시켰고, ABMLCE와 ABMLCE + EA도 TS의 함량을 증가시켰다. TS 전구체 생성에 관여하는 HSD3B2 효소 활성은 두 조건에서 모두 EA, ABMLCE, ABMLCE + EA에 의해서 증가되었다. 또한 TS를 DTH로 전환시켜 TS함량을 감소시키는 역할을 하는 $5{\alpha}-R2$ 효소활성은 정상 조건 및 산화스트레스 조건에서 ABMLCE에 의해서만 감소되었다. Free radical로 작용하는 NO의 함량은 두 조건 모두 EA, ABMLCE, ABMLCE + EA에 의해 감소되었다. 이 결과는 EA, ABMLCE, ABMLCE + EA 처리가 TM3 세포의 HSD3B2 효소 활성을 증가시키고, NO 생성을 억제하여 TS 함량을 증가시켰음을 의미하며 EA + ABMLCE 혼합물이 남성 성기능개선 물질로 사용될 수 있음을 의미한다.

• The Korean Journal of Physiology
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• 제16권2호
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• pp.177-186
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• 1982

The effect of ethacrynic acid (EA) on the renal secretion of PAH was examined in cat kidney. $C_{PAH}$ and $T_{PAH}$ were measured before and after infusion of EA $(0.5{\sim}50mg/kg)$ through the femoral vein. The following results were obtained: 1) In the dosage range of 0.5 to 25 mg/kg, EA increased the urine flow, and sodium and potassium excretion in dose-dependent manner, but the glomelular filtration rate was decreased as the dosage of EA was increased. 2) $C_{PAH}$ and $T_{PAH}$ were decreased by EA in the dosage range of 3 to 25 mg/kg and 1 to 50 mg/kg, respectively, in dose·dependent manner with the dosage to cause 50% inhibition of about 5 mg/kg. 3) With dosage of 0.5mg/kg, EA appeared to exert a great effect on diuretic response without the influence on $T_{PAH}$. At 10min after infusion of EA, a potent diuretic effect appeared, while $T_{PAH}$ did not show a significant change. These results suggest that the action mechanism of EA on tubular secretion of PAH may be different from that on natriuresis. 4) With dosage of 5 mg/kg, EA did not inhibit the Na-K-ATPase activity in microsomal fractions from both cortex and medulla. 5) The double reciprocal plot ($l/T_{PAH}$ versus $l/P_{PAH}$) suggested that EA inhibited the P AH secretion by a competitive pattern. However, probenecid, a prototypic inhibitor of the organic acid pump, had no influence on both the inhibitory effect of $T_{PAH}$ and the natriuretic effect by EA. These results suggest that in vivo EA altered tubular secretion of P AH through interactions with receptors that are not identical with the Na-K-ATPase.

• 대한한의학회지
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• 제33권3호
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• pp.20-32
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• 2012

Objectives: The purpose of this study was to investigate the effect of acupuncture and electro-acupuncture (EA) of low and high frequencies at Haegye (ST41) in rats. Methods: The intestinal motility of rats was experimentally suppressed with loperamide. Acupuncture, low frequency EA and high frequency EA were carried out before the loperamide administration in the pre-treatment group, and after the loperamide administration in the post-treatment group. The rats were fed charcoal and the travel rate of charcoal in the gastrointestinal track was measured to analyze the effect of acupuncture, low frequency EA and high frequency EA on the intestinal hypo-motility. Results: 1. None of acupuncture, low frequency EA or high frequency EA at ST41 showed significant influences on intestinal motility of rats in normal status. 2. Pre-treatment with acupuncture at ST41 showed no significant effect on the intestinal hypo-motility induced by loperamide in rats. 3. Pre-treatment with low frequency EA and high frequency EA at ST41 significantly reduced the suppression of intestinal motility by loperamide in rats. 4. Post-treatment of acupuncture, low frequency EA and high frequency EA at ST41 had no significant influences on the intestinal hypo-motility induced by loperamide in rats. Conclusions: These results suggest that low and high frequency EA at ST41 may be effective to prevent gastric disorders such as intestinal hypo-motility.