• 한국균학회지
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• 제19권1호
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• pp.11-17
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• 1991

전주(全州)교외에 위치한 만덕산(萬德山)과 그 부근에서 많은 외대버섯속(屬)을 채집(採集)하여 동정(同定) 하였다 . 그 결과(結果) 한국산(韓國産) 미기록종(未記錄種)으로 확인된 것은 다음과 같으며 이들에 대하여 보통명(普通名)을 신칭(新稱)하였다.;Entoloma cuboideum Hesler(네모외대버섯), E. subquadratum Hesler(네모외대버섯아재비), E. albinellum Hesler(흰배꼽외대버섯), E. albidum(Murr.) Hesler(흰색외대버섯), E. commune Murr.(보통외대버섯) E. amplifolium(Murr.) Hesler(큰옆외대버섯), E. fragran. Hesler(향외대버섯), E. lampropum(Fr.) Hesler(빛외대버섯) .

• 생약학회지
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• 제37권3호
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• pp.206-211
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• 2006

The methanol extract from seed of Myristica fragrans (Myristicaceae) demonstrated a potent inhibition on the pro-liferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro. By the continuous effort to purify the active components responsible far the anti-proliferative effect on tumor cell lines, we have isolated eleven kinds of lignan components, i. e., safrole (1), machilin A (2), licarin B (3), macelignan (4), mere-dihydroguaiaretic acid (5), mγnstargenol A (6), methoxyeugenol (7), machilin F (8), licarin A (9), nectandrin B (10), and 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (11) together with a novel furan fatty acid, (E)-3-(3-methyl-5-pentylfuran-2-yl) acrylic acid (12) from seed extract of M. fragrans. Chemical structures of the isolated components (1-12) were established bγ the aid of NMR spectroscopic analyses, i. e., COSY HMQC and HMBC. Each of the Isolates demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OY-3 (ovary), SK-MEL-2 (melanoma) and HCT-15 (colon) in vitro.

• 생약학회지
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• 제36권3호통권142호
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• pp.240-244
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• 2005

The methanol extract of the seed of Myristica fragrans (myristicaceae) demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2(melanoma), XF498 (central nerve system) and HCT-15(colon). The MeOH extract was fractionated into three portions by serial solvent partition i,e., EtOAc soluble part, BuOH soluble part and remaining water layer. Among them, the EtOAc soluble part of the extract demonstrated a potent inhibition on the proliferation of cultured human tumor cells, Bioassay-guided fractionation of the EtOAc soluble part led to the isolation of six lignan constituents, i.e., safrole(1), machilin A (2), licarin B (3), macelignan (4), mesodihydroguaiaretic acid (5) and myristargenol A (6) as well as a large amount of myristic acid as active ingredients. Structures of the isolated active components (1-6) were established by chemical and spectroscopic means.