• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.375-381
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• 2022

Safety accidents are of concern during construction projects, even given the recent innovations in digital technologies. These projects remain focused on overcoming specific and limited applications on construction sites. For this reason, the development of an inclusive safety management system has become crucial. This study aims to build a Big Data platform to inform decisions on how to proactively eliminate worker hazards on construction sites. The platform consists of about 100,000 real records and a real-time monitored database featuring various safety indices, such as workers' altitudes, heart rates, and fatigability during construction, which are determined through various wearable devices. The data types are customized and integrated by a research team in accordance with the characteristics of a specific project using hypertext transfer protocol (HTTP). The results can be helpful as efficient tools to ensure successful safety management in complex construction situations. This study is expected to provide three significant contributions to the field, including real-time fatigability analysis and tracking of workers on-site; providing early GPS-based warnings to workers who might be accessing dangerous spaces or places; and monitoring the workers' health indices, based on details from 100,000 cases.

• Clinical Endoscopy
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• 제55권2호
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• pp.197-207
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• 2022

Background/Aims: Endoscopic visualization of the microscopic anatomy can facilitate the real-time diagnosis of pancreatobiliary disorders and provide guidance for treatment. This study aimed to review the technique, image classification, and diagnostic performance of confocal laser endomicroscopy (CLE). Methods: We conducted a systematic review of CLE in pancreatic and biliary ducts of humans, and have provided a narrative of the technique, image classification, diagnostic performance, ongoing research, and limitations. Results: Probe-based CLE differentiates malignant from benign biliary strictures (sensitivity, ≥89%; specificity, ≥61%). Needle-based CLE differentiates mucinous from non-mucinous pancreatic cysts (sensitivity, 59%; specificity, ≥94%) and identifies dysplasia. Pancreatitis may develop in 2-7% of pancreatic cyst cases. Needle-based CLE has potential applications in adenocarcinoma, neuroendocrine tumors, and pancreatitis (chronic or autoimmune). Costs, catheter lifespan, endoscopist training, and interobserver variability are challenges for routine utilization. Conclusions: CLE reveals microscopic pancreatobiliary system anatomy with adequate specificity and sensitivity. Reducing costs and simplifying image interpretation will promote utilization by advanced endoscopists.

• 디지털융복합연구
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• 제15권7호
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• pp.445-456
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• 2017

모바일 헬스케어 앱은 기기로서의 특성도 가지지만 사용자가 요구하는 특정 영역의 관리와 연관이 있기 때문에 해당 콘텐츠에 대한 이해가 요구된다. 이에 본 연구는 심리적 요인으로서 도구적 효능감, 정보적 효능감, 건강정보지향, 유희성과 반응성이 모바일 헬스케어 앱 사용의도에 미치는 영향을 연구하고자 하였다. 이에 확장된 기술수용모델(TAM II)를 바탕으로 모바일 헬스케어 앱의 지속사용의도를 설명하는 다양한 외생변인들의 영향력을 살펴보기 위해 구조방정식 분석을 실시하였다. 연구결과 정보적 효능감과 도구적 효능감은 용이성과 유용성을 매개하여 사용의도에 영향을 미치는 것으로 나타났다. 유희성은 인지된 용이성과 유용성을 매개하여 지속사용의도에 영향을 미칠 뿐만 아니라 지속사용의도에 직접적인 영향을 미치는 것으로 나타났다. 건강정보지향과 반응성은 인지된 유용성을 매개로 지속사용의도에 영향을 미치는 것으로 나타났다. 이러한 연구결과는 도구적 관점, 정보적 관점, 유희적 관점에서 모바일 헬스케어 앱의 연구 및 제작의 필요성에 대한 접근을 시사한다.

• 한국축산식품학회지
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• 제38권5호
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• pp.878-888
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• 2018

In the current study, the probiotic potential of approximately 250 strains of lactic acid bacteria (LAB) isolated from piglet fecal samples were investigated; among them Lactobacillus plantarum strain JDFM LP11, which possesses significant probiotic potential, with enhanced acid/bile tolerance, attachment to porcine intestinal epithelial cells (IPEC-J2), and antimicrobial activity. The genetic characteristics of strain JDFM LP11 were explored by performing whole genome sequencing (WGS) using a PacBio system. The circular draft genome have a total length of 3,206,883 bp and a total of 3,021 coding sequences were identified. Phylogenetically, three genes, possibly related to survival and metabolic activity in the porcine host, were identified. These genes encode p60, lichenan permease IIC component, and protein TsgA, which are a putative endopeptidase, a component of the phosphotransferase system (PTS), and a major facilitator in the gut environment, respectively. Our findings suggest that understanding the functional and genetic characteristics of L. plantarum strain JDFM LP11, with its candidate genes for gut health, could provide new opportunities and insights into applications in the animal food and feed additive industries.

• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.7.1-7.7
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• 2015

Objectives The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nanano-materials (GFNs) in alternative in vitro and in vivo toxicity testing models. Methods The GFNs used in this study are graphene nanoplatelets ([GNPs]-pristine, carboxylate [COOH] and amide [$NH_2$]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs' toxicity. Results In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine > $NH_2$ > COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media. Conclusions The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial's physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.

• 융합보안논문지
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• 제14권7호
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• pp.75-84
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• 2014

예방 의료에서 유비쿼터스 헬스케어는 노인 환자들의 수명연장에 대한 연구로 발전되고 있다. 이와 같은 연구들은 수명 연장 및 불의의 사고를 예방하기 위하여 모바일과 무선센서 기술을 사용하여 삶의 질을 향상 시켜 수명을 연장시키고 있다. 그러나 인터넷을 통해 유비쿼터스 헬스케어 응용프로그램이 모바일화 및 보급이 용이해짐에 따라 u-헬스정보 보호와 보안에 대한 위협이 증가하고 관심을 받고 있다. 따라서 본 논문에서는 보안 헬스 정보 교환 기술을 적용한 온톨로지를 이용하는 유헬스 케어 어플리케이션의 지식기반 상황인식 서비스 프레임워크를 제안한다. 본 연구에서는 유비쿼터스 컴퓨팅 환경에서 상황 영역의 보안 헬스 정보 교환 기술을 적용한 온톨로지를 위한 보편적인 어플리케이션 영역에서 상황 추론, 상황 모델링, 지식 기반 지원을 적용하는 것이다. 본 논문에서는 예방 서비스 질 변화를 위한 모바일 웹서비스, 상황 기술, 지식베이스에 대하여 논의한다.

• Smart Structures and Systems
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• 제10권3호
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• pp.229-251
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• 2012

Guided waves have shown a great potential for structural health monitoring (SHM) applications. In contrast to traditional non-destructive testing (NDT) methodologies, a key element of SHM approaches is the high process of automation. The monitoring system should decide autonomously whether the host structure is intact or not. A basic requirement for the realization of such a system is that the sensors are permanently installed on the host structure. Thus, baseline measurements become available that can be used for diagnostic purposes, i.e., damage detection, localization, etc. This paper contributes to guided wave-based inspection in anisotropic materials for SHM purposes. Therefore, computational strategies are described for both, the solution of the complex equations for wave propagation analysis in composite materials based on exact elasticity theory and the popular global matrix method, as well as the underlying equations of two active damage localization algorithms for anisotropic structures. The result of the global matrix method is an angular and frequency dependent wave velocity characteristic that is used subsequently in the localization procedures. Numerical simulations and experimental investigations through time-delay measurements are carried out in order to validate the proposed theoretical model. An exemplary case study including the calculation of dispersion curves and damage localization is conducted on an exemplary unidirectional composite structure where the ultrasonic signals processed in the localization step are simulated with the spectral element method. The proposed study demonstrates the capabilities of the proposed algorithms for accurate damage localization in anisotropic structures.

• Toxicological Research
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• 제23권3호
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• pp.271-278
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• 2007

Several recent studies demonstrated the potential of bioengineering using stem cells in regenerative medicine. Adult mesenchymal stem cells (MSCs) have the pluripotency to differentiate into cells of mesodermal origin, i.e., bone, cartilage, adipose, and muscle cells; they, therefore, have many potential clinical applications. On the other hand, stem cells possess a self-renewal capability similar to cancer cells. For safety evaluation of MSCs, in this study, we tested tumorigenecity of canine adipose derived mesenchymal stem cells (cAD-MSCs) using Balb/c-nu mice. In this study, there were no changes in mortality, clinical signs, body weights and biochemical parameters of all animals treated. In addition, there were no significant changes between control and treated groups in autopsy findings. These results indicate that cAD-MSC has no tumorigenic potential under the condition in this study.

• 한국의학물리학회지:의학물리
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• 제20권3호
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• pp.145-151
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• 2009

본 연구는 관전압(kVp), 관전류량(mAs)과 같은 물리적 인자의 변화에 따른 다양한 구성 물질의 하운스필드 단위(HU, Hounsfield Unit) 평가를 통해 전산화단층촬영(Computed Tomography) 장치에 대한 성능을 평가하고 이들의 응용가능성을 연구하고자 하였다. MDCT (Siemens SOMATOM Sensation 4, Germany)를 이용하여 밀도가 다른 다양한 물질의 물리적 인자의 변화에 따른 HU 값을 측정하였다. 실험결과 관전압이 증가함에 따라 물질의 HU 값은 대체적으로 감소하고, 특히 뼈와 조영제의 구성물질인 요오드(iodine)의 경우 관전압이 80 kVp에서 140 kVp로 증가했을 때 HU 값은 각각 32%, 42% 감소하였다. 반면, 50 mAs에서 400 mAs로 관전류량이 증가함에 따라 HU 값에는 큰 변화가 없었다. 그리고 물질의 밀도가 0.00 $g/cm^3$에서 1.82 $g/cm^3$로 증가함에 따라 HU 값은 선형적으로 증가하였다. 조영제의 구성물질인 요오드의 경우에는 농도가 증가함에 따라 HU 값은 선형적으로 증가하였고 관전압이 증가함에 따라 HU 값이 감소하였다. 관전압 증가에 따른 감소정도는 요오드의 농도에 따라 차이가 있으며 3%의 농도에서 가장 큰 차이를 보였다. 이러한 결과를 이용하여 single source CT 장치에서 혼합물의 물질분리 효과를 얻을 수 있었다. 본 연구를 통해 다양한 물질에 대한 물리적 인자와 HU의 상관관계를 확인하였고, single source CT 장치를 이용하여 물질분리 효과를 구현함으로써 CT 장치의 효율성을 증가시키고, 응용분야를 확장할 수 있을 것으로 기대한다.

• 대한한의학회지
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• 제33권4호
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• pp.60-68
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• 2012

Objectives: By grasping trends in research, technology, and general characteristics of learning support tools, this study was conducted to present a model for research on Korean Medicine (KM) to make use of information technology to support teaching and learning. The purpose is to improve the future clinical competence of medical personnel, which is directly linked to national health. Methods: With papers and patents published up to 2011 as the objects, 438 papers were extracted from "Web of Science" and 313 patents were extracted from the WIPS database (DB). Descriptive analysis and network analysis were conducted on the annual developments, academic journals, and research fields of the papers, patents searched were subjected to quantitative analysis per application year, nation, and technology, and an activity index (AI) was calculated. Results: First, research on medical learning support tools has continued to increase and is active in the fields of computer engineering, education research, and surgery. Second, the largest number of patent applications on medical learning support tools were made in the United States, South Korea, and Japan in this order, and the securement of remediation technology-centered patents, rather than basic/essential patents, seemed possible. Third, when the results of the analysis of research trends were comprehensively analyzed, international research on e-PBL- and medical simulation-centered medical learning support tools was seen to expand continuously to improve the clinical competence of medical personnel, which is directly linked to national health. Conclusions: The KM learning support tool model proposed in the present study is expected to be applicable to computer-based tests at KM schools and to be able to replace certain functions of national KM doctor license examinations once its problem DB, e-PBL, and TKM simulator have been constructed. This learning support tool will undergo a standardization process in the future.