• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.291-295
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• 2007

Prostaglandin $E_1\;(PGE_1)$ was formulated as two self-microemulsifying drug delivery systems (SMEDDS) composed of Cremophor $EL^{(R)}$ or Cremophor $ELP^{(R)}$ as a surfactant, ethanol as a cosurfactant and Labrafac $CC^{(R)}$ as an oil to develop liquid preparation for the treatment of erectile dysfunction. In pseudo-ternary phase diagram, viscous gel area and microemulsion area were defined. In the measurement of viscosity, the viscosity of two formulations increased gradually upon the addition of water and it decreased from the water contents over 40%. With excessive water, the present systems formed a microemulsion spontaneously. From these results, rte could expect that the present liquid $PGE_1$ SMEDDS formulations might stay within the urethra in the viscous state when contacting the moisture of the urethra and can be easily eliminated by urination. In long-term stability study, we could select one formulation more stable at the shelf storage condition of $4^{\circ}C$.

• Proceedings of the KSME Conference
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• 대한기계학회 2000년도 추계학술대회논문집A
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• pp.328-332
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• 2000

Following the method described in ASTM E1737, J resistance curves are measured for Cr-Mo steel SA387, and Cr steel A240 which are used as piping materials in nuclear industry. Crack driving force diagrams are generated in order to find out instability points in crack growth. The $J_{appl}$ curves, which are used in the crack driving force diagram, are obtained from EPRI J estimation method and the finite element analysis. Crack growth instability points are plotted in load-crack length plane and the results are discussed.

• Journal of the Korean Data and Information Science Society
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• 제13권2호
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• pp.341-354
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• 2002

This paper is planned to use randomized response technique which is an indirect response technique on internet as a way of obtaining much more precise information, not revealing secrets of responsors, considering that respondents are generally reluctant to answer in a survey to get sensitive information targeting employees, customers, etc.

• Journal of the Korean Data and Information Science Society
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• 제14권3호
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• pp.489-499
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• 2003

In this paper we implement the system for the forced answer model which is an indirect response technique on the internet as a way of obtaining much more precise information, not revealing secrets of responsors. In this system we consider that respondents are generally reluctant to answer in a survey to get sensitive information targeting employees, customers, etc.

• Journal of the Korean Data and Information Science Society
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• 제14권3호
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• pp.591-603
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• 2003

This paper is planned to use randomized response technique which is an indirect response technique on internet as a way of obtaining much more precise information, not revealing secrets of responsors, considering that respondents are generally reluctant to answer in a survey to get sensitive information targeting employees, customers, etc.

• 한국데이터정보과학회:학술대회논문집
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• 한국데이터정보과학회 2002년도 춘계학술대회
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• pp.107-118
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• 2002

This paper is planned to use randomized response technique which is an indirect response technique on internet as a way of obtaining much more precise information, not revealing secrets of responsors, considering that respondents are generally reluctant to answer in a survey to get sensitive information targeting employees, customers, etc.

• Journal of the Korean Data and Information Science Society
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• 제15권4호
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• pp.731-741
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• 2004

This paper is planned to use multi-proportions randomized response model for sensitive information on internet survey. This is an indirect response technique as a way of obtaining much more precise information. In this system we consider that respondents are generally reluctant to answer in a survey to get sensitive information targeting employees, customers, etc.

• Bulletin of the Korean Chemical Society
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• 제12권6호
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• pp.674-678
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• 1991

Methanolysis of a ${\beta}$-lactam ring of a cephalosporin was simulated with AM1 semiempirical quantum mechanical calculation. The tetrahedral intermediate TD1 from an O-protonated cephalosporin and a methanol transfers the proton intramolecularly to the C-4 carboxylate to generate an oxyanion, i.e., second tetrahedral intermediate TD2, which undergoes the amide bond cleavage without further protonation on the N-5. For this cleavage a low-energy barrier TS2 was located. According to the energy diagram, tetrahedral intermediates easily undergo ring cleavage even without the protonation on the amide nitrogen.

• Journal of the Korean Geotechnical Society
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• 제30권3호
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• pp.59-72
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• 2014

For circular rigid footings with a rough base on sand, combined vertical - moment loading capacity was studied by three-dimensional numerical modelling. Mohr-Coulomb plasticity model with the associated flow-rule was used for the soil. After comparing the results of the swipe loading method, which can construct the interaction diagram with smaller number of analyses, and those of the probe loading method, which can simulate the load-paths in the conventional load tests, it was found that both loading methods give similar results. Conventional methods based on the effective width or area concept and the results by eccentricity factor ($e_{\gamma}$) were reviewed. The results by numerical modelling of this study were compared with those of previous studies. The combined loading capacity for vertical (V) - moment (M) loading was barely affected by the internal friction angle. It was found that the effective width concept expressed in the form of eccentricity factor can be applied to circular footings. The numerical results of this study were smaller than the previous experimental results and the differences between them increased with the eccentricity and moment load. Discussions are made on the reason of the disparities between the numerical and experimental results, and the areas for further researches are mentioned.

• Journal of the Korean earth science society
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• 제27권5호
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• pp.557-568
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• 2006

We present CCD UBVI photometry for more than 10,000 stars in $20'.5{\times}20'.5$ field of the halo globular cluster M30. From a color-magnitude diagram, main sequence turnoff was obtained when $V_{TO},\;(B-V)_{TO},\;and\;(V-I)_{TO}\;are\;8.63{\pm}0.05,\;0.44{\pm}0.05\;and\;0.63{\pm}0.05$, respectively. From a (U-B)-(B-V) diagram, reddening parameter, E(B-V) equals $0.05{\pm}0.01$ and a UV color excess ${\delta}(U-B)\;is\;0.27{\pm}0.01$. The abundance is derived, where [Fe/H] equals $-2.05{\pm}0.09$ according to the photometric method and spectroscopic data. The observed luminosity function of M30 shows an excess in the number of red giants relative to the number of turnoff stars, when comparing with the predictions of canonical models. Using the Hipparcos parallaxes for subdwarfs, we estimate distance modulus, $(m-M)_o\;as\;14.75{\pm}0.12$. Using the R and R' method, we find helium abundances, Y(R) as $0.23{\pm}0.02$, Y(R') as $0.29{\pm}0.02$, respectively. Finally, the cluster' sage dispersion was deduced from 10.71 Gyr to 17 Gyr.