• 디지털콘텐츠학회 논문지
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• 제10권3호
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• pp.433-439
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• 2009

최근 인터넷 보급의 확산은 e-Health 분야의 급속한 발전을 가져오고 있으며, 그 결과 개인의 건강정보에 대한 기록 및 관리의 디지털화에 대한 관심이 증대되고 있다. 본 연구에서는 개인전자건강기록의 특징을 검토하고, 인터넷 기반의 개인전자건강기록 시스템을 적용한 구글헬스 서비스의 구조를 분석해 보고자 하였다. 구글헬스를 통하여 소비자들은 개인의 건강기록을 구축하고 병원과 약국의 의무기록을 불러와 저장하며 자신의 건강기록을 타인과 공유함으로써 보다 편리하게 건강관리를 할 수 있을 뿐 아니라 온라인 건강정보 검색을 손쉽게 할 수 있다. 이는 현재의 의료시스템에 큰 변화의 흐름뿐 아니라 미래 의료시스템의 발전 방향의 예측을 가능하게 하는 사례로서 중요한 의미를 가진다. 따라서 본 연구는 다양한 서비스로의 발전이 예상되는 e-Health 산업에서 개인전자건강기록의 중요성을 인식시켜 줄 뿐 아니라 장단점을 비교분석함으로써 보다 보완적인 개인전자건강기록의 체계를 제시하여 준다.

• 보건행정학회지
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• 제31권4호
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• pp.508-517
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• 2021

Background: After the first case of coronavirus disease 2019 (COVID-19) in January 2020, Korea has experienced three waves in 2020. This study aimed to analyze changes in health care utilization according to the period of the 1st to 3rd waves of the COVID-19 pandemic. Methods: We analyzed 3,354,469,401 national health insurance claims from 59,104 medical facilities between 2017 and 2020. Observed-to-expected ratios (O:E ratio) with data from 2017 to 2019 as expected values and data from 2020 as observed values were obtained to analyze changes in medical utilization. T-test was used to test whether the difference of observed and expected values was statistically significant. Results: In 2020, the O:E ratio was 0.894, indicating a decrease in health care utilization overall during the pandemic. The O:E ratio of the 1st wave was 0.832, which was lower than those of the second (0.886) and third (0.873) waves. Health care utilization decreased relatively more among outpatient, women, children and adolescents, and health insurance patients. And health care utilization decreased more in small medical facilities and in Daegu and Gyeongbuk during the first wave. During the pandemic, the O:E ratios of respiratory diseases were 0.486-0.694, while chronic diseases and mental diseases were more than 1.0. Conclusion: Health care utilization decreased during the COVID-19 pandemic overall, and there were differences by COVID-19 waves, and by the characteristics of patients and medical facilities. It is necessary to understand the cause of changes in health care utilization in order to cope with the prolonged COVID-19 pandemic.

• Smart Structures and Systems
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• 제21권2호
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• pp.225-234
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• 2018

E-Health allows you to supersede the central patient wireless healthcare system. Wireless Body Sensor Network (WBSN) is the first phase of the e-Health system. In this paper, we aim to understand e-Health architecture and configuration, and attempt to minimize energy consumption and latency in transmission routing protocols during restrictive latency in data delivery of WBSN phase. The goal is to concentrate on polling protocol to improve and optimize the routing time interval and schedule communication to reduce energy utilization. In this research, two types of network models routing protocols are proposed - elemental and clustering. The elemental model improves efficiency by using a polling protocol, and the clustering model is the extension of the elemental model that Destruct Supervised Decision Tree (DSDT) algorithm has been proposed to solve the time interval conflict transmission. The simulation study verifies that the proposed models deliver better performance than the existing BSN protocol for WBSN.

• Journal of Chest Surgery
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• 제53권6호
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• pp.368-374
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• 2020

Background: The extracorporeal ventricular assist device (e-VAD) system is designed for left ventricular support using a permanent life support console. This study aimed to determine the impact of temporary e-VAD implantation bridging on posttransplant outcomes. Methods: We reviewed the clinical records of 6 patients with the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1, awaiting heart transplantation, who were provided with temporary e-VAD from 2018 to 2019. The circuit comprised a single centrifugal pump without an oxygenator. The e-VAD inflow cannula was inserted into the apex of the left ventricle, and the outflow cannula was positioned in the ascending aorta. The median follow-up duration was 8.4±6.9 months. Results: After e-VAD implantation, lactate dehydrogenase levels significantly decreased, and Sequential Organ Failure Assessment scores significantly improved. Bedside rehabilitation was possible in 5 patients. After a mean e-VAD support duration of 14.5±17.3 days, all patients were successfully bridged to transplantation. After transplantation, 5 patients survived for at least 6 months. Conclusion: e-VAD may reverse end-organ dysfunction and improve outcomes in INTERMACS I heart transplant patients.

• 디지털융복합연구
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• 제17권11호
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• pp.357-367
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• 2019

본 연구의 목적은 직장인의 인터넷 건강정보에 대한 태도, e-헬스 리터러시가 건강정보 추구행동과 건강관련 행위의도에 미치는 영향을 파악하기 위함이다. 서울, 경기도, 충청도 거주하고 있는 직장인 152명에게 구조화된 설문지를 이용하여 조사하였다. 자료는 t-test, ANOVA, 다중회귀분석으로 분석하였다. 연구결과, 건강정보 추구행동 영향요인으로는 e-헬스 리터러시(${\beta}=.33$, p<.011)와 인터넷 건강정보에 대한 지각된 유용성(${\beta}=.28$, p=.002)이, 건강관련 행위의도 영향요인으로는 인터넷 건강정보에 대한 지각된 유용성(${\beta}=.33$, p=.001)과 정보활용도(${\beta}=.24$, p=.003), e-헬스리터러시(${\beta}=.18$, p=.002)가 확인되었다. 이상의 결과를 토대로 직장인의 e-헬스 리터러시를 고려하여 정보활용도를 높이는 인터넷 건강정보의 전달시스템 구축과 교육프로그램 개발이 필요하다.

• 한국보건간호학회지
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• 제17권1호
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• pp.26-34
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• 2003

The purpose of this study was to analyze the activities of Community Health Nurse Practitionses using the Community Health Post Information System(CHPIS). The information system that have been introduced in 1994 and used by 400 Community Health Posts(CHPs) since 1997, which is about $20\%$ of the total CHPs nationwide. Twenty-five CHPs from two provinces participated in the analysis. Seventy-two percent of the CHPs among the participating CHPs started using the system since 1996. The degree of utilization of the information system was classified into three groups (i. e., high. medium, and low). The results revealed that only $48\%$ utilized the system with high level. The areas of analysis of the information system included characteristics of community residents, environmental attributes, and job analysis of Community Health Nurse Practitioners(CHNPs). The study results indicated that primary health care and drug demand and supply system showed the highest level of satisfaction in utilizing the information system by CHNPs.

• Mycobiology
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• 제39권4호
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• pp.243-248
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• 2011

The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 ubiquitin ligases that transfer ubiquitin to the substrates that are subjected to degradation in the 26S proteasome. The Skp1, Cullin, F-box protein (SCF) E3 ligases are the largest E3 gene family, in which the F-box protein is the key component to determine substrate specificity. Although the SCF E3 ligase and its F-box proteins have been extensively studied in the model yeast Saccharomyces cerevisiae, only limited studies have been reported on the role of F-box proteins in other fungi. Recently, a number of studies revealed that F-box proteins are required for fungal pathogenicity. In this communication, we review the current understanding of F-box proteins in pathogenic fungi.

• Child Health Nursing Research
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• 제13권4호
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• pp.436-443
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• 2007

Purpose: An exploratory study was done to examine the validity of the new Ballard scale with extended scoring system(eNBS) in estimating gestational age(AG) in full-term newborns. Method: The eNBS scoring system was extended to include all numbers of total score of NBS and GA to allow a 3-days variation in GA estimatio compared to the original scale which has a 2-week variation due to the application of a 5-score interval for the total NBS score and only even numbers for GA. GA by eNBS(GA-eNBS) was compared with GA by LMP(GA-LMP) and GA by standard NBS(GA-sNBS) in 133 full-term newborns. Difference between GA-LMP and GA-eNBS was analyzed for each GA. Results: Positive correlations were observed in GA-sNBS and GA-eNBS with GA-LMP. There was no difference between GA-LMP and GA-eNBS at 39GA and 40GA. At 37GA and 38GA, GA-eNBS overestimated GA-LMP up to 1 week, while underestimating up to 1 week at 41GA. Conclusions: The accuracy of eNBS was validated within 3 days of variation in GA estimation at 39-40GA. Overestimation by eNBS suggests the possible acceleration of fetal maturity in premature newborns, while underestimation, of the deceleration of fetal maturity in postterm newborns.

• Anatomy and Cell Biology
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• 제56권2호
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• pp.228-235
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• 2023

Toll-like receptors (TLRs) are the mammalian ortholog of Drosophila melanogaster protein Toll, originally identified for its involvement in embryonic development. In mammals, TLRs are mainly known for their ability to recognize pathogen- or damage-associated molecular patterns and, consequently, to initiate the immune response. However, it is becoming clear that TLRs can play a role also in mammal embryo development. We have previously described TLR4 and TLR7 expression in developing mouse peripheral nervous system and gastrointestinal tract. In the present study, we extended the investigation of TLR4 and TLR7 to the respiratory system and to the two main accessory organs of the digestive system, the liver and pancreas. TLR4 and TLR7 immunostaining was performed on mouse conceptuses collected at different stages, from E12 to E18. TLR4 and TLR7 immunoreactivity was evident in the embryo pancreas and liver at E12, while, in the respiratory apparatus, appeared at E14 and E17, respectively. Although further studies are required to elucidate the specific role of these TLRs in embryo development, the differential spatiotemporal TLR4 and TLR7 appearance may suggest that TLR expression in developing embryos is highly regulated for a possible their direct involvement in the formation of the organs and in the acquisition of immune-related features in preparation for the birth.

• 한국의학물리학회지:의학물리
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• 제23권1호
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• pp.26-32
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• 2012

확대촬영은 일반촬영뿐 아니라 미세골촬영, 유방촬영 및 다른 진단 영역에서 널리 사용되고 있다. 유한한 X선 초점의 크기로 인해 확대촬영은 분해능, 노이즈, 대조도 등 영상 시스템 전체에 영향을 미친다. 본 연구의 목적은 유효검출양자효율(effective detective quantum efficiency, eDQE)을 이용하여 영상시스템에 있어서 확대도와 초점크기의 영향을 알아보고자 함이다. 전체적인 영상 시스템 특성을 반영하는 eDQE는 초점에 의한 흐림 현상, 확대, 산란 그리고 격자 반응 등의 영향을 고려한다. 본 실험에서는 Food and Drug Administration (FDA)에서 고안된 흉부 팬텀을 사용하여 실제 가슴 촬영조건에서 측정된 유효변조전달함수(effective modulation transfer function, eMTF), 유효잡음력스펙트럼(effective noise power spectrum, eNPS), 산란율(scatter fraction, SF) 및 투과율(transmission fraction, TF)을 통해 eDQE 값을 도출하였다. 연구 결과를 통해 살펴보면 소초점을 사용했을 경우, eMTF의 값이 10%일 때의 공간주파수는 확대도가 1.2, 1.4, 1.6, 1.8, 2.0일때 각각 2.76, 2.21, 1.78, 1.49 그리고 1.26 lp/mm이었다. 대초점을 사용했을 경우, MTF의 값이 10%일 때의 공간주파수는 확대도가 1.2, 1.4, 1.6, 1.8, 2.0일 때 각각 2.21, 1.66, 1.25, 0.93 그리고 0.73 lp/mm이었다. 확대도가 증가할수록 eMTF 값이 떨어지고, 소초점을 사용했을 때가 대초점을 사용했을 때보다 eMTF가 전체적으로 높다는 것을 확인할 수 있었다. 초점의 크기에 따른 zero frequency에서의 eDQE 값의 변화는 크게 보이지 않았다. 그러나 대초점을 사용했을 경우, 소초점을 사용했을 때보다 저 주파수에서 고 주파수로 갈수록 eDQE가 급격하게 감소하는 것을 확인할 수 있었다. 일반적으로 확대촬영은 작은 병변을 확대시키고 낮은 유효잡음과 air-gap에 의한 산란선의 감소로 인해 대조도를 증가시킨다. 이로 인해 크기가 작은 병변을 고대조도로 확대시킴으로써 진단율을 높일 수 있다. 그러나 초점 크기로 인한 흐림 현상이 확대도에 따라 공간 분해능에 더 큰 영향을 미친다. 이러한 결과를 바탕으로, 디지털 일반촬영 시스템에서의 확대촬영을 시행하기 위한 적절한 초점크기와 확대도가 확립되어야 한다.