• 성인간호학회지
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• 제25권4호
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• pp.432-443
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• 2013

Purpose: The purpose of this study was to investigate the factors related to dyslipdemia and hypertension among male office workers. Methods: This study was a cross-sectional survey. The sample was 204 male office workers aged 30 to 62 years without cardiovascular disease and not taking medication for hypertension and dyslipidemia. Data were collected from November, 2011 to March, 2012. Dyslipidemia was examined by checking serum lipid profiles. Results: Dyslipidemia was related to career (adjusted OR 1.06, 95% CI 1.03~1.51), time spent at desk (adjusted OR 1.25, 95% CI 1.03~1.51), job stress of Q25-49 (adjusted OR 2.72, 95% CI 1.24~5.93), inactivity (adjusted OR 6.86, 95% CI 2.62~17.93), and snack intake frequency (adjusted OR 1.57, 95% CI 1.03~2.38). Hypertension was related to career (adjusted OR 1.07, 95% CI 1.01~1.14), heavy drinking (adjusted OR 5.00, 95% CI 1.25~20.04), and snack intake frequency (adjusted OR 2.10, 95% CI 1.33~3.34). Conclusion: Work and lifestyle-related factors were associated with dyslipidemia and hypertension in male office workers. These findings suggest that lifestyle intervention and improvement of working conditions are integral parts of cardiovascular disease prevention.

• 대한약침학회지
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• 제27권2호
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• pp.101-109
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• 2024

Objectives: Dyslipidemia has currently become a major health challenge that still opens for safer and more effective modes of treatment. The plant Pandanus amaryllifolius Roxb. (pandan) has been indicated to contain active ingredients that interfere with the pathological pathway of dyslipidemia. The aim of the study was to test the effects of pandan leaves ethanol extract on lipid and proinflammatory profiles in a rat dyslipidemic model. Methods: Dyslipidemia was induced by administration of high-fat feed for 8 weeks. Treatments (vehicle, the reference drug simvastatin at 1.8 mg/kg, and extract at 200, 300 or 600 mg/kg) were given for 4 weeks following the completion of induction. Results: Significant post-treatment decreases in total cholesterol, low density lipoprotein (LDL), and triglyceride levels in groups receiving all doses of extract and simvastatin were observed. Similar results were also found in regards to proinflammatory cytokines levels. Pandan extracts significantly lowered the concentrations of IL-6, TNF-α, and NFκB p65. Characterization of metabolite contents of the extract confirmed the presence of the previously suggested active alkaloids pandamarilactonine-A and B. Conclusion: Taken together, results of the present study implied the ameliorating effects of pandan leaves ethanol extract in dyslipidemic condition which is potential for opening an avenue in combating this essential component of metabolic disorder.

• 동아시아식생활학회지
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• 제21권6호
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• pp.789-807
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• 2011

The purpose of this study was to examine the association between fatty acid intake and dyslipidemia in Korean adults, using data from the Korean National Health and Nutrition Examination Survey (KNHANES)I, II, III, and IV. After excluding subjects who had missing data for the dietary intakes, anthropometric measurments and laboratory tests, a total of 15,804 subjects aged 20~64 y (6,838 men and 8,966 women) from KNHANES 1998~2007 were included. All data were analyzed using SPSS Statistics software (version 18.0). Associations between fatty acid intakes and dyslipidemia were analyzed by logistic regression analysis after adjusting for age, BMI, energy intake, marital status, job, education level, alcohol intake, and smoking status. Fatty acid intakes were significantly higher in men than in women. The risk of hypertriglyceridemia was significantly and negatively associated with intakes of TFA, SFA, MUFA, PUFA, EPA, DHA, n-3 PUFA, and n-6 PUFA in both men and women. The risk of hypercholesterolemia was not significantly associated with any fatty acid intakes in either sex. The risk of high LDL cholesterolaemia was significantly and positively associated with intakes of TFA, MUFA, PUFA, LNA, n-3 PUFA, and n-6 PUFA in men however, there was no significant association with any fatty acids in women. The risk of low HDL cholesterolaemia was significantly and positively associated with intakes of TFA, MUFA, PUFA, LNA, n-3 PUFA, and n-6 PUFA in men, and was significantly and negatively associated with intakes of MUFA, PUFA, LNA, and n-3 PUFA in women. These results show that dyslipidemia is significantly associated with individual intake of fatty acids, suggesting that fatty acid type may be related to the risk of dyslipidemia.

• 대한한방내과학회지
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• 제38권3호
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• pp.367-375
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• 2017

Objective: To investigate the effect of Artemisiae Iwayomogii Herba, Curcumae Radix, and Aurantii Fructus Immaturus complex extract (ACA) on dyslipidemia-related factor expression and anti-oxidation in HepG2 cells. Method: After treatment with ACA in the HepG2 cells, DPPH, ABTS radical scavenging activity, ROS production, and glutathione (GSH) production were measured. The free fatty acid, lipid peroxidation (MDA), ACAT1, and HMG-CoA reductase mRNA expression were measured in the HepG2 cells after treatment with ACA. Results: 1. DPPH, ABTS radical scavenging activity increased in an ACA concentration-dependent manner. 2. ACA significantly decreased ROS production in comparison to the control group. 3. ACA significantly increased glutathione production. 4. ACA significantly decreased free fatty acid and lipid peroxidation (MDA) in the HepG2 cells. 5. ACA decreased the mRNA expression of ACAT1 and HMG-CoA reductase. Conclusion: These results suggest that Artemisiae Iwayomogii Herba, Curcumae Radix, and Aurantii Fructus Immaturus complex extract (ACA) inhibits dyslipidemia-related factor expression and that it is effective in anti-oxidation. A future in vivo experiment with ACA is needed to investigate the effect on anti-dyslipidemia. It is expected that ACA is effective in anti-dyslipidemia and applied to cardiovascular disease, ischemic heart disease, stroke, etc.

• 한국식생활문화학회지
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• 제34권6호
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• pp.748-760
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• 2019

This study examined the difference of dietary intake behavior between groups of adults aged >20 years with or without dyslipidemia, and comparing the various types of dyslipidemia, based on the Seventh (2016) KNHANES. Men showed higher rate for triglyceridemia and LDL-cholesterolemia than women and subjects in the age group 50-59 years exhibited the highest incidence of triglyceridemia, total cholesterolemia and HDL-cholesterolemia. The ratio of obese people was higher in most types of dyslipidemias. The top five foods in each group of cereal & grain, meat, vegetable, and fruit were selected for analysis, based on the food frequency. The dyslipidemia group showed higher intake frequencies for mixed grains, cabbage kimchi and leafy vegetable than the no-dyslipidemia group, and the group with high blood total cholesterol for mixed grains, apple, and cutlassfish-croaker. Group with high blood triglyceride showed higher intake frequencies of rice and mackerel-mackerel pike than the other groups of high blood triglyceride. No food showed significant difference in the frequencies between groups of LDL-cholesterol. Group with high blood HDL-cholesterol showed higher intake frequency of bibim-fried rice, deep fried chicken, stir fried chicken, apple, tangerine, banana and butter-margarine. These results indicate that people with high levels of blood total cholesterol are more concerned with food having health benefits than those with abnormal levels of other blood lipid. More information on dietary benefits need to be provided to patients having high levels of triglyceride, LDL-cholesterol and HDL-cholesterol.

• 보건행정학회지
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• 제29권3호
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• pp.357-367
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• 2019

Background: This study evaluated the cost-effectiveness of 21 different national dyslipidemia screening strategies according to total cholesterol (TC) cutoff and screening interval among 40 years or more for the primary prevention of coronary heart disease over a lifetime in Korea, from a societal perspective. Methods: A decision tree was used to estimate disease detection with the 21 different screening strategies, while a Markov model was used to model disease progression until death, quality-adjusted life years (QALYs) and costs from a Korea societal perspective. Results: The results showed that the strategy with TC 200 mg/dL and 4-year interval cost \4,625,446 for 16.65105 QALYs per person and strategy with TC 200 mg/dL and 3-year interval cost \4,691,771 for 16.65164 QALYs compared with \3,061,371 for 16.59877 QALYs for strategy with no screening. The incremental cost-effectiveness ratio of strategy with TC 200 mg/dL and 4-year interval versus strategy with no screening was \29,916,271/QALY. At a Korea willingness-to-pay threshold of \30,500,000/QALY, strategy with TC 200 mg/dL and 4-year interval is cost-effective compared with strategy with no screening. Sensitivity analyses showed that results were robust to reasonable variations in model parameters. Conclusion: In this study, revised national dyslipidemia screening strategy with TC 200 mg/dL and 4-year interval could be a cost-effective option. A better understanding of the Korean dyslipidemia population may be necessary to aid in future efforts to improve dyslipidemia diagnosis and management.

• 응용통계연구
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• 제32권4호
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• pp.619-630
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• 2019

이상지질혈증은 한국인의 대표적인 성인병이며 지속적인 관리가 필요한 만성질환이다. 또한 고혈압이나 당뇨병과 함께 심혈관계 질환의 위험 요인으로 잘 알려져 있다. 하지만 혈관 질환은 검사 없이는 질병 판단을 하기 어려운 것이 현실이다. 본 연구에서는 이상지질혈증의 인지와 예방을 위하여 관련된 위험 요인을 확인한다. 이들을 종합하여 시각화하면서 발병률 예측까지 가능한 통계적 도구 노모그램을 구축하였다. 데이터는 국민건강영양조사 6기, 7기 제1차년도 (2013-2016) 데이터를 사용하였다. 분석 순서로는 먼저 이상지질혈증의 총 12가지 위험 요인을 교차분석을 통해 확인하였다. 그리고 순수 베이지안 분류기를 이용하여 이상지질혈증에 대한 모형으로 노모그램을 구축하였다. 구축한 노모그램은 ROC 곡선과 Calibration plot을 사용하여 신뢰성을 검증하였다. 마지막으로 이전에 제시했던 로지스틱 노모그램과 본 연구에서 제안한 베이지안 노모그램을 비교하였다.

• 대한중풍순환신경학회지
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• 제17권1호
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• pp.55-66
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• 2016

Dyslipidemia is a major risk factor for cardiovascular accidents (CVA) and heart disease, especially the ischemic type. Lowering of serum low-density lipoprotein cholesterol (LDL-C) levels is a primary measure for preventing atherosclerosis. Many medications are available for the treatment of dyslipidemia; however, these drugs have some side effects. Therefore, we treated dyslipidemia patients with Chunghyul-plus. Before treatment, patients' levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), and LDL-C were measured on an empty stomach. Thereafter, patients were administered 1000 mg (2 capsules) of Chunghyul-plus two or three times a day for 2 weeks. After treatment with Chunghyul-plus, patients' serum triglyceride, LDL-C, and total cholesterol levels decreased. The results of this study suggest that Chunghyul-plus might be useful in the treatment of dyslipidemia.

• 한국산학기술학회논문지
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• 제18권3호
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• pp.647-656
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• 2017

본 연구는 국가자료인 제 6기(2013년, 2014년) 국민건강영양조사 자료를 이용하여 19세 이상 한국 성인에서 비타민 D 수준과 이상지질혈증과의 관련성을 알아보고자 실시하였다. 연구 결과에서 성인의 비타민 D 결핍 수준은 인구대비 74.4%로 나타났으며, 이상지질혈증의 유병 수준은 39.6%이었다. 교차분석에서 이상지질혈증과의 관련요인 중에 유의한 차이를 보이는 변수는 성별(p<0.001), 연령(p<0.001), 흡연여부(p<0.001), 주관적 건강 상태(p<0.001), 체질량지수(p<0.001), 혈압(p<0.001), 공복혈당(p<0.001), 신체 활동(p<0.001) 및 Vitamin D(p<0.001) 등이었다. 로지스틱 회귀분석에서 비타민 D가 20.0 ng/mL 미만으로 결핍일 때 이상지질혈증의 발생 위험이 교차비가 1.29(95% C1, 1.11-1.51)로 유의하였다. 신체 활동 변수를 통제한 상태에서도 비타민 D와 이상지질혈증 진단 지표 중 총 콜레스테롤에서 교차비가 1.41(95% C1, 1.04-1.81)로, 중성지방에서 교차비가 1.36(95% C1, 1.11-1.66)으로 유의하였다. 결론은 우리나라 정상 성인에서 비타민 D 수준과 이상지질혈증과의 관련성은 유의하였고, 그 중에서 총 콜레스테롤과 중성지방에서 관련성이 유의한 것으로 확인되었다. 향후에 비타민 D 수준과 이상지질혈증에 대한 좀 더 체계적인 코호트 연구 등 다양한 연구를 시행할 수 있다면 비타민 D와 이상지질혈증의 인과관계를 확인하는데 도움이 될 수 있을 것이다.

• 농촌의학ㆍ지역보건
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• 제35권1호
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• pp.77-88
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• 2010

이 연구는 고혈압, 당뇨병, 이상지질혈증으로 지출된 진료비 중 과체중 및 비만의 기여분을 추계하기 위한 질병비용연구로서 국민건강보험공단의 건강검진 및 건강보험급여 자료를 활용한 연구이다. 연구결과 2005년 현재 고혈압, 당뇨병, 이상지질혈증 때문에 지출된 총 진료비 중 과체중 및 비만의 기여분은 각각 4,561억원(4,328억원-4,805억원), 2,823억원(2,487억원-3,176억원), 165억원(147억원-183억원)이었고, 이를 모두 합하면 7,549억원(6,961억원-8,164억원)이었다. 이는 해당 연도의 고혈압 총 진료비의 34.6%(32.9%-36.5%), 당뇨병 총 진료비의 32.5%(28.6%-36.6%), 이상지질혈증 총 진료비의 19.4%(17.3%-21.6%)를 차지한다. 또한 이 세 가지 질병의 총 진료비를 기준으로 했을 때 과체중 및 비만이 기여한 금액은 33.3%(30.7%-36.0%)에 해당하였다. 이는 과체중과 비만을 예방한다면 고혈압, 당뇨병, 이상지질혈증으로 지출되는 총 진료비의 33.3%를 감소시킬 수 있다는 의미이며, 향후 만성질환 예방과 관련하여 과체중 및 비만의 예방관리사업이 얼마나 중요한가를 시사해 주는 것이다.