• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.10-18
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• 2018

Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has emphasized a uniformly elevated aerobic glycolysis as a critical feature of tumorigenecity. This led to extensive efforts of targeting glycolysis in human cancers. However, clinical attempts to target glycolysis and glucose metabolism have proven to be challenging. Recent advancements revealing a high degree of metabolic heterogeneity and plasticity embedded among various human cancers may paint a new picture of metabolic targeting for cancer therapies with a renewed interest in glucose metabolism. In this review, we will discuss diverse oncogenic and molecular alterations that drive distinct and heterogeneous glucose metabolism in cancers. We will also discuss a new perspective on how aberrantly altered glycolysis in response to oncogenic signaling is further influenced and remodeled by dynamic metabolic interaction with surrounding tumor-associated stromal cells.

• Nuclear Engineering and Technology
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• v.49 no.2
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• pp.306-312
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• 2017

The purpose of this research is to introduce the technical standard of accident sequence precursor (ASP) analysis, and to propose a case study using the dynamic-probabilistic safety assessment (D-PSA) approach. The D-PSA approach can aid in the determination of high-risk/low-frequency accident scenarios from all potential scenarios. It can also be used to investigate the dynamic interaction between the physical state and the actions of the operator in an accident situation for risk quantification. This approach lends significant potential for safety analysis. Furthermore, the D-PSA approach provides a more realistic risk assessment by minimizing assumptions used in the conventional PSA model so-called the static-PSA model, which are relatively static in comparison. We performed risk quantification of a steam generator tube rupture (SGTR) accident using the dynamic event tree (DET) methodology, which is the most widely used methodology in D-PSA. The risk quantification results of D-PSA and S-PSA are compared and evaluated. Suggestions and recommendations for using D-PSA are described in order to provide a technical perspective.

• Geomechanics and Engineering
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• v.23 no.1
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• pp.1-13
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• 2020

To give a solution for seismic stability of tunnel faces subjected to earthquake ground shakings, the pseudo-dynamic approach is originally introduced to analyze tunnel face stability in this study. In the light of the upper-bound theorem of limit analysis, an advanced three-dimensional mechanism combined with pseudo-dynamic approach is proposed. Based on this mechanism, the required support pressure on tunnel face can be obtained by equaling external work rates to the internal energy dissipation and implementing an optimization searching procedure related to time. Both time and space feature of seismic waves are properly accounted for in the proposed mechanism. For this reason, the proposed mechanism can better represent the actual influence of seismic motion and has a remarkable advantage in evaluating the effects of vertical seismic acceleration, soil amplification factor, seismic wave period and initial phase difference on tunnel face stability. Furthermore, the pseudo-dynamic approach is compared with the pseudo-static approach. The difference between them is illustrated from a new but understandable perspective. The comparison demonstrates that the pseudo-static approach is a conservative method but still could provide precise enough results as the pseudo-dynamic approach if the value of seismic wavelengths is large or the height of soil structures is small.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.12
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• pp.465-471
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• 2021

The study investigates the dynamic correlation of cryptocurrencies and equity in Vietnam and tests the safe-haven property of them from the perspective of the stock market in Vietnam during the pandemic crisis by applying the dynamic conditional correlation (DCC) GARCH model and regression with a dummy variable, respectively. This study employs time series data on the daily dataset from September 2014 to September 2021 with the focus on the two most popular cryptocurrencies - Bitcoin and Litecoin. The results show that the dynamic conditional correlations between cryptocurrencies and equity in Vietnam increased during the pandemic, however, in most periods, positive dynamic correlations often dominate. Besides, the regression results also indicate that Bitcoin and Litecoin act as weak safe-haven investments for stocks in Vietnam during the COVID-19 turmoil. They are more suitable for diversification purposes although the dynamic correlations between them and the stock index in Vietnam vary stronger during the pandemic crisis than before. The findings of this study suggest that in the period of pandemic crisis, cryptocurrencies are not concerned as effective safe-haven assets for stock in Vietnam. Instead, cryptocurrencies are only playing a potential role in diversification benefit in this economy.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.3
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• pp.192-206
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• 2021

The pharmaceutical industry is an industry that provides medicines related to the health and life of the people. The pharmaceutical industry is a traditional regulation industry with the characteristics of R&D(Research and Development), purchasing, manufacturing, distribution and consumption under strict government management. Until now, pharmaceutical companies have continued to make efforts to maintain competitiveness through patent management, new product development, and marketing. However, industries are rapidly changing, including rising costs for developing new products and expanding generic markets. As these changes and uncertainties in the management environment increase, efforts are required to improve the competitiveness of the pharmaceutical industry from a new perspective. In this study, we intend to examine the impact of SCM(Supply Chain Management) dynamic capability of pharmaceutical companies on corporate performance through partnerships to respond to market changes and uncertainties. It was determined that the agility, visibility and flexibility that constitutes the SCM dynamic capabilities would affect the performance of pharmaceutical companies. In this study, the importance of SCM dynamic capabilities and cooperative relationships was identified through surveys by SCM managers of pharmaceutical companies. Consequently, in the pharmaceutical industry, which is a regulatory industry, we have identified that SCM dynamic capabilities and cooperative relationships with partner companies have a significant impact on corporate performance.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.233-236
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• 2001

This study explores on the static and dynamic growth patterns of high-tech ventures in Korea. We developed an integrative framework with target market (local vs. global), product/market maturity (existing vs. emerging), and technological capability (follower vs. pioneer). We also identified seven new ventures strategies as follows: i) reactive imitation, ii) proactive localization, iii) import substitution, iv) creative imitation, v) early market-entry, vi) global niche, and vii) global innovation. With five successful Korean new ventures, we found different competitive behaviors and performance among new venture strategic types. This study also observed two different growth patterns: growth through strategic replication and growth through strategic change. It depends on whether they are pursuing similar strategy over time or different strategy within for growth. In addition, we found that creative imitation plays a stepping-stone role in two-step internationalization processes. Although this study is exploratory and needs more empirical studies, it can provide new ventures with meaningful guidelines for growth and internationalization with a dynamic perspective.

• The Journal of Information Systems
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• v.33 no.2
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• pp.143-168
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• 2024

Purpose This study highlights the crucial role of external APIs in driving dynamic evolution within a digital ecosystem. Drawing on the concept of evolutionary network biology perspective, this study hypothesizes that APIs' (non)network properties can significantly impact a digital ecosystem's product variety. Design/methodology/approach This study analyzes plug-in source code data from WordPress.org between January 2004 and December 2014, using survival analysis to test this hypothesis. Findings The empirical results demonstrate that external APIs have a more significant impact on promoting ecosystem evolution over time than those offered by a focal platform system. This research enhances our understanding of ecosystem dynamics and emphasizes the critical role of the generative nature of APIs in fostering ecosystem growth.

• Journal of Information Processing Systems
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• v.15 no.4
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• pp.724-736
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• 2019

Dynamic thermal rating technology can effectively improve the thermal load capacity of transmission lines. However, its availability is limited by the quantity and high cost of the hardware facilities. This paper proposes a new dynamic thermal rating technology based on global/regional assimilation and prediction system (GRAPES) and geographic information system (GIS). The paper will also explore the method of obtaining any point meteorological data along the transmission line by using GRAPES and GIS, and provide the strategy of extracting and decoding meteorological data. In this paper, the accuracy of numerical weather prediction was verified from the perspective of time and space. Also, the 750-kV transmission line in Shaanxi Province is considered as an example to analyze. The results of the study indicate that dynamic thermal rating based on GRAPES and GIS can fully excavate the line power potential without additional cost on hardware, which saves a lot of investment.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.4
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• pp.1013-1020
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• 2021

This study examines the role of dynamic socio-emotional capabilities to increase proactive stakeholder engagement in family businesses. The research sample includes all furniture enterprises scattered in Jepara Regency sub-districts as many as 3,945 companies. The sampling in this research is purposive; as many as 210 respondents, 181 could be used. The sampling unit is the owners and managers, considering that most company owners are also company managers. This study examines how learning and supply chain management in the family business can be integrated to enable a set of resources and capabilities provided by the family to be developed to build closer relationships with stakeholders. The findings showed the importance of a family business's supply chain management perspective in the relationship between dynamic socio-emotional capabilities to mediate organizational learning to proactive stakeholder engagement significantly. Based on this study's results, companies can build dynamic socio-emotional capabilities through organizational learning to increase proactive stakeholder engagement. Dynamic socio-emotional capabilities proved to play a role as a mediator for organizational learning by family companies for proactive stakeholder engagement.

• Korean Institute of Interior Design Journal
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• v.22 no.5
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• pp.114-125
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• 2013

Kengo Kuma used to be very known well as a critic before being an architect. He usually mentioned quite unique type of comments for subjects whenever his criticism, also even his works results have been able to be targets of criticism materials by his method. His works are the achievements of challenges based on his continuous dynamic criticism. Hence, to have well understanding of his architectural thinking and works result, his complexes criticism structure must be needed to understand. And also, this study is using 'KJ Method' type to analyze his architectural thinking which is complicated making by a type of non-linear. Kengo Kuma's structures of architectural thinking and critiques perspective of modern architecture have been created by 'KJ Method'. Critiques types of keywords and consequences words collected from among the local dedicated professional architecture books to get this research result. First of all, Kengo Kuma desired even modern architecture problems to be melt as a specific architecture result such as modern type of power structure. To have result, Kengo Kuma had experienced sensible activity through materials which have specific characteristic. Also place of materiality created to get relationship between environments and architecture. Secondly, he wanted to recover troubled traditional Japanese architectural perspective which blocked relationship by dichotomy as a right way. In conclusion, this research reaches Kengo Kuma's type of architecture which strongly emphasizes harmony among related components such as human being, materials, substances based on accepted natural environments and lives' principle. Also, much more specific methods have been derived by related works results analyzing which have similar characteristic as Kengo Kuma's one.