• 제목/요약/키워드: Duke University

검색결과 293건 처리시간 0.021초

윌리엄스버그 컬러니얼 정착마을의 건축양식과 파사드 형태의 보존특징에 관한 연구 (A Study on Conservation Characteristics of Architectural Style and Facade Form in the Colonial Settlement City of Williamsburg)

  • 정건채
    • 한국농촌건축학회논문집
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    • 제23권2호
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    • pp.1-8
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    • 2021
  • The aim of this study is to find what architectural restoration and street-scaping conservation of early settlement in Virginia, which have processed on the style of 18th centuries. One of the settlements in Virginia was Williamsburg that located in the high land between Jamestown and Yorktown. In 1698, the capital of Virginia was moved from Jamestown for the safer environment. At that time they constructed the town like a small urban that had a straight-lined Duke Glocester Street, Georgian style buildings, and landscapes of 18th centuries. Before 1928 the village was flown into ruins, but Rector of the church, Dr. W.A.R. Goodwin, understood the value of reservation to restore the village as colonial architectural style that has an original figure. John Rockefeller Jr. has taken part in his restoration of colonial style of architecture and culture. This paper surveyed nine cases of buildings and srtreet-scape on Duke Glocester Street. Most of the buildings on the street have a proposition, balance, and equipment of Georgian architectural facade in 18th centuries. The conclusion has three points. First, the Williamsburg has been reserved as an early colonial settlement through the restoration of architecture and street-scape design. Second, main architectural style is a Georgian form that has a balance, proportion, and simplicity of facade. Also new buildings and additions of architecture have to keep 'Design Review Guideline of Colonial Williamsburg' in order to contribute the existing colonial buildings. Third, the main street-scape, Duke Glocester Street shows Georgian architecture and cultural life pattern with tradition.

Identification and Characterization of Calcineurin Targets in Cryptococcus neoformans

  • Park, Hee-Soo;Heitman, Joseph;Cardenas, Maria E.
    • 한국균학회소식:학술대회논문집
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    • 한국균학회 2016년도 춘계학술대회 및 임시총회
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    • pp.17-17
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    • 2016
  • Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Herein, we identified and characterized calcineurin substrates in C. neoformans by employing phosphoproteomic $TiO_2$ enrichment and quantitative mass spectrometry. The identified targets include the zinc finger transcription factor Crz1 and proteins whose functions are linked to P-bodies/stress granules (PBs/SGs) and mRNA translation and decay, such as Pbp1 and Puf4. We show that Crz1 is a bona fide calcineurin substrate, and localization and transcriptional activity of Crz1 are controlled by calcineurin. Several of the calcineurin targets localized to PBs/SGs, including Puf4 and Pbp1, and are required for survival at high temperature and for virulence. Genetic epistasis analysis revealed that Crz1 and the novel targets Lhp1, Puf4, and Pbp1 function in a branched calcineurin pathway that orchestrates stress survival and virulence. These findings propose that calcineurin controls thermal stress and virulence at the transcriptional level via Crz1 and post-transcriptionally by regulating target factors involved in mRNA metabolism.

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HYPERGEOMETRIC FUNCTIONS AND EICHLER INTEGRALS

  • Lim, Su-Bong
    • Journal of the Korean Society for Industrial and Applied Mathematics
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    • 제12권4호
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    • pp.223-226
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    • 2008
  • Duke and Imamo$\bar{g}$lu express the Eichler integrals associated to modular forms of weight 3 in terms of generalized hypergeometric functions. We extend this result to most general modular forms of weight 3.

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