• Archives of Pharmacal Research
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• v.21 no.6
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• pp.645-650
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• 1998

The dual drug-loaded alginate beads simultaneously containing drug in inner and outer layers were prepared by dropping plain (single-layered) alginate beads into $CaCl_2$ solution. The release characteristics were evaluated in simulated gastric fluid for 2 h followed by intestinal fluids thereafter for 12 h. The surface morphology and cross section of dual drug-loaded alginate beads was also investigated using scanning electron microscope (SEM). The poorlv water-soluble ibuprofen was chosen as a model drug. The surface of single-layered and dual drug-loaded alginate beads showed very crude and roughness, showing aggregated particles, surface cracks and rough crystals. The thickness of dual drug-loaded alginate beads surrounded by outer layer was ranged from about 57 to 329mcm. The distinct chasm between inner and outer layers was also observed. In case of single-layered alginate bead, the drug was not released in gastric fluid but was largely released in intestinal fluid. However, the release rate decreased as the reinforcing $Eudragit^{\circledR}$ polymer contents increased. When the plasticizers were added into polymer, the release rate largely decreased. The release rate of dual drug-loaded alginate beads was stable in gastric fluid for 2 h but largely increased when switched in intestinal fluid. The drug linearly released for 4 h followed by another linear release thereafter, showing a distinct biphasic release characteristics. There was a difference in the release profiles between single-layered and dual drug-loaded alginate beads due to their structural shape. However, this biphasic release profiles were modified by varying formulation compositions of inner and outer layer of alginate beads. The release rate of dual drug-loaded alginate beads slightly decreased when the outer layer was reinforced with $Eudragit^{\circledR}$ RS1OO polymers. In case of dual drug-loaded alginate beads with polymer-reinforced outer layer only, the initial amount of druc released was low but the initial release rate (slope) was higher due to more swellable inner cores when compared to polymer-reinforced inner cores. The current dual drug-loaded alginate beads may be used to deliver the drugs in a time dependent manner.

• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.177-182
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• 2008

The purposes of this study were to prepare dual-layered coated compact pellets containing three nutrients Glucose, Chromium picolinate, Vitamin C) for rumen bypass. The core compact pellets were prepared by an extrusionspheronization method and then double layered coated with pH independent EC (ethyl cellulose) and pH-dependent polymers ($Eudragit^{(R)}$ E100) using a fluid-bed spray coater. Depending on the coating levels of EC and $Eudragit^{(R)}$ E100, release profiles were variable in simulated rumen (pH 6.8) and abomasums (pH 2.0) fluid using USP apparatus I (basket method). When compact pellets were coated with EC (about 10% level in inner layer) and then $Eudragit^{(R)}$ E100 (20% level in outer layer) in a dual-layered manner, rumen-bypass delivery resisting rumen fluid followed by release in abomasums fluid could possible. The friability was also satisfactory based on chewing behavior of ruminants. The dual-layered coated compact pellets showed smooth surface and distinct inner/outer layers using scanning electron microscopy (SEM). The current rumen bypass delivery system can be also applicable to deliver other nutrients in ruminants.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.493-501
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• 2005

Effect of solvents on physical characteristics and release characteristics of monolithic acetaminophen (APAP) hydroxypropylmethylcellulose (HPMC) matrix granules and tablets were examined. Various types and amounts of solvents were employed for granulation and coating. APAP and other excipients were mixed and were then wet-granulated in a high-speed mixer. The dried granules were then directly compressed and film-coated with low viscosity grade HPMC. As the amount of water increased, the size of granules also increased, showing more spherical and regular shape. However, manufacturing problems such as capping and lamination in tableting occurred when water was used alone as a granulating solvent. The physical properties of HPMC matrix granules were not affected by the batch size. The initial release rate as well as the amount of APAP dissolved had a tendency to decrease as the water level increased. Addition of nonaqueous solvent like ethanol to water resulted in good physical properties of granules. When compared to water/ethanol as a coating solvent, the release rate of film-coated HPMC matrix tablets was more sensitive to the conditions of coating and drying in methylene chloride/ethanol. Most of all, monolithic HPMC matrix tablet when granulated in ethanol/water showed dual release with about $50\%$ drug release immediately within few minutes followed by extended release. It was evident that the type and amount of solvents (mainly water and ethanol) were very important for wet granulation and film-coating of monolithic HPMC matrix tablet, because the plastic deforming and fragmenting properties of material were changed by the different strengths of the different solvents.

• Annual Conference of KIPS
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• 2009.11a
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• pp.543-544
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• 2009

본 논문은 Linux에서 사용되는 Shared Memory는 동일한 메모리 영역에 여러 개의 프로세스가 접근할 수 있도록 해 주는 기술이다. 본 논문에서는 Shared Memory의 큰 두 갈래 중 커널 단계에서 처리 되는 SVR(System V Release) 형식의 Shared Memory를 다룬다. 본 논문에서는 리눅스 운영체제의 공유 메모리 기능을 Dual Core 시스템에서 동작하도록 구현한다.

• The Journal of the Korea Contents Association
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• v.8 no.9
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• pp.27-33
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• 2008

This paper designs Shared Memory on the Dual Core system so that it operates a general System V IPC on the Linux O.S. Shared Memory is the technique that many processes can access to identical memory area. We treat Shared Memory which is SVR in a kernel step. We design a share memory facility of Linux operating system on the Dual Core System. In this paper the suggesting of share memory facility design plan in Dual Core system is enhance the performance in existing an unity processor system as a dual core practical use. We attemp a performance enhance in each CPU for each process which uses a share memory.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.8
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• pp.1448-1455
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• 2008

This paper designs Shared Memory on the Dual Core system so that it operates a general System V IPC on the Linux O.S. Shared Memory is the technique that many processes can access to identical memory area. We treat Shared Memory in this paper among big two branches of Shared Memory which are SVR in a kernel step format. We design a share memory facility of Linux operating system on the Dual Core System. In this paper the suggesting design plan of share memory facility in Dual Core system is enhancing the performance in existing unity processor system as a dual core practical use. We attempt a performance enhance in each CPU for each process which uses a share memory.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.4
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• pp.43-50
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• 2002

In the present study, reduction of harmful exhaust gas in a diesel engine using stratified injection system of dual fuel (diesel fuel and methanol) was tried. The nozzle and fuel injection pump of conventional injection system were remodeled to inject dual fuel in order from the same injector. The quantity of each fuel was controlled by micrometers, which were mounted at rack of injection pumps. The injection ratio of dual fuel was certificated by volumetric ratio in injection quantity test. Cylinder pressure and exhaust gas were measured and analyzed under various supply condition of duel fuel. We confirmed that combustion of dual fuel was performed successful1y by using modified injection system in a D.I. diesel. Soot and NOx are simultaneously reduced by stratified injection without large deterioration of thermal efficiency, but THC and CO are relatively increased.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.4
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• pp.699-708
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• 1997

Production control is usually composed of due-dote assignment, production input control, and priority dispatching rule. A production input control(PIC) is mainly to control the WIP level on the shop floor. On the other hand, a priority dispatching rule(PDR) is mainly to control the tardiness/earliness of on order and number of tardy jobs. Therefore, if we select a particular PIC which can control only a particular performance measure(i.e., tardiness), it may cause worsening other performance measure(i.e., WIP level, shopfloor time, etc.) This newly developed production input control, DRD(Dual Release-Dates), is mainly designed to control the WIP level on the shop floor by employing two different release-dates of an order(earliest release. date and latest release-date and the release condition (relationship between the current WIP level and the pre-defined maximum WIP level) while trying to meet the due-date of the order.

• Journal of the Korean Society of Combustion
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• v.19 no.1
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• pp.29-38
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• 2014

This paper described an experimental investigations of combustion instability mode in a lean premixed dual swirl combustor for micro-gasturbine system. When such the instability occurs, a strong coupling between pressure oscillations and unsteady heat release excites a self-sustained acoustic wave which results in a loud, annoyed sound and may also lead a structural damage to the combustion chamber. The detailed period of flame behavior and heat release in combustion instability mode have been examined with high speed OH and CH-PLIF system and $CH^*$ chemiluminescence measurement, flame tomography with operated at 10 kHz and 6 kHz each. Experiment results suggest that unstable flame behavior has a specific frequency with 200 Hz and this frequency is accords with about 1/2 sub-harmonic of combustor resonance frequency, not fundamental frequency. This is very interesting phenomenon that have not reported yet from other previous works. Therefore, when a thermo-acoustic instability with Rayleigh criterion occurs, the fact that the period of heat release and flame behavior are different each other was proposed for the first time through this work.

• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1800-1808
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• 2013

Dual-responsive amphiphilic block copolymers were synthesized by combining enzymatic ring-opening polymerization (eROP) of ${\varepsilon}$-caprolactone (CL) and ATRP of N,N-dimethylamino-2-ethyl methacrylate (DMAEMA). The obtained block copolymers were characterized by gel permeation chromatography (GPC), $^1H$ NMR and FTIR-IR. The critical micelle concentration (CMC) of copolymer was determined by fluorescence spectra, it can be found that with hydrophilic block (PDMAEMA) increasing, CMC value of the polymer sample increased accordingly, and the CMC value was 0.012 mg/mL, 0.025 mg/mL and 0.037 mg/mL for $PCL_{50}$-b-$PDMAEMA_{68}$, $PCL_{50}$-b-$PDMAEMA_{89}$, $PCL_{50}$-b-$PDMAEMA_{112}$, $PCL_{50}$-b-$PDMAEMA_{89}$ was chosen as drug carrier to study in vitro release profile of anti-cancer drug (taxol). The temperature and pH dependence of the values of hydrodynamic diameter (Dh) of micelles, and self-assembly of the resulting block copolymers in water were evaluated by dynamic light scattering (DLS). The result showed that with the temperature increasing and pH decreasing, the Dh decreased. Drug-loaded nanoparticles were fabricated using paclitaxel as model. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) had been explored to study the morphology of the hollow micelles and the nanoparticles, revealing well-dispersed spheres with the average diameters both around 80 nm. In vitro release kinetics of paclitaxel from the nanoparticles was also investigated in different conditions (pH and temperature, etc.), revealing that the drug release was triggered by temperature changes upon the lower critical solution temperature (LCST) at pH 7.4, and at $37^{\circ}C$ by an increase of pH.