Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Controlled Release of Three Nutrients from Dual-layered Coated Compact Pellets

이중 코팅된 압착 펠렛으로부터 3종 영양소의 방출 제어

  • Piao, Zong-Zhu (National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University) ;
  • Lee, Eung-Seok (National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University) ;
  • Choi, Yun-Jaie (School of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Beom-Jin (National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University)
  • Published : 2008.06.20
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Abstract

The purposes of this study were to prepare dual-layered coated compact pellets containing three nutrients Glucose, Chromium picolinate, Vitamin C) for rumen bypass. The core compact pellets were prepared by an extrusionspheronization method and then double layered coated with pH independent EC (ethyl cellulose) and pH-dependent polymers ($Eudragit^{(R)}$ E100) using a fluid-bed spray coater. Depending on the coating levels of EC and $Eudragit^{(R)}$ E100, release profiles were variable in simulated rumen (pH 6.8) and abomasums (pH 2.0) fluid using USP apparatus I (basket method). When compact pellets were coated with EC (about 10% level in inner layer) and then $Eudragit^{(R)}$ E100 (20% level in outer layer) in a dual-layered manner, rumen-bypass delivery resisting rumen fluid followed by release in abomasums fluid could possible. The friability was also satisfactory based on chewing behavior of ruminants. The dual-layered coated compact pellets showed smooth surface and distinct inner/outer layers using scanning electron microscopy (SEM). The current rumen bypass delivery system can be also applicable to deliver other nutrients in ruminants.

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References

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