• Tuberculosis and Respiratory Diseases
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• 제83권4호
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• pp.289-294
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• 2020

Background: Line probe assay (LPA) is standard diagnostic tool to detect multidrug resistant tuberculosis. Non-interpretable (NI) results in LPA (complete missing or light wild-type 3 and 8 bands with no mutation band in rpoB gene region) poses a diagnostic challenge. Methods: Sputum samples obtained between October 2016 and July 2017 at the Intermediate Reference Laboratory, All India Institute of Medical Sciences Hospital, New Delhi, India were screened. Smear-positive and smear-negative culture-positive specimens were subjected to LPA Genotype MTBDRplus Ver 2.0. Smear-negative with culture-negative and culture contamination were excluded. LPA NI samples were subjected to phenotypic drug susceptibility testing (pDST) using MGIT-960 and sequencing. Results: A total of 1,614 sputum specimens were screened and 1,340 were included for the study (smear-positive [n=1,188] and smear-negative culture-positive [n=152]). LPA demonstrated 1,306 (97.5%) valid results with TUB (Mycobacterium tuberculosis) band, 24 (1.8%) NI, three (0.2%) valid results without TUB band, and seven (0.5%) invalid results. Among the NI results, 22 isolates (91.7%) were found to be rifampicin (RIF) resistant and two (8.3%) were RIF sensitive in the pDST. Sequencing revealed that rpoB mutations were noted in all 22 cases with RIF resistance, whereas the remaining two cases had wild-type strains. Of the 22 cases with rpoB mutations, the most frequent mutation was S531W (n=10, 45.5%), followed by S531F (n=6, 27.2%), L530P (n=2, 9.1%), A532V (n=2, 9.1%), and L533P (n=2, 9.1%). Conclusion: The present study showed that the results of the Genotype MTBDRplus assay were NI in a small proportion of isolates. pDST and rpoB sequencing were useful in elucidating the cause and clinical meaning of the NI results.

• 한국해안해양공학회:학술대회논문집
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• 한국해안해양공학회 1996년도 정기학술강연회 발표논문 초록집
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• pp.124-128
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• 1996

인천항의 검조소의 검조기록은 우리나라의 수치측지기준(vertical geodetic datum)을 제공하는 중요한 자료이다. 본 연구에서는 최(1990)가 62년부터의 14년 자료를 처리, 발표한 것에 이어 83년에 다시 계속적인 분석을 보고하였지만 92년까지의 검조기록을 재분석하여 보고코저 한다. 분석에서 61년 이전의 자료는 하계의 DST(Daylight Saving Time)적용에 따른 자료가 보정되어 있지 못하므로 사용하지 않았으며 73, 74년 역시 검조소 이전에 따른 년자료의 연장이 완전하지 않아 취하지 않았다. (중략)

• 대한전자공학회논문지
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• 제21권6호
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• pp.70-77
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• 1984

This paper represents a fast computational algorithm for the discrete sine transform defined by Kekre and Solanki. Techniques are developed to factor the discrete sine trans form matrix into M=log2 2N matrices, where the number(N) of sampled data points is a power of two. Each factorial matrix contains not more than two non-zero real elem tints in any row or column. As a result of this method, the exact a배orithm for the fast discrete sine transform is accomplished. The algorithm is illustiated by a signal flow graph, which may be readily translated to hardware or software implementation.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.222-224
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• 1988

In this paper, the transform coding method was selected out of image compression techniques. Each characteristic of transform coefficients for five transform(DCT, DST, WHT, HAT, SLT) was observed, and their performances were compared and reviewed, based on the results from the experiment where image samples were applied to five transform. As the result of image processing experiment, DCT was found to have the best performance.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2003년도 하계학술대회 논문집
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• pp.83-83
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• 2003

• Journal of Astronomy and Space Sciences
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• 제31권1호
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• pp.7-13
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• 2014

Variabilities in the solar wind cause disturbances throughout the heliosphere on all temporal and spatial scales, which leads to changeable space weather. As a view of space weather forecasting, in particular, it is important to know direct and indirect causes modulating the space environment near the Earth in advance. Recently, there are discussions on a role of the interaction of the solar wind with Mercury in affecting the solar wind velocity in the Earth's neighborhood during its inferior conjunctions. In this study we investigate a question of whether other parameters describing the space environment near the Earth are modulated by the inner planets' wake, by examining whether the interplanetary magnetic field and the proton density in the solar wind observed by the Advanced Composition Explorer (ACE) spacecraft, and the geomagnetic field via the Dst index and Auroral Electrojet index (AE index) are dependent upon the relative position of the inner planets. We find there are indeed apparent variations. For example, the mean variations of the geomagnetic fields measured in the Earth's neighborhood apparently have varied with a timescale of about 10 to 25 days. Those variations in the parameters we have studied, however, turn out to be a part of random fluctuations and have nothing to do with the relative position of inner planets. Moreover, it is found that variations of the proton density in the solar wind, the Dst index, and the AE index are distributed with the Gaussian distribution. Finally, we point out that some of properties in the behavior of the random fluctuation are to be studied.

• 천문학회지
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• 제50권2호
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• pp.29-39
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• 2017

We investigate two abnormal CME-Storm pairs that occurred on 2014 September 10 - 12 and 2015 March 15 - 17, respectively. The first one was a moderate geomagnetic storm ($Dst_{min}{\sim}-75nT$) driven by the X1.6 high speed flare-associated CME ($1267km\;s^{-1}$) in AR 12158 (N14E02) near solar disk center. The other was a very intense geomagnetic storm ($Dst_{min}{\sim}-223nT$) caused by a CME with moderate speed ($719km\;s^{-1}$) and associated with a filament eruption accompanied by a weak flare (C9.1) in AR 12297 (S17W38). Both CMEs have large direction parameters facing the Earth and southward magnetic field orientation in their solar source region. In this study, we inspect the structure of Interplanetary Flux Ropes (IFRs) at the Earth estimated by using the torus fitting technique assuming self-similar expansion. As results, we find that the moderate storm on 2014 September 12 was caused by small-scale southward magnetic fields in the sheath region ahead of the IFR. The Earth traversed the portion of the IFR where only the northward fields are observed. Meanwhile, in case of the 2015 March 17 storm, our IFR analysis revealed that the Earth passed the very portion where only the southward magnetic fields are observed throughout the passage. The resultant southward magnetic field with long-duration is the main cause of the intense storm. We suggest that 3D magnetic field geometry of an IFR at the IFR-Earth encounter is important and the strength of a geomagnetic storm is strongly affected by the relative location of the Earth with respect to the IFR structure.

• 대한기계학회논문집B
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• 제39권1호
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• pp.109-113
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• 2015

과거의 무기체계는 체계의 목적과 비용 등의 문제로 운용환경에 대한 관심이 부족하여 특히 냉방장치가 탑재되지 않은 체계가 많이 개발되었다. 근래 개발되는 무기체계는 고도의 정밀조준 및 고감도 시스템으로 진화함에 따라 무기체계를 효과적으로 제어하기 위하여 운용자의 운용환경도 중요한 요소로 대두되고 있다. 현재의 무기개발자들은 대부분 통합형 환경제어장치를 장착하도록 설계하고 있다. 본 연구에서는 기 개발된 내부 탄통을 가진 대공포 장갑차에서, 포탑이 회전을 하더라도 효율적으로 차가운 냉기를 전달할 수 있게 하기 위해 드럼바스켓 해석 및 시험을 통해 냉방개선 방안을 도출하고 결과를 실제 장비에 적용하였다.

• Journal of Astronomy and Space Sciences
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• 제24권4호
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• pp.269-274
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• 2007

강한 지자기 폭풍이 발생하였을 때 한반도 상공의 전리층내 총전자수(TEC, Total Electron Contents) 변화를 분석하기 위해 GPS 기준국망을 데이터를 이용한 지역적인 전리층 감시모델을 개발하였다. 전리층 총전자수 감시모델 개발을 위해 한국천문연구원에서 운용중인 대전 IGS(International GNSS Service) 기준국을 포함한 전국에 고르게 분포하고 있는 9개의 GPS 기준국 데이터를 이용하였다. 또한 순간적인 전리층 변화 특성을 분석하기 위해 CSS(Cubic Spline Smoothing)기법을 적용하였고, 그 결과 2003년 11월 20일 강한 지자기 폭풍이 발생했을 때 한반도 상공에서 총전자수의 순간적인 변화를 검출할 수 있었다. 이때에는 평일과 비교했을 때 특정시각의 약 1.5배 이상 총전자수가 증가함을 보였다. 마지막으로 지구 자기장 활동 정도를 나타내는 Kp 지수, Dst 지수 그리고 천문연 GPS 기준국망 데이터를 이용해 산출된 총전자수 변화와의 연관성을 제시했다.

• 생물정신의학
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• 제4권2호
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• pp.272-278
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• 1997

Many investigators are trying to elucidate the pathogenesis of psychiatric disorders on the basis of neuroendocrine responses to stimulation or perturbation. Dexamethasone(DEX) suppression has been the most widely utilized as the prototypical challenge test. Dexamethasone suppression test(DST) has proven to be valuable in diagnosing the depressive spectrum disorder. Reported specificity of diagnosis of depression is relatively high, but sensitivity is limited. Some researchers used the combination of dexamethasone and corticotropin releasing hormone(CRH) in order to improve the sensitivity. They reported that combined DEX/CRH test is more sensitive than DST alone. In this study the authors modified the DEX/CRH test, i.e., we administered the insulin instead of CRH. Total subjects were 28(7 normal controls, 10 manic patients, 11 schizophrenic patients). Subjects were taken DEX(1.5mg p.o.) at 11 p.m., insulin 16 hours later(0.1 unit/kg i.v.). Five blood samples for the determination of cortisol and ACTH were serially drawn at 15 minute interval. The results are as followings : 1) The cortisol and ACTH levels of manic subjects increased following insulin administration. Manic subjects showed higher levels of cortisol and ACTH than schizophrenic and normal control subjects. The cortisol and ACTH levels of schizophrenic and normal control subjects did not show gross changes. 2) The sensitivity of the test was lower than that of reported DEX/CRH test.