• 한국약용작물학회지
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• 제27권6호
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• pp.390-396
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• 2019

Background: Usually ginseng seeds are sown during autumn and spring. Sowing in spring often results in poorer seedling establishment than in autumn. One of the reasons for poor germination could be cold-treatment condition for breakage of physiological dormancy during winter. Here we tested the effects of storage temperature used during cold treatment on germination. Methods and Results: Germination properties were observed after dehiscent seeds were stored as wet and dry at 2℃, -2℃, -3.5℃ and alternating temperature (AT). Seed dryness and storage temperature affected germination properties (p < 0.01). Wet and AT condition germinated highest, and wet and -3.5℃ condition germinated lowest, which was 91.2% and 1.4% respectively. Mean germination time (MGT) of the wet and AT condition was faster than other treatments at 2.4 days, and the dry and -2℃ condition was the longest. Germination performance index (GPI) was highest for wet and AT condition (37.7%) and the lowest for wet and -3.5℃ condition (0.5%). The growth of above-ground and below-ground were the best for wet and 2℃ condition, and wet seeds showed better growth than dry seeds (p < 0.01). Conclusions: For cold treatment, ginseng seeds may not be stored below -2℃ for successful germination during spring sowing.

• 한국수자원학회논문집
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• 제51권2호
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• pp.89-98
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• 2018

위성자료는 광범위한 지역의 변동성을 관측하기에 매우 유리하다는 특성 때문에 최근 기후변화로 인한 자연재해 등의 연구에서 각광받고 있다. 하지만 위성자료에도 여전히 시 공간적인 해상도의 한계가 있으며, 이를 극복하기 위해 다양한 센서의 융합이나 1차 산출물들을 조합하는 방법을 사용한다. 본 연구에서는 천리안 위성의 GOCI와 MI에서 관측되는 자료를 융합함으로써 500 m 공간 해상도의 지표면 온도 자료를 생산하였고, 정규 식생지수와 함께 사용하여 TVDI를 산정하였다. 산정된 TVDI를 통해 한반도의 토양수분 상태를 모니터링 하고자 하였으며, 이를 비교하기 위해 ASCAT 지표 토양수분 자료를 통해 산정된 SSMI와 비교하였다. 그 결과 천리안 TVDI와 SSMI가 대한민국 전역에서 비슷한 공간 분포를 나타냈으며, 천리안 위성을 활용하여 토양수분을 관측할 수 있는 가능성을 제시하였다. 따라서 본 연구에서 산정 된 한반도의 TVDI가 고해상도의 토양수분을 산정하는 기반이 될 수 있고, 이를 통해 천리안 위성의 활용 범위가 보다 확장되어 다양한 연구의 기반이 될 수 있을 것으로 보인다.

• Environmental Analysis Health and Toxicology
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• 제24권2호
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• pp.149-157
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• 2009

In this study, recognized building-related health symptoms of various workers in dental college hospitals are surveyed and analyzed in order to improve indoor environment at dental college hospitals. We conducted a questionnaire survey for 682 workers in three dental college hospitals located in Seoul from Sep. 20 to Oct. 8, 2004. Most workers at dental hospitals complained about noise, poor ventilation, dusty environment, and air dryness. SBS symptoms score for subjects was 1.43${\pm}$0.74 (often feel) and major symptoms was throat, CNS, eye, and nose symptoms. Recognized Building-related health symptoms are significantly related to tasks, working experience, job-satisfaction, indoor environment recognition index, medical history, used to special material, and number of dental unit chair. Also working places and ventilation are significantly related to the symptom. Based on the results, it can be said that special dental treatment causes undesirable environment such as noise, dust, and bad odor. It is also related to recognized building related health symptoms reported by workers at dental hospitals. So managemental efforts are needed to improve indoor environment which is related by dental treatment.

• 대한원격탐사학회지
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• 제34권1호
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• pp.25-43
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• 2018

The effects of hydro-meteorological and surface variables on the frequency of Asian dust events (FAE) were investigated using ground station and satellite-based data. Present weather codes 7, 8, and 9 derived from surface synoptic observations (SYNOP)were used for counting FAE. Surface wind speed (SWS), air temperature (Ta), relative humidity (RH), and precipitation were analyzed as hydro-meteorological variables for FAE. The Normalized Difference Vegetation Index (NDVI), land surface temperature (LST), and snow cover fraction (SCF) were used to consider the effects of surface variables on FAE. The relationships between FAE and hydro-meteorological variables were analyzed using Z-score and empirical orthogonal function (EOF) analysis. Although all variables expressed the change of FAE, the degrees of expression were different. SWS, LST, and Ta (indices applicable when Z-score was < 0) explained about 63.01, 58.00, and 56.17% of the FAE,respectively. For NDVI, precipitation, and RH, Asian dust events occurred with a frequency of about 55.38, 67.37, and 62.87% when the Z-scores were > 0. EOF analysis for the FAE showed the seasonal cycle, change pattern, and surface influences related to dryness condition for the FAE. The intensity of SWS was the main cause for change of FAE, but surface variables such as LST, SCF, and NDVI also were expressed because wet surface conditions suppress FAE. These results demonstrate that not only SWS and precipitation, but also surface variables, are important and useful precursors for monitoring Asian dust events.

• 한국환경과학회지
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• 제32권1호
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• pp.67-76
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• 2023

Under constant environmental pollution, the incidence of Atopic Dermatitis (AD) caused by air pollutants and allergens has increased. AD is an allergy inflammatory skin disease characterized by pruritus, eczema, and skin dryness. In herbal medicine, Anemarrhena asphodeloides (Anemarrhenae Rhizoma; AR) has been utilized to treat Alzheimer's disease, osteoporosis, hypertension, and inflammation. The purpose of study evaluated the effect of AR in a mouse model of 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions. After acclimatization for 5 days, the mice (6-week-old, male Balb/c) were divided into five groups (n=6/group): NC (normal control), DNCB (control), Dex (5 mg·kg-1, p.o.), AR100 (100 mg·kg-1, p.o.), and AR300 (300 mg·kg-1, p.o.). On days 1 and 3, 1% DNCB was applied to the skin and ears. After 4 days, 0.5% DNCB was applied once every 2 days for 2 weeks. Then, skin and ears eczema area and severity index (EASI); skin nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels; and plasma immunoglobulin E (IgE) levels were examined. The AR groups showed lower EASI, skin and ear thickness, mast cell count, and IgE levels than the control groups. Moreover, AR reduced iNOS, COX-2, and PGE2 levels. Therefore, AR possesses anti-inflammatory properties and can improve skin damage, indicating its therapeutic potential against AD.

• 대한한방부인과학회지
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• 제22권2호
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• pp.189-208
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• 2009

Purpose: In oriental medicine, doctors have mainly made diagnosis and treatment with amenorrhea or delayed menstrual period based on overall analysis of symptoms and signs patients have. We think patients with amenorrhea or delayed menstrual period to have symptoms that are classified into one differentiation of syndromes, and then studied to make the index. This study has been carried out to investigate pattern identifications and classify symptoms according to them. Methods: We examined 52 patients who visited Dong-eui university oriental medical center from June 2005 to February 2009 for undergoing treatment for amenorrhea or delayed menstrual period and made OB & GY questionnaires up Results: We investigated whether the patients had symptoms concerned with symptom types by analyzing the result of DSOM(Diagnos System of Oriental Medicine, hearafter DSOM). It came out 51 cases among 52 with pathogenesis that was related to the symptom types. The symptom types of were surveyed into Insufficiency of Kidney and Liver(肝腎不足), Insufficiency of Qi and Blood(氣血虛弱), Insufficiency of Yin & Dryness of blood(陰虛血燥), stagnation of Qi and Blood(氣滯血瘀), phlegm and damp(痰濕阻滯), coldness of Blood(血寒), Heat of Heart(心火). Conclusion: As a result of the investigation, one case did not have symptoms of differentiation of syndromes of amenorrhea or delayed menstrual period. 29 cases had 1 or 2 differentiation of syndromes. 21 patients had such complex symptoms of diverse differentiation of syndromes that it was difficult to diagnose a differentiation of syndromes in clinical survey. It is necessary to put the priority among the differentiation of syndromes in diagnosis in the future.

• 셀메드
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• 제13권14호
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• pp.15.1-15.15
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• 2023

Background and objective: A new formular CPC22 consists of Cynanchum wilfordii root, Pueraria thomsonii flower, and Citrus unshiu peel and has been developed to improve the postmenopausal symptoms. The research intended to evaluate whether CPC22 would regulate bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized (OVX) postmenopausal mice. Method: The OVX mice were orally administered with CPC22 daily for 7 weeks. Results: CPC22 regulated OVX-induced bon loss by enhancing serum osteoprotegerin, alkaline phosphatase, and osteocalcin levels and diminishing serum receptor-activator of the NF-κB ligand (RANKL), collagen type 1 cross-linked N-telopeptide, and tartrate-resistant acid phosphatase levels. As a result of CPC22 treatment, notable decreases in tail skin temperature and rectal temperature were observed, along with diminishment in hypothalamic RANKL and monoamine oxidase A levels and enhancement in hypothalamic serotonin (5-HT), norepinephrine, dopamine, 5-HT2A, and estrogen receptor-β levels. CPC22 enhanced levels of serum estrogen and diminished levels of serum follicle-stimulating hormone and luteinizing hormone. CPC22 regulated levels of serum lipid metabolites, including total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Furthermore, CPC22 diminished levels of serum blood urea nitrogen, creatine kinase, alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase and restored vaginal dryness without affecting uterus atrophy index and vagina weights. Conclusion: Therefore, these results indicated that CPC22 improves OVX-induced bone loss, hot flashes, and dysregulated lipid metabolism by compensating for estrogen deficiency without side effects, suggesting that CPC22 may be used for the prevention and treatment of post menopause.

• 한국농림기상학회지
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• 제15권4호
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• pp.234-244
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• 2013

본 연구는 느티나무 집단의 종자특성 변이에 영향을 미치는 요인과 종자특성이 유묘생장에 미치는 영향을 구명하고자 수행되었다. 이를 위해 느티나무16개 집단에서 종자를 채취하여 특성을 조사하였으며, 포지에서 1년간 양묘한 후 묘목의 생장을 조사했다. 종자특성과 유묘생장에 영향을 미치는 요인을 구명하고자 조사형질과 종자채취 집단의 지리적기후적 인자와의 상관분석을 실시했다. 종자특성에 대한 분산분석 결과, 모든 측정형질에서 집단 간에 유의한 차이가 있었다. 지리적 요인과의 상관을 분석한 결과, 종자길이와 종자폭은 위도, 경도, 해발고, 해안으로부터 거리와 정의 상관을 보여준 반면, 종자형상비는 부의 상관을 나타냈다. 기후인자와의 상관을 분석한 결과, 종자길이와 종자폭은 종자채취 집단의 연평균 기온 및 생육기(3~8월)의 평균기온과 부의 상관을 나타냈으며, 종자형상비는 이들과 정의 상관을 보여주었다. 천립중은 지리적요인과 상관이 없었고, 기후인자 중 건조지수와 유의하지만 낮은 정의 상관을 나타냈다. 용적중은 위도, 경도와 낮은 부의 상관을 나타냈으며, 생육기 (3~8월)의 평균 습도와 정의 상관을 나타냈다. 종자충실율은 위도, 경도와 유의한 부의 상관을 보였으며, 건조지수와는 유의한 부의 상관을 나타냈다. 유묘의 생장은 묘고와 근원경 모두 집단 간, 집단 내 가계 간 그리고 가계 내 개체 간에 유의한 차이가 있는 것으로 나타났다. 묘고와 근원경은 모두 경도 및 생육기(3~8월) 평균 습도와 유의한 부의 상관을 나타냈다. 종자특성과 유묘생장의 상관을 분석한 결과, 묘고생장은 종자특성과 상관이 없었으며, 근원경은 천립중 및 용적중과 유의하지만 낮은 부의 상관을 나타냈다. 이러한 점을 볼 때, 느티나무 1년생 유묘의 생장은 종자특성의 영향이 크지 않은 것으로 판단되었다. 전반적으로 볼때, 종자특성과 유묘생장은 집단 간에 유의한 차이가 있었지만, 지리적 또는 기후적 요인과의 상관성이 낮아 그 경향성이 뚜렷하지 않은 것으로 나타났다. 따라서, 1년생 유묘에 대한 분석만으로는 느티나무 집단의 유전적 특성 및 지리적 변이를 정확히 추정하기 어렵다고 판단되며, 추후 산지시험을 통한 조림지 적응성 및 생장특성 검정 결과를 토대로 느티나무 집단에 대한 평가가 이루어져야 할 것으로 보인다.

• 동의생리병리학회지
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• 제21권1호
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• pp.250-257
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• 2007

Uterus myoma is a benign tumor of smooth muscle in the wall of the uterus, In oriental medicine, we used to made an effort to management this patients without surgical operation. Doctors have treated patients of uterus myoma mainly by checking over each symptom they have. Then we think that patients have some symptoms in relation to an etiological cause. So I have carried out this study to investigate association of DSOM scores and an attack of uterus myoma in oriental medicine. We chose 3 groups, the first one is 257 uterus myoma patients who visited Dongeui University Oriental Medical Center from May 2001 to June 2006, the second one is 558 outpatients who didn't have uterus myoma from May 2005 to June 2005, the third one is 129 clinical trials who volunteered for Sasang constitutional medicine. Then we made up 3 groups to checkup DSOM, and investigated the All DSOM Fluents which effect uterus myoma patients using regression model. Logistic regression analysis indicate as follows ; In comparison with 558 outpatients data, blood stasis(血瘀), dryness(燥) is associated positively and insufficiency of Yang(陽虛), spleen(脾), phlegm(痰) negatively, and mean of the index for pathogenic factor(病機指標 平均) of deficiency of qi(氣虛), heart(心) negatively. In comparison with 129 clinical trials data, blood stasis(血瘀) is associated positively and phlegm(痰) negatively, and mean of the index for pathogenic factor(炳機指標 平均) of deficiency of Yin(陰虛), liver(肝), diarrhea positively, heart(心) negatively. 3. In investigation of DSOM items, items of blood stasis(血瘀), deficiency of Yin(陰虛), coldness(寒) is associated positively and items of heart(心), spleen(脾), Phlegm(痰) negatively.

• 대한임상검사과학회지
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• 제49권2호
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• pp.150-160
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• 2017

아토피피부염은 만성 염증성 피부질환으로 습진성병변, 피부건조 및 가려움증의 특징적 증상을 보이는 질환이다. 현재 사용되고 있는 아토피피부염 치료약제들은 오래 사용시 여러 부작용이 있어서 이를 대신할 새로운 대체 치료법의 개발이 요구되고 있다. Curcumin은 항염, 항알러지와 같은 효과를 나타내는 천연 폴리페놀(polyphenol)이며, 발광다이오드(light emitting diode, LED) 광치료는 아토피피부염과 상처치유에 효과가 있는 것으로 알려져 있다. 본 연구는 DNCB로 유도한BALB/c 마우스의 아토피피부염에서 curcumin 투여와 630 nm LED 조사를 병용하여 그 치료 효과를 높일 수 있는가를 조사하기 위해 시도하였다. 아토피피부염의 치료 효과를 조사하기 위해 modified SCORAD 지수, 조직병리학적 분석, 면역조직화학염색 및 TUNEL 검사를 사용하였다. 그 결과 curcumin 투여와 630 nm LED 조사가 각각 SCORAD 지수, 비만세포 및 탈과립세포의 수, 호산구 수, 표피세포의 증식능 및 자멸세포의 수를 의미 있게 감소시키고, 비만세포의 탈과립을 억제하여 섬유모세포에 의한 콜라겐 생성을 의미 있게 감소시켰으며, curcumin 투여와 LED 조사를 병용하였을 경우 단일 처리군에 비해 이들 수치가 의미 있게 감소하는 것을 확인하였다. 이러한 결과는 아토피피부염 치료에 curcumin 투여와 LED 조사가 각각 효과가 있음을 의미하며, 병용 치료 시 그 효과가 좀 더 향상된다는 것을 의미하는 것으로, 아토피피부염의 대체치료 전략으로 curcumin 투여와 630 nm 조사의 병용 치료를 제안한다.