• Journal of the Korean Society of School Health
• /
• v.12 no.1
• /
• pp.57-70
• /
• 1999

This study was conducted to examine factors in relation to attitude and behavior of drug abuse in middle school students, and provide guidelines for drug education for adolescents. The summary of results was as follows: 1. The mean of attitude about drug abuse were 3.44 (1st graders), 3.40 (2nd graders), 3.20 (3rd graders) of full score 4.00. Attitude about drug abuse related to sex in girls is more desirable than boys' (p<0.001). 2. 3rd grade students experienced smoking and alcohol use to the highest degree in the last one month. Boys had more experiences of smoking and alcohol use than girls. Most motivations of students' drug abuse were curiosity and the influence of peer: 3. The higher the scores of self-assertion is, the higher the scores of attitude about drug abuse is. And the higher the scores of problem solving ability is, the higher the scores of attitude about drug abuse is. 4. Self-assertion and problem solving ability were positively correlated with attitude about drug abuse. Otherwise, the attitude about drug abuse was negatively correlated with drug abuse behavior. 5. Stepwise multiple regression analysis revealed that the most powerful predictor to drug abuse behavior was the attitude about drug abuse, Problem solving ability and self-assertion is accountable factor to the attitude about drug abuse. This result indicated that effective problem solvers or self-asserters have desirable attitude about drug abuse and less possibility to abuse drug. In conclusions, school drug education is necessary to enhance the ability of self-assertion by which students cope against peer pressure and problem solving ability by which students identify or discover effective strategies of coping with problematic situations encountered in daily living.

• Korean Journal of Social Welfare Studies
• /
• no.39
• /
• pp.395-423
• /
• 2008

This study investigated population characteristics that influencing treatment service use of people who are voluntarily using drug dependency treatment services by using logistic and hierarchical regression analysis. The research model of the current study was driven by the framework of the 'the Behavioral Model of Health Services Use(the Andersen model)' that has been broadly applied to study on health behavior. This study used data from a sample group of 80 adults by using purposive sampling. This study found that some predisposing factors, enabling factors and need factors have direct effects on service use. In detail, individuals who graduated from high school use drug dependency treatment utilities more than those who did not. Further, individuals who were given more support from family, peers, or others, use the treatment utilities more frequently and were more willing to use the utilities continuously. Furthermore, the greater the perceived need felt by the dependent, the greater the tendency to enter hospitals or shelters. The important implications of this study for social work practice and social policy can be summarized as follows: first, this study supports the idea that intervention for drug dependents in Korea should be focused on environment resources rather than population characteristics; and government must support drug dependent treatment systems; the present study was the first to investigate Korean drug dependents through taking a more positive view, as well as the first to apply 'the Behavioral Model of Health Services Use', and as such represents an example of how studies could be productively conducted in the future. Despite these implications, there remain some limitations in this study. These include the following: limitation in generalizability of the results; the cross-sectional nature of the study design; survey research through the questionnaire method; using foreign scales; and the difficulty of classifying treatment settings.

• The Korean Journal of Health Service Management
• /
• v.4 no.2
• /
• pp.11-22
• /
• 2010

In this study, adolescent understanding of and attitude towards unintentional drug use were investigated. 22 elementary, middle and high schools in cities and counties in Jeollanam-do Province were selected randomly and a survey was carried out. 489 students (46.9%) replied that they had received training on drug prevention and 553 (53.1%) said they never received training about drug prevention. That does one or two drugs with curiosity, thinks that is bad(p=0.002), and drug using thought that does not become the help in stress(p<0.001). With regards to the question on whether they would use drugs if suggested by friends, 88.7% answered they would decline the offer. 91.4% indicated they will participate if there is training about drug misuse in the future. 91.0% replied that this training about drug misuse was "satisfaction". Therefore it is be very important to understand the characteristics of adolescent and provide continuous training and campaign to help them to acquire correct habits to maintain good health and in doing so; help them to establish a healthy foundation for adulthood.

• 한국임상약학회:학술대회논문집
• /
• 2007.12a
• /
• pp.196-197
• /
• 2007

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.94-95
• /
• 2002

Drug targeting to the central nervous system (CNS) is the limiting factor in CNS drug development because most of drug do not cross the brain capillary endothelial wall, which forms the blood-brain barrier (BBB) in vivo. One strategy for drug targeting to the brain is to use endogenous BBB transport systems. (omitted)

• Toxicological Research
• /
• v.31 no.2
• /
• pp.137-149
• /
• 2015

Human hepatocytes, with complete hepatic metabolizing enzymes, transporters and cofactors, represent the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and hepatotoxicity. Successful cryopreservation of human hepatocytes enables this experimental system to be used routinely. The use of human hepatocytes to evaluate two major adverse drug properties: drug-drug interactions and hepatotoxicity, are summarized in this review. The application of human hepatocytes in metabolism-based drug-drug interaction includes metabolite profiling, pathway identification, P450 inhibition, P450 induction, and uptake and efflux transporter inhibition. The application of human hepatocytes in toxicity evaluation includes in vitro hepatotoxicity and metabolism-based drug toxicity determination. A novel system, the Integrated Discrete Multiple Organ Co-culture (IdMOC) which allows the evaluation of nonhepatic toxicity in the presence of hepatic metabolism, is described.

• Health Policy and Management
• /
• v.22 no.4
• /
• pp.579-596
• /
• 2012

The purpose of the study is to examine the use of medication among adults by comparing the pattern of outpatient prescription drug use with the pattern of long term taking lifestyle drug use. Furthermore, the study investigates factors associated with the use of medication, particularity focusing on socioeconomic factors. Korea Health Panel data of 2008 was used to conduct the study analysis. By performing four different logistic regression models, the study noticed different patterns of the medication use between prescription drugs and lifestyle drugs. More specifically, the study showed that adults with lower education level tend to more frequently receive prescriptions while adults with higher education as well as income level tend to more use lifestyle drugs than their counterparts. Furthermore, other control factors such as age and gender were statistically significant for the use of both prescription and lifestyle drugs in different patterns. The study findings expect that reimbursement structure of drugs may be significantly associated with the different patterns and accordingly the accessability of medicine in particularly vulnerable population. Therefore, these policy factors should be considered in future study to more comprehensively understand about the diverse patterns in the medication use.

• Korean Journal of Pharmacognosy
• /
• v.41 no.2
• /
• pp.136-140
• /
• 2010

This study was carried out to utilize non-toxic solvents instead of harmful solvents for the TLC(Thin Layer Chromatography) identification test of herbal medicines. It is recommended not to use harmful solvent such as chloroform at a viewpoint of clean analysis. In this study, we revised the identification test of 10 items in the Korea Pharmacopoeia(KP) and the Korean Herbal Pharmacopoeia(KHP) such as Cornus officinalis S. containing the harmful solvents on the developing solvent and established identification test that is utilized non-toxic solvents by HPTLC(High Performance Thin Layer Chromatography).

• Journal of Pharmaceutical Investigation
• /
• v.34 no.4
• /
• pp.333-340
• /
• 2004

A new medical system of separation of dispensary from medical practice was started in 2000 in Korea. To expand bioequivalence-proven drug products and to ensure the credibility of the therapeutic equivalence of generic drug are hot issues in Korea. The KFDA also has a plan to revise the pharmaceutical affairs law that bioequivalence reports of all the generic prescription drugs should be submitted to the KFDA in the application for drug approval. Therefore, it becomes more necessary to develop bioequivalence-demonstrating methods for specific preparations such as topical drug products. There are some differences between US and Japanese guidances of bioequivalence studies of generic drug products for topical use. In this paper, we examined the recently published Japanese guideline, Guideline for Bioequivalence Studies of Generic Products For Topical Uses, and Q&A of the guideline, which will be references to make a guidance on bioequivalence studies of topical drug products in Korea.

• Korean Journal of Clinical Pharmacy
• /
• v.3 no.1
• /
• pp.89-104
• /
• 1993

The use of drug or substance for altering consciousness among adolescence is a practice in modern society, especially in Korea. The choice and pattern of use are strongly influenced by the user6s personality and expectations. The goverment and society institute must be declared the emergency of Drug abuse, for the purpose of protecting adolescence from pscychotropic agents.