• Title/Summary/Keyword: Double-Throw

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Shelterin Proteins and Cancer

  • Patel, Trupti NV;Vasan, Richa;Gupta, Divanshu;Patel, Jay;Trivedi, Manjari
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3085-3090
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    • 2015
  • The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG sequence bound with specialised protein complex called the "shelterin complex". It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1. All of these assemble together to form a complex with double strand and single strand DNA repeats at the telomere. Such an association contributes to telomere stability and its protection from undesirable DNA damage control-specific responses. However, any alteration in the structure and function of any of these proteins may lead to undesirable DNA damage responses and thus cellular senescence and death. In our review, we throw light on how mutations in the proteins belonging to the shelterin complex may lead to various malfunctions and ultimately have a role in tumorigenesis and cancer progression.

Design of Broadband FET Switch Using Drain Impedance Transformation Network (드레인 임피던스 변환회로를 이용한 광대역 FET 스위치 설계)

  • Choi, Won;No, Hee-Jung;Oh, Chung-Kyun;Koo, Kyung-Heon
    • Proceedings of the IEEK Conference
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    • 2003.11c
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    • pp.60-63
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    • 2003
  • This paper describes the design and the simulation of a V-band single pole double throw (SPDT) FET switch fur millimeter-wave applications using drain impedance transformation network with CPW transmission line. The designed switch has about 10% bandwidth at 60GHz. Insertion loss is better than 3dB fur the ON state and Isolation is larger than 30dB fer the OFF state. The maximum isolation is 43.4dB at 60GHz with input power of 10dBm. The yield analysis is done considering the effects of pHEMT variations.

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RF protection technique of antenna tuning switch in all-off condition (전차단 상태에서 동작하는 안테나 튜닝스위치의 RF 보호기술)

  • Jhon, Heesauk;Lee, Sanghun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.26 no.10
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    • pp.1567-1570
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    • 2022
  • This paper, we presents a RF protection technique of antenna switch by improving the power handling capability in worst case environment mode for mobile phone applications without critical payment of circuit performances such as insertion loss, isolation and ACBV (AC breakdown voltage). By applying a additional capacitive path located in front of the antenna in cell-phone, it performs the effective reduction of input power in high voltage standing wave ratio (VSWR) condition. Under the all-path off condition which causes a high VSWR, it achieved 37.7dBm power handling level as high as 5.7dB compared to that of conventional one at 2GHz. In addition, insertion loss and isolation performances were 0.31dB and 42.72dB at 2 GHz, respectively which were almost similar to that of the conventional circuit. The proposed antenna switch was fabricated in 130nm CMOS SOI technology.

A Study on Efficient Frequency Control of Transducer for Skin Treatment Using Multi-Frequency Ultrasound (멀티주파수 초음파를 사용하는 피부 치료기기 트랜스듀서의 효율적인 주파수 제어 연구)

  • Park, Jong-Cheol;Kim, Min-Sung
    • Journal of Korea Multimedia Society
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    • v.25 no.8
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    • pp.1038-1048
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    • 2022
  • Ultrasound is one of the effective methods for skin treatment. The skin penetration depth of the ultrasound depends on the ultrasonic frequency, that is, when the ultrasonic frequency is high, the depth is shallow. We have developed a transducer which can generate effectively 3 different ultrasonic frequencies removing interference between 3 types of frequencies according to impedance matching technology. The generated powers of transducer are 40.67W at 3.MHz, 17.46W at 11.7 MHz, and 14.79W at 21.5 MHz. The signal interference between the three frequencies is designed so that they do not interfere with each other by separating the signals using the SPDT (Single Pole, Double Throw) switch. The developed hybrid ultrasound transducer can be applied in skin care or skin treatment and beauty therapy.

Design of pHEMT channel structure for single-pole-double-throw MMIC switches (SPDT 단일고주파집적회로 스위치용 pHEMT 채널구조 설계)

  • Mun Jae Kyoung;Lim Jong Won;Jang Woo Jin;Ji, Hong Gu;Ahn Ho Kyun;Kim Hae Cheon;Park Chong Ook
    • Journal of the Korean Vacuum Society
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    • v.14 no.4
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    • pp.207-214
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    • 2005
  • This paper presents a channel structure for promising high performance pseudomorphic high electron mobility transistor(pHEMT) switching device for design and fabricating of microwave control circuits, such as switches, phase shifters, attenuators, limiters, for application in personal mobile communication systems. Using the designed epitaxial channel layer structure and ETRI's $0.5\mu$m pHEMT switch process, single pole double throw (SPDT) Tx/Rx monolithic microwave integrated circuit (MMIC) switch was fabricated for 2.4 GHz and 5 GHz band wireless local area network (WLAN) systems. The SPDT switch exhibits a low insertion loss of 0.849 dB, high isolation of 32.638 dB, return loss of 11.006 dB, power transfer capability of 25dBm, and 3rd order intercept point of 42dBm at frequency of 5.8GHz and control voltage of 0/-3V These performances are enough for an application to 5 GHz band WLAN systems.

Paper-Based Pattern Switchable Antenna Using Inkjet-Printing Technology (잉크젯 프린팅 기술을 이용한 종이 기반의 방사패턴 가변 안테나)

  • Eom, Seung Hyun;Lim, Sungjoon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.26 no.7
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    • pp.613-619
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    • 2015
  • In this paper, we proposed a paper-based pattern-switchable antenna using inkjet-printing technology. The proposed antenna is composed of two bow-tie antennas and a switching network. The bow-tie antennas are inkjet-printed on paper using a low cost home printer. The switching network is built on a printed-circuit-board(PCB) and consists of a single-pole-double-throw(SPDT) switch and balun element. A double-sided parallel-strip line(DSPSL) can convert the unbalanced microstrip mode to the balanced strip mode. Two bow-tie antennas have different radiation patterns because of the different orientation of the reflectors. It is demonstrated from EM simulation and measurement that the radiation patterns of the proposed antenna are successfully switched by the SPDT.

Broadband Microwave SPDT Switch Using CPW Impedance Transform Network (CPW 임피던스 변환회로를 이용한 광대역 마이크로파 SPDT 스위치)

  • Lee Kang Ho;Park Hyung Moo;Rhee Jin Koo;Koo Kyung Heon
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.42 no.7 s.337
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    • pp.57-62
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    • 2005
  • This paper describes the design of a high performance microwave single pole double throw (SPDT) monolithic microwave integrated circuit switch using GaAs pHEMT process. The switch design proposes a novel coplanar waveguide (CPW) impedance transform network which results in the low insertion loss and high isolation by compensating for the FET parasitics to get the low on-resistance and low off-capacitance. The proposed switch has the measured isolation of better than 24 dB and insertion loss of less than 2.6 dB from 53 to 61 GHz. The chip is fabricated with the size of 2.2mm $\times$ 1.6 mm.

Hwang Woo-Suk, Pasteur and ANT (황우석과 파스퇴르 그리고 ANT)

  • Kang, Yun-Jae
    • Journal of Science and Technology Studies
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    • v.7 no.1
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    • pp.67-90
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    • 2007
  • Could STS throw another-colored light on the Hwang's Affair, the scientific fraud committed by Hwang Woo-Suk and his research team in Korea? And could analytic tools of STS unfold another meanings which have been overlooked in most of the traditionally social-sciences-oriented analyses? In this essay, I try to answer these questions by analyzing the Hwang's Affair in the view of STS, especially by using some concepts of actor-network theory(ANT): movement, translation and displacement. I want to say that the Hwang's Affair seems to be a part of normal scientific activity, not an abnormal phenomenon, and as an evidence, focus on the similarities of their life styles between "pure/real scientist" Louis Pasteur and "impure/political scientist" Hwang Woo-Suk. I try to mobilize some concepts of ANT, especially movement, and find out why scientists came to move toward the opposed direction on the pure/real-impure/political line. I suggest that there exists "laboratory politics" as the key factor in this bifurcation. My tentative conclusion is that Pasteur can take a position to make his great world, so-called the Pasteurian world, owing to the success of "double movement" in which he treated his laboratory as a fulcrum to lift up the world, but Hwang degrades himself to "ugly scientific politician" due to the loss of the momentum of his movement; Hwang treated his laboratory only as the symbolic resources and in turn failed to solidify material entities, his real political resources, even though he knew the importance of laboratory.

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A Medium Power Single-Pole-Double-Throw MMIC Switch for IEEE 802.11a WLAN Applications (IEEE 802.11a 무선랜용 중간전력 SPDT 초고주차단일집적회로 스위치 제작 및 특성)

  • Mun JaeKyoung;Kim Haecheon;Park Chong-Ook
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.30 no.10A
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    • pp.965-970
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    • 2005
  • In this paper, SPDT Tx/Rx MMIC switch applicable to IEEE 802.11a WLAN systems is designed and fabricated using a specific designed epitaxial layered pHEMT wafer and ETRI's $0.5{\mu}m$ pHEMT switch process. The SPDT switch exhibits a low insertion loss of 0.68dB, high isolation of 35.64dB, return loss of 13.4dB, power transfer capability of 25dBm, and 3rd order intercept point of 42dBm at frequency of 5.8GHz and control voltage of 0/-3V. The comparison of the measured performances with commercial products based on the GaAs pHEMT technology for low voltage operating at ${\pm}$ 3V/0V shows that the return loss is somewhat inferior to the commercial products and insertion loss is compatible with each other however, isolation characteristics are much better than in conventional chips. Based on these performances, we can conclude that the developed SPDT switch MMIC has an enough potential for IEEE802.11a standard 5 GHz-band wireless LAN applications.

Design of a Wide-Frequency-Range, Low-Power Transceiver with Automatic Impedance-Matching Calibration for TV-White-Space Application

  • Lee, DongSoo;Lee, Juri;Park, Hyung-Gu;Choi, JinWook;Park, SangHyeon;Kim, InSeong;Pu, YoungGun;Kim, JaeYoung;Hwang, Keum Cheol;Yang, Youngoo;Seo, Munkyo;Lee, Kang-Yoon
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.16 no.1
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    • pp.126-142
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    • 2016
  • This paper presents a wide-frequency-range, low-power transceiver with an automatic impedance-matching calibration for TV-white-space (TVWS) application. The wide-range automatic impedance matching calibration (AIMC) is proposed for the Drive Amplifier (DA) and LNA. The optimal $S_{22}$ and $S_{11}$ matching capacitances are selected in the DA and LNA, respectively. Also, the Single Pole Double Throw (SPDT) switch is integrated to share the antenna and matching network between the transmitter and receiver, thereby minimizing the systemic cost. An N-path filter is proposed to reject the large interferers in the TVWS frequency band. The current-driven mixer with a 25% duty LO generator is designed to achieve the high-gain and low-noise figures; also, the frequency synthesizer is designed to generate the wide-range LO signals, and it is used to implement the FSK modulation with a programmable loop bandwidth for multi-rate communication. The TVWS transceiver is implemented in $0.13{\mu}m$, 1-poly, 6-metal CMOS technology. The die area of the transceiver is $4mm{\times}3mm$. The power consumption levels of the transmitter and receiver are 64.35 mW and 39.8 mW, respectively, when the output-power level of the transmitter is +10 dBm at a supply voltage of 3.3 V. The phase noise of the PLL output at Band 2 is -128.3 dBc/Hz with a 1 MHz offset.