• 한국지형학회지
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• 제28권2호
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• pp.59-70
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• 2021

This study aims to determine the sunlight exposure according to depositional environment to improve the accuracy of optically simulated luminescence (OSL) dating. Sufficient sunlight exposure during transportation of sediment is a basic assumption of the OSL dating, and if the process does not occur enough, the results may be overestimated compared to the actual depositional age. Therefore, the main purpose of this study is to establish a correction method by determining residual or unbleachable dose after sunlight exposure in the actual deposition process, not in the laboratory measurement. Four samples from two sites were collected according to the depositional environment from rivers and coasts, and various OSL signals, including the size of residual dose, degree of dispersion between grains, and OSL signal sensitivity, were measured. As a result, it was confirmed that sediments formed under temporarily high energy environments, such as floods and surges, had relatively high residual dose or large dispersion of residual dose between particles. In further studies, the OSL signal characteristics of river sediments by flow velocity will be identified and the relationship between energy and OSL signal characteristics will be identified in more detail. Moreover, a method of reconstructing the paleo-environment at the time of deposition for existing sediments will be devised. It is expected to provide important information for the frequency of disaster recurrence and prediction of future climate change.

• 한국콘텐츠학회논문지
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• 제19권12호
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• pp.517-526
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• 2019

본 연구는 자동노출제어장치 사용 시 파라미터 조합에 따른 영상 화질과 방사선 출력을 분석하여 임상에 적용할 수 있는 최적의 방법을 모색하고자 하였다. 실험방법은 관전압 70, 81 kVp와 자동노출제어장치(Automatic Exposure Control, AEC)의 감도 S200, S400, S800, S1000을 조합해서 복부와 골반부의 입사표면선량, 관전류량, 신호 대 잡음비(Signal to Noise Ratio, SNR), 대조도 대 잡음비(Contrast to Noise Ratio, CNR), 시간-방사선량 곡선을 구하였다. 그 후 영상 화질과 출력의 안정성을 평가하였다. 그 결과 입사표면선량, 관전류량, 신호 대 잡음비, 대조도 대 잡음비는 관전압과 감도가 높게 설정될수록 감소하였다. 또한 관전압과 감도가 높게 설정될수록 시간-방사선량 곡선은 출력의 안정성이 줄어드는 양상을 보였다. 결론적으로 복부와 골반부 검사 시 관전압과 감도를 높게 조합할수록 검출기는 영상 화질과 방사선 출력을 정상적으로 재현해내지 못하였다. 따라서 비교적 낮은 관전압과 감도를 조합하여 검출기가 파라미터의 조합을 인식할 때 발생하는 오차 범위를 최소화해야 영상 화질과 방사선 출력의 안정성을 최적화할 수 있다는 것을 알 수 있었다.

• Journal of Radiation Protection and Research
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• 제16권2호
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• pp.67-74
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• 1991

육상 섭취 경로에 따른 내부 피폭선량 계산 모델 KFOOD의 파라메터 불착실성 및 민감도를 몬테칼로법을 사용하여 수치 분석하였다. 쌀을 통한 섭취 경로의 경우 KFOOD 코드에 의한 예측치는 아주 보수적인 값을 나타내었다 모델에서 민감도가 큰 입력변수는 방사능의 침적속도와 식물전이제수였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1991년도 하계학술대회 논문집
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• pp.753-756
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• 1991

This paper aimed to analyse dose sensitivity to the controllable parameters of in-door radon $(^{222}Rn)$ and its decay products(Rn-D) by applying the input-output linear system theory. Physical behaviors of $^{222}Rn$ & Rn-D were analyzed in terms of $^{222}Rn$ gas generation, -migation and - infiltration to indoor environments, and the performance output-function(i.e. mean dose equivalent to Tracho-Bronchial(TB) lung region was assessed to the following ranges of the controllable parameters; a) the ventilation rate constant $({\lambda}_v)$ : $0{\sun}500[h^{-1}]$. b) the attachment rate constant$({\lambda}_a)$ : 0-500 $[h^{-1}]$. c) deposition rate constant $({\lambda}{_{d}^{u}})$: 0-50$[h^{-1}]$. A linear input-output model was reconstructed from the original models in literatures, as follows, which was modified into the matrices consisting of 111 nodal equations. a) indoor ${222}Rn$ & Rn-D Behaviour: jacobi- Porstendorfer- Bruno model. b) lung dosimerty : Jacobi-Eisfeld model. Some of the major findings, which identify the effectiveness of this model, were as follows. a) ${\lambda}_v$ is most effective, dominant controllable parameters in dose reduction, if mechanical ventilation is applied. b) ${\lambda}_v$, depending on the air particle-concentration, reduces the dose somewhat within ${\lambda}_v$<1 $h^{-1}R range. However, the dose increases conversely, ${\lambda}_v$>1 $h^{-1}R range range. c) ${\lambda}{_{d}^{4}}$ reduces the dose linearly as ${\lambda}_v$ dose. Such dose(z-axis) sentivities are shown with three-dimensional plots whoes x,y-axes are combined 2out the 3 parameter${\lambda}_v{\lambda}_s,\;{\lambda}_d^s$.

• 한국의학물리학회지:의학물리
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• 제21권1호
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• pp.1-8
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• 2010

CT 촬영 장치를 기반으로 한 MAGAT (Methacrylic Acid, Gelatin gel And THPC) 정상 산소 중합체 겔 선량계의 화합물 조성비와 CT 영상 스캔 인자의 변화에 따른 선량 반응성을 평가하였다. 다양한 농도의 메타크릴산(MAA, MethAcrylic Acid)과 젤라틴을 조성하여 MAGAT 선량계를 제작하고 20 Gy까지의 방사선을 조사하였다. 조사된 겔 선량계는 CT 촬영 장치(Brilliance Big bore scanner, Phillps, Netherlands)를 이용하여 다양한 스캔 인자(관전압, 관전류, 단면두께)로 같은 위치에서 20회까지의 CT 영상을 획득하였다. 획득된 영상으로 $N_{CT}$-선량 반응곡선($N_{CT}$-dose response), 선량 감도(dose sensitivity), 선량 분해능(dose resolution)을 측정, 평가하였다. 각 조성비 별 MAGAT 선량계의 $N_{CT}$-선량 반응곡선에서 메타크릴산과 젤라틴의 양이 증가함에 따라 기울기와 절편이 증가하였다. 선량 감도는 $0.338{\pm}0.08$에서 $0.859{\pm}0.1$까지 나타났고 메타크릴산이 증가, 젤라틴이 감소할수록 증가하였으나 그 변화는 메타크릴산 농도의 증가에 따라 감도가 증가되는 것에 비해 아주 작은 변화를 보였다. 선량 분해능은 약 2.6에서 6 Gy까지 다양하게 나타났으며 감도와 영상 내의 노이즈에 의해 큰 변화를 보였다. 영상 스캔 인자의 변화에 대한 반응곡선은 관전압, 관전류, 단면두께의 변화에 따른 곡선의 기울기와 감도는 큰 변화를 보이지 않았으나 영상 내의 노이즈(평균 CT number의 표준편차)는 위의 3개의 인자가 증가할수록 감소함을 보였다. 본 연구는 CT 촬영장치를 이용한 MAGAT 중합체 겔의 선량 반응성을 평가하여 적정한 조성비와 스캔 인자를 얻을 수 있었으며 CT를 기반으로 한 3차원 선량계를 간단하고 효율적으로 임상에 적용할 수 있을 것으로 사료된다.

• Communications for Statistical Applications and Methods
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• 제22권5호
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• pp.401-413
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• 2015

In this article, we review the statistical methods and theory for dose finding in early phase clinical trials, where the primary objective is to identify an acceptable dose for further clinical investigation. The dose finding literature is initially motivated by applications in phase I clinical trials, in which dose finding is often formulated as a percentile estimation problem. We will present some important phase I methods and give an update on new theoretical developments since a recent review by Cheung (2010), with an aim to cover a broader class of dose finding problems and to illustrate how the general dose finding theory may be applied to evaluate and improve a method. Specifically, we will illustrate theoretical techniques with some numerical results in the context of a phase I/II study that uses trinary toxicity/efficacy outcomes as basis of dose finding.

• Advances in Traditional Medicine
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• 제7권2호
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• pp.205-210
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• 2007

The objectives of the study were (1) To evaluate the safety and tolerability of Damtab. (2) To characterize hypoglycemic effect of Damtab, if any. (3) To evaluate insulin sensitivity effect of Damtab, if any. Hypoglycemic effect of Damtab (700 mg and 1,400 mg) were examined. Gliclazide (80 mg) was used as an active control. Placebo was used as control. Breakfast was given, half an hour before dosing whereas lunch, snacks and dinner were given at 6, 10 and 14 h post dose. An oral glucose tolerance test was conducted to calculate the insulin sensitivity index from the values of glucose and insulin during oral glucose tolerance test. Both giclazide 80 mg and Damtab 1,400 mg significantly lowered plasma glucose level up to 6 h. Insulin sensitivity index of Damtab (1,400 mg) was found to be similar to that of placebo. A significant increase in insulin level at 1 h post dose of Damtab (1,400 mg) was observed. Damtab 700 mg shows placebo like effect whereas Damtab 1,400 mg possesses hypoglycemic effect.

• 대한방사선기술학회지:방사선기술과학
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• 제2권1호
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• pp.15-22
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• 1979

Author made a experiment on the exposure dose with various intensifying screens in taking chest roentgenogram and obtained the results as follows; 1. Special speed type was the most sensitive intensifying screen, the r(gamma) value of this screen was distributed from 2.6 to 2.9. 2. The resolution activity of intensifying screen was inversely proportional to its sensitivity. If, the sensitivity and detail of the fine detail speed type intensifying screen at 100 KV were 100, those of the special speed type were 549 and 54.44 respectively. 3. If the exposure dose of the fine detail type intensifying screen was 1.0 at 60 KV, that of the special speed type intensifying screen was 0.1 at 80KV, and the skin dose of patient was as follows; it was 64.8 mRad at 60KV in mid speed type, 8.1 mRad at 80KV in super high speed type, and 7.2 mRad at 80KV in special speed type intensifying screen respectively.

• 한국산학기술학회논문지
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• 제4권3호
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• pp.223-229
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• 2003

ICRP-60 신권고에 맞게 수정된 방사선피폭선량 계산프로그램인 K-DOSE 60을 4개 발전소 (고리, 월성, 울진, 영광)에 적용하여 주변주민 최대개인피폭선량을 평가하였다 핵종, 장기, 경로별로 결정변수값들을 도출한 결과, 경로는 성인의 경우 농작물, 유아의 경우 우유가, 핵종은 ³H, /sup 133/Xe, /sup 60/Co (고리 1,2발전소), /sup 14/C, /sup 41/Ar(월성 1,2발전소)로 나타났으며, 모든 장기에 대한 피폭선량차이가 매우 작았다. "출력 대 입력" 변동에 근거한 민감도 분석결과, 핵종의 화학적 형태가 타 입력변수들보다 10² factor만큼 높은 민감도를 보였으며, 전이/농축계수에 의한 민감도는 섭취량이나 방출량의 그것에 비하여 상대적으로 매우 낮았다. PCC를 이용한 상관성 민감도의 경우는 4가지 입력변수 모두 0.97 이상의 높은 상관성을 보였다.

• 대한방사선기술학회지:방사선기술과학
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• 제46권3호
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• pp.219-229
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• 2023

In this study, basic characteristics such as reproducibility, linearity, and directionality of RPL glass dosimeters were evaluated to improve the reliability of dose evaluation through RPL glass dosimeters, and uncertainty elements such as sensitivity by glass element and magazine slot sensitivity were evaluated. Using a mathematical model to calibrate the measured values of the RPL glass dosimeter, the measurement uncertainty was calculated assuming an example. As a result of the characteristic evaluation, the RPL glass dosimeter showed excellent performance with a standard deviation of ±1% (1 SD) for the reproducibility of the reading process, a coefficient of determination for linearity of 0.99997. And the read-out of the RPL glass dosimeter are affected by the circular rotation direction of the glass dosimeter during irradiation, fading according to the period after irradiation, the number of laser pulses of the reader, and response degradation due to repeated reading, it is judged that measurement uncertainty can be reduced by irradiation and reading in consideration of these factors. In addition, it was confirmed that the dose should be determined by calculating the correction factors for the sensitivity of each element and, the sensitivity of each reading magazine slot. It is believed that the reliability of dosimetry using glass dosimeters can be improved by using a mathematical model for correction of glass dosimeter readings and calculating measurement uncertainty.