• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10381-10385
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• 2015

SKI-II has been reported as an inhibitor of sphingosine kinase 1 and has been extensively used to prove the involvement of sphingosine kinase and sphingosine-1-phosphate (Sphk1) in cellular processes. In the current study, we investigated the effects of SKI-II and its potential mechanisms in human gastric cancer SGC7901 cells. After treatment with SKI-II, cell growth, cell cycle distribution, apoptosis, expression of Sphk1, NF-${\kappa}B$, Bcl-2, Bax and p27 were assessed by MTT assay, flow cytometry, electron microscopy, immunocytochemistry and Western-blot assay, respectively. Our results showed that SKI-II markedly inhibited SGC7901 cell survival in a dose-dependent manner, reduced cell proliferation with accumulation of cells in the G0/G1 phase and induced apoptosis in the tumor cells. Furthermore, Western blotting and immunocytochemistry showed that the expression of p27 and Bax was increased significantly, but the expression of NF-${\kappa}B$, Bcl-2 and Sphk1 decreased by different degrees. These results indicate that SKI-II induced cell growth arrest and apoptosis. The increased apoptotic sensitivity of SGC7901 was correlated with NF-${\kappa}B$ or Bcl-2/Bax activation.

• Journal of Astronomy and Space Sciences
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• 제19권2호
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• pp.151-162
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• 2002

인공위성에서의 우주방사선 차폐계산을 위한 근사계산 방법으로 sectoring method를 적용하는 방법과 chord-length 분포를 이용하는 방법을 상세 계산 결과와 비교하였다. 저 궤도 위성인 우리별 1호를 대상으로 양성자의 차폐계산을 수행하였다. 이때 방사선환경은 AP-8 model을 이용하여 구한 SAA(South Atlantic Anomaly)지역으로 가정하였다. Sectoring method와 chord-length 분포를 이용하는 방법은 양성자가 물질내에서 직진한다는 기본적인 가정을 사용하므로 3차원 상세계산 결과와 비교하여 어느 정도의 오차를 갖는다. 그러나 우리별 1호를 대상으로 수행된 계산 결과에서 두 계측기 위치에서의 피폭량 예측은 2가지 근사모델이 모두 상세계산 결과와 근사하게 일치하였다.

• 한국응용과학기술학회지
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• 제19권1호
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• pp.56-62
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• 2002

Microemulsion is stable to aggregation, sedimentation, fusion and has $3nm{\sim}200nm$ of particle size which is transparent and semitransparent. The isoflavone as a derivatives of Flavone is colorless crystalline compounds. It has similar basic structure to steroid materials which is hormone that acts to skin physiological phenomenon. On this study, we tried to search and demonstrate system content rate of dermal translocation system for cosmetics using O/W type microemulsion containing isoflavone. We manufactured O/W microemulsions by phase inversion emulsification method. It's was found that POE(20) monostearate with HLB value 14 caused microemulsion to be formed, which had $4nm{\sim}18nm$ of average diameter and $3nm{\sim}33nm$ of particle size distribution. Apparent viscosities of the microemulsions have increased in proportion to add surfactant dose.

• 한국응용과학기술학회지
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• 제15권4호
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• pp.11-20
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• 1998

The propagation of light radiation in a turbid medium is an important problem that confronts dosimetry of therapeutic laser delivery and the development of diagnostic spectroscopy. Scattered light is measured as a function of the position(distance r, depth z) between the axis of the incident beam and the detection spot. Turbid sample yields a very forward-directed scattering pattern at short range of position from source to detector, whereas the thicker samples greatly attenuated the on-axis intensity at long range of position. The portions of scattered light reflected from or transmitted throughphantom depend upon internal reflectance and absorption properties of the phantom. Monte Carlo simulation method for modelling light transport in tissue is applied. It uses the photon is moved a distance where it may be scattered, absorbed, propagated, internally reflected, or transmitted out of tissue. The photon is repeatedly moved until it either escape from or is absorbed by the phantom. In order to obtain an optimum therapeutic ratio in phantom material, optimum control the light energy fluence rate is essential. This study is to discuss the physical mechanisms determining the actual light dose in phantom. Permitting a qualitative understanding of the measurements. It may also aid in designing the best model for laser medicine and application of medical engineering.

• 상하수도학회지
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• 제32권2호
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• pp.183-192
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• 2018

Applicability of corrosion inhibitor was evaluated using pilot scale water distribution pipe simulator. Calcium hydroxide was used as corrosion inhibitor and the corrosion indices of the water were investigated. Corrosion indices, Langelier saturation index (LI) increased by 0.8 and calcium carbonate precipitation potential (CCPP) increased by 9.8 mg/L. This indicated that corrosivity of water decreased by corrosion inhibitor and the effects lasted for 18 days. Optimum calcium hydroxide dose was found to be 3~5 mg/L for corrosion inhibition. We suggest that monitoring of CCPP as well as LI need to be conducted to control corrosivity of water.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8419-8423
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• 2016

Purpose: Anti-cancer activity evaluation of aqueous extract of CRUEL (herbomineral formulation) capsules on renal cell carcinoma cell lines, and exploration of mechanisms of cell death. Materials and Methods: To detect the cytotoxic dose concentration in renal cell carcinoma (RCC) cells, MTT assays were performed and morphological changes after treatment were observed by inverted microscopy. Drug effects against RCC cell lines were assessed with reference to cell cycle distribution (flow cytometry), anti-metastatic potential (wound healing assay) and autophagy(RT-PCR). Results: CRUEL showed anti-proliferative effects against RCC tumor cell lines with an IC50 value of ${\approx}4mg/mL$ in vitro., while inducing cell cycle arrest at S-phase of cell cycle and inhibiting wound healing. LC3 was found to be up-regulated after drug treatment in RT-PCR resulting in an autophagy mode of cell death. Conclusions: This study provides the experimental validation for antitumor activity of CRUEL.

• Nuclear Engineering and Technology
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• 제52권6호
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• pp.1282-1288
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• 2020

In the first study, the Radon emanation and radiological hazards associated with radionuclides in soil samples, collected from 9 various date palm farms located in 3 different districts in Saudi Arabia were determined through a high purity Germanium (HPGe) gamma-ray spectrometer. The estimated average values of Radon emanation coefficient and Radon mass exhalation rate for soil samples were 0.535 ± 0.016 and 50.063 ± 7.901 mBqkg^-1h^-1, respectively. The annual effective dose of radionuclides in all sampling locations was found to be lower than UNSCEAR's recommended level of 0.07 mSvy^-1 for soil in an outdoor environment. In the secondary study, gross α and gross β activities in soil and date palm pits samples were measured by a low background α/β counting system. Average values of gross α and gross β activities in soil and date palm pits samples were 5.761 ± 0.360 Bqkg^-1, 38.219 ± 8.619 Bqkg^-1 and 0.556 ± 0.142 Bqkg^-1, 24.266 ± 1.711 Bqkg^-1, respectively.

• 대한지리학회지
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• 제46권1호
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• pp.81-99
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• 2011

본 연구는 다각적으로 이루어지고 있는 물류산업의 공간적 연구를 종합적으로 정리하여 이를 체계화 하고자 함이다. 물류산업은 물류기능별 독립적 최적화, 전문화된 물류서비스를 제공하는 자재관리와 물적유통, 로지스틱스, 정보통신 기술과 경영이 포함된 공급사슬관리 단계로 발전하면서 복잡한 공간조직을 형성한다. 물류산업의 복잡한 공간조직은 지리공간과 가상공간, 분업과 통합, 매개화와 탈매개화로 체계화된다. 또한 이들 세 가지의 영역이 공간상에서 혼재하는 역동적 특성을 보인다. 이 역동적 특성은 정보통신 기술과 경제활동의 공간 간의 상호작용과 밀접한 관계가 있다.4

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.247-255
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• 1995

The purpose of this study was to evaluate the polymorphism in parotid middle-band protein(Pm) of the patients with diabetes mellitus. Saliva from the parotid glands was collected from 60 healthy Korean who were live in Kwan-ju and from 33 diabetes mellitus patients who had more than 140mg/dl of fasting blood sugar for on week. In the saliva collected from parotid glands, Pm was analyzed to evaluate the distribution of phenotype using acid-urea starch gel elecrophores is The following results were obtained : 1. The phenotypes of parotid middle band protein(Pm) observed in parotid saliva of the control group(60 people) were Pm(+) in 38 people (63.3%) and Pm(-) in 22 people (36.7%). The gene frequency of Pm+ was0.394, and that of Pm- was 0.606. 2. The phenotypes of parotid middle band protein(Pm) observed in parotid saliva of the diabetes mellitus patient group(33 patients) were Pm(+) n 21 patients(63.6%) and Pm(-) in 12 patients (36.4%). The gene frequency of Pm+ was 0.397, and that of Pm- was 0.693 3. Pm dose not have significant differences between phenotypes on both the control group and the diabetes mellitus patient group.

• Archives of Pharmacal Research
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• 제12권3호
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• pp.154-159
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• 1989

Pharmacokinetics and urinary excretion of sulfamethoxazole were investigated in healthy sheep. From the plasma disappearance curves after intravenous bolus injection (50 mg/kg), the half-life and volume of distribution were found to be 76 $\PM$14 min and 0.41 $\PM$ 0.18 lit/kg respectively. Body clearance was 4.06 $\PM$ 1.03 ml/kg/min. Very low Concentration of ddrug was present in plasma after 3 hours of administration and plasma level at 6 hour was only 4.4 $\PM$ 2.0 $\mu$g/ml. The renal clearance of sulfamethoxazole (22 $\PM$ 2.17 ml/min/10 kg) exeeded the creatinine clearance (9.78 $\PM$ 1, 57 ml/min/ 10 kg) which may be due to involvement of active tubular secretion and pH dependent back diffusion. Half of the dose of sulfamethoxazole was excreted as unchanged free drug while acetylated amine comprised of 20 percent within the first 6 hours of drug administration.