• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.2
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• pp.89-97
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• 2020

In this study, a numerical analysis was performed on 26 inch single and coaxial propeller using the ANSYS Fluent 19.0 Solver to analyse the effect of the distance between coaxial propellers as one of the design parameter. The Moving Reference Frame (MRF) method was used for single propeller, while the sliding mesh method was used for a coaxial propeller to analyse the flow field varying with azimuth angle. The thrust and power are decreased as the upper and lower propeller approaching each other. As H/D is increased, interference between the propellers is decreased. According to the flow field variable contour of the coaxial propeller, it appears that the change in aerodynamic performance is due to the loading effect and the tip vortex wake effect.

• Journal of Genetic Medicine
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• v.12 no.2
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• pp.118-122
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• 2015

Noninvasive prenatal test (NIPT) is a novel screening method for the diagnosis of fetal chromosomal aneuploidies. NIPT is based on technology that detects cell-free fetal DNA in maternal plasma and analyzes it with massively parallel sequencing technology to determine whether the fetus is at risk of trisomy 21, trisomy 18, trisomy 13 or sex chromosome abnormalities (SCAs). NIPT has been reported to have sensitivity of 99% and a false positive rate of less than 1% for detecting trisomy 21 and trisomy 18. Although extension of the application of NIPT to other SCAs has been attempted, there are concerns in extending NIPT to SCAs because of maternal or fetal mosaicism, undetected maternal SCAs, and multiple pregnancies. Recently, we assessed a pregnancy with the rare Turner syndrome mosaicism 45, X/47, XXX, which was reported as 45, X with NIPT. We present the case here and briefly review the current literatures on NIPT in testing for fetal monosomy X. To the best of our knowledge, this is the first report of the 45, X/47, XXX mosaicism in Korea to be reported as 45, X by NIPT with whole genome sequencing. This case report will provide valuable information for counseling women who want to undergo NIPT.

• Journal of Advanced Marine Engineering and Technology
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• v.36 no.6
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• pp.802-807
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• 2012

Self-piercing rivet is sheet joining method. It is being used more to join aluminum alloy sheets. Self-piercing riveting is a large-deformation process that involves piercing. The self-piercing rivet, under the press from the punch, pierces the top sheet and forms a mechanical interlock with the bottom sheet. In this study, forging process was designed for manufacturing self-piercing rivet. The forging process has been simulated by using commercial FEM code DEFORM-2D. In simulation of forging process for manufacturing rivet, process sequence, formability, forging load, and distributions of stress and strain were investigated. The suitable forging process could be designed by comparisons of simulation results. The developed process consists of four stages: upsetting, first chamfering, back extrusion, and second chamfering. The simulated results for forging process were confirmed by experimental trials with the same conditions.

• The Journal of Korean Medicine
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• v.27 no.1 s.65
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• pp.78-90
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• 2006

Background : Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well. In recent years, extensive focus was laid on adulteration of the herbal medicine with liver damage. The use of herbal preparations as remedies for various medical conditions has continuously increased in Korea. Large proportions of Korean patients use herbal medicinal products, folk remedies, and health food. However, studies on the safety of herbal products are conducted on a less than sufficient basis even in the countries like Korea where herbal medicine is being used extensively. Some of the reports on the safety of herbs were done by the doctors of western medicine but lack of knowledge and misclassification led to misunderstandings. Objectives : This study aims to verify the evidences on safety of frequently used 4 herbal medications (Sipjeondaebo-tang, Bojungikgi-tang, Ohjeok-San, Yukmaijihwang-tang) in the lab animal model. Methods : Sprague-Dawley rats was treated by 4 herbal medications during 31 days. After 1 month, we checked body weight, liver weight, and serum enzyme associated with liver function. Results : There is no significant difference in body weight and liver weight after 1 month of administrations. In all experimental groups, no abnormal findings was observed in histotogical research and lab liver Functions test(AST, ALT etc). Conclusions : These four herbal medications, frequently used in oriental medicine clinics and hospitals, are safe from hepatoxic events in the lab animal model.

• The Journal of Internal Korean Medicine
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• v.25 no.3
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• pp.633-639
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• 2004

A varicose vein of the lower limbs is dilated, tortuous and elongated vein. Western medical treatment involves conservative management, sclerotherapy, and surgery. Currently, internal medicinal treatment is inadequate. Recently a patient was diagnosed with varicose veins of the lower limbs based on clinical symptoms. In this case, Guibi-tang was administered and clinical symptoms improved. This report suggests that oriental medicinal treatment is efficacious in treating varicose veins of the lower limbs. We think that further oriental medical studies on various surgical diseases are needed.

• The Journal of Internal Korean Medicine
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• v.37 no.1
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• pp.26-46
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• 2016

Objectives: The purpose of this study was to present the clinical guidelines and traditional Korean medicines for gastric cancer.Results: Gastric cancer is the second most common cancer in Korea. Recent studies have reported that applying integrative Oriental and Western medicine can suppress the tumor, improve the survival, the immune system, and the quality of life in gastric cancer. However, there still is no unified protocol for gastric cancer treatment, which produces difficulty in clinical applications. In Korea, a “Synopsis on the Clinical Practice Guidelines of Gastric Cancer” was published by the Korean Journal of Gastroenterology in 2014. In China, Oriental medicine clinical practice guidelines were published for the first time in 2014. The present author proposed “Clinical Practice Guidelines of Korean Medicine for Gastric Cancer” in 2014, but there is a need for more advanced guidelines with reference to the aforementioned Oriental and Western guidelines. This study will be helpful for understanding and building systems for integrative gastric cancer treatment.Conclusions: Further studies on integrative gastric cancer treatment are needed to improve the survival of gastric cancer patients and build the clinical practice guidelines for gastric cancer.

• The Journal of Internal Korean Medicine
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• v.41 no.2
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• pp.177-185
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• 2020

This study investigated the clinical effect of Korean medicine treatments on two patients who experienced gastrointestinal symptoms with anxiety disorder. The patients were treated with herbal medicine (Yukgunja-tang, Banhabakchulchunma-tang) and acupuncture for 11 days and 26 days, respectively. The Beck Anxiety Inventory (BAI) and Gastrointestinal Symptom Rating Scale (GSRS) scores on the day of hospital admission and after treatment were compared; both the BAI and GSRS scores decreased after treatment. Moreover, the grade of the gastrointestinal symptoms changed from severe to mild or none. Therefore, these cases are useful for describing Korean medicine treatments for anxiety disorders in patients who experience gastrointestinal symptoms. However, additional case reports and studies are be needed in the future to confirm these findings.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.780-786
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• 2003

This study was carried out to know the immunity responses of the Spatholubus suberectus Dunn(hereinafter referred to STSD) to the synovial cells isolated from patients with rheumatoid arthritis. Various experiments were performed in vitro to analyse the immunity effects of STSD. Gene expression and production of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, iNOS and COX-2 were determined by RT-PCR and ELISA kit. And also the binding activity of NF-kB and AP-1 were measured by Electromobility shift assay (EMSA) and the production of ROS was measured by flow cytometry. The results were obtained as follows 1. The gene expression and production of pro-inflammatory cytokines IL-1β, IL-6, TNF-α were reduced significantly. 2. The gene expression of iNOS and COX-2 were reduced. 3. The binding activity of NF-kB and AP-1 were inhibited. 4. The production of ROS in human synovial cells was reduced significantly. Comparison of the results for this study showed that STSD had immunomodulatory effects of suppressing or enhancing. So we expect that STSD should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

• Parasites, Hosts and Diseases
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• v.44 no.3
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• pp.187-196
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• 2006

The mammalian trematode Paragonimus westermani is a typical digenetic parasite, which can cause paragonimiasis in humans. Host tissues and blood cells are important sources of nutrients for development, growth and reproduction of P. westermani. In this study, a cDNA clone encoding a 47 kDa hemoglobinase of P. westermani was characterized by sequencing analysis, and its localization was investigated immunohistochemically. The phylogenetic tree prepared based on the hemoglobinase gene showed high homology with hemoglobinases of Fasciola hepatica and Schistosoma spp. Moreover, recombinant P. westermani hemoglobinase degradaded human hemoglobin at acidic pH (from 3.0 to 5.5) and its activity was almost completely inhibited by E-64, a cysteine proteinase inhibitor. Immunohistochemical studies showed that P. westermani hemoglobinase was localized in the epithelium of the adult worm intestine implying that the protein has a specific function. These observations suggest that hemoglobinase may act as a digestive enzyme for acquisition of nutrients from host hemoglobin. Further investigations may provide insights into hemoglobin catabolism in P. westermani.

• Journal of Korea Spatial Information System Society
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• v.11 no.3
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• pp.31-39
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• 2009

Requirement level regarding processing and managing real-time datastream in an ubiquitous environment is increased. Especially, due to the unbounded, high frequency and real-time characteristics of datastream, development of specialized stroge manager for DSMS is necessary to process such datastream. Existing DSMS, e.g. Coral8, can support datastream processing but it is not scalable and cannot perform well when handling large-volume real-time datastream, e.g. 100 thousand over per second. In the case of Oracle10g, which is generally used in related field, it supports storing and management processing. However, it does not support real-time datastream processing. In this paper, we propose specialized storage manager of DSMS for real-time compressed storing on semiconductor or LCD production facility of Samsung electronics, Hynix and HP. Hynix and HP. This paper describes the proposed system architecture and major components and show better performance of the proposed system compared with similar systems in the experiment section.