Molecular and biochemical characterization of hemoglobinase, a cysteine proteinase, in Paragonimus westermani
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Choi Joon-Hyuck
(Department of Parasitology, Kyungpook National University School of Medicine)
Lee Jae-Hyuk (Department of Parasitology, Kyungpook National University School of Medicine) Yu Hak-Sun (Department of Parasitology, Pusan National University School of Medicine) Jeong Hae-Jin (Department of Parasitology, Pusan National University School of Medicine) Kim Jin (Department of Parasitology, College of Medicine, Seonam University) Hong Yeon-Chul (Department of Parasitology, Kyungpook National University School of Medicine) Kong Hyun-Hee (Department of Parasitology, Kyungpook National University School of Medicine) Chung Dong-Il (Department of Parasitology, Kyungpook National University School of Medicine) |
1 | Becker MM, Harrop SA, Dalton JP, Kalinna BH, McManus DP, Brindley PJ (1995) Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation. J Biol Chem 270: 24496-24501 DOI ScienceOn |
2 | Brown A, Burleigh JM, Billett EE, Pritchard DI (1995) An initial characterization of the proteolytic enzymes secreted by the adult stage of the human hookworm Necator americanus. Parasitology 110: 555-563 DOI |
3 | Carmona C, Dowd AJ, Smith AM, Dalton JP (1993) Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles. Mol Biochem Parasitol 62: 9-17 DOI ScienceOn |
4 | Dahl EL, Rosenthal PJ (2005) Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol 139: 205-212 DOI ScienceOn |
5 | Hamajima F, Yamakami K, Fujino T (1985) Localization of a thiol protease in metacercarial lung fluke. Jpn J Parasitol 34: 507-508 |
6 | el Meanawy MA, Aji T, Phillips NF, Davis RE, Salata RA, Malhotra I, McClain D, Aikawa M, Davis AH (1990) Definition of the complete Schistosoma mansoni hemoglobinase mRNA sequence and gene expression in developing parasites. Am J Trop Med Hyg 43: 67-78 DOI |
7 | Merckelbach A, Hasse S, Dell R, Eschlbeck A, Ruppel A (1994) cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32. Trop Med Parasitol 45: 193-198 |
8 | Na BK, Kim SH, Lee EG, Kim TS, Bae YA, Kang I, Yu JR, Sohn WM, Cho SY, Kong Y (2006) Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae. Cell Microbiol 8: 1034-1046 DOI ScienceOn |
9 | Silva FP Jr, Ribeiro F, Katz N, Giovanni-De-Simone S (2002) Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling. FEBS Letter 514: 141-148 DOI ScienceOn |
10 | Toscano C, Yu SH, Nunn P, Mott KE (1995) Paragonimiasis and tubeculosis, diagnostic confusion: a review of the literature. Trop Dis Bull 92: R1-R26 |
11 | Williamson AL, Brindley PJ, Abbenante G, Datu BJ, Prociv P, Berry C, Girdwood K, Pritchard DI, Fairlie DP, Hotez PJ, Zhan B, Loukas A (2003) Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion. J Infect Dis 187: 484-494 DOI ScienceOn |
12 | Williamson AL, Brindley PJ, Abbenante G, Prociv P, Berry C, Girdwood K, Pritchard DI, Fairlie DP, Hotez PJ, Dalton JP, Loukas A (2002) Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity. FASEB J 16: 1458-1460 DOI |
13 | Yang SH, Park JO, Lee JH, Jeon BH, Kim WS, Kim SI, Yun KJ, Jeong ET, Lee KW, Kim YM, Lee MH, Park H (2004) Cloning and characterization of a new cysteine proteinase secreted by Paragonimus westermani adult worms. Am J Trop Med Hyg 71: 87-92 |
14 | Park H, Hong KM, Sakanari JA, Choi JH, Park SK, Kim KY, Hwang HA, Paik MK, Yun KJ, Shin CH, Lee JB, Ryu JS, Min DY (2001) Paragonimus westermani: cloning of a cathepsin F-like cysteine proteinase from the adult worm. Exp Parasitol 98: 223-227 DOI ScienceOn |
15 | Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ (2001) Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem J 360: 481-489 DOI |
16 | Auriault C, Pierce R, Cesari IM, Capron A (1982) Neutral protease activities at different developmental stages of Schistosoma mansoni in mammalian hosts. Comp Biochem Physiol B 72: 377-384 DOI ScienceOn |
17 | Berry C, Humphreys MJ, Matharu P, Granger R, Horrocks P, Moon RP, Certa U, Ridley RG, Bur D, Kay J (1999) A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum. FEBS Letter 447: 149-154 DOI ScienceOn |
18 | Chung YB, Yang HJ, Kang SY, Kong Y, Cho SY (1997) Activities of different cysteine proteases of Paragonimus westermani in cleaving human IgG. Korean J Parasitol 35: 139-142 DOI |
19 | Gotz B, Klinkert MQ (1993) Expression and partial characterization of cathepsin B-like enzyme(Sm31) and a proposed 'haemoglobinase' (Sm32) from Schistosoma mansoni. Biochem J 290: 801-806 DOI |
20 | Park GM, Lee KJ, Im KI, Park H, Young TS (2001) Occurence of a diploid type and a new first intermediate host of a human lung fluke, Paragonimus westermani, in Korea. Exp Parasitol 99: 206-212 DOI ScienceOn |
21 | Serrano-Luna JJ, Negrete E, Reyes M, de la Garza M (1998) Entamoeba histolytica HM1: IMSS: hemoglobin-degrading neutral cysteine proteases. Exp Parasitol 89: 71-77 DOI ScienceOn |
22 | Silva AM, Lee AY, Gulnik SV, Maier P, Collins J, Bhat TN, Collins PJ, Cachau RE, Luker KE, Gluzman IY, Francis SE, Oksman A, Goldberg DE, Erickson JW (1996) Structure and inhibition of plasmepsin II, a hemoglobin degrading enzyme from Plasmodium falciparum. Proc Natl Acad Sci USA 93: 10034-10039 |
23 | Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH (1989) Serine proteases from nematode and protozoan parasites isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci USA 86: 4863-4867 |
24 | Gallego SG, Slade RW, Brindley PJ (1998) A cDNA encoding a pepsinogen-like, aspartic protease from the human roundworm parasite Strongyloides stercoralis. Acta Trop 71: 17-26 DOI ScienceOn |
25 | Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ (2004) Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis 189: 1952-1961 DOI ScienceOn |
26 | Piekarski G (1989) Medical Parasitology. Springer, Berlin, p. 154 |
27 | Shim YS, Cho SY, Han YC (1991) Pulmonary paragonimiasis: a Korean perspective. Semin Respir Med 12: 35-45 DOI |
28 | Caffrey CR, McKerrow JH, Salter JP, Sajid M (2004) Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol 20: 241-248 DOI ScienceOn |
29 | Hata H, Yokogawa M, Kobayashi M, Niimura M, Kojima S (1987) In vitro cultivation of Paragonimus miyazakii and P. ohirai. J Parasitol 73: 792-796 DOI ScienceOn |
30 | Ray C, McKerrow JH (1992) Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Mol Biochem Parasitol 51: 239-249 DOI ScienceOn |
31 | Tamashiro WK, Rao M, Scott AL (1987) Proteolytic cleavage of IgG and other protein substrates by Dirofilaria immitis microfilarial enzymes. J Parasitol 73: 149-154 DOI ScienceOn |
32 | Harrop SA, Prociv P, Brindley PJ (1996) Acasp, a gene encoding a cathepsin D-like aspartic protease from the hookworm Ancylostoma caninum. Biochem Biophys Res Commun 227: 294-302 DOI ScienceOn |
33 | Baig S, Damian RT, Peterson DS (2002) A novel cathepsin B active site motif is shared by helminth bloodfeeders. Exp Parasitol 101: 83-89 DOI ScienceOn |
34 | Hawthorne SJ, Halton DW, Walker B (1994) Identification and characterization of the cysteine proteinase and serine proteinases of the trematode, Haplometra cylindracea and determination of their haemoglobinase activity. Parasitology 108: 595-601 DOI |
35 | Moon RP, Tyas L, Certa U, Rupp K, Bur D, Jacquet C, Matile H, Loetscher H, Grueninger-Leitch F, Kay J, Dunn BH, Berry C, Ridley RG (1997) Expression and characterisation of plasmepsin I from Plasmodium falciparum. Eur J Biochem 244: 552-560 DOI ScienceOn |
36 | Brady CP, Dowd AJ, Brindley PJ, Ryan T, Day SR, Dalton JP (1999) Recombinant expression and localization of Schistosoma mansoni cathepsin L1 support its role in the degradation of host hemoglobin. Infect Immun 67: 368- 374 |
37 | Longbottom D, Redmond DL, Russell M, Liddell S, Smith WD, Knox DP (1997) Molecular cloning and characterization of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus. Mol Biochem Parasitol 88: 63-72 DOI ScienceOn |
38 | McKerrow JH (1989) Parasite protease. Exp Parasitol 68: 111- 115 DOI ScienceOn |
39 | Dalton JP, Hola-Jamriska L, Brindley PJ (1995) Asparaginyl endopeptidase activity in adult Schistosoma mansoni. Parasitology 111: 575-580 DOI |
40 | Goldberg DE, Slater AF, Cerami A, Henderson GB (1990) Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proc Natl Acad Sci USA 87: 2931-2935 |
41 | Otto HH, Schirmeister T (1997) Cysteine proteinase and their inhibitors. Chem Rev 97: 133-172 DOI ScienceOn |
42 | Yun DH, Chung JY, Chung YB, Bahk YY, Kang SY, Kong Y, Cho SY (2000) Structural and immunological characteristics of a 28-kilodalton cruzipain-like cysteine protease of Paragonimus westermani expressed in the definitive host stage. Clin Diagn Lab Immunol 7: 932-939 DOI |
43 | Chung YB, Kong Y, Joo IJ, Cho SY, Kang SY (1995) Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease. J Parasitol 81: 137-142 DOI ScienceOn |
44 | Kim TS, De-Guzman JV, Kong HH, Chung DI (2006) Comparison of gene representation between diploid and triploid Paragonimus westermani by expressed sequence analyses. J Parasitol 92: (in press) |
45 | Rosenthal PJ, Mckerrow JH, Aikawa M, Nagasawa H, Leech JH (1988) A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest 82: 1560-1566 DOI |
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