• BMB Reports
• /
• v.43 no.1
• /
• pp.17-22
• /
• 2010

In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicates that a 77 kD protein specific for KBTBD7 is wildly expressed in all embryonic tissues examined. In COS-7 cells, KBTBD7 proteins are localized to the cytoplasm. KBTBD7 is a transcription activator when fused to GAL4 DNA-binding domain. Deletion analysis indicates that the BTB domain and kelch repeat motif are main regions for transcriptional activation. Overexpression of KBTBD7 in MCF-7 cells activates the transcriptional activities of activator protein-1 (AP-1) and serum response element (SRE), which can be relieved by siRNA. These results suggest that KBTBD7 proteins may act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

• The Journal of the Korea Contents Association
• /
• v.20 no.3
• /
• pp.200-208
• /
• 2020

The domain of Web design gradually expands with the utilization of the Web and the development of technologies, but there are insufficient related studies. Thus, this study would recognize the importance of the Web design market and present the direction of designs in the future by investigating the process of changes in Web design. This study investigated the background of the revelation and evolution of design expression techniques and the flow of the information technology affecting the design and conducted a study analyzing the process of changes of Web design based on this. It is judged that this study has significance as the baseline research material for the expansion of the Web design domain of the future. As for the scope of the research, based on 30 years of the history of the Web, this study was conducted with materials on Websites, which had become issues from 1990 through the early-2000s and selected the winners of a grand prize in Web Award Korea since the mid-2000s as the subjects of analysis. This study analyzed the formative characteristics of design expression techniques and the characteristics of the information technology that affected Web design. As a result of the research, changes in design expression techniques could be divided broadly into minimalism and skeuomorphism, and it was found that the methods of expressing Web designs changed in various ways, affected by the development of information technology. It is predicted that with the emergence of various devices and the vitalization of video contents, the designs affected by minimalism, which can harmonize with them, will continue in the future.

• Journal of Intelligence and Information Systems
• /
• v.13 no.1
• /
• pp.59-79
• /
• 2007

P2P (Peer to Peer) techniques have been well applied to file sharing due to its cost-effectiveness and convenience. Dynamic network evolution is another good thing for P2P according to addition and deletion of nodes and change of files a node has. Our research proposes a P2P-based KMS (Knowledge Management System). Knowledge of enterprises spreads all over sub-organizations like oversea factories and sales departments and is changed in dynamic manner. P2P techniques are, therefore well matched with knowledge management domain. In order to increase search efficiency, we introduce social network theory into P2P-based KMS. Social network technique makes the most similar nodes (in KMS domain, nodes which has the most similar knowledge) its own neighbors, which makes eventually search efficiency increase. We developed our prototype system P2P-SN-KMS and evaluated by simulation.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.41 no.1
• /
• pp.40-47
• /
• 2013

The similarity in internal flow of solid and hybrid rocket suggests that hybrid rocket combustion can be susceptible to instability due to vortex sheddings and their interaction. This study focuses on the evolution of interaction of vortex generated in pre-chamber with other types of vortex in the combustor and the change of combustion characteristics. Baseline and other results tested with disks show that there are five different frequency bands appeared in spectral domain. These include a frequency with thermal lag of solid fuel, vortex shedding due to obstacles such as forward, backward facing step and wall vortices near surface. The comparison of frequency behavior in the cases with disk 1 and 3 reveals that vortex shedding generated in pre-chamber can interact with other types of vortex shedding at a certain condition. The frequency of Helmholtz mode is one of candidates resulting to a resonance when it was excited by other types of oscillation even if this mode was not discernable in baseline test. This selective mechanism of resonance may explain the reason why non-linear combustion instability occurs in hybrid rocket combustion.

• Bulletin of the Korean Chemical Society
• /
• v.33 no.3
• /
• pp.933-940
• /
• 2012

Recently, it has been shown that quantum coherence appears in energy transfers of various photosynthetic lightharvesting complexes at from cryogenic to even room temperatures. Because the photosynthetic systems are inherently complex, these findings have subsequently interested many researchers in the field of both experiment and theory. From the theoretical part, simplified dynamics or semiclassical approaches have been widely used. In these approaches, the quantum-classical Liouville equation (QCLE) is the fundamental starting point. Toward the semiclassical scheme, approximations are needed to simplify the equations of motion of various degrees of freedom. Here, we have adopted the Poisson bracket mapping equation (PBME) as an approximate form of QCLE and applied it to find the time evolution of the excitation in a photosynthetic complex from marine algae. The benefit of using PBME is its similarity to conventional Hamiltonian dynamics. Through this, we confirmed the coherent population transfer behaviors in short time domain as previously reported with a more accurate but more time-consuming iterative linearized density matrix approach. However, we find that the site populations do not behave according to the Boltzmann law in the long time limit. We also test the effect of adding spurious high frequency vibrations to the spectral density of the bath, and find that their existence does not alter the dynamics to any significant extent as long as the associated reorganization energy is changed not too drastically. This suggests that adopting classical trajectory based ensembles in semiclassical simulations should not influence the coherence dynamics in any practical manner, even though the classical trajectories often yield spurious high frequency vibrational features in the spectral density.

• The Transactions of the Korea Information Processing Society
• /
• v.2 no.1
• /
• pp.23-33
• /
• 1995

This paper describes a visual programming tool which provides novice programmer as well expert with the abilites to capture real physical world of problem domain and to manipulate it user-friendly using icons and symbols. Therefore, novice can understand object-oriented features of C＋＋ incrementally and construct classes easily. For this, we introduce some visual metaphors which are displayed as tables. The tables can not only represent objects and classes, but also be considered themselves as icons. We have named these tables as table-icons. Three levels of table-icons(i.e., Super Table-Icons, Intermediate Table-Icons and Detailed Table-Icons) are proposed to follow up appropriate evolution of object-oriented concepts. Table-icons are not simple pictographs but are activated and expanded to table forms. And then, developer can inset necessary entities into table body and delete useless entities from it. These table-icons are applied to a diagramming technique, C＋＋gram［18］, which is suggested for designing and implementing C＋＋ programs.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.7 no.5
• /
• pp.925-933
• /
• 2003

Network is expected to be developed into optical Internet network collected IP layer and optical layer, but GMPLS is risen at the transitional evolution stage because of the present technology level. GMPLS that MPLS is extended and generalized is able to support not only the packet switching device but also the devices which perform switching in time, wavelength, and space domain. To implement the common control plane to these various switching types, GMPLS extends the existing MPLS signaling and routing protocol. In this paper, we describe the overview of GMPLS technology, and then we will refer to the OSPF(Open Shortest Path First), which was used to exchange the status information of link, as the plan of routing extension to exchange the information of various link type, bandwidth, link protection type etc. And also, we describe the definition of new protocol, so called, LMP that is a signaling protocol for solving complex problem which manages hundreds and thousands of links between two nodes. And we will examine and analyze the plan of signaling protocol extension to apply signaling protocol RSVP-TE(Resource Reservation Protocol) for traffic engineering in MPLS to network, and the message objects and formats associated with modified RSVP.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.7 no.1
• /
• pp.41-55
• /
• 2003

A dynamically-interfaced multi-grid finite difference model for simulation of tsunamis in the East Sea(Choi et al.) was established and further applied to produce detailed feature of coastal inundations along the whole eastern coast of Korea. The computational domain is composed of several sub-regions with different grid sizes connected in parallel of inclined directions with 16 innermost nested models. The innermost sub-region represents the coastal alignment reasonably well and has a grid size of about 30 meters. Numerical simulations have been performed in the framework of shallow-water equations(linear, as well as nonlinear) over the plane or spherical coordinate system, depending on the dimensions of the sub-region. Results of simulations show the general agreements with the observed data of run-up height for both tsunamis. The evolution of the distribution function of tsunami heights is studied numerically and it is shown that it tends to the log-normal curve for long distance from the source.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2014.02a
• /
• pp.114.1-114.1
• /
• 2014

Copper is considered to be the most promising substrate for the growth of high-quality and large area graphene by chemical vapor deposition (CVD), in particular, on the (111) facet. Because the interactions between graphene and Cu substrates influence the orientation, quality, and properties of the synthesized graphene, we studied the interactions using angle-resolved photoemission spectroscopy. The evolution of both the Shockley surface state of the Cu(111) and the p band of the graphene was measured from the initial stage of CVD growth to the formation of a monolayer. Graphene growth was initiated along the Cu(111) lattice, where the Dirac band crossed the Fermi energy ($E_F$) at the K point without hybridization with the d-band of Cu. Then two rotated domains were additionally grown as the area covered with graphene became wider. The Dirac energy was about 0.4 eV and the energy of the Shockley surface state of Cu(111) shifted toward the $E_F$) by 0.15 eV upon graphene formation. These results indicate weak interactions between graphene and Cu, and that the electron transfer is limited to that between the Shockley surface state of Cu(111) and the p band of graphene. This weak interaction and slight lattice mismatch between graphene and Cu resulted in the growth of rotated graphene domains ($9.6^{\circ}$ and $8.4^{\circ}$), which showed no significant differences in the Dirac band with respect to different orientations. These rotated graphene domains resulted in grain boundaries which would hinder a large-sized single monolayer growth on Cu substrates.

• Development and Reproduction
• /
• v.23 no.4
• /
• pp.333-344
• /
• 2019

In vertebrate reproductive system, estrogen receptor (ER) plays a pivotal role in mediation of estrogenic signaling pathways. In the present study, we report the cDNA cloning, expression analysis, and transcriptional activity of ERβ1 subtype from medaka Oryzias dancena. The deduced O. dancena ERβ1 (odERβ1; 519 amino acids) contained six characteristic A/B to E/F domains with very short activation function 2 region (called AF2). A phylogenetic analysis indicated that odERβ1 was highly conserved among teleost ERβ1 subgroup. A conventional RT-PCR revealed that the odERβ1 transcripts were widely distributed in the multiple tissues, the ovary, brain, gill, intestine, kidney, and muscle. Further, the relatively higher odERβ1 expressions in the ovary and brain were clearly reproduced in RT-qPCR assay. When HA-fused odERβ1 expression vector was transfected into HEK293 cells, an immunoreactivity for odERβ1 was mainly detected in the nucleus part. Finally, an estrogen responsive element driven luciferase reporter assays demonstrated that the transcriptional activity of odERβ1 significantly increased by estradiol-17β (E2) in a dose dependent manner (p<0.05). However, fold-activation of odERβ1 in the presence of E2 was markedly weak, when it compared with those of O. latipes ERβ1. Taken together, these data suggest that odERβ1 represents a functional variant of teleost ERβ subtype and provides a basic tool allowing future studies examining the function of F domain of ERβ1 subtype and expanding our knowledge of ERβ evolution.