• Animal cells and systems
• /
• 제2권2호
• /
• pp.153-164
• /
• 1998

Cytokines regulate proliferation, differentiation and functions of haemotopoietic cells. Each cytokine possesses a variety of activities on various target cells (pleiotropy) and various cytokines have similar and overlapping activities on the same target cells (redundancy). The nature of these cytokine activities predicts unique feature of cytokine receptors, namely, cytokine has multiple receptors, different cytokines share a common receptor, and different cytokine receptors are linked to common signaling pathways. cDNA cloning of genes for cytokine receptors revealed distinct sets of receptor family with different structural features. The cytokine receptor superfamily consists of a largest family, and contains more than twenty cytokine receptor subunits. This receptor has common structural features in both extracellular and intracellular regions without tyrosine kinase domain. Another striking feature of the receptor is to share common subunit of multiple cytokines, which partly explains the redundancy of activities of some cytokines. Recent studies revealed detailed signaling events of the cytokine receptor, the primary activation of JAK and subsequent phosphorylation of tyrosine residues of receptor, and various cellular proteins. Many SH2 containing adapter proteins play an important role in cytokine signals, and this system has similarities with tyrosine kinase receptor signal transduction. STAT may mainly account for cytokine specific functions as suggested by knockout mice studies. It is of importance to note that cytokine activates multiple signaling pathways and the balance and combination of related signaling events may determine the specificity of functions of cytokines.

• 대한수학회논문집
• /
• 제16권4호
• /
• pp.679-690
• /
• 2001

Doubly stochastic matrices are n$\times$n nonnegative ma-trices whose row and column sums are all 1. Convex polytope $\Omega$$_{n}$ of doubly stochastic matrices and more generally (R,S), so called transportation polytopes, are important since they form the domains for the transportation problems. A theorem by Birkhoff classifies the extremal matrices of , $\Omega$$_{n}$ and extremal matrices of transporta-tion polytopes (R,S) were all classified combinatorially. In this article, we consider signed version of $\Omega$$_{n}$ and (R.S), obtain signed Birkhoff theorem; we define a new class of convex polytopes (R,S), calculate their dimensions, and classify their extremal matrices, Moreover, we suggest an algorithm to express a matrix in (R,S) as a convex combination of txtremal matrices. We also give an example that a polytope of signed matrices is used as a domain for a decision problem. In this context of finite reflection(Coxeter) group theory, our generalization may also be considered as a generalization from type $A_{*}$ n/ to type B$_{n}$ D$_{n}$. n/.

• Computers and Concrete
• /
• 제16권2호
• /
• pp.287-309
• /
• 2015

FormWorks-Plus is a generalized public domain user-friendly preprocessor developed to facilitate the process of creating finite element models for structural analysis programs. The lack of a graphical user interface in most academic analysis programs forces users to input the structural model information into the standard text files, which is a time-consuming and error-prone process. FormWorks-Plus enables engineers to conveniently set up the finite element model in a graphical environment, eliminating the problems associated with conventional input text files and improving the user's perception of the application. In this paper, a brief overview of the FormWorks-Plus structure is presented, followed by a detailed explanation of the main features of the program. In addition, demonstration is made of the application of FormWorks-Plus in combination with VecTor programs, advanced nonlinear analysis tools for reinforced concrete structures. Finally, aspects relating to the modelling and analysis of three case studies are discussed: a reinforced concrete beam-column joint, a steel-concrete composite shear wall, and a SFRC shear panel. The unique mixed-type frame-membrane modelling procedure implemented in FormWorks-Plus can address the limitations associated with most frame type analyses.

• 한국환경교육학회지:환경교육
• /
• 제13권1호
• /
• pp.1-13
• /
• 2000

The purpose of this study is to formulate the direction lot improvement of the curriculum on environmental education teacher training. The results of this study are summarized as follows: First, the nature of the courses related to subject matter education should be changed from the course of teaching profession into the course of special study, Second, the combination of the courses related to environmental education and environmental science is needed, Third, the curriculum should sufficiently include the contents of the 7th curriculum, Fourth, the curriculum should contain the courses of environmental science which can help the pre-service teachers to understand the fundamentals and concepts of ecology, This curriculum should also include the courses which can improve the pre-service teacher's ability to teach for the development of student's affirmative environmental value and attitude, Fifth, the curriculum should include the courses which are useful for the pre-service teachers to learn teaching method such as case study and simulation for the education of environmental knowledge and of cognitive domain about environmental issues. Sixth, the curriculum should reflect the contents of the regulation for teacher certificate which was renewed in Jan. of 2000.

• Current Optics and Photonics
• /
• 제6권3호
• /
• pp.337-343
• /
• 2022

Microfluidic chips are new devices that can manipulate liquids at the micrometer level, and terahertz (THz) time-domain spectroscopy has good applicability in biochemical detection. The combination of these two technologies can shorten the distance between sample and THz wave, reduce THz wave absorption by water, and more effectively analyze the kinetics of biochemical reactions in aqueous solutions. This study investigates the effects of different external magnetic field intensities on the THz transmission characteristics of deionized water, CuSO₄, CuCl₂, (CH₃COO)₂Cu, Na₂SO₄, NaCl, and CH₃COONa; the THz spectral intensity of the sample solutions decrease with increasing intensity of the applied magnetic field. Analysis shows that the magnetic field leads to a change in the dipole moment of water molecules in water and electrolyte solutions, which enhances not only the hydrogen-bond networking ability of water but also the hydration around ions in electrolyte solutions, increasing the number of hydrogen bonds. Increasing the intensity of this magnetic field further promotes the hydrogen-bond association between water molecules, weakening the THz transmission intensity of the solution.

• International Journal of Advanced Culture Technology
• /
• 제10권3호
• /
• pp.287-294
• /
• 2022

This paper examines the change and its meaning of marketing strategy in business administration, which is changing along with the development of digital technology. Unlike conventional marketing, digital marketing is creating new relationships and making changes through a two-way approach rather than a one-way approach between producers and consumers. And these changes are creating new approaches not only in the problems between businesses and consumers, but also in the relationship between public institutions and citizens. In particular, the potential of platforms, which are emerging as important in digital management, is applied to public policies, and efforts are being made to establish marketing strategies for public institutions. One case of this was applied to the cultural contents industry and policy to examine specific measures and visions. The cultural big data platform is in line with digital management and continuously utilizes digital marketing strategies in the public domain, and aims to promote creative work as well as publicize it to citizens and workers in the cultural content industry. The synergy effect that will emerge from the combination of the cultural big data platform and digital management is expected to continue.

• 대한임베디드공학회논문지
• /
• 제17권6호
• /
• pp.309-317
• /
• 2022

In this paper, we propose a machine learning-based copy-move forgery detection network with dual branches. Because the rotation or scaling operation is frequently involved in copy-move forger, the conventional convolutional neural network is not effectively applied in detecting copy-move tampering. Therefore, we divide the input into rotation-invariant and scaling-invariant features based on the wavelet coefficients. Each of the features is input to different branches having the same structure, and is fused in the combination module. Each branch comprises feature extraction, correlation, and mask decoder modules. In the proposed network, VGG16 is used for the feature extraction module. To check similarity of features generated by the feature extraction module, the conventional correlation module used. Finally, the mask decoder model is applied to develop a pixel-level localization map. We perform experiments on test dataset and compare the proposed method with state-of-the-art tampering localization methods. The results demonstrate that the proposed scheme outperforms the existing approaches.

• Structural Engineering and Mechanics
• /
• 제83권4호
• /
• pp.451-463
• /
• 2022

The present study deals with forced vibrations of an elastic circular plate supported along its circular edge by unilateral elastic springs. The plate is assumed to be subjected to a uniformly distributed and a concentrated load. Under the combination of these loads, equations of motion are explicitly derived for static and dynamic response analyses by assuming a series of the displacement functions of time and other unknown parameters which are to be determined by employing Lagrangian functional. The approximate solution is sought by applying the Lagrange equations of motions by using the potential energy of the external forces that includes the contributions of the edge forces and the external moments, i.e., those of the effects of the boundary condition to the analysis. For the numerical treatment of the problem in the time domain, the linear acceleration procedure is adopted. The tensionless character of the support is taken into account by using an iterative process and, the coordinate functions for the displacement field are selected to partially fulfill the boundary conditions so that an acceptable approximation can be achieved faster. Numerical results are presented in the figures focusing on the nonlinearity of the problem due to the plate lift-off from the unilateral springs at the edge support.

• Steel and Composite Structures
• /
• 제44권5호
• /
• pp.603-617
• /
• 2022

Structural design, in general, is developed through trial and error technique which is guided by standards criteria and based on the intuition and experience of the engineer, a context that leads to structural over-dimensioning, with uneconomic solutions. Aiming to find the optimal design, structural optimization methods have been developed to find a balance between cost, structural safety, and material performance. These methods have become a great opportunity in the steel structural engineering domain since they have as their main purpose is weight minimization, a factor directly correlated to the real cost of the structure. Assuming an objective function of minimum weight with stress and displacement constraints provided by Brazilian standards, the present research proposes the sizing optimization and combined approach of sizing and shape optimization, through a software developed to implement the Simulated Annealing metaheuristic algorithm. Therefore, two steel plane frame layouts, each admitting four typical truss geometries, were proposed in order to expose the difference between the optimal solutions. The assessment of the optimal solutions indicates a notable weight reduction, especially in sizing and shape optimization combination, in which the quantity of design variables is increased along with the search space, improving the efficiency of the optimal solutions achieved.

• 한국농림기상학회지
• /
• 제18권4호
• /
• pp.307-319
• /
• 2016

국가농림기상센터(NCAM)에서는 수요자 맞춤형 영농 영림을 지원하기 위하여 전용 수치모델링시스템인 지면대기모델링패키지(LAMP) 버전 1을 구축하였다. 이 패키지는 두 가지의 큰 축으로 구성되어 있다. 하나는 WRF 기상모델과 Noah-MP 지면모델의 결합시스템인 WRF/Noah-MP 시스템이고, 다른 하나는 Noah-MP 지면 모델의 오프라인 독립구동형 1차원 버전이다. 전자는 7일 이상의 중기 기상예측 자료를 1km 내외의 고해상도로 생산하는 일을 담당하고, 후자는 대표적인 농림생태계에 대하여 1년 지면모의 자료를 15분 간격으로 생산하는 일을 담당한다. 본 연구의 목적은 NCAM-LAMP의 두 구성 요소를 간단히 설명하고, 초기의 수치모의 성능을 평가하는데 있다. WRF/Noah-MP 결합시스템은 동아시아를 포함하는 어미격자 도메인에 최고 810m의 수평 해상도를 갖는 3개의 둥지격자로 구축되었으며, 가장 안쪽 도메인은 광릉 활엽수림 관측지와 침엽수림 관측지(GDK 및 GCK)를 포함한다. 이 결합시스템은 현재 미국 환경예측센터의 FNL 자료를 초기 및 경계자료로 이용하여 구동되며, 여러 개의 약 8일 모의 결과를 연결시켜 장기간에 대한 모의 자료를 생산하였다. 정량적 검증 변수는 WRF/Noah-MP 결합시스템의 2m 기온, 10m 바람, 2m 습도, 강수이며, 기상청 ASOS 관측 자료와 WRF/Noah-MP 결합시스템 모의 자료 사이의 차이를 이용하여 각 도메인에서 동적 식생 포함 유무에 따른 모의 오차를 계산하였다. 강수 모의의 정확도는 탐지확률(POD)과 공평위협점수(ETS)로 구성된 표를 이용하여 조사하였다. 오프라인 독립구동형 지면모델은 1년 기간에 대해 모의 결과를 생산하였으며, KoFlux 관측자료와 비교하여, 순복사 플럭스, 현열 플럭스, 잠열 플럭스 및 토양 수분 함량을 평가하였다. WRF/Noah-MP 결합시스템의 모의 결과에 따르면, 모든 도메인 중에서 도메인 4(810m 해상도)에서 2m 기온, 10m 바람 및 2m 습도에 대하여 가장 작은 RMSE를 보였다. 동적 식생을 포함시키면 모든 도메인에서 10m 바람의 모의 오차가 감소하게 되는 경향을 보였다. 도메인 2(7,290m 해상도)에서는 강수 모의 점수가 가장 높았으나, 동적 식생을 포함시킴에 따른 효과는 별로 없었다. 독립구동형 1차원 Noah-MP의 지면모의 결과는 복사 플럭스와 토양 수분의 패턴 및 크기를 포착하였으며, 엽면적지수의 모델 입력 부분을 보충하고, 모델 물리과정의 적절한 조합을 찾아내는 노력을 통해 개선될 수 있는 여지를 남겼다.