• Journal of Korea Water Resources Association
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• v.49 no.9
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• pp.773-787
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• 2016

A coupled river-overland hydrodynamic model was applied to estimate flood risk by a scenario-based approach. The study area is Seongseo Industrial Complex in Daegu which is located near Nakdong river and Geumho river. Inundation depth and velocity at each time were calculated by applying a coupled 1D/2D hydrodynamic model to the target area of interest. The 2D inundation analysis for river and overland domain was performed with the scenario-based approach that there are levee overflow against 100/200 year high quantile (97.5%) design flood and levee break against 100/200 year normal quantile (50%) design flood. The level of flood risk was displayed for resident/industrial area using information about maximum depth and velocity of each node computed from the 2D inundation map. The research outcome would be very useful in establishing specified emergency action plans (EAP) in case of levee break and overflowing resulting from a flood.

• Computational Structural Engineering
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• v.6 no.4
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• pp.89-98
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• 1993

As the construction of nuclear power plants are increased, nuclear wastes disposal has been faced as a serious problem. If nuclear wastes are to be buried in the underground stratum, thermo-mechanical behavior of stratum must be analyzed, because high temperature distribution has a significant effect on tunnel and surrounding stratum. In this study, in order to analyze the structural behavior of the underground which is subject to concentrated heat sources, a coupling method of nonlinear finite elements and linear boundary elements is proposed. The nonlinear finite elements (NFE) are applied in the vicinity of nuclear depository where thermo-mechanical stress is concentrated. The boundary elements are also used in infinite domain where linear behavior is expected. Using the similar method as for the problem in mechanical field, the coupled nonlinear finite element-boundary element (NFEBE) is developed. It is found that NFEBE method is more efficient than NFE which considers nonlinearity in the whole domain for the nuclear wastes depository that is expected to exhibit local nonlinearity behavior. The effect of coefficients of the rock mass such as Poisson's ratio, elastic modulus, thermal diffusivity and thermal expansion coefficient is investigated through the developed method. As a result, it is revealed that the displacements around tunnel are largely dependent on the thermal expansion coefficients.

• BMB Reports
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• v.54 no.7
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• pp.380-385
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• 2021

Proper targeting of the βPAK-interacting exchange factor (βPIX)/G protein-coupled receptor kinase-interacting target protein (GIT) complex into distinct cellular compartments is essential for its diverse functions including neurite extension and synaptogenesis. However, the mechanism for translocation of this complex is still unknown. In the present study, we reported that the conventional kinesin, called kinesin-1, can transport the βPIX/GIT complex. Additionally, βPIX bind to KIF5A, a neuronal isoform of kinesin-1 heavy chain, but not KIF1 and KIF3. Mapping analysis revealed that the tail of KIF5s and LZ domain of βPIX were the respective binding domains. Silencing KIF5A or the expression of a variety of mutant forms of KIF5A inhibited βPIX targeting the neurite tips in PC12 cells. Furthermore, truncated mutants of βPIX without LZ domain did not interact with KIF5A, and were unable to target the neurite tips in PC12 cells. These results defined kinesin-1 as a motor protein of βPIX, and may provide new insights into βPIX/GIT complex-dependent neuronal pathophysiology.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.19 no.3
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• pp.173-186
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• 2024

This paper analyzes a case of successful faculty entrepreneurship through a coupled process of open innovation in a university context, using the core competency theory perspective. Initially, the current state of faculty entrepreneurship is examined, and the effects of interdisciplinary coupled processes of open innovation are explored, focusing on the case of 'Omotion Inc.,' a startup utilizing generative AI technology for hyper-realistic 3D virtual human experiences. The research methodology involves in-depth interviews with Omotion Inc.'s co-founders, technology commercialization professionals, and experts in the field, followed by analysis based on foundational theories. Applying the core competency theory, this paper scrutinizes the process of integrating diverse expertise and technologies from various academic disciplines. The analysis goes beyond the limitations of faculty entrepreneurship confined to a single technology-centric research domain. Instead, it explores the possibilities of enhancement and value creation through coupled processes, providing practical implications for the university entrepreneurial ecosystem. The aim is to extend the traditional roles of education and research within the university, presenting a role in economic value creation beyond the boundaries of conventional faculty entrepreneurship. Through the collaboration of two faculty members, this study showcases the creation of novel technology and business models. It establishes that successful coupled processes of open innovation in faculty entrepreneurship, from a core competency theory perspective, require the entrepreneurial firm to possess (1) entrepreneurial capabilities, (2) technological capabilities, and (3) networking capabilities. The implications of this research highlight the positive impact of coupled processes of open innovation in faculty entrepreneurship, as evidenced by the Omotion Inc. case, offering guidance on entrepreneurial directions for university members preparing for entrepreneurship.

• Korean Journal of Agricultural and Forest Meteorology
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• v.18 no.4
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• pp.307-319
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• 2016

A Land-Atmosphere Modeling Package (LAMP) for supporting agricultural and forest management was developed at the National Center for AgroMeteorology (NCAM). The package is comprised of two components; one is the Weather Research and Forecasting modeling system (WRF) coupled with Noah-Multiparameterization options (Noah-MP) Land Surface Model (LSM) and the other is an offline one-dimensional LSM. The objective of this paper is to briefly describe the two components of the NCAM-LAMP and to evaluate their initial performance. The coupled WRF/Noah-MP system is configured with a parent domain over East Asia and three nested domains with a finest horizontal grid size of 810 m. The innermost domain covers two Gwangneung deciduous and coniferous KoFlux sites (GDK and GCK). The model is integrated for about 8 days with the initial and boundary conditions taken from the National Centers for Environmental Prediction (NCEP) Final Analysis (FNL) data. The verification variables are 2-m air temperature, 10-m wind, 2-m humidity, and surface precipitation for the WRF/Noah-MP coupled system. Skill scores are calculated for each domain and two dynamic vegetation options using the difference between the observed data from the Korea Meteorological Administration (KMA) and the simulated data from the WRF/Noah-MP coupled system. The accuracy of precipitation simulation is examined using a contingency table that is made up of the Probability of Detection (POD) and the Equitable Threat Score (ETS). The standalone LSM simulation is conducted for one year with the original settings and is compared with the KoFlux site observation for net radiation, sensible heat flux, latent heat flux, and soil moisture variables. According to results, the innermost domain (810 m resolution) among all domains showed the minimum root mean square error for 2-m air temperature, 10-m wind, and 2-m humidity. Turning on the dynamic vegetation had a tendency of reducing 10-m wind simulation errors in all domains. The first nested domain (7,290 m resolution) showed the highest precipitation score, but showed little advantage compared with using the dynamic vegetation. On the other hand, the offline one-dimensional Noah-MP LSM simulation captured the site observed pattern and magnitude of radiative fluxes and soil moisture, and it left room for further improvement through supplementing the model input of leaf area index and finding a proper combination of model physics.

• Journal of Life Science
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• v.17 no.6 s.86
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• pp.783-790
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• 2007

G protein coupled receptors (GPCRs) transmit various extracellular signals into the cells. Upon binding of the ligands, conformational changes in the extracellular and/or transmembrane (TM) domains of CPCRs were propagated into the cytoplasmic (CP) domain of the molecule leading to the activation of their cognate heterotrimeric C proteins and kinases. Constitutively active GPCR mutants causing the activation of C Protein signaling even in the absence of ligand binding are of interest for the study of activation mechanism of GPCRs. Two classes of constitutively active mutations, categorized by their effects on the salt bridge between Ell3 and K296, were found in the TM domain of rhodopsin. Opsin mutants containing combinations of the mutations were constructed to study the conformational changes required for the activation of rhodopsin. Rhodopsin chromophore regenerated with 11-cis-retinal showed a thermal stability inversely correlated with its constitutive activity. In contrast, rhodopsin mutants exhibited a binding affinity to an agonist, all-trans-retinal, in a constitutive activity-dependent manner. In order to test whether the conformational changes responsible for the activation of trans-ducin (Gt) are the same as the conformation required for the recognition of rhodopsin kinase, analysis of the mutants were carried out with phosphorylation by rhodopsin kinase. Rhodopsin mutants containing combinations of different classes of the mutations showed a strong synergistic effect on the phosphorylation of the mutants in the dark as similar to that of Gt activation. The results suggest that at least two or three kinds of segmental and independent conformational changes are required for the activation of rhodopsin and the conformational changes responsible for activating rhodopsin kinase and Gt are similar to each other.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.11 no.1
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• pp.45-53
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• 1991

The underground structure, which has infinite or semi-infinite boundary conditions, is subjected by body forces and in-situ stresses. It also has stress concentration, which causes material nonlinear behavior, in the vicinity of the excavated surface. In this paper, some methods which can be used to transform domain integrals into boundary integrals are reviewed in order to analyze the effect of the body forces and the in-situ stresses. First, the domain integral of the body force is transformed into boundary integral by using the Galerkin tensor and divergence theorem. Second, it is transformed by writing the domain integral in cylindrical coordinates and using direct integration. The domain integral of the in-situ stress is transformed into boundary integral applying the direct integral method in cylindrical coordinates. The methodology is verified by comparing the results from the boundary element analysis with those of the finite element analysis. Coupling the above boundary elements with finite elements, the nonlinear behavior that occurs locally in the vicinity of the excavation is analyzed and the results are verified. Thus, it is concluded that the domain integrals of body forces and in-situ stresses could be performed effectively by transforming them into the boundary integrals, and the nonlinear behavior can be reasonably analyzed by coupled nonlinear finite element and boundary element method. The result of this research is expected to he used for the analysis of the underground structures in the effective manner.

• Ocean Systems Engineering
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• v.6 no.1
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• pp.1-21
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• 2016

The global performance of the 5 MW OC4 semisubmersible floating wind turbine in random waves with or without steady/dynamic winds is numerically simulated by using the turbine-floater-mooring fully coupled dynamic analysis program FAST-CHARM3D in time domain. The numerical simulations are based on the complete second-order diffraction/radiation potential formulations along with nonlinear viscous-drag force estimations at the body's instantaneous position. The sensitivity of hull motions and mooring dynamics with varying wave-kinematics extrapolation methods above MWL(mean-water level) and column drag coefficients is investigated. The effects of steady and dynamic winds are also illustrated. When dynamic wind is added to the irregular waves, it additionally introduces low-frequency wind loading and aerodynamic damping. The numerically simulated results for the 5 MW OC4 semisubmersible floating wind turbine by FAST-CHARM3D are also extensively compared with the DeepCWind model-test results by Technip/NREL/UMaine. Those numerical-simulation results have good correlation with experimental results for all the cases considered.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.20 no.4
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• pp.429-453
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• 2022

Numerical modeling and scenario composition are needed to characterize the geological environment of the disposal site and analyze the long-term evolution of natural barriers. In this study, processes and features of the hydro-mechanical behavior of natural barriers were categorized and represented using the interrelation matrix proposed by SKB and Posiva. A hydro-mechanical coupled model was evaluated for analyzing stress field changes and fracture zone re-activation. The processes corresponding to long-term evolution and the hydro-mechanical mechanisms that may accompany critical processes were identified. Consequently, practical numerical methods could be considered for these geological engineering issues. A case study using a numerical method for the stability analysis of an underground disposal system was performed. Critical stress distribution regime problems were analyzed numerically by considering the strata's movement. Another case focused on the equivalent continuum domain composition under the upscaling process in fractured rocks. Numerical methods and case studies were reviewed, confirming that an appropriate and optimized modeling technique is essential for studying the stress state and geological history of the Korean Peninsula. Considering the environments of potential disposal sites in Korea, selecting the optimal application method that effectively simulates fractured rocks should be prioritized.

• Journal of Advanced Research in Ocean Engineering
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• v.1 no.2
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• pp.85-93
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• 2015

The nonlinear time-domain analysis method was implemented to carry out a series of integrated simulations for a deep-water crane vessel system composed of four sub components, including a floating vessel, lifted equipment, hoisting cable and dynamic positioning (hereinafter DP) system. The analysis of the coupled dynamics consists of the crane vessel and equipment connected using the crane wire, and the DP is modeled according to the wind, wave and current conditions. The DP systems were numerically implemented using a classical PD feedback controller, and various simulations of the deepwater installation were conducted using different conditions in order to evaluate the global performance of the floating crane vessel combined with the DP system.