• Journal of the Korean Society for information Management
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• v.21 no.3
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• pp.1-14
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• 2004

Visualization of documents will help users when they do search similar documents. and all research in information retrieval addresses itself to the problem of a user with an information need facing a data source containing an acceptable solution to that need. In various contexts. adequate solutions to this problem have included alphabetized cubbyholes housing papyrus rolls. microfilm registers. card catalogs and inverted files coded onto discs. Many information retrieval systems rely on the use of a document surrogate. Though they might be surprise to discover it. nearly every information seeker uses an array of document surrogates. Summaries. tables of contents. abstracts. reviews, and MARC recordsthese are all document surrogates. That is, they stand infor a document allowing a user to make some decision regarding it. whether to retrieve a book from the stacks, whether to read an entire article, etc. In this paper another type of document surrogate is investigated using a grouping method of term list. lising Multidimensional Scaling Method (MDS) those surrogates are visualized on two-dimensional graph. The distances between dots on the two-dimensional graph can be represented as the similarity of the documents. More close the distance. more similar the documents.

• Proceedings of the Korean Information Science Society Conference
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• 2000.10b
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• pp.317-319
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• 2000

문서는 자연어로 구성된 비정형화된 데이터이다. 이를 처리하기 위하여 문서를 정형화된 데이터로 표현하여 저장할 필요가 있는데, 이를 문서 대용물(Document Surrogate)라 한다. 문서 대용물은 대표적으로 인덱싱 과정에 의해 추출된 단어 리스트를 나타낸다. 문서 내의 모든 단어가 내용을 반영하지 않는다. 문서의 내용을 반영하는 중요한 단어만을 선택할 필요가 있다. 이러한 단어를 키워드라 하며, 기존에는 단어의 빈도와 역문서 빈도(Inverse Document Frequency)에 근거한 공식에 의해 키워드를 선택하였다. 실제로 문서내 빈도와 역문서 빈도뿐만 아니라 제목에 포함 여부, 단어의 위치 등도 고려하여야 한다. 이러한 인자를 추가할 경우 이를 수식으로 표현하기에는 복잡하다. 이 논문에서는 이를 단어의 특징으로 추출하여 특징벡터를 형성하고 이를 학습하여 키워드를 선택하는 신경망 모델인 역전파의 접근을 제안한다. 역전파를 이용하여 키워드를 판별한 결과 수식에 의한 경우보다 그 성능이 향상되었음을 보여주고 있다.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.1-11
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• 2009

Since the Committee for Proprietary Medicinal Products (CPMP) of the European Union issued in 1997 a "points to consider" document for the assessment of the potential for QT interval prolongation by non-cardiovascular agents to predict drug-induced torsades de pointes (TdP), the QT liability has become the critical safety issue in the development of pharmaceuticals. As TdP is usually linked to delayed cardiac repolarization, international guideline (ICH S7B) has advocated the standard repolarization assays such as in vitro IKr (hERG current) and in vivo QT interval, or in vitro APD (as a follow up) as the best biomarkers for predicting the TdP risk. However, the recent increasing evidence suggests that the currently used above biomarkers and/or assays are not fully predictive for TdP, but also does not address potential new druginduced TdP due to the selective disruption of hERG protein trafficking to the cell membrane or VT and/or VF with QT shortening. There is, therefore, an urgent need for other surrogate markers or assays that can predict the proarrhythmic potential of drug candidate. In this review, we provide an ideal pre-clinical strategy to predict the potentials of QT liability and lethal arrhythmia of the drug candidates with recent issues in this field in mind, not at the expense of discarding therapeutically innovative drugs.

• The Journal of Information Systems
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• v.12 no.1
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• pp.87-116
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• 2003

One of the important applications for business-to-business electronic commerce is in procurement and inventory management using electronic data interchange(EDI). Using online catalogs and approved supplier lists, firms can easily create requisitions and purchasing documents. The emerging trend in EDI technology is changed from VAN(Value Added Network) based EDI to XML based EDI. This paper intends to suggest a component-based XML/EDI system using Unified Modeling Language(UML), as an application system for automobile part industry. Applying component based XML/EDI systems designed with UML methodology, we analyzed the workflow and the document on procurement process between trading partners and implemented a prototype of efficient XML/EDI system, as a surrogate of existing VAN/EDI. The result of applying object-oriented CBD(Component Based Development) technique is to minimize the risk of life cycle and facilitate the reuse of software as mentioned to limitation of information engineering methodology. It enables the interoperability with corporate legacy systems such as ERP(Enterprise Resource Planning), SCM(Supply Chain Management). This system proposes a solution to apply analysis phase and design phase in implementation of XML/EDI system. The implementation of XML/EDI system using CBD shows the ease of use in software reuse and the interoperability with corporate internal information system. The purchasing department with XML/EDI system can electronically communicate purchase orders, delivery schedules to external suppliers and interoperate with other application systems.

• The Korean Society of Law and Medicine
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• v.11 no.2
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• pp.239-274
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• 2010

Advance directive refers to a description of the treatment method a patient wants to be provided with in case where the person is unconscious or lacks an ability to decision making in a future period or a declaration of intention that delegates and appoints another person who makes a decision regarding a treatment method on behalf of the person. Advance directive is usually a document form, but oral statement is acceptable as well. Advance directive may have a variety of forms though, it basically consists of two basic forms. That is, one is a living will, and the other is a surrogate decision making. Though the importance of advance directive has been emphasized, and the necessity of adopting the system has been strongly argued for so far, the debates on criteria, method, and procedure alike have not yet reached an agreement. It is because even the concept of advance directive is more or less ambiguous, and each specific method has its own theoretical limitations and practical constraints. Thus the inquiries on advance directive raised in the study are summarized as the meaning, practicability, and philosophical foundation of the advance directive. Firstly, the theoretical limitations of Advance directive may be categorized into conceptual and moral limitations. In case of conceptual limitations, authors of advance directives may not be well aware, in advance, of the particular situation in which he or her will experience in the future, and patients may experience the change in his or her values and lack the understanding and information about the future situation due to the changes in treatment methods. In case of moral limitations, a patient has a limited moral autonomy right and self identity that have an impact on his or her preference. Secondly, in case of practical constraints for advance directive, there exist cultural features, low ratio of documentation, as patients themselves admit, and low predictability and stability of patient's own preference regarding life-sustaining care. And the problem of validity and accuracy in proxy's decision making is also raised. Those who administer a living will, especially, may have a difficulty in understanding the directive by a patient, so that the accuracy of execution cannot be secured. In the sense, it is needed to implement a legal device in order to solve such problems. In summary, it is urgently required to understand the limitations and explore desired alternatives to overcome the relevant problems in advance, which must contribute to successfully adopting and effectively operating the advance directive system in Korea.

• The Journal of Information Systems
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• v.12 no.2
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• pp.129-149
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• 2003

One of the important applications in Enterprise Resource Planning(ERP) systems is the Manufacturing Resource Planning(MRPII) system using Bill of Material(BOM). The manufacturing resource planning determines the quantity and timing of the production or purchase of subassemblies and raw materials needed to support the Master Production Scheduling(MPS). The bill of material is the recipe, a list of the materials needed to make a product. This paper intends to suggest a component-based materials management system using Unified Modeling Language(UML), as an application system for automobile part industry. Applying component based materials management systems designed with UML methodology, we analyzed the workflow and the document on materials management process from production planning to inventory management, and implemented a prototype of efficient materials management system, as a surrogate of existing material requirement planning(MRPI) system. To produce many other assemblies for a automobile part firm, component parts are assembled into subassemblies that are joined to assemble the finished product. Through the system suggested in this study, the level of inventory has cut down and the cost of inventory management has decreased. Also, the development method using UML makes the analysis and design phase to shorten in implementation period of MRPII system. The implementation of materials management system using CBD shows the ease of use in software reuse and the interoperability with corporate Internal information system. The result of applying object-oriented CBD technique is to minimize the risk of life cycle and facilitate the reuse of software as mentioned to limitation of information engineering methodology.

• Journal of the Korean Society of Systems Engineering
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• v.18 no.2
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• pp.75-93
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• 2022

Machine learning (ML) data-driven meta-model is proposed as a surrogate model to reduce the excessive computational cost of the physics-based model and facilitate the real-time prediction of a nuclear power plant's transient response. To forecast the transient response three machine learning (ML) meta-models based on recurrent neural networks (RNNs); specifically, Long Short Term Memory (LSTM), Gated Recurrent Unit (GRU), and a sequence combination of Convolutional Neural Network (CNN) and LSTM are developed. The chosen accident scenario is a control element assembly withdrawal at power concurrent with the Loss Of Offsite Power (LOOP). The transient response was obtained using the best estimate thermal hydraulics code, MARS-KS, and cross-validated against the Design and control document (DCD). DAKOTA software is loosely coupled with MARS-KS code via a python interface to perform the Best Estimate Plus Uncertainty Quantification (BEPU) analysis and generate a time series database of the system response to train, test and validate the ML meta-models. Key uncertain parameters identified as required by the CASU methodology were propagated using the non-parametric Monte-Carlo (MC) random propagation and Latin Hypercube Sampling technique until a statistically significant database (181 samples) as required by Wilk's fifth order is achieved with 95% probability and 95% confidence level. The three ML RNN models were built and optimized with the help of the Talos tool and demonstrated excellent performance in forecasting the most probable NPP transient response. This research was guided by the Systems Engineering (SE) approach for the systematic and efficient planning and execution of the research.