• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3213-3222
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• 2016

Background: Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyl-donor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. Materials and Methods: The human cervical cancer cell line, C4-II, was grown in complete medium and medium depleted of folate (F-M+) and folate and methionine (F-M-). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT-PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. Results: Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant down-regulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. Conclusions: Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.

• KIPS Transactions on Software and Data Engineering
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• v.9 no.4
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• pp.137-144
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• 2020

Delirium is among the most common mental disorders encountered in patients with a temporary cognitive impairment such as consciousness disorder, attention disorder, and poor speech, particularly among those who are older. Delirium is distressing for patients and families, can interfere with the management of symptoms such as pain, and is associated with increased elderly mortality. The purpose of this paper is to generate useful clinical knowledge that can be used to distinguish the outcomes of patients with delirium in long-term care facilities. For this purpose, we extracted the clinical classification knowledge associated with delirium using a local covering rule acquisition approach with the rough lower approximation region. The clinical applicability of the proposed method was verified using data collected from a prospective cohort study. From the results of this study, we found six useful clinical pieces of evidence that the duration of delirium could more than 12 days. Also, we confirmed eight factors such as BMI, Charlson Comorbidity Index, hospitalization path, nutrition deficiency, infection, sleep disturbance, bed scores, and diaper use are important in distinguishing the outcomes of delirium patients. The classification performance of the proposed method was verified by comparison with three benchmarking models, ANN, SVM with RBF kernel, and Random Forest, using a statistical five-fold cross-validation method. The proposed method showed an improved average performance of 0.6% and 2.7% in both accuracy and AUC criteria when compared with the SVM model with the highest classification performance of the three models respectively.

• The Journal of Industrial Distribution & Business
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• v.9 no.8
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• pp.41-50
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• 2018

Purpose - As an important participant in the financial markets, the commercial bank will be impacted by the interest rate marketization. Owing to the special condition of China, this paper tries to explore the impact of operating mechanisms between interest rate marketization and the profitability of the commercial Bank. Research design, data and methodology - This paper applies time series data from 2005 to 2016. Due to the short period of time series, autocorrelation often occurs. Therefore, the fully modified least squares(FMOLS) will be used to conduct an empirical analysis. The reason is that it can move off the autocorrelation between variables and disturbance term. And FMOLS also can make estimated cointegrating parameters closed to normal distribution. More importantly, in order to avoid spurious regressions, the Augmented Dickey-Fuller Test will be used to verify the stationarity of all variables. The total return of asset is treated as the profitability of commercial bank. The net interest spread is treated as a measurement of interest rate marketization. Both are regarded as dependent variables. The non-interest income or gross revenues and impaired loans or gross loans are treated as independent variables. The sixteen representative listed commercial banks are divided into three categories (state-owned, share-holding and city-owned) to conduct an estimation. Results - Via empirical analysis, the findings show that the net interest spread has a positive effect on the profitability of the commercial bank. More specifically, 1% increase in the net interest spread will lead 0.157% increase in the profitability of state-owned commercial bank, 0.269% increase in the profitability of share-holding commercial bank and 0.263% increase in the profitability of city-owned commercial bank. If regarding the sixteen listed commercial city as a whole, 1% increase in the net interest spread will lead 0.267% increase in the profitability of the commercial bank. Conclusions - As the interest rate marketization, the importance of interest rate on the profitability of commercial bank has become more and more significant. The empirical evidences also prove that the net interest spread can bring about the change of the commercial bank's profitability. Therefore, policy-makers of commercial banks should fully understand the operating mechanism between them.

• The Journal of Korean Academy of Prosthodontics
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• v.36 no.2
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• pp.245-257
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• 1998

This study was performed to measure the changes of the mandibular movement and the masticatory muscular activities - anterior temporal and masseter muscle of both side - reflected by intentional increase of anterior guidance angie. For this study, 5 volunteers (3 males and 2 females with average age of 24.0) were selected. Each volunteer had Angle's classification I and did not have any missing tooth except third molar and any extensive restorations. Metallic guide plate was made at volunteer's working model fabricated by improved dental stone and cemented to the palatal surface of maxillary central incisor using resin cement(Panavia $21^{(R)}$) and then adjusted not to give any occlusal interferences at intercuspal position. The activity of masticatory muscles and the changes of mandibular movement were recorded by EMG and Sirognathograph in Biopak analysing system(Bioresearch Inc., Milwaukee, Wisconsin, USA). Measurement was done at before experiment, immediatley after placement, 1 week after placement, immediately after removal, and 1 week after removal. The results were as follows: 1. Moderate phonetic disturbance and mild headache were occured to 3 volunteers for 2 days after setting and 1 volunteer had positive reaction to percussion and slight midline diastema. But all of these clinical signs were diappeared 1 week after removal and the other volunteer did not have any special clinical sign. 2. In the EMG of the mandibular rest position, the mean value of anterior tempotal muscle was increased immediately after placement(p<0.01) and then decreased 1 week after placement(p<0.05) and increased 1 week after removal(p<0.05) but not recovered as before experiment. The mean value of masseter muscle was decreased during the experiment period. 3. In the EMG during mandibular protrusive movement, all muscular activity was decreased during the experiment period. Reduced activity was not recovered 1 week after removal(p<0.03). 4. During the habitual opening, anteroposterior movement of mandible was decreased immediately after placement(p<0.05) and then increased 1 week after placement but not statistically significant(p>0.1). Vertical movement was not shown significant difference during the experiment period(p>0.1). Lateral movement was decreased immediately after placement(p<0.05) and then increased 1 week after placement but not recovered as before experiment. The opening and closing velocity of mandible was shown minor changes but not statistically significant. 5. During the habitual opening, anteroposterior movement of mandible was decreased 1 week after placement(p<0.05) and then increased immediately after removal and recovered 1 week after removal as before experiment. Vertical movement was not shown significant changes. Lateral displacement of mandible was increased continuously and recovered 1 week after removal. Opening velocity was temporarily increased immediately after removal but recovered and closing velocity was not shown significant changes. 6. During the right side chewing, anteroposterior movement of mandible was increased immediately after removal but recovered and vertical movement was not shown statistically significant results. Lateral displacement and velocity of mandible were not shown significant results. 7. During the left side chewing, the changes of mandibular movement pattern were not shown statistically significant results.

• Journal of Hospice and Palliative Care
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• v.19 no.2
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• pp.145-153
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• 2016

Purpose: This study was conducted to investigate patients' characteristics and actual conditions of home-based services offered by a free-standing hospice center. Methods: A retrospective review was performed with the medical records of 75 patients who received home-based hospice care from a free-standing hospice center from January 2014 through December 2014. Results: Most patients (54.7%) were enrolled via self-directed referral. The reason for the service termination was death at home 25.3%, admission to a hospice ward 50.7%, hospitalization 22.6% and patients' refusal 2.7%. Seventy three patients had cancer, and two patients had ALS. Among all, 58.7% were in a dying phase, and 34.7% were almost completely bedfast at the time of their enrollment in this study. When they enrolled, the patients' physical symptoms were characterized as pain (89.4%), sleep disturbance (71.2%), urinary difficulties (35.8%) and defecation difficulties (47.8%). Among all, 77.4% terminated the home visit service within one month. The mean frequency of the home visits was 3.25 (${\pm}3.98$), and less than five in 82.7% of patients. The mean frequency of the phone service was 3.40 (${\pm}3.12$). The frequency of doctor's home visits was $1.21{\pm}0.79$ on average, and the figure increased when patients' conditions turned unstable. Conclusion: It is necessary to develop a home-based hospice care model with consideration of patients' characteristics and the actual service conditions delivered by free-standing hospice facilities.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.6
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• pp.408-415
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• 2016

Small fishing ports and coastal structures installed in a relatively low sea water depth disturb the wave induced current and cause the collapse of equilibrium state of sediment transport. These structures creates diffracted waves and matter the concentration of waves to cause the beach erosion. In order to mitigate these eroding problems on the beach, many counter measurements were proposed such as detached breakwater, groin or headland; however, these methods interrupt the aesthetic view of sandy beach due to the exposed structures above the sea level and have difficulty of applying to those beaches with the good scenery. Furthermore, some of these methods create secondary environmental problems after the installations. To eliminate these problems, one of the countermeasures, artificial reefs have been selected and used worldwide to minimize the disturbance of the scenery and secondary effects on the environment. Meanwhile, it is important to set the design elements for installing the artificial reefs such as that of length, opening width, clearing distances from the shoreline and more. Nevertheless, there are no construction manuals or standards for designing the artificial reefs with these important design elements yet. In this study, different conditions of artificial reefs were used with various cases throughout hydraulic model test to precisely analyze the changes of waves and currents to propose the standards of design elements to install the artificial reefs.

• Journal of the Korean Geotechnical Society
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• v.27 no.7
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• pp.17-33
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• 2011

Recently, the utilization of recycled aggregates for backfilling a power transmission pipeline trench has been considered due to the issues of eco-friendly construction and a lack of natural aggregate resource. It is important to identify the physical and thermal properties of domestic recycled aggregates that can be used as a backfill material. This paper evaluated thermal properties of concrete-based recycled aggregates with various particle size distributions. The thermal properties of the recycled aggregates and river sand provided by local vendors were measured using the transient hot wire method and the transient needle probe method after performing the standard compaction test. The needle probe method considerably overestimated the thermal resistivity of recycled aggregates especially at the dry of optimum water content because of experiencing disturbance while the needle probe is being inserted into the specimen. Similar to silica sand, the thermal resistivity of recycled aggregates decreased when the water content increased at a given dry density. Also, this paper evaluated some of the existing prediction models for the thermal resistivity of recycled aggregates with the experimental data, and developed a new prediction model for recycled aggregates. This study shows that recycled aggregates can be a promising backfill material substituting for natural aggregates when backfilling the power transmission pipeline trench.

• Journal of the Korean earth science society
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• v.27 no.3
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• pp.279-288
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• 2006

We incorporated cooperative learning focusing on the 'Crustal Deformation' in five classes of second grade students, at an all-girls' middle school of Gimje city. The groups of cooperative learning were composed of four members of students each, according to the heterogeneous level. We conducted a pretest on the students' preference before incorporating the cooperative learning. After ten weeks of cooperative school work, the students took a post test with the same questions as the pretest. The result of this method greatly impacted the change on the students' scientific preference. It means that the students showed a positive change in their awareness of and participation in science classes, compared to before. However it is difficult to distinguish the differences in their scientific attitude on the recognition about scientists and habits which make them think scientifically. This resulted from the short period of ten weeks which is not sufficient to carry out the study strategy effectively. Surveys of the students on cooperative learning indicates that the middle level students prefer this method unlike the higher or lower level students. we are convinced that they can learn from the students of higher level and are able to help the lower level with the interaction through cooperative learning. According to the result of the survey, the method has some weaknesses; it arouses the high noise levels and consequent disturbance due to verbal interaction and of conflicts due to disagreements when they discuss the process. On the contrary, advantages are developing the students's interest in science class, helping them to learn, creating positive participation in class, and fostering mutual collaboration with other students through cooperative learning.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.1
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• pp.62-74
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• 2004

Baekdu-daegan is the greatest mountain chain as well as the major ecological axis of the Korean Peninsula. In recent year, however, this area is faced with the various kinds of developmental urge. To cope adequately with these problems, this study was executed to prepare synthetic and systematic management with conservation-oriented strategy for Baekdu-daegan and to suggest spatially definite zoning for the managerial area. This study is to take into consideration the traditional concepts of stream and watershed as well as the actual disturbance on Baekdu-daegan area. The study area is selected with semi-mountainous type, from Namdeokyusan to Sosagogae. To propose the process for reasonably establishing the managerial boundary adjacent to the Ridges, the analysis was carried out that ArcGIS was mainly used for its analysis with digital maps, Landsat TM image and ArcGIS Hydro Model. Landsat TM image was classified by 5 land use types such as cultivated land, urban area, barren area, water body and forest. Based on these analyses results, the managerial boundaries as alternatives from the Ridges were produced by watershed expansion process, and used for tracing the changes of areal ratio of various land use types to the relevant watersheds to search out the adequate managerial boundary. The results show that watershed expansion process could be effective tool for establishing the managerial boundary, and eighth expanded watershed toward Muju-Gun(west) and fifth expanded watershed toward Geochang-Gun(east) might be included for the adequate managerial boundary of the case site.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.4
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• pp.591-598
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• 2021

The digital phase-locked loops(DPLL) is a circuit used for phase synchronization and has been generally used in various fields such as communication and circuit fields. State estimators are used to design digital phase-locked loops, and infinite impulse response state estimators such as the well-known Kalman filter have been used. In general, the performance of the infinite impulse response state estimator-based digital phase-locked loop is excellent, but a sudden performance degradation may occur in unexpected situations such as inaccuracy of initial value, model error, and disturbance. In this paper, we propose a minimum variance finite impulse response filter with optimal horizon for designing a new digital phase-locked loop. A numerical method is introduced to obtain the measured value interval length, which is an important parameter of the proposed finite impulse response filter, and to obtain a gain, the covariance matrix of the error is set as a cost function, and a linear matrix inequality is used to minimize it. In order to verify the superiority and robustness of the proposed digital phase-locked loop, a simulation was performed for comparison and analysis with the existing method in a situation where noise information was inaccurate.