• YAKHAK HOEJI
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• v.29 no.6
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• pp.362-366
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• 1985

These paper was attempted to investigate the mechanism of increased blood level of sulfisomidine by cimetidine pretreatment pharmacokinetically. Especially, effect of cimetidine pretreatment on both renal clearance and biliary clearance of sulfisomidine was studied in rabbits. The results are as follows. The blood level of sulfisomidine administered intravenously in dose of 25mg/kg was elevated significantly by cimetidine pretreatment. Relative bioavailability and biological half-life were increased significantly by cimetidine pretreatment. Overall elimination rate constant ($betha$) and distribution rate constant ($K_{13}$) of sulfisomidine were decreased significantly by cimetidine pretreatment. The renal and biliary clearance of sulfisomidine were decreased significantly compared with those of control rabbits by cimetidine pretreatment. The results may be also related to the inhibition of sulfisomidine metabolism enzyme activity or reduction of blood flow in the liver.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.23 no.7 s.166
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• pp.1139-1146
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• 1999

Reliability analysis of structures based on fracture mechanics requires knowledge on statistical characteristics of the parameter C and m in the fatigue crack growth law, $da/dN=C({\Delta}K)^m$. The purpose of the present study is to investigate if it is possible to predict fatigue crack growth rate by only the fluctuation of the parameter C. In this study, Paris-Erdogan law is adopted, where the author treat the parameter C as random and m as constant. The fluctuation of crack growth rate is assumed only due to the parameter C. The growth resistance coefficient of material to fatigue crack growth (Z=1/C) was treated as a spatial stochastic process, which varies randomly on the crack path. The theoretical crack growth rates at various stress intensity factor range are discussed. Constant ${\Delta}K$ fatigue crack growth tests were performed on the structural steel, SM45C. The experimental data were analyzed to determine the autocorrelation function and Weibull distributions of the fatigue crack growth resistance. And also, the effect of the parameter m of Paris' law due to variation of fatigue crack growth resistance was discussed.

• International Journal of Reliability and Applications
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• v.15 no.2
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• pp.125-150
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• 2014

Accelerated life tests (ALTs) are extensively used to determine the reliability of a product in a short period of time. Test units are subject to elevated stresses which yield quick failures. ALT can be carried out using constant-stress, step-stress, progressive-stress, cyclic-stress or random-stress loading and their various combinations. An ALT with linearly increasing stress is ramp-stress test. Much of the previous work on planning ALTs has focused on constant-stress, step-stress, ramp-stress schemes and their various combinations where the stress is generally increased. This paper presents an optimal design of ramp soak-stress ALT model which is based on the principle of Thermal cycling. Thermal cycling involves applying high and low temperatures repeatedly over time. The optimal plan consists in finding out relevant experimental variables, namely, stress rates and stress rate change points, by minimizing variance of reliability function with pre-specified mission time under normal operating conditions. The Burr type XII life distribution and time-censored data have been used for the purpose. Burr type XII life distribution has been found appropriate for accelerated life testing experiments. The method developed has been explained using a numerical example and sensitivity analysis carried out.

• Journal of Advanced Marine Engineering and Technology
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• v.20 no.5
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• pp.68-75
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• 1996

The vacuum drying characteristics of water-saturated porous media were studied experimentally. The water-saturated porous media, water-saturated sand layer, was heated by the isothermal bottom wall of the rectangular vessel. The vacuum drying rate and temperature distribution of the sand layer were measured and calculated under a variety of conditions of heated wall temperature, vacuum rate, and thickness of the test material. It was found that the drying rate due to the heat and mass teansfer is greatly influenced by the heated wall temperature, vacuum rate, and thickness of the test material.

• Journal of agriculture & life science
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• v.52 no.6
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• pp.111-125
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• 2018

In this study, we evaluated the uniformity of deposition rate and particle size distributions of the variable rate application technique using the unmanned rotorcraft by measuring the spray pattern according to path location in the range of spraying flight. The coefficient of variation (CV) of the lateral coverage rate for the overlapped distribution with the spray swath of 3.6 m in both guidance and auto-pilot flight modes maintaining constant flight speed was about 30% and the CV of the coverage rate by the flight path location was extremely small. Therefore, it was assessed that the variable rate application technology compensating for the variation of ground speed was superior in terms of spray uniformity. In addition, the droplet size distributions in both volume median diameter(VMD) and number median diameter(NMD) were adequate for aerial application and uniform in terms of lateral distribution. Thereafter, we intend to contribute to a precise application on small-scaled fields using the unmanned agricultural rotorcraft by the variable rate application.

• Analytical Science and Technology
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• v.34 no.2
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• pp.87-98
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• 2021

In this study, we developed the nanoparticle multi-generator by 3D printer fusion deposition modeling (FDM) method that can reliably generate and deliver nanoparticles at a constant concentration for inhalation risk assessment. A white ABS filament was used as the test material, and SMPS was used for concentration analysis such as particle size and particle distribution. In the case of particle size, the particle size was divided by 100 nm or less and 100 to 1,000 nm, and the number of particles concentration, mass concentration, median diameter of particles, geometric average particle diameter, etc were measured. The occurrence conditions were the extruder temperature, the extruding speed of the nozzle, and the air flow rate, and experiments were conducted according to the change of conditions including the manufacturer's standard conditions. In addition, the utility of inhalation risk assessment was reviewed through a stability maintenance experiment for 6 h. As a result of the experiment, the size of the nanoparticles increased as the discharger temperature increased, as the discharge speed of the nozzle increased, and as the air flow rate decreased. Also, a constant pattern was shown according to the conditions. Even when particles were generated for a long time (6 h), the concentration was kept constant without significant deviation. The distribution of the particles was approximately 80 % for particles of 60 nm to 260 nm, 1.7 % for 1 ㎛ or larger, 0.908 mg/㎥ for the mass concentration, 111 nm for MMAD and 2.10 for GSD. Most of the ABS particles were circular with a size of less than 10 nm, and these circular particles were aggregated to form a cluster of grape with a size of several tens to several hundred nm.

• Journal of Power System Engineering
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• v.18 no.1
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• pp.91-98
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• 2014

In this investigation, the effect of crack orientation on spatial randomness of fatigue crack growth rate (FCGR) in friction stir welded (FSWed) 7075-T651 aluminum alloy joints has been statistically analyzed by Weibull distribution. The fatigue crack growth tests are conducted under three different constant stress intensity factor range (SIFR) control at room temperature with R = 0.1 and frequency 10Hz on compact tension (CT) specimen machined at base metal (BM) and weld metal (WM). The experimental fatigue crack growth rate data were obtained for two types of specimens having LT and TL orientations. LT specimens both base metal and weld metal showed higher fatigue crack growth rate as compared to TL specimens. In the lower SIFR region, FCGR were found to be almost 3 times higher in higher SIFR region. The shape parameter of Weibull both LT and TL orientation for FCGR was increased with increasing SIFR, the scale parameter was also increased with increasing SIFR. The smallest value of the shape parameter was shown in weld metal specimens having LT orientation at lower SIFR region.

• Journal of Mechanical Science and Technology
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• v.14 no.6
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• pp.690-698
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• 2000

The laminar boundary layer flow and heat transfer of anisotropic fluids in the vicinity of a wedge have been examined with constant surface temperature. The similarity variables found by Falkner and Skan are employed to reduce the stream wise-dependence in the coupled nonlinear boundary layer equations. The numerical solutions are presented using the fourth-order Runge - Kutta method and the distribution of velocity, micro-rotation, shear and couple stresses and temperature across the boundary layer are plotted. These results are also compared with the corresponding flow problems for Newtonian fluid over wedges. It is found that for a constant wedge angle, the skin friction coefficient is lower for micropolar fluid, as compared to Newtonian fluid. For the case of the constant material parameter K, however, the magnitude of velocity for anisotropic fluid is greater than that of Newtonian fluid. The numerical results also show that for a constant wedge angle with a given Prandtl number, Pr = I, the effect of increasing values of K results in increasing thermal boundary layer thickness for anisotropic fluid, as compared with Newtonian fluid. For the case of the constant material parameter K, however, the heat transfer rate for anisotropic fluid is lower than that of Newtonian fluid.

• Journal of the Korea Safety Management & Science
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• v.13 no.1
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• pp.195-202
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• 2011

The study interprets each of three classification models based on Bath-Tub Failure Rate (BTFR), Extreme Value Distribution (EVD) and Conjugate Bayesian Distribution (CBD). The classification model based on BTFR is analyzed by three failure patterns of decreasing, constant, or increasing which utilize systematic management strategies for reliability of time. Distribution model based on BTFR is identified using individual factors for each of three corresponding cases. First, in case of using shape parameter, the distribution based on BTFR is analyzed with a factor of component or part number. In case of using scale parameter, the distribution model based on BTFR is analyzed with a factor of time precision. Meanwhile, in case of using location parameter, the distribution model based on BTFR is analyzed with a factor of guarantee time. The classification model based on EVD is assorted into long-tailed distribution, medium-tailed distribution, and short-tailed distribution by the length of right-tail in distribution, and depended on asymptotic reliability property which signifies skewness and kurtosis of distribution curve. Furthermore, the classification model based on CBD is relied upon conjugate distribution relations between prior function, likelihood function and posterior function for dimension reduction and easy tractability under the occasion of Bayesian posterior updating.

• Communications for Statistical Applications and Methods
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• v.23 no.5
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• pp.423-432
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• 2016

In this paper, we stochastically analyze the continuous time surplus process in a risk model which involves a continuous type investment. It is assumed that the investment of the surplus to other business is continuously made at a constant rate, while the surplus process stays over a given sufficient level. We obtain the stationary distribution of the surplus level and/or its moment generating function by forming martingales from the surplus process and applying the optional sampling theorem to the martingales and/or by establishing and solving an integro-differential equation for the distribution function of the surplus level.