• Journal of Pharmaceutical Investigation
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• v.23 no.1
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• pp.27-32
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• 1993

Pharmacokinetic drug interaction between phenytoin and diltiazem was investigated following i.v. administration concomitantly to rabbits. Diltiazem was coadministered at doses of 1, 2 and 3 mg/kg, respectively, with phenytoin (5 mg/kg) to rabbits. Plasma concentration and AUC of phenytoin were increased significantly, but volume of distribution and total body clearance were decreased significantly (p<0.05) at doses of 2 mg and 3 mg/kg of diltiazem. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and that therapeutic drug monitoring should be practiced for reduction of side or toxic effect when phenytoin should be administered with diltiazem in clinical practice.

• The Journal of Engineering Geology
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• v.22 no.3
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• pp.275-281
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• 2012

Thermal distribution in soils must be considered in engineering designs and constructions, including estimates of frost heave and thaw settlement, infrastructure in cold regions, and geothermal systems. Because thermal conductivity is a key parameter for evaluation of thermal distribution in soils, it must be accurately estimated. The thermal conductivity of fine-grained soils has been widely studied in recent years; however, few studies have reported a reliable method for experimental measurement. The present study presents the results of an experimental investigation of the thermal conductivity of a saturated kaolinite-silica mixture with respect to the variation of dry density. Thermal conductivities were measured in Constant Rate of Strain (CRS) consolidation tests, and the experimental data were analyzed to evaluate the accuracy of the new measurement system. In addition, we present an evaluation method for predicting thermal conductivity in fine-grained soils.

• Journal of Korean Society of Water and Wastewater
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• v.28 no.4
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• pp.441-451
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• 2014

The flushing is important to maintain good water quality in water main. It is a technique of using water velocity to remove sediments in water distribution system. The variety of water quality problems can occur in a distribution system, so too can a variety of benefits be gained by system flushing. In order to effectively perform the flushing, the contaminants to be removed to set up and it can be solved, it is necessary to ensure the proper flow rate. In this study, the removal of contaminants present in the inner water pipe attached loose deposits such as fine particles of granular activated carbon, sand and iron corrosion product sought to derive flow rates. Thus, the constant observation of using pilot plant scale water distribution plant for the movement of floating characteristics of particles were assessed.

• Journal of ILASS-Korea
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• v.21 no.2
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• pp.78-87
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• 2016

This study experimentally investigated the effects of droplet temperature on the heat transfer characteristics during collision of a single droplet on a heated wall above the Leidenfrost temperature. Experiments were performed by varying temperature from 40 to $100^{\circ}C$ while the collision velocity and wall temperature were maintained constant at 0.7 m/s at $500^{\circ}C$, respectively. Evolution of temperature distribution at the droplet-wall interface as well as collision dynamics of the droplet were simultaneously recorded using synchronized high-speed video and infrared cameras. The local heat flux distribution at the collision surface was deduced using the measured temperature distribution data. Various physical parameters, including residence time, local heat flux distribution, heat transfer rate, heat transfer effectiveness and vapor film thickness, were measured from the visualization data. The results showed that increase in droplet temperature reduces the residence time and increases the vapor film thickness. This ultimately results in reduction in the total heat transfer by conduction through the vapor film during droplet-wall collision.

• Biomolecules & Therapeutics
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• v.8 no.2
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• pp.171-178
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• 2000

To evaluate the pharmacokinetic properties and tissue distribution of a newly developed recombinant human erythropoietin (GC-rhEPO), we analyzed the plasma and tissue levels of erythropoietin by an ELISA after intravenous (IV) and subcutaneous (SC) adminstration to the male rats at the doses of 20, 100, 500 or 2,500 unit/kg. After single IV bolus injection of GC-rhEPO, the plasma concentration was rapidly increased and decreased with two phases with half-lives of 13.4 min and 2.94 hours. AUC was increased dose- dependently but plasma half-lives remained constant regardless of GC-rhEPO doses. Following SC administration, the plasma concentration increased slowly with half-life of 9.2 hours and reached peak at 8 hours. Mean residence time and bioavailability were 18.2 hours and 44%, respectively. After single IV dose of 100 unit/kg, tissue GC-rhEPO level was higher in bone marrow and spleen, while the depletion rate was slower in liver and bone marrow, indicating the higher affinity of GC-rhEPO to bone marrow. Taken together, the experimental results indicate that GC-rhEPO contained the typical pharmacokinetic properties and the tissue distribution patterns inherent to human erythropoietin.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.7
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• pp.2159-2166
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• 1996

The stochastic properties of variation in fatigue crack growth are important in reliability and stability of structures. In this study,the stochastic model for the variation of fatigue crack growth rate was proposed in consideration of nonhomogeneity of materials. For this model, experiments were ocnducted on 7075-T6 aluminum alloy under the constant stress intensity factor range. The variation of fatigue crack growth rate was expressed by random variables Z and r based on the variation of material coefficients C and m in the paris-Erodogan's equation. The distribution of fatigue life with respect to the stress intensity factor range was evaluated by the stochastic Markov chain model based on the Paris-Erdogan's equation. The merit of proposed model is that only a small number of test are required to determine this this function, and fatigue crack growth life is easily predicted at the given stress intensity factor range.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.10
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• pp.1119-1124
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• 2009

This paper deals with the variability analysis of short term creep rupture test data based on the previous creep rupture tests and the possibility of the creep life prediction. From creep tests performed by constant uniaxial stresses at 600, 650 and $700^{\circ}C$ elevated temperature, in order to investigate the variability of short-term creep rupture data, the creep curves were analyzed for normalized creep strain divided by initial strain. There are some variability in the creep rupture data. And, the difference between general creep curves and normalized creep curves were obtained. The effects of the creep rupture time (RT) and steady state creep rate (SSCR) on the Weibull distribution parameters were investigated. There were good relation between normal Weibull parameters and normalized Weibull parameters. Finally, the predicted creep life were compared with the Monkman-Grant model.

• Proceedings of the KWS Conference
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• 1996.10a
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• pp.3-15
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• 1996

The formation of a thicker hard alloyed layer have been investigated on the surface of aluminum cast alloy (AC2B) by PTA overlaying process with Cr, Cu and Ni motel powders under the condition of overlaying current 125-200A. overlaying speed 150 mm/min and different powder feeding rate 5-20 g/min. In addition the characteristics of hardening and wear resistance of alloyed layer here been examined in relation to the microstructure of alloyed layer. Main results obtained were summarized as follows: 1) There was an optimum overlaying condition to get a good alloyed layer with smooth surface. This good layer became easy to be formed as increasing overlaying current and decreasing powder feeding rate under a constant overlaying speed. 2) Cu powder was the most superior one in metal powders used due to a wide optimum overlaying condition range, uniform hardness distribution of Hv250-350, good oar resistance and freedom from cracking in alloyed layer with fine hyper-eutectic structure. 3) On the contrary, irregular hardness distribution was usually obtained in Cr ar Ni alloyed layers of which hardness was increased as Cr or Ni contents and reached to maximum hardness of about Hv400-850 at about 60wt%cr or 40wt%Ni in alloyed layer. 4) Cracking occurred in Cr or Ni alloyed layers with higher hardness than Hv250-300 at mere than 20-25wt% of Cr or Ni contents in alloyed layer. Porosity was observed in all alloyed layers but decreased by usage of spherical powder with smooth surface.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.5
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• pp.815-821
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• 1994

Short-term fading in a mobile radio channel is mainly caused by multipath reflected wave by local scatterers or natural obstacles surrounding a mobile unit. In this paper, we analyze probability density function(PDF), level crossing rate(LCR) and widths and depths of fades for the measured field strength data in Seoul and Daejeon areas. As a result, the satatistical distribution of signal variations within any small area with the constant mean value becomes the Rayleigh distribution The variation of fade depths is small regardless of the environment such as urban, suburban. etc. However, the variation of fade widths is large with the change of circumstantial structures and environment. the maximum level crossing rate is obtained near the mean value.

• The Journal of Fisheries Business Administration
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• v.35 no.1
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• pp.117-132
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• 2004

This study attempts to suggest a new approach of the estimation of range and degree of fisheries damages caused by a large scale of reclamation undertaken in coastal area using the central limit theorem(CLT) in statistics. The key result of the study is the introduction of the new concept of critical variation of environmental factor($d_{c}$). The study defines $d_{c}$ as a standard deviation of the sample mean($\bar{X}$) of environmental factor(X), in other words, $\frac{\sigma}{ \sqrt{n}}$. The inner bound of $d_{c}$ could be the area of fisheries damages caused by public coastal undertaking. The study also defines the decreasing rate of fisheries production$\delta_{\varepsilon}$, in other words, degree of fisheries damages, as the rate of change in the distribution of sample mean(($\bar{X}$), caused by the continuous and constant variation of environmental factor. Therefore $\delta_{\varepsilon}$ can be easily calculated by the use of table of the standardized normal distribution.