• Parasites, Hosts and Diseases
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• 제60권5호
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• pp.317-325
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• 2022

Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the master regulators of immune and metabolic cellular functions. HIF-1α, a transcriptional factor whose activity is closely related to oxygen levels, is a target for understanding infectious disease control. Several studies have demonstrated that HIF-1α plays an important role during the infectious process, while its role in relation to parasite virulence has not been addressed. In this work, we studied the expression levels of HIF-1α and related angiogenic vascular endothelial growth factor A (VEGF-A) in human macrophages infected with promastigotes of hypo- or hyper-virulent Leishmania major human isolates. L. major parasites readily subverted host macrophage functions for their survival and induced local oxygen consumption at the site of infection. In contrast to hypo-virulent parasites that induce high HIF-1α expression levels, hyper-virulent L. major reduced HIF-1α expression in macrophages under normoxic or hypoxic conditions, and consequently impeded the expression of VEGF-A mRNA. HIF-1α may play a key role during control of disease chronicity, severity, or outcome.

• Journal of Yeungnam Medical Science
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• 제37권4호
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• pp.286-295
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• 2020

Respiratory infections are very common and highly contagious. Respiratory infectious diseases affect not only the person infected but also the family members and the society. As medical sciences advance, several diseases have been conquered; however, the impact of novel infectious diseases on the society is enormous. As the clinical presentation of respiratory infections is similar regardless of the pathogen, the causative agent is not distinguishable by symptoms alone. Moreover, it is difficult to develop a cure because of the various viral mutations. Various respiratory infectious diseases ranging from influenza, which threaten the health of mankind globally, to the coronavirus disease 2019, which resulted in a pandemic, exist. Contrary to human expectations that development in health care and improvement in hygiene will conquer infectious diseases, humankind's health and social systems are threatened by novel infectious diseases. Owing to the development of transport and trading activity, the rate of spread of new infectious diseases is increasing. As respiratory infections can threaten the members of the global community at any time, investigations on preventing the transmission of these diseases as well as development of effective antivirals and vaccines are of utmost importance and require a worldwide effort.

• Journal of Veterinary Science
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• 제21권3호
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• pp.51.1-51.5
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• 2020

A novel coronavirus emerged in human populations and spread rapidly to cause the global coronavirus disease 2019 pandemic. Although the origin of the associated virus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) remains unclear, genetic evidence suggests that bats are a reservoir host of the virus, and pangolins are a probable intermediate. SARS-CoV-2 has crossed the species barrier to infect humans and other animal species, and infected humans can facilitate reverse-zoonotic transmission to animals. Considering the rapidly changing interconnections among people, animals, and ecosystems, traditional roles of veterinarians should evolve to include transdisciplinary roles.

• Journal of applied mathematics & informatics
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• 제27권3_4호
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• pp.779-793
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• 2009

This paper deals with a delayed SEIRS epidemic model with pulse vaccination and crowded incidence rate. Moreover, the case of vertical and horizontal transmission is considered. By using the discrete dynamical system determined by the stroboscopic map, the exact infection-free periodic solution of the SEIRS model is obtained. Further, by employing the comparison arguments, we prove that under the condition that $R_*$ < 1 the infection-free periodic solution is globally attractive, and that under the condition that $R^*$ > 1 the disease is uniformly persistent, which means that after some period of time the disease will become endemic.

• Clinical Endoscopy
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• 제55권2호
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• pp.191-196
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• 2022

Unlike simple forward-viewing endoscopes such as gastroscope or colonoscope, duodenoscope houses much more complex design to fulfil its function. This design differences leave duodenoscopes more prone to contamination from inadequate disinfection process and potential dissemination of pathogens. Recent reports on dissemination of infection through the duodenoscope mandated an overhaul of duodenoscope utilization including development of a disposable duodenoscope. This article reviews the current state of disposable duodenoscope development, including reported early efficacy as well as its future direction and utilization.

• 한국재난정보학회 논문집
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• 제17권2호
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• pp.275-288
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• 2021

연구목적: 본 연구는 가축전염병 가축사체처리 및 방역관리에 대한 특성을 분석하고, 가축전염병 방역과 사후 관리의 실효성을 제시하는 것을 목적으로 한다. 연구방법: 실제로 가축전염병이 발생하여 가축 사체를 처리한 매몰지 및 매몰 관리시설을 현장 방문하여 관리현황과 문제점을 분석하였다. 연구결과: 가축전염병 발생 가축의 매몰방식과 그에 따른 장기적인 후속 관리는 많은 인력과 예산을 투입하게 만들어 비효율적인 방역시스템임을 알 수 있었다. 결론: 2차적인 감염병 전파우려가 없고 후속 관리가 필요 없는 정부와 광역 시도 및 시군구 차원의 통합 가축전염병동물 사체처리 시설 설립 방안의 검토가 필요하다.

• 디지털융복합연구
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• 제16권10호
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• pp.389-398
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• 2018

본 연구는 호흡기 감염 전파 예방을 위한 기침예절에 대한 지식과 실행수준 및 영향요인을 파악하기 위해 시행하였다. 2018년 8월 13일부터 9월 19일까지 19세 이상 성인 250명을 대상으로 자가보고식 설문지를 이용하여 자료를 수집하였으며, 이 중 213명의 자료를 분석에 이용하였다. 연구결과 기침예절 지식과 실행수준은 100점으로 환산 시 평균 지식수준이 $70.99{\pm}19.92$점, 실행수준은 $70.63{\pm}10.25$점으로 중간 수준이었다. 기침예절 지식과 실행수준 간에는 유의한 양의 상관관계가 있었으며, 다중회귀분석에서 기침예절 실행에 영향을 미치는 요인으로는 성별, 평소 손수건을 가지고 다님, 평소 휴지를 가지고 다님, 일평균 손씻기 횟수, 기침예절에 대해 알고 있음, 기침예절 지식 수준이 유의하였다. 본 연구결과에서 확인된 기침예절 실행 영향 요인을 반영한 교육 프로그램의 개발과 적용이 필요하며, 기침예절 실행수준이 높아짐에 따라 호흡기 감염 전파 예방에 도움이 될 것이다.

• 한국동물위생학회지
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• 제42권2호
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• pp.117-120
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• 2019

Bovine viral diarrhea Virus (BVDV) infections cause respiratory, gastrointestinal, and reproductive problems, such as infertility, abortion, stillbirth, and sickly offspring. Many countries have reduced the economic damage through the application of different control programmes, and some have successfully eradicated BVD. Detection and elimination of cattle persistently infected (PI) with BVDV is important for BVD eradication because PI cattle are a main source of BVD transmission. In this study, the prevalence of Korean native cattle persistently infected (PI) with BVDV was investigated and determined in 49 farms with 3,050 cattle. The all samples were collected by ear notch sampling. Korean native cattle with initial positives on antigen-ELISA (Ag-ELISA) were sampled again after 3~4 weeks and cattle with second positives in both Ag-ELISA and immunohistochemistry (IHC) were identified as PI cattle. Among the 49 farms, 14 (28.6%) farms had at least more than one PI cow and 21 (0.69%) of 3,050 cattle were determined as PI cattle. As a result of this work, it is suggested that national BVD eradication program is required to reduce economic losses by BVDV infection in Korean cattle industries.

• 기본간호학회지
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• 제23권2호
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• pp.136-148
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• 2016

Purpose: This study was done to investigate the level of nursing students' awareness, attitude, safety climate, and performance of infection control, and to identify factors influencing performance. Methods: The sample consisted of 239 nursing students from 5 nursing schools. Data were collected from November 15 to December 11, 2013 and analyzed by frequency, t-test, ANOVA, Pearson correlation coefficients, and multiple stepwise regression with SPSS/WIN 21.0. Results: Of the participants, 216 (90.4%) had experienced contact with infectious diseases. The performance of personal hygiene was scored the highest followed by standard precautions, transmission precautions, and vaccination. There were significant correlations between awareness, attitude, safety-climate and performance. Awareness, safety-climate, attitude, contents of infection control education, and direct exposure to infectious disease collectively explained 30% of the variance in performance, and awareness was the most influential factor. Conclusion: The results indicate that performance of infection control by nursing students can be increased if awareness, safety climate, attitude, and contents of infection control education are improved, and exposure to infectious disease is decreased. These findings can be utilized to improve performance by developing education programs for infection control.

• 한국빅데이터학회지
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• 제7권2호
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• pp.103-111
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• 2022

감염병 대응과 관련된 기관, 조직, 사이트 등의 다수 운영되고 있으나 코로나-19와 같은 팬더믹 상황이 수년간 지속됨에 따라 초기양상과 현재 양상의 수많은 변화가 있으며 이에 따른 정책과 대응체계도 진화하고 있다. 이에 따른 지역별 격차가 발생하고 정책에 대한 신뢰와 불신, 이행도에 따른 여러 가지 문제들이 산재해 있다. 따라서 본 연구에서는 정보전염이 포함된 소셜 데이터를 분석하는 과정에서 루머가 포함된 데이터를 수집하는 과정에서 팩트 체크가 되는 언론 매체와 다르게 정확한 출처를 알 수 없는 부정확한 정보들이 포함되는 주요 소셜 미디어 플랫폼 중의 하나인 트위터 데이터를 수집하여 사실과 무관한 내용을 사전 차단하는 시스템을 개발했다. 비정형데이터인 소셜데이터를 기반으로 감염병 위협을 자동 감지할 수 있는 알고리즘을 개발하여 감염병 위기 대응과 관련된 객관적인 근거를 창출함으로써 관련 분야 국제경쟁력을 공고히 하고자 한다.