• 대한예방한의학회지
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• 제18권2호
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• pp.47-58
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• 2014

Objective : In Oriental medicine, the concept of Preventive Treatment Disease(治未病, PTD) is intended to actively deal with changes in modern disease patterns due to increase in chronic diseases. In China, preventive health service program based on PTD Theory are being carried out aimed at improving and/or preventing people's health. Method : For the introduction of PTD program based preventive service in Korea for the promotion of people's health, I would like to consider its possibility by reviewing the PTD program being conducted in China. Results : China's preventive health service programs based on PTD Theory started in 2008 for the purpose of promoting people's health and reducing medical expenses by providing medical services tailored to individuals. Regarding the effects of PTD program based preventive health service, improvement of discomforting symptoms comprised 73.04% of responses. As to service items, health guidance, Traditional Chinese Medicinal diagnosis, and preparation of health records were answered as being important. The importance of food and internal medicines for preventing and/or curing PTD Theory are also recognized. Also, as to satisfaction level, 90.64% responded as being satisfied in the order of the level of service providers, their attitudes, service processes, items, costs, and environments. Conclusion : As shown above, according to assessments on China's PTD programs, the PTD Theory is being applied to actual public health programs with highly effective results. Hence, it can be seen that such attempt could also be implemented in Korea as part of a scheme for promoting health by means of Korean medicine health promotion programs. However, further researches into concrete implementation schemes will have to be developed in the future as medical systems are different in Korea from in China.

• 대한한의학방제학회지
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• 제25권4호
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• pp.437-447
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• 2017

Objective : Zhang zhi-cong insisted the theory related to the 'Six-meridian qi transformation', and Zhen xiu-yuan inherited that theory understanding six-meridian disease of "Shang-Han-Lun". This emphasizes that the disease of 'three yin and three yang' in "Shang-Han-Lun" is a disease caused by Six-meridian qi transformation, not a lesion of meridian itself. He said, "If you do not know brightly in the 'Tip, Root and Middle qi', you can not read the "Shang-Han-Lun"." Therefore, in this paper, we examine the interpretation of the "Shang-Han-Lun"by using the theory of 'five circuits and six qi'. Method : First, extract sentences related to 'Tip, Root and Middle qi' from the sentences of "Shang-Han-Lun" Second, the sentence is interpreted through the Zhen xiu-yuan's "Sang han lun qian zhu". Third, the meaning of the sentence is examined and summarized. Result : Zhen xiu-yuan proposed a clear and systematic theory that can understand the meaning of Six-meridian in "Shang-Han-Lun", by utilizing the discipline that 'Tip, Root and Middle qi' Conclusion : The change of 'Tip, Root and Middle qi' is a very central theory that explains the properties of 'Yin and Yang' and mutual correspondence among Korean medicine theories. It also provides basic directions for understanding the changing patterns of disease.

• Journal of Nutrition and Health
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• 제30권4호
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• pp.451-457
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• 1997

This study was designed to investigate the effect of the ratio of energy from carbohydrate to total calories on dietary intake, obesity index, blood pressure, and blood lipid content in cardiovascular disease patients over 35 years old. A total of 552(227 male, 325 female) subjects were divided into three groups according to carbohydrate/total energy ratio : carbohydrate ratios below 25 percent were in the low carbohydrate group( <61.1%), between 25 and 75 percent carbohydrate were medium($\geq$61.1-<74.7%), and higher than 75 percent were in the high carbohydrate group($\geq$74.7%). The anthropometric data, nutrient intake, serum lipid levels, and blood pressure of each group were compared with one another. For men and women with high carbohydrate intakes, Inadequate nutritional intake was observed. Abdominal fat accumulation and blood TC level for men in the high carbohydrate group were higher than in medium or low carbohydrate groups. Therefore, it seems that high carbohydrate intake may produce adverse effects on abdominal fat accumulation and blood lipid patterns. Blood pressure, however, was significantly higher for women in low and high carbohydrate groups than in medium carbohydrate group. These results suggest that extremely high and low carbohydrate intake may raise the risk of cardiovascular disease and that it is necessary to consume nutritionally balanced meals. This can be done by controlling the ratio of dietary carbohydrate at a medium level in order to prevent and/or to reduce the risk.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3057-3060
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• 2015

Background: Cytological examination of pleural effusions is very important in the diagnosis of malignant lesions. Thoracentesis is the first investigation to be performed in a patient with pleural effusion. In this study, we aimed to compare traditional with cell block methods for diagnosis of lung disease accompanied by pleural effusion. Materials and Methods: A total of 194 patients with exudative pleural effusions were included. Ten mililiters of fresh pleural fluid were obtained by thoracentesis from all patients in the initial evaluation. The samples gathered were divided to two equal parts, one for conventional cytological analysis and the other for analysis with the cell block technique. In cytology, using conventional diagnostic criteria cases were divided into 3 categories, benign, malignant and undetermined. The cell block sections were evaluated for the presence of single tumor cells, papillary or acinar patterns and staining with mucicarmine. In the cell block examination, in cases with sufficient cell counts histopathological diagnosis was performed. Results: Of the total undergoing conventional cytological analyses, 154 (79.4%)were reported as benign, 33 (17%) as malignant and 7 (3.6%) as suspicious of malignancy. With the cell block method the results were 147 (75.8%) benign, 12 (6.2%) metastatic, 4 (2.1%) squamous cell carcinoma, 18 (9.3%) adenocarcinoma, 5 (2.6%) large cell carcinoma, 2 (1%) mesothelioma, 3 (1.5%) small cell carcinoma, and 3 (1.5%) lymphoma. Conclusions: Our study confirmed that the cell block method increases the diagnostic yield with exudative pleural effusions accompanying lung cancer.

• 대한간호학회지
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• 제38권4호
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• pp.582-592
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• 2008

Purpose: The purpose of this research was to analyze the effects of an eye protective device and ear protective device application on sleep disorder with coronary disease patients in CCU. Methods: The research design was set up as a nonequivalent control group non-synchronized design. The subjects were coronary disease patients in the CCU of a tertiary hospital. The subjects were composed of 20 in the group with an eye protective device, 18 in the group with an ear protective device, 17 in the group with an eye protective device and ear protective device and 20 in the control group. The data was analyzed by $X^2-test$, ANOVA, Repeated measures ANOVA, Sheffe-test, Simple main effect and Time contrast using SPSS Win 12.0. Results: The hypothesis, 'There are significant differences in sleep quantity among the four groups' was supported (F=1,342.71, p=.000). The hypothesis, 'There are significant differences in the subjective evaluation of the general sleep patterns among the four groups' was supported (F=3,638.73, p=.000). In addition the hypothesis, 'There are significant differences in degree of sleep among the four groups' was supported (F=1,616.61, p=.000). Conclusion: It is cost effective and a simple eye protective device and ear protective device should be applied to patients according to their preference and characteristics in the clinical setting.

• Journal of Yeungnam Medical Science
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• 제25권2호
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• pp.117-123
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• 2008

Dermatomyositis is characterized by progressive, symmetric, proximal muscle weakness and a nonsuppurative inflammatory myopathy of unknown etiology involving predominantly skeletal muscles. It is also characterized by typical skin lesions. Interstitial lung disease has a poor prognosis when it is associated with dermatomyositis. Organizing pneumonia is a disease in which granulation tissue fills the lumina of terminal and respiratory bronchioles and extends into the distal airspaces. The cryptogenic nature of the process is appreciated in that organizing pneumonia patterns of injury can be seen in secondary forms of the disease (secondary organizing pneumonia). Organizing pneumonia has been reported to occur in 5~10% in dermatomyositis-polymyositis patients. Anti-histidyl tRNA synthetase antibody (anti-Jo-1) is a predictive disease marker that is reported to occur in up to 70% of patients. We describe a 49-year-old male dermatomyositis patient who presented with organizing pneumonia and was found to have negative anti-Jo-1 antibody.

• 혜화의학회지
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• 제13권1호
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• pp.27-38
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• 2004

Saam acupuncture has an evident principles of prescription based on acupuncture tonification and purgation of Nan-gyeong but many prescriptions of Saam acupuncture are not typical patterns. Therefore it is difficult to understand principles of those prescriptions. Understanding the principles of any prescription means understanding the physiology and pathology of that prescription and it have an important role in selecting the best prescription and taking the most effective treatment. This paper studies principles of prescriptions of the king fire and the premier fire. The theoretical authorities of analysis are Nan-gyeong, works of Joo dan-gye and Li dong-won and Uihakimmun. The damage of fire to mentality is very intensive and severe. The prescriptions of the king fire and premier fire have a good effect on diseases by fire. The fire of human body are two types, the king fire and the premier fire but the water of human body is only one and then inferior to fire. The fire superior to the water is unstable and the fire influences rapidly and intensively on four elements, wood, earth, metal, water. So the control of the water is the key to treat the disease by fire. Considering the attack and the treatment of disease, heart and liver are attacked with a disease by fire in its early stage and kidney and lung are the key to treatment. Consequently the pathology of the disease by fire is corresponding to the theory- Yang Sufficient, Yin Deficient- of Joo dan-gye. It seems that the theory of Joo dan-gye influenced on the medical theory of Saam Acupuncture. On that account I believe that the study of medical theories of the Geum and Won Dynasty that various medical theories appeared is very available.

• Journal of Periodontal and Implant Science
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• 제47권3호
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• pp.174-181
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• 2017

Purpose: Epitope spreading is a phenomenon in which distinct subdominant epitopes become major targets of the immune response. Heat shock protein (HSP) 60 from Porphyromonas gingivalis (PgHSP60) and peptide 19 from PgHSP60 (Pep19) are immunodominant epitopes in autoimmune disease patients, including those with periodontitis. It remains unclear whether Pep19 is a dominant epitope in subjects without periodontitis or autoimmune disease. The purpose of this study was to determine the epitope spreading pattern and verify Pep19 as an immunodominant epitope in healthy teenagers using dot immunoblot analysis. The patterns of epitope spreading in age-matched patients with type 1 diabetes mellitus (type 1 DM) and healthy 20- to 29-year old subjects were compared with those of healthy teenagers. Methods: Peptide from PgHSP60, Mycobacterium tuberculosis HSP60 (MtHSP60), and Chlamydia pneumoniae HSP60 (CpHSP60) was synthesized for comparative recognition by sera from healthy subjects and patients with autoimmune disease (type 1 DM). Dot immunoblot analysis against a panel of peptides of PgHSP60 and human HSP60 (HuHSP60) was performed to identify epitope spreading, and a densitometric image analysis was conducted. Results: Of the peptide from PgHSP60, MtHSP60, and CpHSP60, PgHSP60 was the predominant epitope and was most consistently recognized by the serum samples of healthy teenagers. Most sera from healthy subjects and patients with type 1 DM reacted more strongly with PgHSP60 and Pep19 than the other peptides. The relative intensity of antibody reactivity to Pep19 was higher in the type 1 DM group than in the healthy groups. Conclusions: Pep19 is an immunodominant epitope, not only in autoimmune disease patients, but also in healthy young subjects, as evidenced by their robust immunoreactivity. This result suggests that the Pep19-specific immune response may be an initiator that triggers autoimmune diseases.

• Asian-Australasian Journal of Animal Sciences
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• 제26권4호
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• pp.588-595
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• 2013

Mesenchymal stem cells (MSCs) are often known to have a therapeutic potential in the cell-mediated repair for fatal or incurable diseases. In this study, canine umbilical cord MSCs (cUC-MSCs) were isolated from umbilical cord matrix (n = 3) and subjected to proliferative culture for 5 consecutive passages. The cells at each passage were characterized for multipotent MSC properties such as proliferation kinetics, expression patterns of MSC surface markers and self-renewal associated markers, and chondrogenic differentiation. In results, the proliferation of the cells as determined by the cumulative population doubling level was observed at its peak on passage 3 and stopped after passage 5, whereas cell doubling time dramatically increased after passage 4. Expression of MSC surface markers (CD44, CD54, CD61, CD80, CD90 and Flk-1), molecule (HMGA2) and pluripotent markers (sox2, nanog) associated with self-renewal was negatively correlated with the number of passages. However, MSC surface marker (CD105) and pluripotent marker (Oct3/4) decreased with increasing the number of subpassage. cUC-MSCs at passage 1 to 5 underwent chondrogenesis under specific culture conditions, but percentage of chondrogenic differentiation decreased with increasing the number of subpassage. Collectively, the present study suggested that sequential subpassage could affect multipotent properties of cUC-MSCs and needs to be addressed before clinical applications.

• 대한수의학회지
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• 제39권4호
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• pp.738-742
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• 1999

The objective of this experiment was to investigate the effect of Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV) vaccination on performance of broiler chicks for five weeks. Two types of poultry houses and three patterns of vaccination ($NDV^-/IBDV^-$, $NDV^+/IBDV^-$ and $NDV^+/IBDV^+$) were factorially assigned to six treatments. NDV, B1 strain and IBDV, Bursin-2 vaccine were orally administered at 5, 14 and 7, 18 days, respectively. Forty eight hundred chicks were grouped into four replications with two hundnyd hybro $\times$ hybro chicks per each treatment. Weight gain, feed conversion ratio (FCR), mortality and product index were surveyed at the end of experiment. Bursa index and IBDV antibody titer of chicks were weekly measured. Weight gain of chicks vaccinated with $NDV^+/IBDV^+$ was significantly increased compared to that of other treatments at both window and windowless poultry houses (p<0.05). Chicks vaccinated with $NDV^+/IBDV^+$ also showed significantly improving the FCR and mortality compared to those of other treatments at both poultry houses (p<0.05). The bursa indecies of both poultry houses were high from one-day- to three-weeks-old, but were low for the rest of two weeks. IBDV antibody of all chicks was detected 100% by agar gel precipitation (AGP) test at one day old, but was not detected in $NDV^-/IBDV^-$ and $NDV^+/IBDV^-$ treatments at four weeks old. However, it showed 100% in $NDV^+/IBDV^+$ treatment. Antibody titer using ELISA showed similar trend to that of AGP test. The results of this experiment confirmed that IBDV and NDV combined vaccine significantly improved the performance of broiler chicks.